{"title":"MycoFold","description":"Products supplied by MycoFold, Inc.","products":[{"product_id":"mycofold-rhu-pdgf-bb-bhp21700001","title":"MycoFold™ Human Recombinant Platelet-Derived Growth Factor BB (PDGF-BB) Protein","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item{background:#f0f6ff;border:1px solid #ccd9f0;border-radius:4px;padding:6px 12px;font-size:14px;display:inline-block;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item strong{color:#003366;display:block;font-size:12px;text-transform:uppercase;letter-spacing:.5px}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cp\u003ePDGF-BB (Platelet-Derived Growth Factor BB) is a potent mitogen with pleiotropic roles in mesenchymal and stromal cell biology. It signals through PDGFRα and PDGFRβ receptor tyrosine kinases, activating RAS\/MAPK, PI3K\/Akt, and PLCγ\/PKC cascades to drive cell proliferation, migration, and survival. Uniquely among PDGF isoforms, PDGF-BB binds and activates all three receptor combinations — PDGFRαα, PDGFRαβ, and PDGFRββ — enabling broad targeting across connective tissue, vascular, and progenitor cell populations.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"bhp-cat-pill\"\u003eExpressed in Pichia pastoris (K. phaffii)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMycoFold™ PDGF-BB is produced in a proprietary engineered yeast platform that ensures chaperone-guided protein folding, lysis-free secretion, and elimination of animal-origin inputs and bacterial endotoxin. The result is a highly pure, bioactive protein that reconstitutes in deionized water — no special buffers required.\u003c\/p\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eCat. No.\u003c\/th\u003e\n\u003ctd\u003eGR1002-10, GR1002-50, GR1002-100, GR1002-250, GR1002-500, GR1002-1000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSource\u003c\/th\u003e\n\u003ctd\u003ePichia pastoris (K. phaffii)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStructure \/ Form\u003c\/th\u003e\n\u003ctd\u003eCarrier protein-free; no affinity tags; lyophilized with no excipients\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e~28 kDa (homodimer, non-reduced); ~14 kDa (monomer, reduced)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt \/ Gene\u003c\/th\u003e\n\u003ctd\u003eP01127 \/ PDGFB (NCBI Gene ID: 5155)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt;95% by SDS-PAGE and HP-SEC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eEndotoxin\u003c\/th\u003e\n\u003ctd\u003e\u0026lt;0.1 EU\/µg by LAL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eLyophilized: ≤−20°C until expiry. Reconstituted: 2–8°C up to 2 weeks; −20°C for extended storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eAmbient temperature; lyophilized formulation requires no cold chain\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eQC \u0026amp; Validation\u003c\/h2\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Lot-specific CoA\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ SDS-PAGE Purity\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ LAL Endotoxin Tested\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Mycoplasma Tested (qPCR)\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ BSE\/TSE Statement Available\u003c\/span\u003e\n\u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eBiosafety\u003c\/strong\u003eBSL-1\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eIntended Use\u003c\/strong\u003eResearch Use Only (RUO)\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eAnimal-Origin\u003c\/strong\u003e100% Animal-Free\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u0026lt;0.1 EU\/µg by LAL\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MycoFold, Inc","offers":[{"title":"10 µg","offer_id":53331920257389,"sku":"GR1002-10","price":91.0,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":53331920716141,"sku":"GR1002-50","price":228.2,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":53331920748909,"sku":"GR1002-100","price":379.4,"currency_code":"USD","in_stock":true},{"title":"250 µg","offer_id":53331920781677,"sku":"GR1002-250","price":876.8,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":53331920814445,"sku":"GR1002-500","price":1504.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53331920847213,"sku":"GR1002-1000","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Vial_Image_GR1002_rHu_PDGFBB_NewBackground.jpg?v=1778786718"},{"product_id":"mycofold-rhu-m-csf-bhp21700002","title":"MycoFold™ Human Recombinant Macrophage Colony-Stimulating Factor (M-CSF) Protein","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item{background:#f0f6ff;border:1px solid #ccd9f0;border-radius:4px;padding:6px 12px;font-size:14px;display:inline-block;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item strong{color:#003366;display:block;font-size:12px;text-transform:uppercase;letter-spacing:.5px}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cp\u003eM-CSF (Macrophage Colony-Stimulating Factor, CSF-1) is a master regulator of macrophage differentiation, polarization, and function. It signals through the M-CSF receptor (M-CSFR \/ CSF-1R), a receptor tyrosine kinase whose dimerization and autophosphorylation activate NF-κB, JAK\/STAT, PI3K\/Akt, MAPK\/ERK, and IL-10\/TGF-β pathways. As an N- and O-glycosylated homodimeric glycoprotein, M-CSF requires correct glycan patterning and disulfide bridging for potent M-CSFR engagement.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"bhp-cat-pill\"\u003eExpressed in Pichia pastoris (K. phaffii)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMycoFold™ M-CSF is produced in a proprietary engineered yeast platform that ensures chaperone-guided protein folding, lysis-free secretion, and elimination of animal-origin inputs and bacterial endotoxin. The result is a highly pure, bioactive protein that reconstitutes in deionized water — no special buffers required.\u003c\/p\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eCat. No.\u003c\/th\u003e\n\u003ctd\u003eGR1003-10, GR1003-50, GR1003-100, GR1003-250, GR1003-500, GR1003-1000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSource\u003c\/th\u003e\n\u003ctd\u003ePichia pastoris (K. phaffii)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStructure \/ Form\u003c\/th\u003e\n\u003ctd\u003eCarrier protein-free; no affinity tags; N- and O-glycosylated homodimer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e~64 kDa (glycosylated homodimer, non-reduced); ~30–50 kDa (multiple glycoform bands by SDS-PAGE reduced)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt \/ Gene\u003c\/th\u003e\n\u003ctd\u003eP09603 \/ CSF1 (NCBI Gene ID: 1435)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt;98% by SDS-PAGE and HP-SEC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eEndotoxin\u003c\/th\u003e\n\u003ctd\u003e\u0026lt;0.01 EU\/µg by LAL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eLyophilized: ≤−20°C until expiry. Reconstituted: 2–8°C up to 4 weeks (verified stable at 108% activity at 30 days 4°C). Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eAmbient temperature; lyophilized formulation requires no cold chain\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eQC \u0026amp; Validation\u003c\/h2\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Lot-specific CoA\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ SDS-PAGE Purity\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ LAL Endotoxin Tested\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Mycoplasma Tested (qPCR)\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ BSE\/TSE Statement Available\u003c\/span\u003e\n\u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eBiosafety\u003c\/strong\u003eBSL-1\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eIntended Use\u003c\/strong\u003eResearch Use Only (RUO)\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eAnimal-Origin\u003c\/strong\u003e100% Animal-Free\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u0026lt;0.01 EU\/µg by LAL\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MycoFold, Inc","offers":[{"title":"10 µg","offer_id":53331920224621,"sku":"GR1003-10","price":100.8,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":53331921043821,"sku":"GR1003-50","price":280.0,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":53331921076589,"sku":"GR1003-100","price":466.9,"currency_code":"USD","in_stock":true},{"title":"250 µg","offer_id":53331921109357,"sku":"GR1003-250","price":970.5,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":53331921142125,"sku":"GR1003-500","price":1656.75,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53331921174893,"sku":"GR1003-1000","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Vial_Image_GR1003_rHu_MCSF_Corrected.jpg?v=1778786719"},{"product_id":"mycofold-rhu-il-2-bhp21700004","title":"MycoFold™ Human Recombinant Interleukin-2 (IL-2) Cytokine","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item{background:#f0f6ff;border:1px solid #ccd9f0;border-radius:4px;padding:6px 12px;font-size:14px;display:inline-block;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item strong{color:#003366;display:block;font-size:12px;text-transform:uppercase;letter-spacing:.5px}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cp\u003eIL-2 (Interleukin-2) is a pleiotropic T-cell growth factor and immunomodulatory cytokine that signals through the high-affinity IL-2 receptor complex (IL-2Rα\/β\/γ chain) to activate JAK\/STAT5, PI3K\/Akt, and MAPK pathways. It plays essential roles in T-cell proliferation, NK cell expansion, regulatory T-cell (Treg) maintenance, and broader lymphocyte homeostasis. As a non-glycosylated single-chain protein (~15.3 kDa), IL-2 activity critically depends on the native Cys58–Cys105 intramolecular disulfide bond.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"bhp-cat-pill\"\u003eExpressed in Pichia pastoris (K. phaffii)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMycoFold™ IL-2 is produced in a proprietary engineered yeast platform that ensures chaperone-guided protein folding, lysis-free secretion, and elimination of animal-origin inputs and bacterial endotoxin. The result is a highly pure, bioactive protein that reconstitutes in deionized water — no special buffers required.\u003c\/p\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eCat. No.\u003c\/th\u003e\n\u003ctd\u003eGR1004-10, GR1004-50, GR1004-100, GR1004-250, GR1004-500, GR1004-1000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSource\u003c\/th\u003e\n\u003ctd\u003ePichia pastoris (K. phaffii)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStructure \/ Form\u003c\/th\u003e\n\u003ctd\u003eCarrier protein-free; no affinity tags; non-glycosylated single-chain monomer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e~15.3 kDa (monomer; non-glycosylated single-chain)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt \/ Gene\u003c\/th\u003e\n\u003ctd\u003eP60568 \/ IL2 (NCBI Gene ID: 3558)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e≥98% by Mass Spectrometry (mass spec confirmed)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eEndotoxin\u003c\/th\u003e\n\u003ctd\u003eSee lot-specific CoA (LAL tested per lot)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eLyophilized: ≤−20°C until expiry. Reconstituted: 2–8°C short-term; −20°C for extended storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eAmbient temperature; lyophilized formulation requires no cold chain\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eQC \u0026amp; Validation\u003c\/h2\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Lot-specific CoA\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ SDS-PAGE Purity\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ LAL Endotoxin Tested\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Mycoplasma Tested (qPCR)\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ BSE\/TSE Statement Available\u003c\/span\u003e\n\u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eBiosafety\u003c\/strong\u003eBSL-1\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eIntended Use\u003c\/strong\u003eResearch Use Only (RUO)\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eAnimal-Origin\u003c\/strong\u003e100% Animal-Free\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eEndotoxin\u003c\/strong\u003eSee lot-specific CoA (LAL tested per lot)\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MycoFold, Inc","offers":[{"title":"10 µg","offer_id":53331920290157,"sku":"GR1004-10","price":37.1,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":53331920552301,"sku":"GR1004-50","price":95.2,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":53331920585069,"sku":"GR1004-100","price":105.7,"currency_code":"USD","in_stock":true},{"title":"250 µg","offer_id":53331920617837,"sku":"GR1004-250","price":180.0,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":53331920650605,"sku":"GR1004-500","price":307.2,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53331920683373,"sku":"GR1004-1000","price":512.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Vial_Image_GR1004_rHu_IL2_NewBackground_Pre-Order.jpg?v=1778786719"},{"product_id":"mycofold-rhu-il-6-bhp21700003","title":"MycoFold™ Human Recombinant Interleukin-6 (IL-6) Cytokine","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item{background:#f0f6ff;border:1px solid #ccd9f0;border-radius:4px;padding:6px 12px;font-size:14px;display:inline-block;margin:4px 4px 4px 0}\n.bhp-desc .bhp-reg-item strong{color:#003366;display:block;font-size:12px;text-transform:uppercase;letter-spacing:.5px}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cp\u003eIL-6 (Interleukin-6) is a pleiotropic cytokine central to immune regulation, inflammation, hematopoiesis, and acute-phase responses. It signals through the IL-6 receptor (IL-6R) complex: IL-6 binding recruits and homodimerizes the signal transducer gp130 (CD130), initiating JAK\/STAT3, MAPK\/ERK, and PI3K\/Akt cascades. IL-6 is a secreted N-glycosylated monomer; proper folding of receptor-binding residues, disulfide bridges, and glycosylation sites are essential for potent IL-6R\/gp130 complex stimulation.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"bhp-cat-pill\"\u003eExpressed in Pichia pastoris (K. phaffii)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMycoFold™ IL-6 is produced in a proprietary engineered yeast platform that ensures chaperone-guided protein folding, lysis-free secretion, and elimination of animal-origin inputs and bacterial endotoxin. The result is a highly pure, bioactive protein that reconstitutes in deionized water — no special buffers required.\u003c\/p\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eCat. No.\u003c\/th\u003e\n\u003ctd\u003eGR1005-10, GR1005-50, GR1005-100, GR1005-250, GR1005-500, GR1005-1000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSource\u003c\/th\u003e\n\u003ctd\u003ePichia pastoris (K. phaffii)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStructure \/ Form\u003c\/th\u003e\n\u003ctd\u003eCarrier protein-free; no affinity tags; N-glycosylated secreted monomer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e~26 kDa (N-glycosylated monomer)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt \/ Gene\u003c\/th\u003e\n\u003ctd\u003eP05231 \/ IL6 (NCBI Gene ID: 3569)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt;95% by SDS-PAGE and HP-SEC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eEndotoxin\u003c\/th\u003e\n\u003ctd\u003eNegative (endotoxin-free; tested per lot)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eLyophilized: ≤−20°C until expiry. Reconstituted: 2–8°C up to 20 days (103% activity confirmed at 20 days 4°C). Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eAmbient temperature; lyophilized formulation requires no cold chain\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eQC \u0026amp; Validation\u003c\/h2\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Lot-specific CoA\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ SDS-PAGE Purity\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ LAL Endotoxin Tested\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ Mycoplasma Tested (qPCR)\u003c\/span\u003e\n\u003cspan class=\"bhp-qc-badge\"\u003e✓ BSE\/TSE Statement Available\u003c\/span\u003e\n\u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eBiosafety\u003c\/strong\u003eBSL-1\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eIntended Use\u003c\/strong\u003eResearch Use Only (RUO)\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eAnimal-Origin\u003c\/strong\u003e100% Animal-Free\u003c\/div\u003e\n\u003cdiv class=\"bhp-reg-item\"\u003e\n\u003cstrong\u003eEndotoxin\u003c\/strong\u003eNegative (endotoxin-free; tested per lot)\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MycoFold, Inc","offers":[{"title":"10 µg","offer_id":53331920191853,"sku":"GR1005-10","price":64.4,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":53331920879981,"sku":"GR1005-50","price":95.2,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":53331920912749,"sku":"GR1005-100","price":291.2,"currency_code":"USD","in_stock":true},{"title":"250 µg","offer_id":53331920945517,"sku":"GR1005-250","price":673.12,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":53331920978285,"sku":"GR1005-500","price":1153.6,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53331921011053,"sku":"GR1005-1000","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Vial_Image_GR1005_rHu_IL6_NewBackground.jpg?v=1778786718"}],"url":"https:\/\/www.ebiohippo.com\/collections\/mycofold.oembed","provider":"BioHippo","version":"1.0","type":"link"}