{"title":"Bacterial \u0026 Fungal Infections","description":null,"products":[{"product_id":"16hbe14o-cell-bhc11101425","title":"16HBE14o- cell","description":"The 16HBE140 cell line is derived from human bronchial epithelial cells, which are essential for studying the respiratory epithelium. These cells retain several key characteristics of primary bronchial epithelial cells, including the ability to form tight junctions, express characteristic markers, and exhibit typical epithelial morphology. They are widely used in research focusing on respiratory diseases, drug transport, and toxicology studies, providing a reliable in vitro model to understand bronchial epithelial cell behavior under various conditions.\nOne of the significant applications of 16HBE140 cells is in the investigation of cystic fibrosis (CF), a genetic disorder affecting the respiratory system. These cells express the cystic fibrosis transmembrane conductance regulator (CFTR) protein, making them a valuable tool for studying CF pathophysiology and for screening potential therapeutic agents. Additionally, 16HBE140 cells are utilized in airway inflammation research, given their response to pro-inflammatory cytokines and pollutants, aiding in the understanding of chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).\n\u003cp style=\"display:none\"\u003eSKU:BHC11101425\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195077485,"sku":"305234","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/16HBE14o_20WaKo_20P1_2020x01_20181024_ch00_1920x1920_4dbb6d23-1d2b-4f74-9bc0-dd509475e130.jpg?v=1769068929"},{"product_id":"2106t-cell-bhc11100246","title":"2106T cell","description":"The 2106T cell line has been established from pulmonary squamous cell carcinoma of a patient by Dr. Sandra Gottschling and Dr. Michael Meister in 2009. The 2106LN cell line was isolated from a lymph node metastasis of the same patient.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100246\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195110253,"sku":"300165","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/2106T_20WaKo_20P1_2010x01_20280525_ch00_1920x1920_b70a4584-a51c-45b5-a3cd-0b0b5953bc35.jpg?v=1769068930"},{"product_id":"2427t-cell-bhc11101374","title":"2427T cell","description":"Originating from a primary tumor of a 64-year-old female Caucasian patient diagnosed with lung squamous cell carcinoma, 2427T provides a valuable in vitro model that recapitulates the morphological traits of the original tumor tissue. Characterized by their distinctive small, round shape and propensity to aggregate into clusters, 2427T cells exhibit key morphological features typical of squamous cell carcinoma (SCC).\nA defining characteristic of the 2427T cell line is its expression of cytokeratin 5\/6 (CK5\/6), a marker indicative of its SCC origin. The heterogeneous expression of CK5\/6 hints at the presence of diverse cell subpopulations within the 2427T culture, presenting an opportunity for further exploration of intratumoral heterogeneity.\nImmunophenotyping of 2427T has revealed its unique profile, including the lack of adenocarcinoma-associated marker CK7, hemato-endothelial progenitor marker CD34, and leukocyte marker CD45, reinforcing its classification within the squamous lineage. Interestingly, while the cell line generally shows negativity for neuroendocrine markers such as CD56, synaptophysin (SYP), neuron-specific enolase (NSE), and chromogranin A (CHGA), the expression of SYP in a subset of cells suggests a degree of neuroendocrine marker heterogeneity.\nCrucially, the 2427T cell line does not harbor mutations in EGF-R or k-ras, distinguishing it from other models and underscoring its potential as a novel resource for delving into the biology and therapeutic vulnerabilities of squamous cell non-small cell lung cancer (NSCLC). This absence of common oncogenic mutations positions 2427T as an invaluable tool for research aimed at uncovering the underlying mechanisms of squamous cell carcinoma pathogenesis and progression.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101374\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195208557,"sku":"300167","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/2427T_20P1_2020x01_20250425_ch00_1920x1920_ea96e0fc-18f0-4a17-adf8-1805029d5373.jpg?v=1769068931"},{"product_id":"a427-cell-bhc11100094","title":"A427 cell","description":"A427 cells originate from lung tissue, specifically a carcinoma, exhibit epithelial morphology and grow adherently. A427 cells have a doubling time of approximately 28 hours in RPMI 1640 medium supplemented with 10% fetal bovine serum (FBS). \nIn ACL-3 medium, the doubling time is slightly extended to 38 hours, while in ACL-3 supplemented with bovine serum albumin (BSA), it reaches 42 hours. These variations in doubling time provide valuable insights into cell behaviour under different experimental conditions.\nAt passage 60, A427 cells display a hypotriploid to hypertriploid karyotype. This means the cells possess abnormal chromosomes, including dicentrics, minutes, and a large subtelocentric marker. Such karyotypic abnormalities are often associated with cancer cells and contribute to the unique characteristics of this cell line. A427 cells exhibit tumorigenic properties, allowing them to form tumours when injected into nude mice. \nThese tumours resemble undifferentiated adenocarcinoma, further emphasizing the relevance of this cell line in studying lung cancer and its progression. With its exceptional features, A427 cells find utility in various applications, particularly in cancer research. Their epithelial morphology and lung origin make them an ideal model for studying lung cancer and related diseases. Additionally, A427 cells are well-suited for 3D cell culture techniques, providing a more physiologically relevant environment to explore the behaviour of lung cancer cells.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100094\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196257133,"sku":"300111","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A427_20WaKo_20P1_2020x01_20080925_ch00_1920x1920_7109e5e2-5269-4661-9243-2a4765d4cecd.jpg?v=1769068938"},{"product_id":"a549-cell-bhc11100147","title":"A549 cell","description":"A549 cells, derived from lung adenocarcinoma tissue, are a primary model used in cancer research, particularly in biomedical laboratories focusing on lung-related cancers. A549 cells are commonly used as an in vitro model for studying lung cancer biology, drug screening, and the effects of toxic compounds.\nIn toxicology research, A549 cells offer a controlled experimental model that enables scientists to explore the mechanisms underlying toxic effects and cellular responses. By understanding these mechanisms, researchers can better assess the safety of substances and potentially mitigate their harmful effects.\nA549 carcinoma cells have been extensively used as an in vitro model to study lung cancer pathogenesis and as an alternative tissue culture model for various pulmonary-related research studies in biomedical laboratories. These cells maintain the characteristics of type II alveolar epithelial cells and are used to examine the epithelial responses to various infections and inflammatory stimuli, including lung inflammation.\nFurthermore, the human cell line A549 serves as a valuable tool in the development of specific antibodies targeting lung cancer-related proteins or markers. By exposing these cells to substances of interest, researchers can investigate how they affect cell viability, proliferation, apoptosis, and other cellular processes. This information aids in the identification of potential therapeutic targets and the development of novel treatments for lung cancer.\nIn summary, A549 carcinoma cells are pivotal in cancer research, especially concerning lung-related cancers, serving as an in vitro model for cancer and toxicology research, developing effective treatments, and drug screening.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100147\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196355437,"sku":"300114","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A549_20P35_20300114-1421_2020x01_2026082022_1920x1920_7da09e07-fa3c-451b-b408-9991b0e4cb71.jpg?v=1769068939"},{"product_id":"a549-ddp-cell-bhc11101352","title":"A549\/DDP cell","description":"The A549\/DDP cell line is a drug-resistant variant of the A549 cell line, which itself is a model of human alveolar basal epithelial adenocarcinoma. This variant has been specifically selected for its resistance to cisplatin (DDP), a common chemotherapy drug used in the treatment of various cancers, including lung cancer. The development of the A549\/DDP cell line enables researchers to study the mechanisms underlying chemoresistance, which is a major challenge in cancer therapy.\n\nIn research, the A549\/DDP cell line is utilized to investigate the biochemical pathways involved in cisplatin resistance. This includes the exploration of changes in gene expression, protein function, and cellular metabolism that confer resistance to cisplatin. The cell line is also valuable in the screening of new drugs or drug combinations that can overcome resistance, providing insights that are crucial for the development of more effective therapeutic strategies against lung cancer.\n\nMoreover, studies using the A549\/DDP cell line contribute to a better understanding of the molecular basis of lung cancer progression and metastasis in the context of chemoresistance. This cell line serves as a critical tool for translational research, bridging experimental findings to potential clinical applications in oncology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101352\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196486509,"sku":"305047","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/a549-ddp-_281_29.jpg?v=1769068939"},{"product_id":"asb-xiv-cell-bhc11100150","title":"ASB-XIV cell","description":"ASB-xIV cells, originating from a female Balb\/c mouse, closely mimic large cell carcinoma that has been induced by chrysotile asbestos in mouse lung cells. These cells are monolayer adherent with an epithelial morphology, positioning them as an exemplary model for primary squamous cell carcinoma (PSCC) research. Their structural and functional characteristics make them particularly suitable for detailed studies on the cellular processes and pathological mechanisms underlying PSCC.\n\nThe ASB-xIV cell line is characterized as an \"inflamed\" or \"hot\" tumor, indicating a high degree of immune cell infiltration which makes it more responsive to immunotherapy. This sensitivity is pivotal in using ASB-xIV cells to evaluate the efficacy of immune checkpoint therapies (ICT). These cells have shown significant responsiveness to such treatments, making them invaluable in oncological research focused on immunotherapeutic efficacy. Additionally, while retinoids have been effective in curbing the growth of these cells in transplanted carcinomas in mice, vitamin C has failed to produce a similar effect. Despite their slow doubling time of approximately 70 hours, ASB-xIV cells maintain robust and stable growth, which is crucial for establishing consistent and reliable in vitro cultures necessary for experimental reproducibility.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100150\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197535085,"sku":"400120","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/asb-xiv-_284_29_1920x1920_809762c0-81cf-4ae2-a15f-eb17b6412e62.jpg?v=1769068948"},{"product_id":"beas-2b-cell-bhc11101339","title":"BEAS-2B cell","description":"BEAS-2B is an immortalized cell line derived from the bronchial epithelium of a non-cancerous individual. This cell line was established by transforming human bronchial epithelial cells with an adenovirus 12-SV40 hybrid virus, which confers the cells with an extended lifespan while maintaining many of the morphological and functional characteristics typical of primary bronchial epithelial cells. BEAS-2B cells are widely used in respiratory disease research, particularly in studies related to the toxicological and pharmacological effects of inhalable substances, owing to their origin from the airway epithelium.\n\nThe cell line exhibits a cobblestone morphology when cultured and retains certain critical features, such as the ability to metabolize xenobiotic compounds, making them highly relevant for studies on drug metabolism and respiratory toxicology. They have also been employed extensively in studies exploring cellular mechanisms of asthma, chronic obstructive pulmonary disease (COPD), and cancer. BEAS-2B cells respond predictably to cytokines, oxidative stress, and other stimuli typical of respiratory tract exposure to environmental agents. This makes them a valuable model for studying inflammation and oxidative stress mechanisms in pulmonary cells.\n\nAs a tool in biomedical research, BEAS-2B cells are also frequently used to assess carcinogenic potential of airborne particles, where they serve as a model to understand the changes in airway epithelial cells following exposure to carcinogens. Their genetic makeup and susceptibility to genetic manipulation further enhance their utility in molecular biology experiments aimed at understanding gene expression and signaling pathways involved in lung diseases and cancer development.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101339\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198059373,"sku":"300311","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/beas-2b-_289_29_1920x1920_f98cbff5-bfb9-4ddf-8f53-24d022c3bc51.jpg?v=1769068954"},{"product_id":"calu-1-cell-bhc11100243","title":"Calu-1 cell","description":"The Calu-1 cell line originates from human lung carcinoma, specifically non-small cell lung cancer (NSCLC). It was established from the pleural effusion of a 47-year-old Caucasian male with epidermoid carcinoma of the lung. This cell line exhibits epithelial-like morphology and has been used extensively in research focused on lung cancer biology, drug screening, and cytotoxicity studies. Calu-1 cells express several markers characteristic of lung epithelial cells and have been a valuable model for studying the molecular pathways involved in lung carcinogenesis and therapy resistance.\n\nCalu-1 cells are known for their high proliferation rate and robustness in culture, making them suitable for in vitro experimental setups. They retain several chromosomal abnormalities typical of cancer cells, which includes multiple copies of chromosomes 7 and 20, demonstrating their utility in genetic and cytogenetic studies. The cell line also exhibits mutations in key oncogenes and tumor suppressor genes like KRAS and TP53, respectively, which are of particular interest in lung cancer research. These genetic characteristics make Calu-1 a useful tool for investigating the impact of genetic alterations on cancer progression and for testing the efficacy of targeted therapies in a controlled environment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100243\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200451437,"sku":"300141","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CaLu-1_20WAKO_20P1_2020x01_20120825_ch00_1920x1920_b3989725-2c8c-4f44-a2b2-e7838e034a87.jpg?v=1769068982"},{"product_id":"calu-3-cell-bhc11101129","title":"Calu-3 cell","description":"Calu-3 cells are a human epithelial cell line derived from the lung adenocarcinoma of a 25-year-old in 1975. These cells exhibit epithelial morphology and are characterized by their ability to form tight junctions, desmosomes, and microvilli, mirroring the structural features of lung epithelium. Calu 3 cells are particularly noted for their high-level secretion of mucins, which are glycoproteins involved in protecting and lubricating the pulmonary airways, making them a relevant in vitro model for studying airway epithelial biology, including mucin production, secretion, and its regulation.\nCalu-3 human lung adenocarcinoma cells are used in drug discovery and development, particularly for assessing the absorption, distribution, metabolism, and excretion (ADME) of inhaled pharmaceuticals. Their ability to form a polarized monolayer when cultured on permeable supports makes them suitable for studying drug transport and the effects of drugs on the airway epithelium.\nCalu 3 cells, derived from human lung cancer cell types, are particularly relevant in the study of airway epithelial cells and their role in respiratory conditions. These cells originate from bronchial submucosal glands and are utilized in cell culture models to mimic the human airway, providing insights into respiratory function, epithelial cell injury, lung injury and the study of dieseases such as cystic fibrosis or SARS.\nThe study of Calu 3 cells and their response to chemotherapeutic agents contributes to the broader field of lung cancer research, offering insights into the efficacy of treatments and the potential for developing more effective therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101129\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200484205,"sku":"305032","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CaLu-3_20P0_20305032-M_2010x01_20270922_1920x1920_ffad64ab-b3bb-478c-a733-f3faa6f1c367.jpg?v=1769068982"},{"product_id":"calu-6-cell-bhc11100473","title":"Calu-6 cell","description":"The Calu-6 cell line is a human non-small cell lung carcinoma (NSCLC) cell line derived from the pleural effusion of a 61-year-old male patient. Established in 1975, this cell line has been a critical model in lung cancer research. Calu-6 cells exhibit a distinct epithelial morphology and have been used extensively to study the biology of lung cancer, including mechanisms of metastasis, drug resistance, and the tumor microenvironment. These cells are particularly noted for their ability to form tumors in xenograft models, which makes them highly valuable for in vivo studies of tumor growth and response to therapeutics.\n\nCalu-6 is characterized by a high level of KRAS mutation, common in NSCLC, and provides a relevant model for studying the role of this oncogene in lung cancer. The cell line also displays several cytogenetic anomalies typical of cancer cells, such as complex karyotypes and aneuploidy, which contribute to its use in genetic studies. Research utilizing the Calu-6 cell line has helped in understanding the cellular mechanisms of lung cancer and in the development of therapeutic strategies. Its robust growth in culture and the ability to mimic clinical aspects of lung cancer make it an indispensable resource in oncological research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100473\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200516973,"sku":"300135","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CaLu-6_20WaKo_20P1_2020x01_20090425_ch00_1920x1920_95d8b1cf-70e4-4211-b43b-fdfc3fbd8a6a.jpg?v=1769068983"},{"product_id":"ccd-18lu-cell-bhc11101465","title":"CCD-18Lu cell","description":"The CCD-18Lu cell line is derived from normal lung fibroblasts of a human adult. These cells were established from the lung tissue of a male patient and are commonly used as a model for studying the behavior of normal human lung fibroblasts. The CCD-18Lu cell line exhibits typical fibroblast morphology, characterized by spindle-shaped cells that grow adherently in culture and form a monolayer.\nResearchers utilize CCD-18Lu cells in various studies related to pulmonary biology, including investigations into lung development, repair, and fibrosis. These cells are instrumental in understanding the mechanisms underlying normal lung function and the response of lung fibroblasts to different environmental stimuli, such as cytokines, growth factors, and extracellular matrix components. Additionally, CCD-18Lu cells are employed in studies examining the effects of various drugs and compounds on lung fibroblast proliferation, differentiation, and collagen production.\nIn cancer research, CCD-18Lu cells serve as a control or reference cell line to compare with lung cancer cell lines, helping to identify specific molecular and cellular alterations associated with lung cancer progression. By providing insights into the behavior of normal lung fibroblasts, the CCD-18Lu cell line contributes to the development of therapeutic strategies for treating lung diseases, including fibrosis and cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101465\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200746349,"sku":"305248","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CCD-18Lu_20WaKo_20P1_2010x01_20200924_ch00_1920x1920_0d936ecf-63cb-4077-a846-3be132c5f25a.jpg?v=1769068987"},{"product_id":"cls-54-cell-bhc11100653","title":"CLS-54 cell","description":"Established in vitro from the primary lung carcinoma of a 65 year-old man in 1998 by CLS.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100653\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201860461,"sku":"300227","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cls-54-_281_29_1920x1920_b2c29cf6-6923-4c72-a1fe-b3c6de7be0d4.jpg?v=1769068997"},{"product_id":"dms-114-cell-bhc11101540","title":"DMS-114 cell","description":"DMS-114 is a human small-cell lung cancer (SCLC) cell line with unique features distinguishing it from other SCLC subtypes. Recent research has indicated that DMS-114, previously classified within the YAP1-expressing SCLC category (SCLC-Y), harbors pathogenic mutations in SMARCA4, an ATPase subunit of the SWI\/SNF chromatin-remodeling complex. These mutations are associated with the absence of RB1 mutations, contrary to the typical mutational landscape of SCLC, which commonly features concurrent TP53 and RB1 alterations. This cell line's profile includes reduced expression of SMARCA4 mRNA and protein, contributing to its reclassification as a SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) rather than a traditional SCLC. Morphological assessments have shown that DMS-114 aligns more closely with thoracic SMARCA4-UT, exhibiting traits such as lower neuroendocrine marker expression and a distinctive immunohistochemical profile.\n\nThe revised classification of DMS-114 as a SMARCA4-deficient malignancy rather than SCLC has significant implications for its use as a preclinical model. It serves as an important resource for studying therapeutic strategies targeting SMARCA4-related pathways and investigating the biology of aggressive thoracic cancers that mimic SCLC. Unlike conventional SCLC, SMARCA4-deficient tumors, including DMS-114, often present with unique gene expression profiles marked by high YAP1 expression, loss of certain neuroendocrine markers, and distinct molecular vulnerabilities. This insight underscores the necessity of comprehensive molecular and histopathological analysis for accurate tumor classification and the development of effective treatment strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101540\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203040109,"sku":"305364","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/DMS-114_20P1_2020x01_20280325_ch00_1920x1920_104ef0a3-a780-4cf2-8409-198db59c429d.jpg?v=1769069010"},{"product_id":"dms-79-cell-bhc11100541","title":"DMS-79 cell","description":"DMS-79 is a human lung cancer cell line derived from a small cell lung carcinoma. These cells exhibit a classical neuroendocrine phenotype, which is characteristic of small cell lung cancer. This phenotype is significant because it implies a potential utility in studying neuroendocrine signaling pathways, which are crucial in the development and progression of lung cancer. The DMS-79 cell line has been widely utilized in research to understand the molecular biology of lung cancers, particularly in the context of tumor genesis, cell proliferation, and apoptosis.\n\nThe cell line is known for its aggressive growth and high tumorigenicity in vivo, making it an excellent model for in vivo studies of tumor behavior and response to therapeutics. DMS-79 cells also serve as a useful tool for pharmacological testing and drug development, offering insights into the cellular responses to various chemotherapeutic agents. Furthermore, these cells have been instrumental in the study of cancer stem cell characteristics and mechanisms of metastasis in small cell lung carcinoma. This extensive usage underscores the importance of DMS-79 in cancer research, particularly in therapies targeting aggressive and hard-to-treat cancers like small cell lung carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100541\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203072877,"sku":"300164","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/DMS-79_20_20WaKo_20P1_2010x01_20021024_ch00_1920x1920_8fcfa439-ddfb-4cd4-875d-d869e11c61c9.jpg?v=1769069010"},{"product_id":"ebc-1-cell-bhc11101543","title":"EBC-1 cell","description":"EBC-1 is a human lung squamous cell carcinoma cell line, primarily noted for its relevance in studying mechanisms related to lung cancer, particularly non-small cell lung carcinoma (NSCLC). This cell line is characterized by MET gene amplification, which has been implicated in oncogenic signaling pathways that drive tumor growth and resistance to therapy. The MET receptor tyrosine kinase activation, typically induced by hepatocyte growth factor (HGF), plays a significant role in the proliferation, survival, and metastasis of these cells. Aberrations in MET signaling are pivotal in EBC-1’s aggressive tumor profile, making it an essential model for studying targeted therapies aimed at MET inhibition.\n\nResearch utilizing EBC-1 cells has explored various resistance mechanisms to MET inhibitors, such as crizotinib. The cell line has demonstrated acquired resistance via pathways involving PAI-1 upregulation and epithelial-to-mesenchymal transition (EMT), contributing to therapeutic challenges. Additionally, sodium butyrate has been shown to modulate gene expression in EBC-1 cells, indicating the potential utility of histone deacetylase inhibitors in affecting gene transcription. These findings underscore the importance of EBC-1 in both therapeutic resistance research and the development of novel treatment strategies for MET-amplified lung cancers.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101543\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203433325,"sku":"305539","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/EBC-1_20WaKo_20P1_2020x01_20080725_ch00_1920x1920_6bdb832c-caca-430c-bbd1-218c44048fef.jpg?v=1769069014"},{"product_id":"gct-cell-bhc11100759","title":"GCT cell","description":"The GCT cell line, originating from a giant cell tumor (GCT) isolated from the lung of an adult male patient with fibrous histiocytoma, is renowned for its robust biological activity in the field of medical research. This line produces Colony Stimulating Activity (CSA) for human granulocyte precursors and Erythropoietin-like Erythroid Activity (EEA) for erythroid precursors, making it invaluable for studying the regulation and development of hematopoietic cells. The granulocyte and erythroid precursors targeted by the GCT cell line's products are key to understanding processes like neutrophil function in the immune response and red blood cell formation, respectively.\n\nAdditionally, the medium conditioned by this cell line is a significant source of prostaglandin E and plasminogen activator. These substances have crucial roles in inflammatory responses and the fibrinolytic pathway, respectively. Prostaglandin E is essential for inflammatory modulation and maintaining physiological balance, while plasminogen activator contributes to the dissolution of blood clots. The presence of these factors in the GCT cell line's conditioned medium underscores its potential for developing therapeutic strategies addressing cardiovascular diseases and conditions related to excessive clot formation and inflammation.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100759\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204252525,"sku":"300155","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/gct-_284_29_1920x1920_78427e64-4f7c-45b8-b36a-a86321dc0d2d.jpg?v=1769069026"},{"product_id":"hara-b-cell-bhc11101139","title":"HARA-B cell","description":"The HARA-B cell line is derived from human squamous cell carcinoma of the lung, specifically established from metastatic bone tissue in a mouse model. This cell line is a secondary development from the original HARA cell line and is characterized by its high expression of parathyroid hormone-related protein (PTHrP), which plays a significant role in the extensive bone metastasis observed in these cells. The HARA-B line has been instrumental in studying the mechanisms of bone metastasis associated with lung cancer.\nScientific studies involving HARA-B often focus on its utility in modeling hypercalcemia, a common paraneoplastic syndrome associated with certain cancers, including lung cancer. The hypercalcemia in this model is induced by hypodermic transplantation of the cells, providing a valuable tool for understanding the interactions between cancer cells and bone cells, as well as the pathways that lead to bone degradation and calcium release. This cell line helps researchers investigate potential therapeutic strategies to mitigate bone metastasis and associated complications in lung cancer patients.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101139\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204711277,"sku":"300465","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hara-b_20_282_29_1920x1920_bf553e2c-ec16-490c-ad9e-19a1134601f8.jpg?v=1769069032"},{"product_id":"hcc366-cell-bhc11101395","title":"HCC366 cell","description":"HCC366 is a cell line derived from a non-small cell lung cancer (NSCLC) specifically categorized as lung adenocarcinoma. This cell line was established from the malignant pleural effusion of an 80-year old female patient. HCC366 is particularly noted for its characteristic expression of mutations in key oncogenes and tumor suppressor genes, which makes it a valuable model for studying the molecular mechanisms of lung adenocarcinoma and for testing therapeutic strategies targeted at these genetic alterations.\n\nIn research contexts, HCC366 has been utilized to explore the efficacy of various chemotherapeutic agents, as well as to understand resistance mechanisms to treatment. This cell line has also contributed to the investigation of the interaction between genetic mutations and response to targeted therapies, offering insights that are crucial for the development of personalized medicine approaches in lung cancer. Studies using HCC366 can help elucidate the biological behaviors typical of lung adenocarcinomas, such as cell proliferation, migration,\n\u003cp style=\"display:none\"\u003eSKU:BHC11101395\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205071725,"sku":"302155","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HCC366_20P1_2010x01_20280923_ch00_1920x1920_ad871d89-ff0b-4d75-8198-a375836a94dc.jpg?v=1769069037"},{"product_id":"hcc4006-cell-bhc11101694","title":"HCC4006 cell","description":"HCC4006 is a human non-small cell lung cancer (NSCLC) cell line derived from a lung adenocarcinoma. It is characterized by an activating exon 19 deletion in the EGFR gene, which makes it particularly sensitive to EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib. This feature has made HCC4006 a widely used model for studying EGFR-mutant NSCLC and resistance mechanisms to EGFR-targeted therapies. In the Cancer Cell Line Encyclopedia (CCLE), HCC4006 has been comprehensively profiled at the genomic, transcriptomic, and epigenetic levels, confirming its high sensitivity to EGFR inhibition and highlighting its use as a pharmacogenomic reference model.\n\nHigh-resolution genomic studies have revealed that HCC4006 displays a relatively simple karyotype compared to other NSCLC models, which may facilitate clearer interpretation of drug responses and genomic alterations. It lacks common resistance mutations such as T790M in the EGFR gene, making it suitable for modeling initial treatment responses. However, resistance can be induced in vitro, allowing researchers to study mechanisms of acquired resistance. For example, resistance to EGFR TKIs in HCC4006 has been linked to epithelial-mesenchymal transition (EMT) and activation of alternative signaling pathways, such as AXL kinase overexpression.\n\nHCC4006 has also been assessed in large-scale transcriptomic comparisons of cell lines and primary tumors. It is one of the lung adenocarcinoma cell lines that demonstrates a moderate correlation to primary tumor gene expression profiles, though the degree of correlation can vary depending on the purity of the tumor samples used for comparison. These analyses underscore the relevance of HCC4006 in modeling certain molecular aspects of lung adenocarcinoma, particularly those associated with EGFR-driven oncogenesis, while also emphasizing its limitations in fully recapitulating the heterogeneity of primary tumors.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101694\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205137261,"sku":"305785","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HCC4006_20WAKO_20P1_2010x01_20120825_ch00_1920x1920_f2275c4a-eb49-41c9-a387-3149412ed77e.jpg?v=1769069037"},{"product_id":"hcc78-cell-bhc11101396","title":"HCC78 cell","description":"HCC78 is a cell line derived from a primary tumor of a lung adenocarcinoma, specifically a subtype known as mucinous bronchioloalveolar carcinoma. This cell line was established from a male adult patient. HCC78 cells are particularly noted for harboring a unique chromosomal rearrangement involving the ROS1 and SLC34A2 genes, which results in the SLC34A2-ROS1 fusion protein. This fusion protein has been implicated in oncogenic signaling pathways, making HCC78 a valuable model for studying the molecular mechanisms of ROS1 fusion-positive lung cancers and for testing targeted therapies against ROS1.\n\nIn research contexts, HCC78 has been utilized extensively to explore the efficacy and mechanism of action of ROS1 inhibitors. These studies have demonstrated the cell line's utility in preclinical assessments of drug sensitivity, resistance mechanisms, and the cellular pathways affected by ROS1 activity. The cell line grows adherently and exhibits epithelial-like morphology, which is characteristic of bronchioloalveolar tumors. The genetic and phenotypic features of HCC78 make it an essential tool for lung cancer research, especially for investigations focused on targeted therapies and personalized medicine in the treatment of ROS1-positive cancers.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101396\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205202797,"sku":"302156","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HCC78_20WaKo_20P1_2010x01_20131023_ch00_1920x1920_2dfc1061-c847-4f16-9915-9cc10e69e563.jpg?v=1769069038"},{"product_id":"hcc827-cell-bhc11101124","title":"HCC827 cell","description":"HCC827 is a human non-small cell lung cancer cell line derived from the lung adenocarcinoma of a middle-aged female patient. These cells exhibit an epithelial morphology and are often used in research related to the epidermal growth factor receptor (EGFR). HCC827 cells are particularly noted for their sensitivity to tyrosine kinase inhibitors (TKIs), specifically those targeting EGFR mutations. This characteristic makes them a valuable model for studying the molecular mechanisms of lung cancer responsiveness to EGFR inhibitors, as well as for testing the efficacy of new therapeutic agents targeting EGFR-dependent pathways.\n\nThe cell line is also used to explore the mechanisms of acquired resistance to targeted therapies, which is a significant challenge in the treatment of lung cancer. Studies utilizing HCC827 cells have contributed to a better understanding of the genetic and epigenetic alterations that confer resistance to EGFR inhibitors. These findings have implications for the development of strategies to overcome resistance and improve treatment outcomes in lung cancer patients. Furthermore, the HCC827 cell line serves as a tool for investigating the broader cellular and molecular landscape of lung adenocarcinoma, including studies on cell signaling, tumor microenvironment, and cancer metastasis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101124\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205235565,"sku":"305041","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HCC827_20P0_20305041-M_2010x01_2014112022_1920x1920_aa02a22a-5322-4241-a65f-0c12b7ac66f5.jpg?v=1769069039"},{"product_id":"hel-299-cell-bhc11100446","title":"HEL-299 cell","description":"HEL-299 is a human lung fibroblast cell line derived from an adult individual. This cell line is particularly noted for its finite capacity to propagate in culture, typically entering senescence after approximately ten passages. This characteristic makes HEL-299 a useful model for studying cellular aging and senescence, as well as the dynamics of cell growth and replication under controlled conditions.\n\nIn addition to its applications in aging research, HEL-299 also serves as a model for studying signal transduction pathways. Specifically, it has been observed that the expression of the M2 muscarinic receptor in these cells is downregulated following stimulation with protein kinase C. This response highlights the cell line's utility in pharmacological research and in the investigation of mechanisms underlying receptor-mediated signaling and regulation. The alteration in receptor expression following kinase activity can provide insights into cellular responses to external stimuli, potentially aiding in the development of therapeutic strategies targeting similar pathways in various diseases.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100446\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206153069,"sku":"300193","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hel-299-_284_29_1920x1920_be879006-347a-4af2-b379-2c1c7d014832.jpg?v=1769069048"},{"product_id":"hfl1-cell-bhc11101338","title":"HFL1 cell","description":"The HFL1 cell line, derived from human fetal lung tissue, is commonly used in biological and medical research. These cells exhibit fibroblast-like properties, making them particularly valuable for studies related to cellular morphology, fibrosis, and tissue repair mechanisms. HFL1 cells are instrumental in the exploration of pulmonary diseases, including investigations into the pathogenesis of lung fibrosis and the evaluation of antifibrotic therapies.\n\nIn addition to their application in disease models, HFL1 cells are often utilized in pharmacological research and toxicology studies. Their sensitivity to viral infections and responsiveness to pharmacological agents enable researchers to study the effects of various drugs and compounds on lung tissues. The HFL1 cell line supports the propagation of viruses, facilitating studies on viral life cycles and host-virus interactions, which are crucial for the development of antiviral drugs and vaccines.\n\nOverall, the HFL1 cell line is a versatile tool in the fields of respiratory disease research, pharmacology, and toxicology, providing insights into cellular processes and potential therapeutic approaches for lung-related diseases.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101338\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207463789,"sku":"305065","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HFL1_20P1_20305065-M_2010x01_20011222_1920x1920_fa1ac987-bbff-4863-9af8-2326be466c73.jpg?v=1769069058"},{"product_id":"h-meso-1-cell-bhc11100791","title":"H-MESO-1 cell","description":"H-MESO-1 cells are a human mesothelioma cell line derived from a patient with malignant pleural mesothelioma, a type of cancer that develops from the cells lining the lungs' or abdomen's protective lining. This cell line is extensively used in oncological research to study the biology, pathogenesis, and therapeutic strategies for mesothelioma.\nH-MESO-1 cells retain several characteristics of mesothelial cells, making them a relevant model for investigating mesothelioma. They exhibit epithelioid morphology, which is one of the common histological types of mesothelioma. These cells are particularly useful for exploring the molecular pathways involved in mesothelioma development, including cell cycle regulation, apoptosis resistance, and the role of asbestos and other environmental factors in inducing mesothelioma.\nIn research, H-MESO-1 cells have been employed to study the interaction between mesothelioma cells and the immune system, especially considering the impact of immune checkpoint molecules and the tumor microenvironment on tumor growth and immune evasion. This cell line is also valuable for testing the efficacy of new drugs and novel immunotherapeutic approaches aimed at targeting specific pathways implicated in mesothelioma progression.\nMoreover, H-MESO-1 cells are used to investigate the genetic and epigenetic alterations characteristic of mesothelioma, providing insights into potential biomarkers for early diagnosis and targets for therapeutic intervention. The cell line's responsiveness to chemotherapeutic agents and its ability to form tumors in xenograft models make it a crucial tool in developing and validating new treatment modalities for mesothelioma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100791\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950208643437,"sku":"300186","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/H-MESO-1_20WaKo_20P1_2010x01_20060325_ch00_1920x1920_dbc03c78-a715-4a06-8561-58020e1ccbad.jpg?v=1769069068"},{"product_id":"h-meso-1a-cell-bhc11100382","title":"H-MESO-1A cell","description":"The H-MESO-1A cell line is derived from human mesothelioma, a type of cancer that originates in the mesothelial cells lining the lungs, abdomen, or heart. This cell line is particularly valuable for research focused on understanding the pathophysiology of mesothelioma and the development of therapeutic strategies. Mesothelioma is often linked to asbestos exposure, and the H-MESO-1A cells can be used to study the molecular mechanisms underlying asbestos-induced carcinogenesis.\nH-MESO-1A cells exhibit the characteristic features of mesothelioma, including aggressive growth and resistance to conventional chemotherapy. They are utilized in preclinical studies to evaluate the efficacy of novel drugs, gene therapy approaches, and immunotherapy strategies. Researchers use this cell line to investigate the genetic and epigenetic alterations associated with mesothelioma, as well as to identify potential biomarkers for early diagnosis and prognosis. The H-MESO-1A cell line is an essential tool in the advancement of mesothelioma research and the quest for effective treatments.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100382\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950208676205,"sku":"300187","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/h-meso-1a-_281_29_1920x1920_d53cdc7e-4286-4b20-99b6-611dc62aaa54.jpg?v=1769069068"},{"product_id":"hroc313met-cell-bhc11100865","title":"HROC313Met cell","description":"This is one cell line of a series of tumor cell lines which have been established by PD Dr. Michael Linnebacher from Primary CRC resection specimens since 2006.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100865\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950210085229,"sku":"300849","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hroc313met-_282_29_1920x1920_0bffb460-8c82-4764-a359-74719b2ceef2.jpg?v=1769069086"},{"product_id":"kln-205-cell-bhc11100711","title":"KLN-205 cell","description":"KLN-205 is a murine lung carcinoma cell line derived from an adult mouse. This cell line is widely used in cancer research, particularly for studying the mechanisms of lung cancer progression, metastasis, and potential therapeutic interventions. KLN-205 cells exhibit characteristics typical of non-small cell lung carcinoma (NSCLC), making them a valuable model for investigating the molecular and cellular underpinnings of this disease. Researchers utilize KLN-205 to evaluate the efficacy of various chemotherapeutic agents, immunotherapies, and targeted treatments, helping to advance the understanding of lung cancer biology and treatment strategies.\n\nKLN-205 cells are known for their robust growth and ability to form tumors when implanted in immunocompromised mice, providing a reliable in vivo model for preclinical studies. These cells are used to explore tumor-host interactions, immune responses to lung cancer, and the impact of genetic and epigenetic modifications on cancer development and progression. The KLN-205 cell line serves as a critical tool in oncology research, aiding in the identification of novel biomarkers and therapeutic targets for lung cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100711\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950213689709,"sku":"400419","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KLN-205_20WaKo_20P1_2020x01_20050925_ch00_1920x1920_e151430b-5b11-48a5-892a-d3d29d62f93d.jpg?v=1769069123"},{"product_id":"la795-cell-bhc11101022","title":"LA795 cell","description":"The LA795 cell line, derived from a lung adenocarcinoma, has been extensively studied for its chromosomal patterns using G and C banding techniques at passages 60 and 100. The chromosomal analysis revealed model chromosome numbers 69, 68, 67, and 66. Detailed G banding analysis of 46 cells across these four clones indicated that the chromosome patterns of LA795 are hypotetraploid male cells, closely resembling those observed in cells transplanted into mice. The two primary configurations of the 69 model chromosome, designated 69I and 69II, suggest a progression in chromosomal evolution from 69 to 68, 67, and 66 as identified through karyotype analysis.\nThe karyotype analysis also highlighted a notable pattern in the loss of specific chromosomes, specifically chromosome No. 4 and No. 14, across the various clones. This recurrent chromosomal loss indicates a potential non-random chromosomal aberration associated with mouse tumor cells. The findings from these studies provide valuable insights into the chromosomal stability and evolution of the LA795 cell line, offering a deeper understanding of the genetic underpinnings of lung adenocarcinoma and its progression.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101022\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950214377837,"sku":"300472","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/la795_20_284_29_1920x1920_9d5ef9ba-ded4-40d9-9a2f-8c42eff1dbe9.jpg?v=1769069132"},{"product_id":"lclc-103h-cell-bhc11100973","title":"LCLC-103H cell","description":"The LCLC-103H cell line is derived from a large cell lung carcinoma (LCLC), specifically established from the pleural effusion of an adult male patient with a diagnosis of large cell lung carcinoma with giant cells. The patient had previously undergone chemotherapy and radiotherapy. This cell line is particularly notable for its partial expression of neuroendocrine markers, which are typically associated with small cell lung cancer (SCLC) and certain neuroendocrine tumors. In particular, the antigen detected by the monoclonal antibody RNL-1 shows a focal surface expression in LCLC-103H cells, similar to that observed in some neuroendocrine carcinomas. However, the expression is not uniform across all cells, indicating heterogeneity within the cell population.\n\nLCLC-103H has been described in the literature as PAS (Periodic Acid-Schiff) negative, distinguishing it from other lung cancer subtypes. It also exhibits remarkable stroma formation, which is a significant characteristic of its histopathological profile. Moreover, this cell line is known to overexpress the proto-oncogene MYC, which plays a critical role in cell proliferation and tumorigenesis. Immunocytochemical studies have shown that LCLC-103H does not exhibit the full spectrum of neuroendocrine differentiation seen in SCLC, as it lacks reactivity with other neuroendocrine markers such as those identified by the antibodies RNL-2 and RNL-3. This distinction is crucial for differentiating LCLC from SCLC, which is more aggressive and typically exhibits a higher sensitivity to certain chemotherapeutic agents. The unique expression profile of LCLC-103H makes it a valuable model for studying the molecular and immunological characteristics of large cell lung carcinoma and its overlap with neuroendocrine features.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100973\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950214476141,"sku":"300169","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/LCLC-103H_20_20_282_29_1920x1920_7b07ac6d-93b6-4db2-9d87-5481c15505a5.jpg?v=1769069133"},{"product_id":"lclc-97tm1-cell-bhc11100419","title":"LCLC-97TM1 cell","description":"The LCLC-97TM1 cell line is derived from a large cell lung carcinoma (LCLC) and was established using a xenograft approach, specifically from the first nude mouse passage of a primary large cell carcinoma. This cell line exhibits densely packed epithelioid islets in culture, with cell borders that are typically indistinguishable under standard microscopic examination. Unlike many other cell lines, LCLC-97TM1 cultures do not generally reach confluency, which may be attributed to their unique growth patterns.\n\nCytologically, LCLC-97TM1 cells are characterized by a large, single, round nucleus that contains one or two prominent nucleoli, and an evenly distributed chromatin pattern. This nuclear morphology is indicative of the aggressive nature often associated with large cell lung carcinoma. The cell line is also noted for being PAS (Periodic Acid-Schiff) negative and showing no reactivity with Alcian blue staining, which are consistent with the characteristics observed in both the original tumor and the xenograft derived from the cell line.\n\nChromosomal analysis of LCLC-97TM1 reveals its complex karyotype, which is typical of large cell carcinomas and suggests significant genetic instability. This genetic profile, combined with its distinct morphological features, makes LCLC-97TM1 a valuable model for studying the pathobiology of large cell lung carcinoma, particularly in the context of tumorigenesis, metastasis, and therapeutic response in non-small cell lung cancer (NSCLC).\n\u003cp style=\"display:none\"\u003eSKU:BHC11100419\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950214508909,"sku":"300409","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/LCLC-97TM1_20WaKo_20P1_2010x01_20180225_ch00_1920x1920_43d67f14-ebb1-4e25-ae51-eea46d5bbb40.jpg?v=1769069134"},{"product_id":"llc1-ll-2-cell-bhc11101351","title":"LLC1 (LL-2) cell","description":"LLC1 (LL-2) cells are a murine cell line derived from the Lewis Lung Carcinoma (LLC), a tumor model extensively used for cancer research. These cells were originally isolated and adapted to in vitro culture from the Lewis Lung Carcinoma in C57BL\/6 mice. LLC1 (LL-2) cells have a doubling time of 21 hours and retain high tumorigenic potential, forming primary tumors and lung metastases in syngeneic C57BL\/6 mice that are histologically similar to the original tumor.\nLLC1 (LL-2) cells have proven valuable for various experimental applications, including studies on cancer metastasis, tumor-host interactions, and drug sensitivity testing. Notably, while these cells show significant in vitro sensitivity to various chemotherapeutic agents, such as cisplatin and methotrexate, their in vivo response can differ, highlighting the complexity of translating in vitro findings to in vivo contexts. The ability of LLC1 (LL-2) cells to form discrete colonies on plastic substrates also makes them suitable for use in focus assays to evaluate drug-induced cytotoxicity, making them an important tool in the evaluation of new cancer therapies.\nLLC1 (LL-2) cells exhibit several features typical of aggressive lung carcinoma, including rapid proliferation, high metastatic potential, and resistance to certain chemotherapeutic agents. These cells provide a relevant model for understanding the molecular and genetic alterations associated with lung cancer progression. Studies utilizing LLC1 (LL-2) have contributed to the identification of key signaling pathways and genetic mutations involved in tumor development and metastasis. Moreover, this cell line has been instrumental in evaluating novel therapeutic strategies aimed at inhibiting tumor growth and spread, thereby advancing the field of oncology research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101351\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950214607213,"sku":"305311","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/LLC1_20WaKo_20P0_201400263-822_2010x01_2005092022_1920x1920_99d1ee4f-52aa-4302-86bd-6bb5ce200083.jpg?v=1769069134"},{"product_id":"lxf-289-cell-bhc11100660","title":"LXF-289 cell","description":"The LxF-289 cell line is a human lung adenocarcinoma cell line established from a 63-year-old male patient. This cell line has a doubling time of approximately 50 hours, making it suitable for studies that require consistent cell proliferation. LxF-289 is particularly valuable in research focused on lung cancer, especially non-small cell lung cancer (NSCLC), as it provides a robust in vitro model for studying the molecular mechanisms underlying cancer progression, treatment resistance, and the effects of therapeutic interventions.\nStudies on LxF-289 have demonstrated that this cell line exhibits characteristics that make it responsive to specific genetic and therapeutic manipulations. For instance, research has shown that LxF-289, along with other lung cancer cell lines, can undergo significant cell death when treated with an adenovirus expressing antisense heat shock protein 70 (Hsp70). This cell death is p53-independent and does not require DNA cleavage, suggesting that Hsp70 plays a crucial role in the survival of lung cancer cells. Notably, this response is selective to cancer cells, as normal lung fibroblasts and bronchial epithelial cells do not show similar levels of cytotoxicity when Hsp70 is downregulated, highlighting the potential of targeting Hsp70 in lung cancer therapy.\nMoreover, LxF-289 has been used to study the effects of irradiation on drug resistance-related proteins. The cell line exhibited overexpression of glutathione S-transferase (GSTπ) at both mRNA and protein levels following irradiation. This overexpression is associated with the development of multidrug resistance, which is a significant challenge in the clinical management of lung cancer. These findings underscore the utility of LxF-289 in exploring the mechanisms of resistance and testing novel strategies to overcome it.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100660\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950215098733,"sku":"300269","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/lxf-289-_283_29_1920x1920_6499aa4e-ff6e-43e5-8bf3-3c70fc9cc9b3.jpg?v=1769069138"},{"product_id":"met-5a-cell-bhc11101455","title":"MET-5A cell","description":"The MET-5A cell line is derived from mesothelial cells of the pleura in a human adult and is often used in research related to mesothelioma, a type of cancer affecting the mesothelial lining of the lungs, abdomen, and heart. These cells are crucial for studying the biology, pathogenesis, and treatment of mesothelioma, particularly in understanding how environmental factors such as asbestos exposure lead to the development of this cancer. MET-5A cells are also used to explore the mechanisms of cellular transformation, tumor progression, and the cellular responses to various chemotherapeutic agents.\nMET-5A cells exhibit a typical epithelial morphology and retain characteristics of normal mesothelial cells, including the expression of mesothelial markers such as cytokeratin and vimentin. These cells are responsive to inflammatory stimuli and can be used to study the inflammatory processes involved in mesothelioma pathogenesis. Researchers employ MET-5A cells to investigate the genetic and molecular alterations associated with mesothelioma, as well as to test the efficacy and toxicity of potential therapeutic compounds. The relevance of MET-5A cells in modeling mesothelial cell biology and their role in mesothelioma research makes them an essential tool for advancing our understanding and treatment of this aggressive cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101455\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950216376685,"sku":"305269","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MET-5A_20WaKo_20P1_2010x01_20311024_ch00_1920x1920_7a5168c4-0257-462f-87c3-245b5c9765ad.jpg?v=1769069150"},{"product_id":"mh-s-cell-bhc11101274","title":"MH-S cell","description":"MH-S is a murine alveolar macrophage cell line derived from adult mice. These cells are widely used in immunological research due to their robust phagocytic activity and their ability to produce a variety of cytokines in response to pathogenic stimuli. As an alveolar macrophage model, MH-S cells are particularly valuable in studying pulmonary immune responses, lung inflammation, and respiratory infections. Their ability to mimic the behavior of primary alveolar macrophages makes them an indispensable tool for understanding the mechanisms of host defense in the respiratory tract.\n\nMH-S cells are also instrumental in the study of macrophage biology and function. They are employed to investigate macrophage activation, differentiation, and the signaling pathways involved in immune responses. Researchers utilize this cell line to explore the interactions between macrophages and pathogens, including bacteria, viruses, and fungi. Additionally, MH-S cells serve as a model to examine the effects of various pharmacological agents on macrophage activity, offering insights into potential therapeutic approaches for respiratory diseases.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101274\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950216606061,"sku":"300487","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MH-S_20WaKo_20P1_20300487_2010x01_20250123_1920x1920_61523dc5-8c31-4097-bd57-34b457f1c1a3.jpg?v=1769069152"},{"product_id":"mle-12-cell-bhc11101597","title":"MLE-12 cell","description":"MLE-12 is a murine lung epithelial cell line established from distal respiratory epithelium using transgenic mice expressing the simian virus 40 (SV40) large tumor antigen under the control of the human surfactant protein C (SP-C) promoter. This cell line is characterized by its ability to maintain certain properties of alveolar type II cells, such as the expression of surfactant proteins SP-B and SP-C, which are crucial for pulmonary surfactant synthesis and lung function. MLE-12 cells also display key morphological features of alveolar type II cells, including microvilli and multivesicular bodies, though they lack some features like lamellar bodies in later passages.\n\nThe MLE-12 cell line is widely used to study surfactant protein regulation, secretion, and pulmonary responses to stimuli. It secretes phospholipids in response to various secretagogues such as ATP and phorbol esters, mimicking aspects of type II alveolar cell function. While this secretion is robust in early passages, it diminishes in later passages, along with changes in receptor-mediated responses. This model is particularly valuable for exploring mechanisms underlying respiratory distress syndromes and surfactant deficiencies. Additionally, the cell line offers insights into pulmonary carcinogenesis, given its derivation from SV40-driven tumorigenesis.\n\nMLE-12 cells serve as a tool for elucidating the pathways of surfactant protein processing and testing therapeutic strategies for surfactant replacement. Their maintenance of SP-C expression, a marker specific to the alveolar epithelium, makes them a relevant in vitro model for investigating lung-specific processes and diseases.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101597\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950216868205,"sku":"305314","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MLE-12_20305314-170625_20WaKo_20P1_2020x01_20250525_ch00_1920x1920_8b651448-a073-4ed4-9bb7-4c8b1c27d136.jpg?v=1769069154"},{"product_id":"mrc-5-cell-bhc11101337","title":"MRC-5 cell","description":"MRC-5 cells, a human lung fibroblast cell line derived from the lung tissue of a 14-week-old male fetus in 1966, are extensively utilized in the production of certain vaccines, including those for hepatitis A, polio, rabies, and more.\nThe susceptibility to various human viruses, notably human poliovirus 1, herpes simplex virus, and vesicular stomatitis virus underscores the role of MRC5 cells in the discovery of antivirals, viral vaccines, vaccine safety and virus replication. MRC-5 and WI-38 cell lines are still used in producing vaccines for varicella, rubella, hepatitis A, and a version of rabies vaccine today. Recently, MRC-5 cells were modified to express the ACE2 receptor, and have been key in SARS research. The modified MRC5 human ace2 cells allow scientists to study how the SARS-CoV virus enters and replicates in host cells. This work has been vital for understanding the virus's behavior and developing targeted antiviral agents and treatments.\nThe MRC5 fetal cell line's utility extends beyond vaccine production to include potential roles in cancer research, with the cell line being employed in studies exploring the tumor microenvironment and cancer cell interactions, owing to their capability to differentiate into multiple cell types, including osteocytes and chondrocytes. This has led to speculation about their similarity to mesenchymal stem cells (MSCs), given their fibroblast-like morphology and maintenance of a normal diploid karyotype over extensive in vitro expansion.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101337\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217261421,"sku":"300395","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MRC-5_20P1_20300395-M_2020x01_2006022023_1920x1920_bc71c714-6df9-4e2f-b292-75f2dbe555fc.jpg?v=1769069158"},{"product_id":"mrc-9-cell-bhc11101401","title":"MRC-9 cell","description":"The MRC-9 cell line is a human diploid fibroblast strain derived from the lungs of a White female fetus at 15 weeks gestation. It was established for long-term use in biological research, vaccine production, and diagnostic virology. The cells exhibit adherent growth properties and maintain a stable, diploid karyotype throughout serial propagation. Importantly, MRC-9 cells possess normal chromosomal features and are non-tumorigenic under typical conditions. However, they have demonstrated tumorigenic properties when tested in semisolid media, but not when implanted in immunosuppressed mice. MRC-9 cells have been widely used for viral susceptibility studies, showing broad susceptibility to various viruses such as poliovirus, adenovirus, rubella, and cytomegalovirus. These cells are particularly valuable for their use in virology research and vaccine development. While their proliferation rate is slower compared to other human fibroblast strains like MRC-5, MRC-9 cells can still undergo a significant number of population doublings, with reports of up to 46 doublings.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101401\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217294189,"sku":"300394","price":395.0,"currency_code":"USD","in_stock":true}]},{"product_id":"msto-211h-cell-bhc11100640","title":"MSTO-211H cell","description":"The MSTO-211H cell line is derived from a patient with biphasic mesothelioma, specifically from a pleural effusion. It is classified as metastatic, and the patient had not undergone prior radiation or chemotherapy treatments before the establishment of the cell line. MSTO-211H cells are notable for expressing several markers that are significant in understanding both their biological behavior and their potential utility in cancer research. These cells possess high-affinity binding sites for epidermal growth factor (EGF), a property that may contribute to their proliferative capabilities, as EGF is a key regulator of cell growth and differentiation. The presence of EGF receptors suggests these cells could be useful in studying pathways related to growth factor signaling in cancer. In addition to EGF receptors, MSTO-211H cells express neuron-specific enolase (NSE), an enzyme typically found in neurons and neuroendocrine cells. NSE expression in MSTO-211H cells may be indicative of a neuroendocrine differentiation potential, a feature that can be significant for understanding the heterogeneity of mesothelioma tumors. Furthermore, the cells express both the alpha and beta subunits of human chorionic gonadotropin (HCG), a hormone typically produced during pregnancy but also known to be secreted by certain cancers. The expression of HCG subunits in MSTO-211H cells suggests a possible role in tumor biology, potentially related to immune evasion or tumor progression mechanisms. These markers collectively highlight the complex nature of this cell line, making it a valuable model for investigating mesothelioma biology and the effects of therapeutic agents.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100640\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217425261,"sku":"300450","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/msto-211h-_283_29_1920x1920_1a44c616-50cb-4e83-9cc0-04522cd82c74.jpg?v=1769069158"},{"product_id":"mv-1-lu-cell-bhc11101269","title":"Mv.1.Lu cell","description":"The Mv.1.Lu cell line, also known as CCL 64, originates from the lung tissue of a fetal mink (Mustela vison). It is an epithelial-like cell line known for its flat, contact-inhibited growth in monolayer cultures, exhibiting a regular polygonal morphology. This cell line has been widely utilized in virological studies due to its broad permissivity for various mammalian Type C viruses, including murine and feline sarcoma viruses, making it a preferred system for focus formation assays and viral transformation studies.\n\nThis cell line's ability to support viral replication and transformation has made it an essential tool in understanding viral pathogenesis and host-pathogen interactions. Mv.1.Lu cells are also used in pulmonary physiology research, benefiting from their origin in lung tissue. Studies on their growth characteristics, including their response to various media and culture conditions, have underscored their adaptability and stability in laboratory settings.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101269\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217458029,"sku":"305192","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Mv.1.Lu_20_20P1_2020x01_20170125_ch00_1920x1920_19f05bd3-49fa-4a40-895c-a1e1c4af70af.jpg?v=1769069159"},{"product_id":"nci-h1299-cell-bhc11101046","title":"NCI-H1299 cell","description":"NCI-H1299, also known as H1299, is a cell line established from a lymph node metastasis of the lung from a 43-year-old white male patient with carcinoma. H1299 and H292 are non-small cell lung cancer (NSCLC) cell lines.\nRegarding their genetic profile, H1299 cells have a homozygous partial deletion of the p53 protein and lack expression of p53 protein. While KRAS mutations are commonly found in various types of cancer, including NSCLC, H1299 expresses KRAS WT. A549 is another NSCLC cell line that homozygously expresses endogenous KRAS G12S. \nUnderstanding the biology of KRAS and its downstream signalling pathways is crucial for developing effective cancer therapies. Therefore, this epithelial-like cell line is commonly used in cancer and immuno-oncology research. \nThe morphology of H1299 cells is characterized by adherent flattened cells with a thickness of fewer than 5 microns. H1299 cells have an approximate doubling time of 22 - 30 hours. H1299 cells express keratin and vimentin but are negative for neurofilament triplet protein. \nThey are also reported to be able to synthesize the peptide neuromedin B (NMB) at 0.1 pmol\/mg protein but not the gastrin-releasing peptide (GRP). Compared to A549 cells with more epithelial characteristics, H1299 cells have more mesenchymal characteristics and less effective epithelial marker expression.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101046\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218047853,"sku":"300485","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/H1299_20P2_2010x01_2006072022_1920x1920_7f81d756-ad7f-444f-b06f-4cda0f200669.jpg?v=1769069162"},{"product_id":"nci-h1299-rfp-cell-bhc11101114","title":"NCI-H1299-RFP cell","description":"The NCI-H1299 RFP cells, modified to include a reporter in the DAPK1 gene, are not only useful for studying specific gene activation but also provide a broader understanding of how cells react to epigenetic drugs globally. By using a technique called Cap Analysis of Gene Expression (CAGE), researchers have been able to detail changes in where transcription starts across the genome in response to treatments with DNMTi (DAC), HDACi (SAHA or SB939), or their combinations. This method reveals not just the expected reactivation of the DAPK1 gene but also the emergence of new transcription start sites, called treatment-induced non-annotated TSSs (TINATs), especially under drug treatment. These new start sites are typically located in regions of the genome that do not usually produce proteins and lead to the creation of new RNA molecules that could potentially code for proteins. Further analysis shows that these new RNA molecules can sometimes merge with existing ones to form what are known as TINAT-exon fusion transcripts. Depending on how these transcripts are spliced, they can translate into new, atypical proteins. This process has been confirmed through laboratory techniques that demonstrate these transcripts can indeed lead to the production of new protein forms. These proteins might interact abnormally within the cell or be recognized as foreign by the immune system, potentially offering new targets for cancer therapy. The activation of these TINATs involves intricate changes in both DNA methylation and histone modifications, illustrating a complex interaction between these epigenetic factors under drug treatment. Particularly, the combined use of DAC and SB939 shows a greater effect, boosting the expression of these novel transcripts more than when either drug is used alone. Understanding these interactions and their outcomes helps clarify how epigenetic therapies alter cell behavior and opens up possibilities for new cancer treatments that leverage these complex molecular changes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101114\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218080621,"sku":"300272","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/H1299-EGFP_20P0_20300272-M_2020x01_20301122_1920x1920_e504fd4c-ce79-40e4-84ea-6216b8e0506b.jpg?v=1769069162"},{"product_id":"nci-h1395-cell-bhc11101122","title":"NCI-H1395 cell","description":"The NCI-H1395 cell line is derived from a non-small cell lung carcinoma (NSCLC) originating from a 55-year-old female patient with a history of significant tobacco use, quantified at 15 pack-years. Established in 1986, this cell line serves as an important biological model in lung cancer research, particularly for studying the pathophysiology and treatment responsiveness of lung adenocarcinomas. The cell line is notable for its derivation from a primary tumor, providing valuable insights into the characteristics and behavior of tumor cells directly from the patient.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101122\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218113389,"sku":"305118","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H1395_20305118-151222_2010x_01_1920x1920_10bc0750-d55f-475d-9912-800acbc73f18.jpg?v=1769069163"},{"product_id":"nci-h1437-cell-bhc11101117","title":"NCI-H1437 cell","description":"The cell line was established in June 1986 from pleural effusion metastasis of lung.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101117\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218146157,"sku":"305110","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/nci-h1437_20_281_29_1920x1920_44265dd5-02ea-4da6-8520-71efbe9a576c.jpg?v=1769069163"},{"product_id":"nci-h146-cell-bhc11100834","title":"NCI-H146 cell","description":"The NCI-H146 cell line was derived by A.F. Gazdar and associates in 1979 from the pleural fluid of a patient with small cell cancer of the lung. The bone marrow specimen was taken prior to therapy.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100834\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218178925,"sku":"300182","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H146_20WaKo_20P1_2010x01_20080525_ch00_1920x1920_33c17c32-46e9-466a-b4c1-8af216dadd2c.jpg?v=1769069163"},{"product_id":"nci-h1563-cell-bhc11101125","title":"NCI-H1563 cell","description":"The NCI-H1563 cell line is derived from a human non-small cell lung carcinoma (NSCLC) and is part of the NCI-Navy Medical Oncology Branch collection. This cell line originates from a lung adenocarcinoma, a subtype of NSCLC, highlighting its utility in studying lung cancer pathogenesis and drug responses. It is a model for exploring cellular and molecular mechanisms of NSCLC, which constitutes a significant proportion of lung cancer cases worldwide.\n\nNCI-H1563 has been characterized extensively in genomic and proteomic studies, including tyrosine kinase signaling pathways, which are pivotal in lung cancer progression. It has been noted for its phosphotyrosine signaling profile, contributing to understanding activated receptor tyrosine kinases and non-receptor tyrosine kinases in NSCLC. Such pathways are key targets for precision therapies, emphasizing the importance of this cell line in translational cancer research.\n\nAs part of a larger database of cancer cell lines, NCI-H1563 has also been utilized to analyze genetic mutations, copy number variations, and chromosomal alterations. It contributes to studies aimed at distinguishing driver mutations from passenger mutations in cancer genomics. These features make NCI-H1563 a valuable tool for identifying therapeutic targets, studying resistance mechanisms, and developing personalized treatment strategies for lung cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101125\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218211693,"sku":"305131","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H1563_20P1_2020x01_20120723_1920x1920_8ce24241-e362-4b1b-97ce-6e385dcf736a.jpg?v=1769069163"},{"product_id":"nci-h1568-cell-bhc11101128","title":"NCI-H1568 cell","description":"The line was established in December 1986 from lymph node metastasis of lung.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101128\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218244461,"sku":"305137","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H1568_20P1_2010x01_20190723_1920x1920_7866221e-0ca4-4f9a-99af-ac356d5d8250.jpg?v=1769069164"},{"product_id":"nci-h157-cell-bhc11101140","title":"NCI-H157 cell","description":"NCI-H157 is a human non-small cell lung carcinoma (NSCLC) cell line, primarily used in cancer research to study tumorigenesis, chemotherapy resistance, and the molecular pathways involved in lung cancer progression. NCI-H157 cells are particularly useful for investigating the role of hypoxia-inducible factor-1 alpha (HIF-1α) in NSCLC. Studies have shown that HIF-1α plays a crucial role in promoting angiogenesis, proliferation, and survival of cancer cells under hypoxic conditions. Downregulation of HIF-1α via siRNA in NCI-H157 cells significantly reduces cell proliferation, induces apoptosis, and impairs the invasive ability of the tumor cells.\nMoreover, combination treatments using HIF-1α siRNA and chemotherapy agents, such as cisplatin (DDP), enhance the cytotoxic effects on NCI-H157 cells. The reduction of HIF-1α expression has been shown to increase the activity of apoptotic proteins like caspases 3 and 9 while decreasing the levels of anti-apoptotic proteins such as Bcl-2. Additionally, HIF-1α knockdown inhibits key signaling pathways involved in tumor growth, including the PI3K\/AKT and Raf\/MEK\/ERK pathways. These molecular alterations contribute to the suppression of tumor cell survival and invasiveness.\nThe NCI-H157 cell line is also responsive to various natural compounds and plant extracts. For example, extracts from *Stellera chamaejasme* L. have been found to induce apoptosis in NCI-H157 cells through the Fas death receptor pathway, further emphasizing the cell line's utility in evaluating novel therapeutic agents for lung cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101140\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218277229,"sku":"300387","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H157_20CM1_20Y2678T7_20WaKo_20P1_2020x01_20070225_ch00_1920x1920_d947f3cf-3d5e-4bbe-ba2b-7c01b6d29a56.jpg?v=1769069164"},{"product_id":"nci-h1650-cell-bhc11101150","title":"NCI-H1650 cell","description":"The NCI-H1650 cell line is derived from a human non-small cell lung carcinoma (NSCLC), specifically adenocarcinoma, and is widely used in cancer research due to its distinctive genetic profile and relevance in drug testing. This cell line features mutations in key oncogenic and tumor suppressor pathways, including a deletion in the PTEN gene and an activating mutation in EGFR. These genetic alterations make NCI-H1650 a suitable model for studying mechanisms of tumorigenesis and therapeutic resistance in NSCLC, especially in the context of targeted therapies aimed at the EGFR signaling pathway.\n\nThe deletion of PTEN in NCI-H1650 results in the loss of phosphatase activity, which deregulates the PI3K\/AKT signaling pathway, contributing to tumor progression and resistance to certain therapeutic agents. The activating EGFR mutation, commonly observed in lung adenocarcinoma, renders the cell line particularly sensitive to tyrosine kinase inhibitors like erlotinib. However, the co-occurrence of these genetic changes often necessitates combination therapies to overcome adaptive resistance mechanisms that involve compensatory signaling pathways, such as mTOR or MET.\n\nIn addition to its genetic and signaling characteristics, NCI-H1650 has been included in numerous studies examining somatic mutations, copy number variations, and epigenetic alterations in cancer cell lines. Its response to inhibitors of EGFR and PI3K pathways highlights its utility in preclinical drug discovery and personalized medicine strategies. This cell line serves as a representative model for investigating the interplay between oncogenic drivers and therapeutic vulnerabilities in lung adenocarcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101150\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218309997,"sku":"305059","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H1650_20P1_20305059_2010x02_20270223_1920x1920_f819e8f8-2822-4c83-a579-a52ce7801a19.jpg?v=1769069164"},{"product_id":"nci-h1703-cell-bhc11101358","title":"NCI-H1703 cell","description":"This cell line was isolated from the same patient as was NCI-H1693.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101358\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218342765,"sku":"305090","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H1703_20P1_20305090-M_2020x01_20021122_1920x1920_19d403e8-bb89-4392-be66-f0612a0bd334.jpg?v=1769069164"}],"url":"https:\/\/www.ebiohippo.com\/collections\/rc-infectious-disease-bacterial-fungal-infections.oembed?page=39","provider":"BioHippo","version":"1.0","type":"link"}