{"title":"Cells","description":"","products":[{"product_id":"12z-cell-bhc11101691","title":"12Z cell","description":"The 12Z cell line is an immortalized human endometriotic epithelial cell model derived from peritoneal endometriotic lesions. It was originally established by transfecting primary endometriotic epithelial cells with the SV40 large T antigen, enabling extended proliferative capacity. The 12Z cells are cytokeratin-positive and E-cadherin-negative, distinguishing them as an epithelial-like population with an invasive phenotype. These cells have been shown to exhibit high migratory and invasive behavior in vitro, similar to metastatic carcinoma cells, and express N-cadherin, a cadherin associated with increased invasiveness and motility. This molecular profile supports their use in studying invasion mechanisms relevant to endometriosis and parallels seen in cancer biology.\n\nFunctionally, 12Z cells express genes involved in estrogen and progesterone signaling, extracellular matrix remodeling, angiogenesis, cytokine production, and prostaglandin E2 (PGE2) biosynthesis and signaling. They exhibit elevated activity of matrix metalloproteinases MMP-2 and MMP-9, which are critical for degrading extracellular matrix components and facilitating tissue invasion. Furthermore, 12Z cells produce high levels of PGE2, an inflammatory mediator implicated in the pathophysiology of endometriosis. These features, along with their responsiveness to steroid hormones, make 12Z cells an effective in vitro model for dissecting the molecular underpinnings of endometriotic lesion establishment, invasion, and hormonal regulation.\n\nImportantly, recent quality control studies have confirmed the genetic authenticity of 12Z cells through STR (short tandem repeat) profiling, mitigating previous concerns about cross-contamination and misidentification in endometriosis research. These cells, along with the closely related Z11 line, have been proposed as standard models for improving reproducibility and reliability in the field of reproductive biology and endometriosis research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101691\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950194946413,"sku":"305733","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/12Z_20WaKo_20DAY1_20P1_2010X01_20240925_Overlay_1920x1920_0cc8ca53-bbf6-413b-b661-4cf210528b1e.png?v=1769068929"},{"product_id":"143b-cell-bhc11101424","title":"143B cell","description":"The 143B cell line is a human osteosarcoma cell line derived from a bone tumor. It is often used in cancer research due to its high metastatic potential and ability to form osteosarcoma tumors in vivo. These cells exhibit several key characteristics of osteosarcoma, including the expression of osteoblastic markers and the ability to produce osteoid. The 143B cell line is especially valuable for studying the mechanisms underlying bone cancer progression and metastasis, as well as for testing potential therapeutic agents aimed at treating osteosarcoma.\n143B cells are known for their rapid growth and high transfection efficiency, making them suitable for genetic manipulation and various experimental applications. These cells have been utilized in studies investigating the role of specific genes and signaling pathways in osteosarcoma development and resistance to chemotherapy. Additionally, the 143B cell line serves as a model for exploring the interactions between osteosarcoma cells and the bone microenvironment, providing insights into the complex biology of bone tumors.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101424\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195011949,"sku":"305232","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/143B_20WaKo_20P1_2010x01_20141024_ch00_1920x1920_870b3359-ae26-4e64-9097-f065ea130d52.jpg?v=1769068928"},{"product_id":"15p-1-cell-bhc11101301","title":"15P-1 cell","description":"15p-1 cells are a mammalian cell line derived from Mus musculus, specifically utilized for the study of cellular responses to steroid hormones. Originating from the testicular tissue of mice, these cells exhibit a unique sensitivity to androgens, which makes them particularly valuable in endocrinology and cancer research. The 15p-1 cell line expresses the androgen receptor (AR), enabling the study of androgenic effects on gene expression, cell growth, and differentiation processes.\nCharacteristically, 15p-1 cells are used to explore the molecular pathways influenced by androgens and their role in diseases such as prostate cancer. They provide a controlled in vitro environment to dissect the interactions between androgens and their cellular receptors, facilitating insights into both normal physiological and pathological states. This cell line is also instrumental in screening potential pharmaceuticals targeting androgen-related pathways, contributing to the development of therapeutic strategies.\nMaintained under standard cell culture conditions, 15p-1 cells require a medium enriched with fetal bovine serum (FBS) and an optimal temperature of 37°C, along with a CO2 concentration of 5% to mimic physiological conditions. Rigorous quality control is essential to preserve their genetic and phenotypic characteristics, ensuring reliable and reproducible results in research applications.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101301\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195044717,"sku":"305191","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/15P-1_20P1_2010x01_20230525_ch00_1920x1920_9839ac6f-f868-4bbd-87aa-9fe50956e0cc.jpg?v=1769068929"},{"product_id":"16hbe14o-cell-bhc11101425","title":"16HBE14o- cell","description":"The 16HBE140 cell line is derived from human bronchial epithelial cells, which are essential for studying the respiratory epithelium. These cells retain several key characteristics of primary bronchial epithelial cells, including the ability to form tight junctions, express characteristic markers, and exhibit typical epithelial morphology. They are widely used in research focusing on respiratory diseases, drug transport, and toxicology studies, providing a reliable in vitro model to understand bronchial epithelial cell behavior under various conditions.\nOne of the significant applications of 16HBE140 cells is in the investigation of cystic fibrosis (CF), a genetic disorder affecting the respiratory system. These cells express the cystic fibrosis transmembrane conductance regulator (CFTR) protein, making them a valuable tool for studying CF pathophysiology and for screening potential therapeutic agents. Additionally, 16HBE140 cells are utilized in airway inflammation research, given their response to pro-inflammatory cytokines and pollutants, aiding in the understanding of chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).\n\u003cp style=\"display:none\"\u003eSKU:BHC11101425\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195077485,"sku":"305234","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/16HBE14o_20WaKo_20P1_2020x01_20181024_ch00_1920x1920_4dbb6d23-1d2b-4f74-9bc0-dd509475e130.jpg?v=1769068929"},{"product_id":"2106t-cell-bhc11100246","title":"2106T cell","description":"The 2106T cell line has been established from pulmonary squamous cell carcinoma of a patient by Dr. Sandra Gottschling and Dr. Michael Meister in 2009. The 2106LN cell line was isolated from a lymph node metastasis of the same patient.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100246\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195110253,"sku":"300165","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/2106T_20WaKo_20P1_2010x01_20280525_ch00_1920x1920_b70a4584-a51c-45b5-a3cd-0b0b5953bc35.jpg?v=1769068930"},{"product_id":"22rv1-cell-bhc11101181","title":"22RV1 cell","description":"The 22Rv1 cell line is a human prostate carcinoma cell line that was established from a xenograft initiated by the inoculation of a hormone-refractory prostate cancer cell line, CWR22, into athymic nude mice. The CWR22 xenograft was derived from a primary prostate carcinoma. Upon regression after castration and subsequent relapse, the 22Rv1 cell line was established from the relapsed tumor, which exhibited androgen-independent growth.\n22Rv1 cells express the androgen receptor (AR) and prostate-specific antigen (PSA), essential markers in prostate cancer research and therapeutic targeting. Notably, this cell line contains a variant form of the AR known as AR-V7. This splice variant lacks the ligand-binding domain, enabling it to remain constitutively active and contribute to the androgen-independent proliferation of 22Rv1 cells, a critical aspect of castration-resistant prostate cancer (CRPC).\nThe 22Rv1 cell line is extensively used to investigate the mechanisms underlying the transition from androgen-dependent to androgen-independent prostate cancer growth, a key challenge in the treatment of advanced prostate cancer. 22Rv1 cells have facilitated significant advancements in understanding the molecular biology of CRPC, including the role of AR variants in resistance to androgen deprivation therapy (ADT) and the development of novel therapeutic strategies aimed at overcoming this resistance.\nIn summary, the 22Rv1 cell line, serves as a critical model for studying CRPC. Exhibiting androgen-independent growth, these cells express key prostate cancer markers such as AR and PSA, and notably contain the AR-V7 variant, which is constitutively active due to the absence of the ligand-binding domain. The 22Rv1 cell line's unique properties make it invaluable for exploring the transition from androgen-dependent to independent growth in prostate cancer, and thereby aid in the development of new therapeutic approaches to tackle advanced stages of the disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101181\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195175789,"sku":"305037","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/22Rv1_20305037_20P0_2020x1_2024112022_1920x1920_e8ccf06f-f9e1-4fab-982d-e4a7224fc4be.jpg?v=1769068930"},{"product_id":"2427t-cell-bhc11101374","title":"2427T cell","description":"Originating from a primary tumor of a 64-year-old female Caucasian patient diagnosed with lung squamous cell carcinoma, 2427T provides a valuable in vitro model that recapitulates the morphological traits of the original tumor tissue. Characterized by their distinctive small, round shape and propensity to aggregate into clusters, 2427T cells exhibit key morphological features typical of squamous cell carcinoma (SCC).\nA defining characteristic of the 2427T cell line is its expression of cytokeratin 5\/6 (CK5\/6), a marker indicative of its SCC origin. The heterogeneous expression of CK5\/6 hints at the presence of diverse cell subpopulations within the 2427T culture, presenting an opportunity for further exploration of intratumoral heterogeneity.\nImmunophenotyping of 2427T has revealed its unique profile, including the lack of adenocarcinoma-associated marker CK7, hemato-endothelial progenitor marker CD34, and leukocyte marker CD45, reinforcing its classification within the squamous lineage. Interestingly, while the cell line generally shows negativity for neuroendocrine markers such as CD56, synaptophysin (SYP), neuron-specific enolase (NSE), and chromogranin A (CHGA), the expression of SYP in a subset of cells suggests a degree of neuroendocrine marker heterogeneity.\nCrucially, the 2427T cell line does not harbor mutations in EGF-R or k-ras, distinguishing it from other models and underscoring its potential as a novel resource for delving into the biology and therapeutic vulnerabilities of squamous cell non-small cell lung cancer (NSCLC). This absence of common oncogenic mutations positions 2427T as an invaluable tool for research aimed at uncovering the underlying mechanisms of squamous cell carcinoma pathogenesis and progression.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101374\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195208557,"sku":"300167","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/2427T_20P1_2020x01_20250425_ch00_1920x1920_ea96e0fc-18f0-4a17-adf8-1805029d5373.jpg?v=1769068931"},{"product_id":"2v6-11-cell-bhc11101246","title":"2V6.11 cell","description":"2v6.11 cells were derived from the human embryonic kidney line HEK-293 in 2001. The 2V6.11 cell line is a valuable resource for studying the adenoviral E4 oncoprotein, particularly the E4 34K protein known to be involved in cellular genome maintenance and repair. 2V6.11 cells, obtained through transfection with the plasmid pVgRxR followed by pEKORF6, result in the inducible expression of the E4 34K protein, which is linked to the inhibition of cellular mechanisms that repair double strand-breaks in DNA. The 2V6.11 cell line demonstrated that the adenoviral proteins E4 34k and E1b 55k inhibit chromosomal DNA repair by disrupting non-homologous end joining (NHEJ) and destabilizing DNA repair proteins, extending their effect from extrachromosomal to cellular genomic DNA.\nThe 2V6.11 inducible cell line, with their adherent epithelial morphology, are ideal for investigating the behavior and characteristics of kidney-derived epithelial cells, including their response to infections by human adenovirus 40. This versatile cell line, which can be detected by western blot, enables researchers to delve into the molecular mechanisms by which the adenovirus E4 oncoprotein inhibits repair processes, thus contributing to our understanding of adenovirus pathology and the potential for developing new therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101246\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195241325,"sku":"305147","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/2V6.11_20P2_20305147-M_2010x01_2010032023_1920x1920_1f1a89c7-bf1c-486e-b823-14f243e5cf86.jpg?v=1769068931"},{"product_id":"3t3-l1-cell-bhc11100010","title":"3T3-L1 cell","description":"3T3-L1 cells are a clonal line of preadipocytes derived from mouse embryonic fibroblasts. These cells have become a widely used in vitro model for studying the process of adipogenesis, including adipogenesis and lipogenesis, which is the differentiation of preadipocytes into adipocytes (fat cells). The name \"3T3\" refers to the transfer (T) protocol that involved transferring the cells every 3 days, and \"L1\" signifies the particular clone that was isolated.\nInitially, 3T3-L1 cells exhibit a fibroblast-like morphology, but upon induction of 3T3-L1 cell differentiation, 3T3-L1 cells change from a preadipocyte to a mature adipocyte state and accumulate lipid droplets, a hallmark of obesity and metabolic syndrome. The differentiation process from 3T3-L1 preadipocytes to 3T3-L1 adipocytes is triggered by a specific cocktail of inducers, typically including dexamethasone, 3-isobutyl-1-methylxanthine (IBMX), and insulin.\nAs 3T3-L1 adipocytes adopt the characteristics of mature adipocytes, they begin to express genes that are crucial for adipocyte function, such as those coding for enzymes involved in fatty acid metabolism and hormones like leptin and adiponectin, which play vital roles in regulating appetite, energy balance, and insulin sensitivity. Studying 3T3-L1 cell transformations enhances our understanding of  adipogenesis and obesity and fat-related diseases, such as type 2 diabetes, by revealing how lipid accumulation in adipocytes leads to cellular dysfunction and broader metabolic issues.\nMoreover, the 3T3-L1 cell line is instrumental in investigating the impact of various substances on adipocyte behavior, such as the effect of pharmacological agents on lipolysis or the anti-inflammatory properties of certain diets that may prevent insulin resistance.\n3T3-L1 cells have been extensively used to study the molecular and cellular mechanisms underlying adipocyte differentiation, insulin sensitivity, lipid metabolism, and the effects of various nutritional and pharmacological agents on these processes. Given their ability to differentiate into adipocytes and their ease of culture in vitro, 3T3-L1 cells provide a valuable model system for obesity and diabetes research, as well as for the discovery of new therapeutic targets related to metabolic dise\n\u003cp style=\"display:none\"\u003eSKU:BHC11100010\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195306861,"sku":"400107","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/3T3-L1_20P1_2020x01_20260423_1920x1920_57ac0083-e5d5-4b53-8774-31208dbb140d.jpg?v=1769068931"},{"product_id":"3t6-swiss-albino-cell-bhc11100114","title":"3T6-Swiss albino cell","description":"The 3T6-Swiss albino cell line originates from the tissue of Swiss albino mice, specifically developed for a broad range of virological and oncological research purposes. This fibroblast cell line is known for its susceptibility to various viruses, including murine sarcoma viruses, making it an invaluable tool in the study of viral oncogenesis and the transformational properties of oncogenes in a controlled environment. The robustness of 3T6-Swiss albino cells in culture allows for detailed genetic manipulation and analysis, facilitating advanced genetic studies that seek to understand the intricacies of cancer progression and viral infection mechanisms.\n\nIn addition to its applications in virology, the 3T6-Swiss albino cell line is frequently used in pharmacological research. Its responsiveness to pharmaceutical agents makes it a suitable model for drug screening and toxicity testing. Researchers utilize these cells to examine the cellular responses to new compounds, evaluating their efficacy and safety before proceeding to more complex in vivo studies. The genetic stability of the 3T6-Swiss albino cell line over multiple passages supports consistent experimental results, which is crucial for the development of reliable therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100114\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195339629,"sku":"400104","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/3t6-swiss-albino-_281_29_1920x1920_2bec40a6-1bcf-4e29-9b46-27dd6cea1c86.jpg?v=1769068932"},{"product_id":"4t1-cell-bhc11101141","title":"4T1 cell","description":"The 4T1 murine mammary carcinoma cell line is a widely used model in cancer research due to its high similarity to human breast cancer. Derived from a BALB\/c mouse, the tumor growth and metastatic spread of the 4T1 cell line closely mimic the behavior of late stage breast cancer in humans. The 4T1 cell line serves as an invaluable tool for studying the progression and metastasis of mammary cancer, including bone metastases and breast cancer metastasis. When injected into BALB\/c mice, 4T1 cells spontaneously produce highly metastatic tumors that can spread to various organs such as the lung, liver, lymph nodes, and bone, while the primary tumor continues to grow in situ. This 4T1 syngeneic model is particularly useful for studies of bone metastases and the metastatic phenotype.\nThe 4T1 cell's utility extends to techniques like bioluminescence imaging, histological analyses, and the use of molecular markers to track the spread and impact of metastatic disease. This approach allows for the examination of spontaneous metastasis from primary tumors to distant organs, aided by techniques like flow cytometry to analyze tumor cells and their receptor expressions. The imagable 4T1 model has enabled biophotonic imaging to track tumor growth and metastasis in vivo in animal models, facilitating studies on metastatic cells in target organs and tumor foci. \nThe immunocompetent nature of the mouse 4T1 breast tumor cell line allows for investigations into the role of the immune system and immunity in metastasis, as well as immunotherapy of cancer. Moreover, the 4T1 syngeneic tumor model has been instrumental in omics characterization and fusion gene detection.\nOverall, the 4T1 mammary carcinoma cell line serves as a versatile tool for studying mammary tumor biology, tumor metastasis, and the development of new treatments in both murine and human contexts.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101141\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195569005,"sku":"300300","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/4T1_20P1_20300300-100223_2010x01_2016022023_1920x1920_e2dd5de1-7a2d-49d3-b8f4-49c56e980c3f.jpg?v=1769068932"},{"product_id":"5637-cell-bhc11100109","title":"5637 cell","description":"5637 is a bladder carcinoma cell line isolated from the urinary bladder of a 68-year-old man with grade II carcinoma. 5637 cells produce and secrete several growth factors, such as SCF, IL-1, IL-6, G-CSF, and GM-CSF. These cytokines are functionally active and can be a valuable source for the culture of growth factor-responsive or dependent hematopoietic primary cells and cell lines.\nThe karyotype modal chromosome number of 5637 cells is 67, ranging from 59 to 71. The stemline modal chromosome number is 67 at 36% and polyploidy at 0.6%. Fourteen marker chromosomes are common to these cells, including 3q+, 11q+, i(13q), t(9q21q), i(17q), i(21q). Additional markers, like der(5)t(5;7)(q31;p11) and 1p, were only found specific to a minor subpopulation, as well as microchromosomes and double minutes (DM). Some cells include one or occasionally two Y chromosomes.\n5637 cells are tumorigenic and have been shown to induce tumours in nude mice inoculated subcutaneously. The doubling time of 5637 cells is approximately 24 hours. The isoenzyme profile of 5637 cells consists of isoform 1 of AK-1, ES-D, Me-2 and PGM1, isoform 1 and 2 of GLO-I, isoform B of G6PD, as well as isoform 2 of PGM3.\nIn terms of oncogenes, 5637 cells are positive for FGFR3, PIK3CA, HRAS, KRAS, NRAS, TERT, and CDKN2A but negative for TP53 and belong to the molecular bladder cancer subtype l5637 is a bladder carcinoma cell line isolated from the urinary bladder of a 68-year-old man with grade II carcinoma. 5637 cells produce and secrete several growth factors, such as SCF, IL-1, IL-6, G-CSF, and GM-CSF. These cytokines are functionally active and can be a valuable source for the culture of growth factor-responsive or dependent hematopoietic primary cells and cell lines.\nThe karyotype modal chromosome number of 5637 cells is 67, ranging from 59 to 71. The stemline modal chromosome number is 67 at 36% and polyploidy at 0.6%. Fourteen marker chromosomes are common to these cells, including 3q+, 11q+, i(13q), t(9q21q), i(17q), i(21q). Additional markers, like der(5)t(5;7)(q31;p11) and 1p, were only found specific to a minor subpopulation, as well as microchromosomes and double minutes (DM). Some cells include one or occasionally two Y chromosomes.\n5637 cells are tumorigenic and have been shown to induce tumours in nude mice inoculated subcutaneously. The doubling time of 5637 cells is approximately 24 hours. The isoenzyme profile of 5637 cells consists of isoform 1 of AK-1, ES-D, Me-2 and PGM1, isoform 1 and 2 of GLO-I, isoform B of G6PD, as well as isoform 2 of PGM3.\nIn terms of oncogenes, 5637 cells are positive for FGFR3, PIK3CA, HRAS, KRAS, NRAS, TERT, and CDKN2A but negative for TP53 and belong to the molecular bladder cancer subtype luminal. \nIn conclusion, 5637 cells are a valuable tool for cancer research, especially with respect to the study of growth factors, cell division, oncogenes, and bladder cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100109\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195601773,"sku":"300105","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/5637_20WaKo_20P1_2020x01_20240425_ch00_1920x1920_bc2e0f0a-8cf1-410e-87a1-2abef404941f.jpg?v=1769068933"},{"product_id":"6t-cem-cell-bhc11101197","title":"6T-CEM cell","description":"The 6T-CEM cell line is a mutant derivative of the human acute lymphoblastic leukemia (ALL) T-cell line CCRF-CEM. It was developed by exposing the parent CEM cells to 6-thioguanine, leading to the selection of a subline that exhibits resistance to this compound. This resistance is a result of the inactivation of the HPRT gene, which is critical in the purine salvage pathway. The 6T-CEM cells have been particularly valuable in studying drug resistance mechanisms, especially concerning purine analogs like 6-thioguanine. Additionally, these cells are characterized by their secretion of a unique T-cell suppressor inducer factor (SIF), which is not only non-mitogenic and non-cytotoxic but also capable of suppressing T-cell proliferation while sparing B-cell proliferation at certain dilutions. 6T-CEM cells and their subclones, like 6T-CEM-20, have shown a significant increase in the production of this suppressor-inducer factor, which has potential applications in immunological research, particularly in the study of T-cell regulation and immune suppression. The SIF secreted by these cells has been shown to suppress up to 90% of mitogen-induced T-cell proliferation at extremely high dilutions (up to 10^-9), making these cells a potent model for exploring therapeutic strategies that involve modulation of the immune response. The use of these cells in various experimental setups has provided insights into the molecular underpinnings of immune suppression, with potential implications for the development of treatments for autoimmune diseases and in the context of organ transplantation to prevent graft rejection.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101197\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195667309,"sku":"305132","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/6T-CEM-_282_29_1920x1920_3bf07d11-d276-419c-8828-0e64aedfa99c.jpg?v=1769068933"},{"product_id":"769-p-cell-bhc11100034","title":"769-P cell","description":"The 769-P cell line is a human renal cell carcinoma (RCC) cell line that was derived from a nephrectomy specimen of a 63-year-old female patient with renal cell adenocarcinoma in 1975. It is widely used in renal cell cancer research, particularly clear cell renal cell carcinoma (ccRCC), which is the most common and lethal form of kidney cancer in adults.\nThe 769-P cell line retains many characteristics of primary RCC and harbors several mutations that are relevant to renal cell carcinoma. They exhibit a loss of function in the von Hippel-Lindau (VHL) tumor suppressor gene, which is an important kidney cancer gene in ccRCC that can activate various oncogenic pathways including angiogenesis, cell proliferation, and metabolic reprogramming.\nThe 769-P cell line is used to understand the molecular mechanisms of kidney cancer pathogenesis, explore the efficacy of anticancer drugs, and investigate the mechanisms of drug resistance. These cells are particularly useful for studying the response to tyrosine kinase inhibitors (TKIs), which are a class of targeted therapies used in the treatment of RCC and RCC subtypes.\nThe 769-P renal cancer cell line is further used to investigate the role of the tumor microenvironment in kidney cancer and to study cellular processes like apoptosis, cell cycle regulation, and metastatic potential. Their responsiveness to hypoxic conditions makes them suitable for research into how ccRCC adapts to and thrives in low-oxygen environments found within solid tumors.\nIn summary, the 769-P cell line and other RCC cell lines are indispensable tools in renal carcinoma research, providing insights into the pathogenesis of ccRCC, drug efficacy, and resistance mechanisms.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100034\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195700077,"sku":"300106","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/769-p-_283_29_1920x1920_ad31ada8-5955-4b2f-9a80-0a4b704c6273.jpg?v=1769068933"},{"product_id":"786-o-cell-bhc11100042","title":"786-O cell","description":"786-O cells are a human renal cell carcinoma cell line derived from a primary clear cell adenocarcinoma of the kidney. This cell line is frequently used in the study of renal cell carcinoma (RCC), providing valuable insights into the biological characteristics and treatment responses of this cancer type.\nThe 786-O cell line exhibits a clear cell morphology, typical of the most common form of kidney cancer, and is characterized by specific genetic alterations, including the loss of the von Hippel-Lindau (VHL) tumor suppressor gene. This genetic feature is significant as it plays a crucial role in the pathogenesis of many clear cell renal carcinomas by influencing hypoxia-inducible pathways, which are central to cellular responses to low oxygen conditions.\nThese cells are particularly useful for studying the molecular mechanisms involved in tumor growth and survival, including pathways related to angiogenesis, metabolism, and cell cycle regulation. Due to their VHL deficiency, 786-O cells are an excellent model for researching the effects of hypoxia and for testing drugs that target hypoxia-related pathways.\nIn addition to their application in basic cancer research, 786-O cells are also used in preclinical studies to evaluate the efficacy of new therapeutic agents, especially those targeting the angiogenic processes driven by the overexpression of hypoxia-inducible factors (HIFs). This includes therapies that inhibit the HIF pathway, tyrosine kinase inhibitors, and immune checkpoint inhibitors.\nOverall, 786-O cells provide a robust model for advancing our understanding of the molecular underpinnings of renal cell carcinoma and for developing targeted therapies that could improve treatment outcomes for patients with this challenging disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100042\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195732845,"sku":"300107","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/786-o-_284_29_1920x1920_8b5c0c2b-e7a3-436c-bea9-3c28f34d0987.jpg?v=1769068934"},{"product_id":"8305c-cell-bhc11101203","title":"8305C cell","description":"The 8305C cell line is a human thyroid carcinoma cell line derived from an undifferentiated anaplastic carcinoma of the thyroid. These cells are characterized by their aggressive growth behavior and poor differentiation, which are hallmarks of anaplastic thyroid carcinomas. This cell line retains several key features that are relevant to the study of thyroid cancer pathophysiology, including alterations in gene expression profiles and signaling pathways that are pivotal in thyroid carcinogenesis.\n\nStudies utilizing the 8305C cell line have demonstrated its utility in exploring the molecular mechanisms underlying thyroid cancer progression, resistance to therapy, and metastasis. Specifically, this cell line has been used to investigate the efficacy of various chemotherapeutic agents and targeted therapies, making it a valuable model for preclinical drug testing. Additionally, 8305C has been employed in research focusing on the role of genetic and epigenetic modifications in thyroid cancer, offering insights into potential therapeutic targets and biomarkers for this aggressive cancer type.\n\nDue to its derivation from a high-grade malignancy, the 8305C cell line serves as an important tool in thyroid cancer research, particularly in studies aimed at understanding the aggressive behavior of anaplastic thyroid carcinoma and developing strategies for its effective treatment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101203\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195765613,"sku":"305101","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/8305C_20P1_2020x01_20090125_ch00_1920x1920_318ff090-2415-4134-b390-45ea0c0bce86.jpg?v=1769068934"},{"product_id":"9l-lacz-cell-bhc11101188","title":"9L\/lacZ cell","description":"The 9L\/lacZ cell line is a well-characterized rat gliosarcoma cell line commonly used in neurobiological and oncological research. Originally derived from a nitrosourea-induced rat brain tumor, this line has been engineered to express the lacZ gene, which encodes the enzyme β-galactosidase. This modification facilitates the tracing and studying of tumor cells in vivo, particularly useful in experiments involving tumor progression and metastasis. The expression of lacZ allows for the easy identification of these cells using X-gal staining, which turns the cells blue when they express β-galactosidase.\n\nThese cells exhibit aggressive tumor-forming capabilities when implanted in immunocompromised or syngeneic hosts, making them a robust model for studying brain cancer dynamics and testing therapeutic strategies against gliomas. Additionally, the 9L\/lacZ cell line has been utilized in gene therapy trials, particularly in assessing the efficacy of suicide genes and other genetic interventions aimed at controlling tumor growth. This line is also pivotal in understanding the interactions between tumor cells and the host's immune system, thereby contributing insights into the complexities of tumor immunology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101188\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195798381,"sku":"305208","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/9L-lacZ_20P0_20305208-M_2020x01_20191022_1920x1920_b21ad7fe-8c29-4f32-ab26-e83801191a08.jpg?v=1769068935"},{"product_id":"a172-cell-bhc11100084","title":"A172 cell","description":"A-172 (A172 or A-172 MG) is a significant cell line used in neuroscience research. It originates from the brain tissue of a 53-year-old male with glioblastoma, a type of brain cancer. These cells adhere and spread on the surface of culture dishes, with a karyotype of n = 80 (80 chromosomes). A-172 cells are hypertriploid, exhibiting over 20 marker chromosomes. They have been shown to be non-tumorigenic in anti-thymocyte serum treated NIH Swiss mice. A-172 cells have a gene expression profile that highlights their mesenchymal lineage and involvement in angiogenesis. \nThey express genes related to mesenchymal markers (CD90, CD105, fibroblast activation protein, tenascin C) and angiogenesis inducers (VEGF, FGF2 (b), TGFb1, thrombospondin-1). Comparisons with the T98G cell line reveal differences in morphology and surface marker expression. Both cell lines show high expression of a2 smooth muscle actin. Changing the fetal serum concentration in the culture medium affects the proportion of cells expressing specific surface antigens, such as CD73 and CD105.\nA-172 and T98G cell lines accurately represent glioblastomas, providing valuable tools for studying this brain tumor. Their gene expression profiles and morphological features allow for investigations into the molecular mechanisms underlying glioblastoma development and progression. Researchers can utilize A-172 cells to gain insights into glioblastoma biology and potentially identify new therapeutic targets for this devastating disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100084\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195831149,"sku":"300108","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A172_20P1_20WaKo_2020x01_20240625_ch00_1920x1920_754cba0a-477b-43e6-b8a3-bfaecc221391.jpg?v=1769068935"},{"product_id":"a20-cell-bhc11101459","title":"A20 cell","description":"The A20 cell line is derived from a reticulum cell sarcoma in a mouse and is widely used in immunology and cancer research. Reticulum cell sarcoma is a type of B-cell lymphoma, and A20 cells provide a valuable model for studying the biology of B-cell lymphomas and the immune response. These cells are particularly useful for investigating the mechanisms of B-cell development, activation, signaling, and the interaction between tumor cells and the immune system. Additionally, A20 cells play a crucial role in research focused on the production and function of cytokines, which are essential for immune regulation.\nA20 cells display a lymphoblastic morphology and express surface markers typical of B-cells, including surface immunoglobulin and major histocompatibility complex (MHC) molecules. Researchers utilize A20 cells to study antigen presentation, B-cell receptor signaling, and the role of various cytokines in immune responses. These cells are also instrumental in the development and testing of immunotherapies, such as monoclonal antibodies and checkpoint inhibitors, aimed at treating B-cell lymphomas and other hematological malignancies. Additionally, A20 cells serve as a model for evaluating the efficacy and safety of novel therapeutic agents in preclinical studies. The utility of A20 cells in immunological research and the understanding of B-cell pathophysiology highlights their importance in advancing cancer research and developing new treatment strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101459\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195994989,"sku":"305263","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a20_20_282_29_1920x1920_4da4d9c0-b202-47a0-b8cc-5cb69b3ea4ba.jpg?v=1769068935"},{"product_id":"a204-cell-bhc11100101","title":"A204 cell","description":"A204 cells are human epithelial cells derived from the muscles of a 1-year-old female patient with rhabdomyosarcoma. With applications in 3D cell culture and tumorigenic properties, A-204 cells provide an opportunity for studying tumour biology and potential therapeutic interventions. Derived from muscle tissue, A-204 cells closely resemble the outer layer of cells found in organs and tissues. \nThe A204 cell line is characterized by its aggressive undifferentiated phenotype, making it a valuable model for investigating the molecular mechanisms of tumorigenesis and metastasis in soft tissue sarcomas.\nThe presence of specific isoenzymes, including AK-1, ES-D, G6PD, GLO-I, Me-2, PGM1, and PGM3, in A-204 cells provides insight into their metabolic characteristics. These isoenzymes may play a role in understanding cellular processes involved in cancer progression and treatment response. \nThese cells exhibit robust growth in vitro and have been used to study cell proliferation, apoptosis, and drug resistance mechanisms. The A204 cell line is also instrumental in the evaluation of new chemotherapeutic agents and in understanding the interaction between rhabdomyosarcoma cells and therapeutic compounds. \nThis cell line serves as an essential tool for cancer researchers aiming to develop more effective treatments for sarcomas and other related malignancies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100101\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196027757,"sku":"300109","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a-204-_281_29_1920x1920_b168676e-cdb4-40bf-bd14-2a09d20bbfbc.jpg?v=1769068936"},{"product_id":"a2058-cell-bhc11101027","title":"A2058 cell","description":"The A2058 cell line is a human melanoma cell line derived from a brain metastasis of a patient with malignant melanoma. This cell line is widely used in cancer research due to its high metastatic potential, which makes it an important model for studying melanoma progression and the mechanisms underlying metastasis. A2058 cells are known to express nerve growth factor (NGF) receptors, which are linked to their aggressive and metastatic characteristics. One of the key features of A2058 cells is their ability to produce transforming growth factors (TGFs) that promote anchorage-independent growth, a common indicator of the transformed, cancerous phenotype. These TGFs interact with epidermal growth factor (EGF) receptors, despite the cells themselves lacking detectable EGF receptors. This interaction is critical for enabling the growth of normal fibroblasts and epithelial cells in soft agar, a standard assay for evaluating the transformation potential of cancer cells. A2058's ability to drive such growth highlights its utility in research focused on understanding and combating the spread of melanoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101027\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196093293,"sku":"305046","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A2058_20P3_2020x01_20170523_1920x1920_78733ab5-0917-4b7d-9883-9dd780255bf5.jpg?v=1769068936"},{"product_id":"a2780-cell-bhc11101365","title":"A2780 cell","description":"A2780 is a human ovarian cancer cell line that was first established in 1972 from a patient with advanced epithelial ovarian cancer. The cells were characterized as being sensitive to cisplatin and doxorubicin, two commonly used chemotherapy drugs for ovarian cancer. Since its establishment, A2780 has been widely used in cancer research studies, particularly in the development and testing of new cancer treatments. \nResearch using A2780 cells has provided valuable insights into the biology of ovarian cancer, including the identification of specific genetic mutations such as TP53 and BRCA1. These mutations are associated with increased risk of ovarian cancer and are also found in other types of cancer. \nAdditionally, A2780 cells have been used to study the role of angiogenesis, the process by which new blood vessels form, in ovarian cancer progression and to evaluate the efficacy of anti-angiogenic drugs. Angiogenesis plays a critical role in the growth and progression of ovarian cancer as it provides oxygen and nutrients for the cancer cells to grow. \nStudies using A2780 cells have demonstrated the overexpression of pro-angiogenic factors such as VEGF and angiopoietin-2, which promote the formation of new blood vessels. Additionally, A2780 cells have been used to test the efficacy of anti-angiogenic drugs such as bevacizumab, which target VEGF and inhibit the formation of new blood vessels. \nFurthermore, A2780 cells have been used to evaluate the efficacy of various therapeutic agents, including chemotherapy drugs, targeted therapies such as PARP inhibitors, and immunotherapies. \nIn particular, A2780 cells have been used to study the effect of different drug combinations on cancer cell proliferation, apoptosis, and drug resistance. Overall, the A2780 cell line has played a significant role in the advancement of ovarian cancer research, providing a valuable tool for understanding the disease and developing new treatments.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101365\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196126061,"sku":"300491","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A2780_20P0_2040x01_2007092022_1920x1920_255020e7-b42a-41be-8126-bd752712eeb5.jpg?v=1769068937"},{"product_id":"a3-cell-bhc11101286","title":"A3 cell","description":"A3 cells are human T lymphoblasts derived from the Jurkat cell line obtained from the laboratory of Gerald Crabtree at Stanford University. These cells possess a lymphoblast morphology, grow in suspension and are highly relevant in studying acute T cell leukaemia, 3D cell culture applications, immune system disorder research, and immunology.\nThese cells are derived from the Jurkat cell line, which was treated with Fas Antibody to obtain a low spontaneous resistance rate to Fas-mediated apoptosis. This characteristic makes A3 cells highly valuable for investigating immune system dysregulation and identifying potential therapeutic targets.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101286\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196191597,"sku":"305143","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A3_20WaKo_20P1_2010x01_20010824_ch00_1920x1920_aabce3f2-7a25-4578-94a2-4c9ad0264bd1.jpg?v=1769068937"},{"product_id":"a375-cell-bhc11100110","title":"A375 cell","description":"The A375 human melanoma cell line, isolated from the skin of a 54-year-old female patient with malignant melanoma, is a significant resource in cancer research, particularly in the study of human melanoma, one of the most aggressive forms of skin cancer. The A375 cell line is known for its rapid growth rate and high tumorigenic potential, making them suitable for various experimental applications, including in vitro studies on cell proliferation, migration, and invasion, as well as in vivo tumorigenesis assays.\nA375 cells exhibit high tumorigenic potential in immunosuppressed mice, forming rapidly growing amelanotic melanomas. The presence of the BRAFV600E mutation in A375 cells makes them highly sensitive to MEK inhibition, providing a valuable tool for investigating targeted therapies in melanoma treatment. The treatment of A375 cells with vemurafenib, for example, has been shown to enhance the induction of MHC Class I and Class II molecules, offering insights into the interactions between melanoma cells and the immune system.\nIn addition to their role in basic melanoma research, A375 cells are used in drug screening and in the investigation of signaling pathways involved in cancer cell survival, proliferation, and metastasis. A375 cells have further been utilized in apoptosis studies and A375 isogenic cell lines and the introduction of reporter proteins like luciferase (luc2) enable the study of gene function and the monitoring of cellular responses in real-time. A375 cells' suitability as a transfection host and their use in stable reporter cell lines also contribute to their versatility in research applications.\nIn summary, the A375 human melanoma cell line is a pivotal tool in the investigation of human melanoma, offering a comprehensive model for studying the molecular and cellular mechanisms underlying melanoma progression, the efficacy of therapeutic agents, and the interaction between cancer cells and the immune system.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100110\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196224365,"sku":"300110","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A375_20WaKo_20P1_2020x01_20230525_ch00_1920x1920_0b915c5b-5646-4293-a74d-4cbc8090b076.jpg?v=1769068937"},{"product_id":"a427-cell-bhc11100094","title":"A427 cell","description":"A427 cells originate from lung tissue, specifically a carcinoma, exhibit epithelial morphology and grow adherently. A427 cells have a doubling time of approximately 28 hours in RPMI 1640 medium supplemented with 10% fetal bovine serum (FBS). \nIn ACL-3 medium, the doubling time is slightly extended to 38 hours, while in ACL-3 supplemented with bovine serum albumin (BSA), it reaches 42 hours. These variations in doubling time provide valuable insights into cell behaviour under different experimental conditions.\nAt passage 60, A427 cells display a hypotriploid to hypertriploid karyotype. This means the cells possess abnormal chromosomes, including dicentrics, minutes, and a large subtelocentric marker. Such karyotypic abnormalities are often associated with cancer cells and contribute to the unique characteristics of this cell line. A427 cells exhibit tumorigenic properties, allowing them to form tumours when injected into nude mice. \nThese tumours resemble undifferentiated adenocarcinoma, further emphasizing the relevance of this cell line in studying lung cancer and its progression. With its exceptional features, A427 cells find utility in various applications, particularly in cancer research. Their epithelial morphology and lung origin make them an ideal model for studying lung cancer and related diseases. Additionally, A427 cells are well-suited for 3D cell culture techniques, providing a more physiologically relevant environment to explore the behaviour of lung cancer cells.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100094\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196257133,"sku":"300111","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A427_20WaKo_20P1_2020x01_20080925_ch00_1920x1920_7109e5e2-5269-4661-9243-2a4765d4cecd.jpg?v=1769068938"},{"product_id":"a431-cell-bhc11100124","title":"A431 cell","description":"The A431 cell line, derived from a solid epidermoid carcinoma tumor in an 85-year-old female patient, is a human tumor cell line with an epithelial morphology, typically growing in clusters. The A-431 cell line is extensively utilized in cancer, toxicity, and immuno-oncology studies, serving as a positive control for epidermal growth factor (EGF) receptor expression due to its high receptor density.\nUpon binding of EGF to its receptor (EGFR) on the surface of A431 cells, a rapid tyrosine phosphorylation of membrane proteins occurs, triggering a cascade of intracellular signaling pathways. These pathways include the MAPK\/ERK and PI3K\/AKT pathways, which are pivotal in regulating cell cycle progression, survival, and proliferation.\nEGFR stimulates cell proliferation at low concentrations, whereas at higher concentrations, it inhibits growth and induces terminal differentiation in A431 cells. This dynamic response to EGFR underscores the cell line's utility in exploring cell signaling pathways and the cell cycle in the context of cancer.\nA-431 cell-derived xenograft models are used for studying tumor behavior in a live environment and evaluating anticancer therapies. These models help assess how treatments such as EGF supplementation and radiation, affect tumor growth and highlight the cells' sensitivity to radiation. \nIn summary, the A-431 cell line serves as an invaluable human epidermoid carcinoma cell model, facilitating a deeper understanding of EGFR signaling, tumor biology, and the development of therapeutic interventions aimed at combating epidermoid carcinoma and other related cancers.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100124\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196289901,"sku":"300112","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a431_20_285_29.jpg?v=1769068938"},{"product_id":"a498-cell-bhc11100167","title":"A498 cell","description":"A498 cells are a human renal cell carcinoma cell line derived from the kidney tissue of a 58-year-old Caucasian male. These cells are extensively used in research related to kidney cancer, particularly for studying clear cell renal cell carcinoma, which is the most common type of kidney cancer in adults.\nThe A498 cell line is characterized by its epithelial-like morphology and has been a valuable model for investigating the molecular and cellular mechanisms of renal carcinogenesis. These cells exhibit several features typical of kidney cancer, including alterations in the expression of genes involved in cell cycle regulation, apoptosis, and angiogenesis.\nA498 cells are particularly useful for examining the metabolic pathways altered in kidney cancer, as they display a distinct metabolic profile that includes changes in lipid and glucose metabolism. This aspect makes them suitable for metabolic targeting studies, which explore how altering metabolic pathways can inhibit tumor growth.\nFurthermore, A498 cells are employed in drug discovery and toxicology studies to test the efficacy of new chemotherapeutic agents and targeted therapies. They are also used to study the response of renal cancer cells to hypoxic conditions-a common feature of solid tumors that significantly influences tumor behavior and treatment response.\nOverall, the A498 cell line serves as an essential tool in renal cancer research, facilitating the development of more effective therapeutic strategies and enhancing our understanding of kidney cancer biology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100167\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196322669,"sku":"300113","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a498-_284_29_1920x1920_78b6fd4e-2086-4b1d-b130-7cc99475e25c.jpg?v=1769068939"},{"product_id":"a549-cell-bhc11100147","title":"A549 cell","description":"A549 cells, derived from lung adenocarcinoma tissue, are a primary model used in cancer research, particularly in biomedical laboratories focusing on lung-related cancers. A549 cells are commonly used as an in vitro model for studying lung cancer biology, drug screening, and the effects of toxic compounds.\nIn toxicology research, A549 cells offer a controlled experimental model that enables scientists to explore the mechanisms underlying toxic effects and cellular responses. By understanding these mechanisms, researchers can better assess the safety of substances and potentially mitigate their harmful effects.\nA549 carcinoma cells have been extensively used as an in vitro model to study lung cancer pathogenesis and as an alternative tissue culture model for various pulmonary-related research studies in biomedical laboratories. These cells maintain the characteristics of type II alveolar epithelial cells and are used to examine the epithelial responses to various infections and inflammatory stimuli, including lung inflammation.\nFurthermore, the human cell line A549 serves as a valuable tool in the development of specific antibodies targeting lung cancer-related proteins or markers. By exposing these cells to substances of interest, researchers can investigate how they affect cell viability, proliferation, apoptosis, and other cellular processes. This information aids in the identification of potential therapeutic targets and the development of novel treatments for lung cancer.\nIn summary, A549 carcinoma cells are pivotal in cancer research, especially concerning lung-related cancers, serving as an in vitro model for cancer and toxicology research, developing effective treatments, and drug screening.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100147\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196355437,"sku":"300114","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A549_20P35_20300114-1421_2020x01_2026082022_1920x1920_7da09e07-fa3c-451b-b408-9991b0e4cb71.jpg?v=1769068939"},{"product_id":"a549-ddp-cell-bhc11101352","title":"A549\/DDP cell","description":"The A549\/DDP cell line is a drug-resistant variant of the A549 cell line, which itself is a model of human alveolar basal epithelial adenocarcinoma. This variant has been specifically selected for its resistance to cisplatin (DDP), a common chemotherapy drug used in the treatment of various cancers, including lung cancer. The development of the A549\/DDP cell line enables researchers to study the mechanisms underlying chemoresistance, which is a major challenge in cancer therapy.\n\nIn research, the A549\/DDP cell line is utilized to investigate the biochemical pathways involved in cisplatin resistance. This includes the exploration of changes in gene expression, protein function, and cellular metabolism that confer resistance to cisplatin. The cell line is also valuable in the screening of new drugs or drug combinations that can overcome resistance, providing insights that are crucial for the development of more effective therapeutic strategies against lung cancer.\n\nMoreover, studies using the A549\/DDP cell line contribute to a better understanding of the molecular basis of lung cancer progression and metastasis in the context of chemoresistance. This cell line serves as a critical tool for translational research, bridging experimental findings to potential clinical applications in oncology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101352\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196486509,"sku":"305047","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a549-ddp-_281_29.jpg?v=1769068939"},{"product_id":"a64-cls-cell-bhc11100046","title":"A64-CLS cell","description":"Established from the primary adenoma of the submaxillary gland.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100046\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196519277,"sku":"300199","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a64-cls-_284_29_1920x1920_a194387f-d467-41a9-9f59-0f95e7c4b232.jpg?v=1769068940"},{"product_id":"a673-cell-bhc11100016","title":"A673 cell","description":"The A673 cell line is a valuable resource in biological science. Derived from the muscle tissue of a 15-year-old female patient diagnosed with Ewings Sarcoma, this cell line exhibits a distinct polygonal morphology.\nOriginally the cell line was thought to be derived from a rhabdomyosarcoma (RMS). \nOne of the remarkable characteristics of A673 cells is their ability to produce several growth factors that possess oncogenic potential. These cells also secrete growth-inhibitory factors, providing a balanced environment for cellular growth regulation. Such properties make A673 cells an excellent model for investigating the interplay between tumour-promoting and tumour-suppressing factors. A673 cells have demonstrated tumorigenic potential, as they can induce tumour formation in immunosuppressed mice. \nMoreover, studies have identified hypermethylated promoters in cancer-related genes within the A673 cell line. These genetic alterations further contribute to its relevance in cancer research, offering a platform to explore epigenetic modifications and their impact on tumour development and progression.\nWhile A673 cells are often referred to as Ewing tumour (ET) or sarcoma (ES), they are also associated with rhabdomyosarcoma (RMS). Notably, the A673 cell line harbours a complex karyotype with a specific translocation involving chromosomes 11 and 22. This translocation leads to the fusion of the EWS and FLI1 genes, which is a characteristic genetic event in Ewing Tumor.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100016\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196584813,"sku":"300454","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a-673-_284_29_1920x1920_a914e1de-a2f1-4191-8b4d-6d77f68b6f2d.jpg?v=1769068940"},{"product_id":"a704-cell-bhc11100081","title":"A704 cell","description":"A-704 is a human epithelial cell line derived from kidney tissue of a 78-year-old male patient with adenocarcinoma. This cell line exhibits an epithelial morphology. It is a valuable resource in cancer research, particularly for studying adenocarcinoma. A-704 is a versatile cell line with applications in 3D cell culture and as a transfection host.\nDerived by D.J. Giard, A-704 maintains consistency and reliability in experimental settings. Karyotype analysis reveals that A-704 cells exhibit abnormalities such as breaks, dicentrics, and endoreduplication, ranging from diploid to hyperdiploid, hypertriploid to hypertetraploid.\nWhile not tumorigenic in immunosuppressed mice, A-704 cells can form colonies in a semisolid medium. A-704 cells exhibit specific isoenzyme profiles, including AK-1, ES-D, G6PD, GLO-I, Me-2, PGM1, and PGM3.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100081\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196617581,"sku":"300217","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A704_20P1_2010x01_20130125_ch00_1920x1920_cf6b4506-5522-4a2f-93ec-49a2b62b8935.jpg?v=1769068940"},{"product_id":"a72-cell-bhc11100178","title":"A72 cell","description":"A72 cells are a canine fibrosarcoma cell line derived from a spontaneously occurring tumor in a dog. These cells are used primarily in veterinary oncology research to study the biology, behavior, and treatment responses of canine fibrosarcomas. Their relevance extends to comparative oncology studies, where insights gained from canine cancers can be applied to human cancer research due to the biological similarities between certain canine and human tumors.\nThe A72 cell line exhibits an adherent, fibroblast-like morphology and is known for its aggressive growth in vitro. It has been utilized to investigate various aspects of cancer cell biology, including proliferation, metastasis, and tumor cell interactions with the extracellular matrix. These cells are particularly valuable for assessing the efficacy of chemotherapeutic agents and exploring new therapeutic strategies, including immunotherapy and targeted therapies.\nA72 cells also provide a useful model for studying the molecular pathways involved in tumor growth and progression, such as signaling through the PI3K\/Akt, MAPK, and other related pathways. They are instrumental in understanding the genetic and molecular underpinnings of fibrosarcoma, which can help identify potential biomarkers for diagnosis and targets for treatment in both veterinary and human oncology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100178\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196650349,"sku":"602398","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A72_20WaKo_20P1_2020x01_20040925_ch00_1920x1920_9bc6eacb-273d-49ec-8b20-b33487f3dd94.jpg?v=1769068941"},{"product_id":"a7r5-cell-bhc11101218","title":"A7r5 cell","description":"Derived from the smooth muscle of the embryonic thoracic aorta in a BDIx rat, the A7r5 cell line is extensively employed in cardiovascular research. These fibroblast-like cells display a unique flat ribbon-like morphology that transitions into parallel arrays of spindle-shaped cells as they differentiate. This distinct structural adaptation facilitates the study of cellular dynamics and morphology under various physiological conditions. During the stationary phase of their growth cycle, A7r5 cells exhibit a significant increase in the activities of myokinase and creatine phosphokinase (CPK), enzymes critical in cellular energy transfer and metabolism.\n\nThe synthesis of a specific muscle type CPK isoenzyme upon cessation of cell division in A7r5 cells provides a valuable model for investigating molecular mechanisms underlying muscle development and differentiation. This cell line has been instrumental in exploring the effects of angiotensin II on vascular oxidative stress, offering insights into how this hormone influences cardiovascular physiology. Additionally, A7r5 cells have been used to study the inhibitory effects of phospholipase A2 (PLA2) on lipid droplet formation, further highlighting their utility in cardiovascular research. These applications underscore the A7r5 cell line's versatility and its pivotal role in elucidating critical pathways and potential therapeutic targets in cardiovascular disease studies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101218\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196683117,"sku":"305198","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A7r5_20P1_20305198_2010x01_20070223_1920x1920_6218df02-60aa-420d-bff6-2fa9f7bc8e10.jpg?v=1769068942"},{"product_id":"a875-cell-bhc11101148","title":"A875 cell","description":"The A875 cell line is a human melanoma cell line derived from a metastatic site in a 40-year-old female. Exhibiting morphological and growth characteristics typical of malignant melanoma, A875 has been extensively utilized in oncological research, particularly focusing on melanoma biology, mechanisms of metastasis, and therapeutic resistance. This cell line is characterized by its aggressive growth and metastatic potential, making it an excellent model for in vivo tumor growth and metastasis studies in xenograft settings.\n\nA875 cells are particularly valuable for investigating the molecular and genetic underpinnings of melanoma progression. Research involving this cell line includes studies on the roles of oncogenes, tumor suppressor genes, and various signaling pathways that are pivotal in cancer development and progression. The cell line has been used in the assessment of novel chemotherapeutic agents and targeted therapies, benefiting from its genetic alterations that mimic those found in human melanomas. Furthermore, A875 serves as a key model for evaluating immune response mechanisms to melanoma, due to its ability to elicit strong immune reactions, thus aiding in the development and testing of new immunotherapies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101148\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196715885,"sku":"305099","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A875_20P1_2010x01_20260723_20_28vor_20MW_29_1920x1920_e0e6c253-391e-40ab-860c-08e551c107f2.jpg?v=1769068942"},{"product_id":"a9-cell-bhc11101296","title":"A9 cell","description":"A9 cells are a fibroblast-like cell line derived from mouse adipose tissue. They were established as a subclone of the L929 parent strain by W. R. Earle in 1940. The parent strain was obtained from normal subcutaneous areolar and adipose tissue of a male C3H\/An mouse. \nA notable feature of these cells is that they express adenosine phosphoribosyl transferase (APRT) and hypoxanthine phosphoribosyl transferase (HPRT), denoted as APRT+ and HPRT+. These cells have been valuable in virus studies, particularly involving pseudorabies virus (PRV), vesicular stomatitis virus (VSV) of the Indiana strain, and herpes simplex virus (HSV). \nA9 cells' sensitivity and response to these viruses have made them useful for studying viral replication, pathogenesis, and potential antiviral treatments. In immunology, A9 cells are used in various research areas. They are a valuable model for studying immune responses, antibody production, monoclonal antibody generation, and hybridoma technology.\nDue to their rapid proliferation (doubling time of approximately 24 hours), A9 cells provide a sufficient cell supply for experiments and downstream applications. A9 cells have a fibroblast-like morphology and adhere to the culture substrate. Categorized as animal cells and belonging to the hybridoma cell type, A9 cells were formed by fusing B lymphocytes from Mus musculus (mouse) with myeloma cells from the same species. \nThis unique combination allows A9 cells to exhibit properties of both B lymphocytes and myeloma cells. Overall, A9 cells are a well-established fibroblast-like cell line utilized for studying viral infections, especially PRV, VSV, and HSV, and in immunology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101296\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196748653,"sku":"305166","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A9_20P1_2020x01_20100523_1920x1920_8ca3b801-5cb2-4d16-9b9e-7d0d4113dbdb.jpg?v=1769068942"},{"product_id":"aav-293-cell-bhc11101241","title":"AAV-293 cell","description":"The AAV-293 cell line is a permanent line established from primary embryonic human kidney transformed with human adenovirus type 5 DNA. The genes encoded by the E1 region of adenovirus (E1a and E1b) are expressed in these cells and participate in transactivation of viral promoters, allowing these cells to produce high levels of protein. \nAAV-293 is derived from the parental 293 cell line, through cloning and multiple rounds of testing, AAV-293 is specifically selected for a high level of AAV production in a helper-free system. It offers several advantages over the regular 293 cells: Larger cell surface area resulting higher transfection and better yield of AAV. \nThe advantages are a flattened morphology, firm attachment to culture plate, and the cells are ideal for large-scale culture and AAV production. Adeno-associated virus (AAV) belongs to the family of Parvoviridae, a group of viruses among the smallest of single-stranded and non-enveloped DNA viruses. \nThere are nine different AAV serotypes reported to date. AAV can infect both dividing and non-dividing cells and can be maintained in the human host cell, creating the potential for long-term gene transfer. Recombinant AAV-2 is the most common serotype used in gene delivery, and can be produced at high titers with a helper virus or AAV-293 cells.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101241\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196781421,"sku":"305127","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AAV-293_20305127_20_2010x1_2018112022_1920x1920_32886b8b-0cee-46c5-9f4c-f25197f55067.jpg?v=1769068943"},{"product_id":"ab2-2-cell-bhc11101692","title":"AB2.2 cell","description":"The AB2.2 cell line is a widely utilized murine embryonic stem (ES) cell line derived from the 129S7 (also known as 129P2\/OlaHsd) mouse strain. It has played a prominent role in gene targeting and transgenic mouse generation due to its robust capacity for in vitro expansion and genetic manipulation. AB2.2 cells are pluripotent, capable of contributing to all germ layers, and have been instrumental in producing germline-competent chimeras. However, like many ES cell lines maintained over extended culture periods, AB2.2 is prone to chromosomal instability, especially aneuploidy involving chromosome 8.\n\nCytogenetic analysis of AB2.2 and its sub-lines has revealed a high frequency of chromosomal abnormalities, with mosaic and pure trisomy 8 being particularly common. In one study, AB2.2 displayed a mosaic karyotype involving gains of chromosomes 8 and Y, including configurations such as 42,XY,+Y,+8 \/ 41,XY,+Y \/ 40,XY. Among its sub-lines, additional karyotypic anomalies were identified, such as double trisomies involving chromosomes 8 and 11, and complex derivative chromosomes arising from unbalanced translocations involving chromosome 8. These structural and numerical aberrations are associated with decreased germline transmission efficiency, and their presence complicates interpretation of genotype-phenotype relationships in chimeric animals.\n\nGiven its genetic background and susceptibility to chromosomal instability, AB2.2 remains a powerful tool in mouse genetics, but it requires careful quality control. Routine karyotype screening-including both G-banding and FISH-is recommended before proceeding with blastocyst injection to ensure the chromosomal integrity necessary for reliable germline transmission and accurate phenotypic analyses.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101692\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196814189,"sku":"305738","price":650.0,"currency_code":"USD","in_stock":true}]},{"product_id":"ac16-cardiomyocyte-cell-line-cell-bhc11101343","title":"AC16 Cardiomyocyte Cell Line cell","description":"The AC16 cell line, derived from human ventricular cells fused with SV40-transformed, showcases characteristics typical of cardiomyocytes, including the expression of transcription factors such as GATA4, MYCD, NFATc4, and contractile proteins like alpha- and beta-myosin heavy chain. AC16 cells also express gap junction proteins connexin-43 and connexin-40, with functional gap junctions confirmed by dye-coupling studies, underscoring their utility in cardiomyocyte research. When the SV40 oncogene is silenced, AC16 transitions towards a more differentiated state, marked by the expression of BMP2, indicative of cardiac differentiation and developmental regulation.\nIn general, scientists employ various techniques, including stem cell differentiation, animal models, molecular analysis, and biomarker discovery, to advance knowledge and potential therapies for heart-related conditions. The involvement of mitogen and senescence pathways, along with thymidine kinase induction, further elucidates the complex nature of human cardiomyocytes and their response to pathological conditions.\nThe AC16 human cardiomyocyte cell line's ability to mimic the behavior of mature cardiomyocytes makes it a valuable model for cardiac research. It closely resembles the genetic makeup of primary cardiomyocytes, allowing for studies on cardiac development, pathology, and the implications of histone loss in vitro, however, the cardiomyocyte behavior and genetic complexity might not fully match that of primary or stem cell-derived cardiomyocytes. In the context of toxicology and cardiovascular disease research, AC16 cells serve as a vital tool for understanding cardiomyocyte development, inflammation, injury, regeneration, and toxicological effects.\nThe unique properties of the AC16 human cardiomyocyte cell line, including its response to developmental cues and the ability to simulate the physiological conditions of human cardiomyocytes, make it an indispensable asset in the quest to unravel the mysteries of heart diseases and devise novel therapeutic interventions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101343\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196846957,"sku":"305215","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AC-16_20_286_29_1920x1920_e6e62d0d-aa27-4ae5-ad60-bb0d430322f1.jpg?v=1769068943"},{"product_id":"achn-cell-bhc11100157","title":"ACHN cell","description":"The ACHN cell line is derived from the malignant pleural effusion of a 22-year-old Caucasian male with widely metastatic renal adenocarcinoma. The cell line was established in November 1979, following direct seeding of the cancer cells into culture flasks containing Eagle's MEM with 10% FBS. Over a period of 150 days, the cells were maintained and passaged in vitro. Subsequently, the cells were inoculated subcutaneously into nude mice, where they formed palpable, locally invasive tumors within four weeks. This cell line is tumorigenic, as evidenced by its ability to induce tumors in 100% of nude mice (5\/5) inoculated with 107 cells, with tumors developing within 21 days.\n\nACHN cells are characterized by an adherent growth pattern and express specific isoenzymes, including G6PD (type B). This cell line is also noted for its response to human interferons and interferon inducers, making it particularly useful for antiproliferative studies. Both the original ACHN cells and those recovered from tumors in nude mice demonstrate growth inhibition in the presence of human interferons, highlighting their potential application in studies exploring the efficacy of interferon-based therapies for renal cancer.\n\nThe ACHN cell line is a valuable tool for cancer research, especially in the context of renal adenocarcinoma. It serves as an important model for studying tumorigenicity, metastatic behavior, and the effects of interferons on cancer cell proliferation. Its ability to form tumors in vivo and respond to interferon treatment provides a robust platform for developing and testing new therapeutic approaches targeting renal cell carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100157\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196879725,"sku":"300117","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/achn-_281_29_1920x1920_443a7cc9-1a10-40a8-93a8-9554f4b28188.jpg?v=1769068944"},{"product_id":"ags-cell-bhc11100003","title":"AGS cell","description":"AGS cells are a human gastric adenocarcinoma cell line derived from the stomach tissue of a 54-year-old Caucasian female. They are extensively used in biomedical research focused on gastric cancer, including studies on cancer cell biology, pathogenesis, and drug testing.\nThe AGS cell line exhibits epithelial-like morphology and is characterized by its aggressive growth pattern and tumorigenic potential in vivo. These cells are commonly used as a model to study the molecular and cellular mechanisms underlying gastric carcinogenesis, including the influence of Helicobacter pylori infection, a well-known risk factor for gastric cancer. AGS cells provide a robust system to explore the interactions between gastric cancer cells and H. pylori, especially regarding how bacterial factors affect cancer cell proliferation, apoptosis, and inflammatory responses.\nAGS cells are also valuable for examining the gastric epithelial barrier's response to various stimuli, including inflammatory cytokines, and for studying signaling pathways implicated in gastric cancer, such as those involving NF-kB, Wnt, and MAPK. Their utility extends to the assessment of new therapeutic agents, where they are used to evaluate the efficacy and mechanisms of action of anticancer drugs, targeted therapies, and natural compounds with potential anti-cancer properties.\nFurthermore, AGS cells are often employed in studies aimed at understanding the genetic and epigenetic alterations in gastric cancer, offering insights into potential diagnostic markers and therapeutic targets for this challenging and frequently fatal disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100003\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196912493,"sku":"300408","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AGS_20WaKo_20P1_2020x01_20290425_ch00_1920x1920_50dda83d-7548-49bf-9f15-0ef0e3492db8.jpg?v=1769068944"},{"product_id":"ah-130-cell-bhc11100091","title":"AH-130 cell","description":"Yoshida et al. have established the ascites hepatoma by converting the aminoazo dyeinduced hepatoma of the rat into the ascetic form (Yoshida 1956). AH-130 is a strain of ascites hepatoma composed of free tumor cells, only small islands of tumor islets are present. The cell line described here was established as in vitro cell culture from this Yoshida AH-130 strain of ascites hepatoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100091\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196945261,"sku":"500412","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ah-130-_281_29_1920x1920_c7f9086b-5c1e-4005-b3d1-be31ef0b6f80.jpg?v=1769068944"},{"product_id":"ah-130-fn-cell-bhc11100152","title":"AH-130 FN cell","description":"AH-130 FN is a variant of the AH-130 rat ascites tumor cell line, used extensively in studies related to coagulation, fibrinolysis, and metastasis. These cells were derived from rats and are typically maintained by serial intraperitoneal implantation in male Donryu rats. The AH-130 line itself is known for its high thromboplastic and fibrinolytic activities, which are linked to its role in promoting blood-borne metastasis, especially in the lungs. In contrast, the AH-130 FN variant has lower thromboplastic and fibrinolytic activity. This difference in enzymatic activity between AH-130 and AH-130 FN is crucial as it influences the formation of thrombi and the number of metastatic foci in the lungs following intravenous inoculation. Research has shown that after intravenous injection, AH-130 cells cause a significant reduction in platelet count and fibrinogen levels, indicative of increased thrombus formation. This effect is notably more pronounced than in AH-130 FN. Histological studies demonstrate that AH-130 forms more abundant metastatic foci in the lungs compared to AH-130 FN, both at 72 hours and 7 days post-inoculation. AH-130 is associated with the formation of thrombi composed of platelets and fibrin around embolized tumor cells, whereas AH-130 FN shows sparse thrombus formation. These findings suggest that AH-130’s higher thromboplastic activity plays a significant role in promoting metastasis through platelet aggregation and fibrin deposition around the tumor cells, a process less prominent in AH-130 FN.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100152\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196978029,"sku":"500451","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ah-130-fn-_282_29_1920x1920_64f4da1b-2481-4063-a4b1-491f09972c0b.jpg?v=1769068944"},{"product_id":"akata-cell-bhc11101519","title":"AKATA cell","description":"The AKATA cell line, derived from Burkitt’s lymphoma, is a widely used model to study Epstein-Barr virus (EBV) latency and reactivation. EBV is a ubiquitous herpesvirus linked to a range of cancers, including Burkitt lymphoma, and typically establishes a latent infection within B cells. In AKATA cells, EBV is maintained in an episomal state with a type I latency program, expressing a limited set of viral genes such as EBNA-1, EBER RNAs, and BamHI-A rightward transcripts (BARTs). This restricted gene expression allows the virus to persist in the host without initiating a full lytic cycle. However, AKATA cells can be triggered to enter the lytic phase, where the virus actively replicates and produces progeny. This reactivation is commonly induced through cross-linking surface immunoglobulins, which makes AKATA cells an excellent tool for studying EBV reactivation dynamics and viral gene regulation.\nResearch utilizing the AKATA cell line has also examined the impact of chemotherapeutic agents on EBV reactivation. For instance, drugs like etoposide and doxorubicin have been shown to influence viral latency. Etoposide induces apoptosis in AKATA cells but reactivates EBV less effectively than doxorubicin, which promotes higher levels of lytic gene expression and viral progeny production. Additionally, studies involving gene editing techniques, such as CRISPR\/Cas9, have explored the role of epigenetic regulators in AKATA cells. For example, knockout of the histone methyltransferase EZH2 in AKATA cells disrupts the maintenance of latency by reducing the trimethylation of histone H3K27, leading to increased expression of both latent and lytic EBV genes, as well as enhanced viral replication and cell proliferation.\nAKATA cells also display distinct phenotypic characteristics based on EBV presence, such as increased sensitivity to apoptosis-inducing agents and variations in gene expression related to apoptotic pathways. These differences make EBV-positive AKATA cells a powerful model for dissecting EBV's influence on host cell survival, gene expression, and the virus's lifecycle, particularly in the context of cancer development and potential therapeutic interventions targeting EBV-associated malignancies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101519\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197010797,"sku":"305510","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AKATA_20P3_2020x01_20110225_ch00_1920x1920_022aa6cd-476e-48c7-9501-05c2af3e1664.jpg?v=1769068945"},{"product_id":"alab-cell-bhc11101019","title":"Alab cell","description":"The ALAB cell line is a human mammary adenocarcinoma cell line derived from a mammary tumor. It has been adapted to grow in vitro, particularly on collagen substrates, which facilitates the study of tumor cell behavior in mammary carcinomas. ALAB cells are notably used in research focused on calcium-binding and collagen-binding proteins (CaBP and CBP, respectively). In these cells, the calcium-binding proteins were isolated and analyzed, revealing a significant 38 kDa protein, which is closely associated with annexins, a family of proteins involved in cellular processes such as membrane trafficking and signal transduction.\nOne of the key proteins identified in ALAB cells is annexin II, a calcium-dependent protein that binds to collagen and plays a role in various cellular functions, including exocytosis and cytoskeletal organization. Immunofluorescence studies of ALAB cells reveal a perinuclear granular pattern of annexin II expression, indicating its involvement in protein secretion and cellular differentiation. The 38 kDa annexin II protein detected in these cells is also associated with collagen-binding properties, which can be crucial for tumor progression and metastasis, making ALAB a valuable model for studying mammary tumor biology and protein interactions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101019\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197043565,"sku":"300280","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Alab-_282_29_1920x1920_afe69b3f-4819-4574-bef3-20946fa1f6ab.jpg?v=1769068946"},{"product_id":"aml12-cell-bhc11101265","title":"AML12 cell","description":"AML12 cells, also known as Alpha Mouse Liver 12 cells, are a non-tumorigenic epithelial cell line derived from the liver of a transgenic mouse. These cells were initially developed to provide a suitable in vitro model for studying the hepatocyte function and liver biology of the adult mouse. AML12 cells express characteristics typical of differentiated hepatocytes, including the production of albumin, transferrin, and other liver-specific proteins, making them an invaluable resource for research in toxicology, drug metabolism, and liver disease.\n\nThe cell line was established from hepatocytes isolated from a mouse harboring a transgene for human transforming growth factor alpha (TGF-alpha), under the control of the mouse metallothionein-I promoter. This genetic alteration contributes to the immortalization of the cells without disrupting their differentiated state. AML12 cells maintain a stable phenotype and karyotype under standard cell culture conditions, which includes a unique requirement for dexamethasone and insulin-transferrin-selenium in the growth medium to promote proliferation and maintain hepatocyte-specific functions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101265\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197076333,"sku":"300643","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/aml12-_282_29_1920x1920_fd1a83ba-979f-4ece-8666-1507a80d1af3.jpg?v=1769068946"},{"product_id":"an3-ca-cell-bhc11100043","title":"AN3 Ca cell","description":"The An3 Ca cell line is derived from a human endometrial adenocarcinoma, a type of cancer originating from the lining of the uterus. This cell line is estrogen receptor negative (ER-) and exhibits aggressive tumorigenic potential when assessed in vivo. An3 Ca cells are used extensively in research focused on understanding the molecular and cellular mechanisms underlying endometrial cancer progression, including studies on cancer cell proliferation, metastasis, and response to therapeutic agents.\n\nCharacteristically, An3 Ca cells display an epithelial morphology and have been utilized to study the impact of various genetic and environmental factors on cancer cell behavior. Research using this cell line has contributed to identifying potential therapeutic targets and understanding the resistance mechanisms against conventional treatments. They serve as a valuable model for evaluating new drugs or treatment strategies that could be effective against aggressive forms of endometrial cancer.\n\nOverall, the An3 Ca cell line is instrumental in advancing the scientific knowledge of endometrial adenocarcinoma, offering insights that might lead to more effective interventions for this challenging and often lethal disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100043\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197109101,"sku":"300119","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/an3-ca-_284_29_1920x1920_59defe71-9b26-4a96-84f0-aa3ac093f9f3.jpg?v=1769068946"},{"product_id":"anglne-cell-bhc11101282","title":"Anglne cell","description":"The Anglne cell line was established by German scholars and is mainly applied to pathological research of ovarian cancer and screening of anti-tumor drugs. The Anglne cell line is adherent and more convenient to culture than the COC1 cell line.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101282\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197207405,"sku":"305144","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Anglne_20_20WaKo_20P1_2020x01_20100425_ch00_1920x1920_f2ffce7b-448a-4633-a21e-4d0984669046.jpg?v=1769068947"},{"product_id":"ar42j-cell-bhc11100120","title":"AR42J cell","description":"AR42J cells are a rat pancreatic tumor cell line derived from azaserine-induced tumors in rats. They are widely used as a model for studying pancreatic exocrine cell functions, pancreatitis, and pancreatic cancer research. AR42J cells exhibit acinar-like characteristics, making them particularly valuable for investigating the physiology and pathology of pancreatic acinar cells.\nOne of the defining features of AR42J cells is their ability to differentiate into cell types exhibiting more pronounced pancreatic exocrine functions when treated with various agents, such as dexamethasone or activators of protein kinase C. Upon differentiation, these cells produce and secrete digestive enzymes, including amylase, lipase, and chymotrypsin, mimicking the enzyme secretion profile of normal pancreatic acinar cells.\nAR42J cells are also used to explore the mechanisms of acute pancreatitis. They respond to stimuli like cerulein, a cholecystokinin analog, which can induce a condition in the cells that resembles acute pancreatitis, characterized by enzyme overproduction, oxidative stress, and inflammatory responses. This makes AR42J cells a useful tool for testing potential therapeutic interventions for pancreatitis.\nFurthermore, the AR42J cell line is utilized in research focused on pancreatic cancer, particularly for studies on tumorigenesis and the malignant transformation of acinar cells. They are instrumental in examining the effects of oncogenes, tumor suppressor genes, and growth factors on the development and progression of pancreatic cancer.\nOverall, AR42J cells provide a versatile and dynamic model system for advancing our understanding of pancreatic diseases and for the development of new therapeutic strategies targeting these conditions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100120\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197272941,"sku":"500478","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ar42j-_284_29_1920x1920_b0c130b0-2f95-4d82-9854-0a0d210cdb1a.jpg?v=1769068947"},{"product_id":"arh-77-cell-bhc11101176","title":"ARH-77 cell","description":"The ARH-77 cell line is a human cell line derived from the peripheral blood of a 33-year-old female patient with plasma cell leukemia, a type of cancer that affects plasma cells in the bone marrow. ARH-77 cells are characterized by their B lymphoblastoid phenotype, which makes them particularly useful for studying B-cell maturation and function as well as plasma cell leukemia pathology. This cell line is also frequently used in research related to Epstein-Barr virus (EBV), as it is EBV-transformed.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101176\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197305709,"sku":"300306","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ARH-77_20P1_2020x01_20290823_20WaKo_ch00_1920x1920_1aff46bc-8eac-4932-81a9-4cb19405ee70.jpg?v=1769068947"}],"url":"https:\/\/www.ebiohippo.com\/collections\/cells.oembed","provider":"BioHippo","version":"1.0","type":"link"}