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Glucocorticoid signaling plays a role in brain function and resilience to stress, suggesting that J9 could be explored for its potential to modulate neuroendocrine responses in psychiatric and neurodegenerative conditions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"10 mg","offer_id":53040941007213,"sku":"SIH-182-10MG","price":144.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-182_J9_Chemical_Structure.png?v=1771837628"},{"product_id":"geldanamycin-bhb11900002","title":"Geldanamycin","description":"\u003cp\u003eGeldanamycin is a benzoquinone ansamycin antibiotic that targets HSP90, disrupting its chaperone function and leading to the degradation of oncogenic and neurotoxic client proteins. While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"1 mg","offer_id":53040941039981,"sku":"SIH-111A","price":74.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040964403565,"sku":"SIH-111B","price":228.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-111_Geldanamycin_Chemical_Structure.png?v=1771837629"},{"product_id":"ym-01-bhb11900012","title":"YM-01","description":"\u003cp\u003eYM-01 is an allosteric inhibitor of Hsp70 that binds within its nucleotide-binding domain, adjacent to the ATP\/ADP pocket. It disrupts Hsc70-Bag1 interactions and enhances Hsp70 binding to misfolded proteins. In neuroscience, YM-01 has shown efficacy in reducing tau protein levels in cellular and animal models of tauopathy, including Alzheimer's disease. It restores long-term potentiation in brain slices from tau-overexpressing mice, indicating potential for cognitive recovery. YM-01’s dual activity in protein quality control and synaptic function makes it a valuable tool for studying and potentially treating tau-related neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"10 mg","offer_id":53040941072749,"sku":"SIH-121-10MG","price":189.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040963715437,"sku":"SIH-121-25MG","price":378.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-121_YM-01_Chemical_Structure.png?v=1771837627"},{"product_id":"geldanamycin-biotin-bhb11900003","title":"Geldanamycin: Biotin","description":"\u003cp\u003eGeldanamycin is a benzoquinone ansamycin antibiotic that targets HSP90, disrupting its chaperone function and leading to the degradation of oncogenic and neurotoxic client proteins. While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"1 mg","offer_id":53040941105517,"sku":"SIH-112A","price":212.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-112_Geldanamycin_Biotin_Chemical_Structure.png?v=1771837626"},{"product_id":"115-7c-bhb11900014","title":"115-7C","description":"\u003cp\u003e115-7C is a small molecule that activates the ATPase activity of Hsp70 and promotes substrate refolding. It binds to the IIA subdomain of DnaK and enhances the formation of the DnaK-DnaJ complex. In neurodegenerative disease research, 115-7C is of interest for its role in maintaining proteostasis and preventing protein aggregation. By stimulating Hsp70’s chaperone activity, 115-7C may help mitigate the accumulation of misfolded proteins such as tau and alpha-synuclein, which are central to the pathology of Alzheimer’s and Parkinson’s diseases.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"5 mg","offer_id":53040941138285,"sku":"SIH-123-5MG","price":137.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040965583213,"sku":"SIH-123-25MG","price":515.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-123-115-7C-Chemical-Structure.png?v=1771837630"},{"product_id":"17-gmb-apa-ga-bhb11900006","title":"17-GMB-APA-GA","description":"\u003cp\u003e17-GMB-APA-GA is a synthetic analog of geldanamycin engineered with a maleimido moiety, enabling its use in the development of immunoconjugates. While its primary application has been in targeted cancer therapies, its potential in neuroscience lies in its ability to selectively bind HSP90, a chaperone protein implicated in neurodegenerative disease pathways. By facilitating the targeted delivery of HSP90 inhibitors to specific cell types, 17-GMB-APA-GA may offer a novel strategy for modulating proteostasis in neural tissues. This targeted approach could enhance the clearance of misfolded proteins such as alpha-synuclein and tau, which are central to the pathology of Parkinson’s and Alzheimer’s diseases. Although further research is needed to validate its efficacy in neural models, 17-GMB-APA-GA represents a promising tool for precision medicine in neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"1 mg","offer_id":53040941171053,"sku":"SIH-115A","price":231.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-115_17-GMB-APA-GA_Chemical_Structure.png?v=1771837631"},{"product_id":"geldanamycin-fitc-bhb11900004","title":"Geldanamycin: FITC","description":"\u003cp\u003eGeldanamycin is a benzoquinone ansamycin antibiotic that targets HSP90, disrupting its chaperone function and leading to the degradation of oncogenic and neurotoxic client proteins. While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. 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Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"1 mg","offer_id":53040941203821,"sku":"SIH-113A","price":231.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-113_Geldanamycin_FITC_Chemical_Structure.png?v=1771837631"},{"product_id":"tpck-bhb11900036","title":"TPCK","description":"\u003cp\u003eTPCK (Tosyl phenylalanyl chloromethyl ketone) is a protease inhibitor known to target serine and cysteine proteases. In neuroscience, TPCK is utilized to study protease-mediated signaling pathways and neuroinflammation. 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SRC kinases are involved in synaptic plasticity and neuroinflammation, and their dysregulation is linked to neurodegenerative diseases. CCT196969’s ability to modulate these pathways may offer therapeutic insights into CNS disorders characterized by aberrant kinase activity.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"10 mg","offer_id":53040941302125,"sku":"SIH-185-10MG","price":403.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-185_CCT196969_Chemical_Structure.png?v=1771837630"},{"product_id":"decitabine-bhb11900140","title":"Decitabine","description":"\u003cp\u003eDecitabine is a DNA methyltransferase inhibitor that induces hypomethylation of DNA, leading to the reactivation of silenced genes. While primarily used as an antineoplastic agent in hematologic malignancies, its epigenetic modulation capabilities have implications in neuroscience. Decitabine has been shown to enhance neuronal plasticity, promote neurogenesis, and influence memory-related gene expression. These properties make it a valuable compound for exploring the role of DNA methylation in neurodevelopmental and neurodegenerative disorders. Its ability to modulate gene expression without altering the DNA sequence positions Decitabine as a powerful tool in epigenetic research related to brain function and disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"10 mg","offer_id":53040941334893,"sku":"SIH-352-10MG","price":98.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040966238573,"sku":"SIH-352-50MG","price":281.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-352_Decitabine_Chemical_Structure.png?v=1771837635"},{"product_id":"necrostatin-bhb11900042","title":"Necrostatin","description":"\u003cp\u003eNecrostatin-1 is a specific inhibitor of necroptosis, a regulated form of necrotic cell death. It has demonstrated neuroprotective effects in models of stroke and excitotoxicity. 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These properties position hinokitiol as a candidate for therapeutic strategies targeting metal dysregulation and oxidative damage in the brain.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"50 mg","offer_id":53040941531501,"sku":"SIH-151-50MG","price":62.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":53040965648749,"sku":"SIH-151-250MG","price":194.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-151_Hinokitiol_Chemical_Structure.png?v=1771837632"},{"product_id":"sulindac-sulfone-bhb11900084","title":"Sulindac Sulfone","description":"\u003cp\u003eSulindac sulfone is a non-COX-inhibiting metabolite of sulindac that retains anti-inflammatory and pro-apoptotic properties. Unlike sulindac sulfide, it does not inhibit prostaglandin synthesis but selectively induces apoptosis in abnormal cells. 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TEMPO derivatives have also been investigated for their role in reducing mitochondrial dysfunction and inflammation, key contributors to neurodegenerative pathology.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc","offers":[{"title":"500 mg","offer_id":53040941597037,"sku":"SIH-155-500MG","price":27.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-155_TEMPO_Chemical_Structure.png?v=1771837628"},{"product_id":"5-azacytidine-bhb11900133","title":"5-Azacytidine","description":"\u003cp\u003e5-Azacytidine is a DNA methyltransferase inhibitor that incorporates into DNA and forms covalent adducts with DNMT1, leading to enzyme depletion and global DNA demethylation. This reactivates silenced genes and alters epigenetic landscapes. In neurodegenerative disease research, 5-Azacytidine is used to study the role of epigenetic regulation in neuronal differentiation, plasticity, and disease progression. 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