{"title":"Reproductive Endocrinology","description":null,"products":[{"product_id":"mouse-prolactin-elisa-kit-ez-set-diy-antibody-pairs-bhe21000008","title":"Mouse Prolactin ELISA Kit EZ-Set™ (DIY Antibody Pairs)","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Prolactin, PRL.\u003c\/p\u003e\u003cp\u003eMouse \u003cstrong\u003eProlactin\u003c\/strong\u003e (\u003cstrong\u003ePrl\u003c\/strong\u003e) is widely studied as a molecular readout in experimental models where changes in protein abundance reflect underlying biology. This target is frequently investigated in \u003cstrong\u003eOncology \u0026amp; Angiogenesis\u003c\/strong\u003e research contexts. This analyte is often discussed in the context of \u003cstrong\u003eendocrine signaling and metabolic homeostasis\u003c\/strong\u003e. Hormonal and adipokine signaling coordinates systemic energy balance, appetite, glucose handling, and tissue-specific metabolic programs.\u003c\/p\u003e\u003ch2\u003eBiological context\u003c\/h2\u003e\u003cp\u003eIn experimental systems, protein abundance can reflect regulated expression, secretion, processing, or clearance. Interpreting changes benefits from considering compartment (cell-associated vs soluble), the time scale of regulation, and whether complexes or modified forms contribute to the measured signal.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems-level readout:\u003c\/strong\u003e Quantification supports comparisons across conditions, time points, and treatment groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic interpretation:\u003c\/strong\u003e Pairing with upstream regulators and downstream markers helps contextualize changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiomarker-style profiling:\u003c\/strong\u003e Measuring panels of related analytes can improve interpretability in complex models.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Boster Bio","offers":[{"title":"5 plates\/kit","offer_id":52920801460589,"sku":"EZ0594","price":500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ez0594-2-ELISA-mouse-prolactin-ez-set-elisa-kit-diy-antibody-pairs.jpg?v=1769077470"},{"product_id":"human-prolactin-elisa-kit-picokine-bhe21000538","title":"Human Prolactin ELISA Kit PicoKine®","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Prolactin, PRL.\u003c\/p\u003e\u003cp\u003eHuman \u003cstrong\u003eProlactin\u003c\/strong\u003e (\u003cstrong\u003ePRL\u003c\/strong\u003e) is an established target in many assay panels, supporting hypothesis testing across diverse biological systems. This target is frequently investigated in \u003cstrong\u003eCoagulation \u0026amp; Hemostasis\u003c\/strong\u003e research contexts. This analyte is often discussed in the context of \u003cstrong\u003eendocrine signaling and metabolic homeostasis\u003c\/strong\u003e. Hormonal and adipokine signaling coordinates systemic energy balance, appetite, glucose handling, and tissue-specific metabolic programs.\u003c\/p\u003e\u003ch2\u003eBiological context\u003c\/h2\u003e\u003cp\u003eIn experimental systems, protein abundance can reflect regulated expression, secretion, processing, or clearance. Interpreting changes benefits from considering compartment (cell-associated vs soluble), the time scale of regulation, and whether complexes or modified forms contribute to the measured signal.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems-level readout:\u003c\/strong\u003e Quantification supports comparisons across conditions, time points, and treatment groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic interpretation:\u003c\/strong\u003e Pairing with upstream regulators and downstream markers helps contextualize changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiomarker-style profiling:\u003c\/strong\u003e Measuring panels of related analytes can improve interpretability in complex models.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920819712365,"sku":"EK0593","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ek0593.png?v=1769077732"},{"product_id":"mouse-prolactin-elisa-kit-picokine-bhe21000539","title":"Mouse Prolactin ELISA Kit PicoKine®","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Prolactin, PRL.\u003c\/p\u003e\u003cp\u003eMouse \u003cstrong\u003eProlactin\u003c\/strong\u003e (\u003cstrong\u003ePRL\u003c\/strong\u003e) is an established target in many assay panels, supporting hypothesis testing across diverse biological systems. This target is frequently investigated in \u003cstrong\u003eMolecular \u0026amp; Cellular Biology\u003c\/strong\u003e research contexts. This analyte is often discussed in the context of \u003cstrong\u003eendocrine signaling and metabolic homeostasis\u003c\/strong\u003e. Hormonal and adipokine signaling coordinates systemic energy balance, appetite, glucose handling, and tissue-specific metabolic programs.\u003c\/p\u003e\u003ch2\u003eBiological context\u003c\/h2\u003e\u003cp\u003eIn experimental systems, protein abundance can reflect regulated expression, secretion, processing, or clearance. Interpreting changes benefits from considering compartment (cell-associated vs soluble), the time scale of regulation, and whether complexes or modified forms contribute to the measured signal.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems-level readout:\u003c\/strong\u003e Quantification supports comparisons across conditions, time points, and treatment groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic interpretation:\u003c\/strong\u003e Pairing with upstream regulators and downstream markers helps contextualize changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiomarker-style profiling:\u003c\/strong\u003e Measuring panels of related analytes can improve interpretability in complex models.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920819745133,"sku":"EK0594","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ek0594.png?v=1769077732"},{"product_id":"mouse-gas6-elisa-kit-picokine-bhe21000815","title":"Mouse GAS6 ELISA Kit PicoKine®","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand, Gas6.\u003c\/p\u003e\u003cp\u003eMouse \u003cstrong\u003eGAS6\u003c\/strong\u003e (\u003cstrong\u003eGAS6\u003c\/strong\u003e) is a commonly measured biological analyte that can provide insight into cellular state and tissue physiology. This target is frequently investigated in \u003cstrong\u003eReproductive Biology\u003c\/strong\u003e research contexts. This analyte is often discussed in the context of \u003cstrong\u003ecell-surface signaling and cell-state markers\u003c\/strong\u003e. Many receptors and surface markers act as gateways for signaling or as phenotypic indicators of specific cell populations and activation states.\u003c\/p\u003e\u003ch2\u003eBiological context\u003c\/h2\u003e\u003cp\u003eIn experimental systems, protein abundance can reflect regulated expression, secretion, processing, or clearance. Interpreting changes benefits from considering compartment (cell-associated vs soluble), the time scale of regulation, and whether complexes or modified forms contribute to the measured signal.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems-level readout:\u003c\/strong\u003e Quantification supports comparisons across conditions, time points, and treatment groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic interpretation:\u003c\/strong\u003e Pairing with upstream regulators and downstream markers helps contextualize changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiomarker-style profiling:\u003c\/strong\u003e Measuring panels of related analytes can improve interpretability in complex models.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920831377773,"sku":"EK1196","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ek1196_dfe5ac67-ef15-43ff-aaa4-0fcc87d61f6c.png?v=1769077870"},{"product_id":"human-shbg-sex-hormone-binding-globulin-elisa-kit-picokine-bhe21001029","title":"Human SHBG \/ Sex Hormone Binding Globulin ELISA Kit PicoKine®","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG.\u003c\/p\u003e\u003cp\u003eHuman \u003cstrong\u003eSHBG \/ Sex Hormone Binding Globulin\u003c\/strong\u003e (\u003cstrong\u003eSHBG\u003c\/strong\u003e) is a commonly measured biological analyte that can provide insight into cellular state and tissue physiology. This target is frequently investigated in \u003cstrong\u003eOncology \u0026amp; Angiogenesis\u003c\/strong\u003e research contexts. This analyte is often discussed in the context of \u003cstrong\u003eendocrine signaling and metabolic homeostasis\u003c\/strong\u003e. Hormonal and adipokine signaling coordinates systemic energy balance, appetite, glucose handling, and tissue-specific metabolic programs.\u003c\/p\u003e\u003ch2\u003eBiological context\u003c\/h2\u003e\u003cp\u003eIn experimental systems, protein abundance can reflect regulated expression, secretion, processing, or clearance. Interpreting changes benefits from considering compartment (cell-associated vs soluble), the time scale of regulation, and whether complexes or modified forms contribute to the measured signal.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems-level readout:\u003c\/strong\u003e Quantification supports comparisons across conditions, time points, and treatment groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic interpretation:\u003c\/strong\u003e Pairing with upstream regulators and downstream markers helps contextualize changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiomarker-style profiling:\u003c\/strong\u003e Measuring panels of related analytes can improve interpretability in complex models.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920842584429,"sku":"EK1236","price":499.0,"currency_code":"USD","in_stock":true}]},{"product_id":"mouse-erap1-elisa-kit-picokine-bhe21001524","title":"Mouse ERAP1 ELISA Kit PicoKine®","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Endoplasmic reticulum aminopeptidase 1, ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP, VEGF-induced aminopeptidase.\u003c\/p\u003e\u003cp\u003eMouse \u003cstrong\u003eERAP1\u003c\/strong\u003e (\u003cstrong\u003eErap1\u003c\/strong\u003e) is an established target in many assay panels, supporting hypothesis testing across diverse biological systems. This target is frequently investigated in \u003cstrong\u003eReproductive Biology\u003c\/strong\u003e research contexts. Growth factors and morphogens regulate cell proliferation, differentiation, survival, and tissue remodeling by engaging surface receptors and activating downstream signaling cascades. Their activity is often context-dependent, shaped by receptor availability, extracellular matrix binding, and feedback regulation.\u003c\/p\u003e\u003ch2\u003eBiological function and mechanism\u003c\/h2\u003e\u003cp\u003eIn many systems, growth-factor signaling integrates environmental cues with developmental or repair programs. Downstream pathways frequently include kinase signaling modules and transcriptional responses that alter cell-cycle control, migration, or lineage specification. Because these signals can be transient, quantitative measurements are useful for understanding timing and dose dependence.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePathway engagement:\u003c\/strong\u003e Concentration changes can indicate activation of growth, survival, or differentiation programs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue remodeling:\u003c\/strong\u003e Levels may relate to repair, fibrosis, angiogenesis, or developmental patterning in model systems.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic studies:\u003c\/strong\u003e Tracking abundance alongside downstream markers helps connect ligand availability to signaling output.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eDisease and translational relevance\u003c\/h2\u003e\u003cp\u003eAltered growth-factor signaling has been reported across diverse conditions, including cancer biology, cardiovascular remodeling, wound repair, and metabolic dysfunction. For research interpretation, consider whether the measured form represents active ligand, bound complexes, or processed fragments, as these can influence apparent levels.\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920879350125,"sku":"EK2028","price":750.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ek2028_db2c9f9c-bcff-4e5e-8541-632567758f2d.jpg?v=1769078272"},{"product_id":"rat-dkk-1-picokine-quick-elisa-kit-bhe21001863","title":"Rat DKK-1 PicoKine® Quick ELISA Kit","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Dickkopf homolog 1 (Xenopus laevis) (Predicted), Dickkopf-like protein 1, Protein Dkk1, Dkk1, Dkk1_predicted, LOC100912050, rCG_48380.\u003c\/p\u003e\u003cp\u003eRat \u003cstrong\u003eDKK-1\u003c\/strong\u003e (\u003cstrong\u003eDkk1\u003c\/strong\u003e) is an established target in many assay panels, supporting hypothesis testing across diverse biological systems. This target is frequently investigated in \u003cstrong\u003eReproductive Biology\u003c\/strong\u003e research contexts. As with many protein targets, abundance can be influenced by transcriptional regulation, secretion or shedding, proteolytic processing, and clearance. Quantitative measurement is often used to connect molecular changes with phenotypes such as stress responses, immune activation, differentiation, or tissue remodeling.\u003c\/p\u003e\u003ch2\u003eBiological context and interpretation\u003c\/h2\u003e\u003cp\u003eProtein-level readouts complement nucleic-acid measurements by reflecting post-transcriptional control and protein stability. Depending on the model system, changes may be transient or sustained, and may represent direct pathway engagement or secondary effects. When interpreting results, consider sample matrix effects, timing relative to stimulation or treatment, and whether complexes or modified forms of the analyte may be present.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eComparative quantification:\u003c\/strong\u003e Supports analysis across experimental groups, time points, or dose ranges.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePathway context:\u003c\/strong\u003e Useful as part of a broader marker panel to triangulate biological mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eModel characterization:\u003c\/strong\u003e Helps profile baseline vs perturbed states in cells, tissues, or biofluids.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated pathways and interacting partners\u003c\/h2\u003e\u003cp\u003eFor many targets, interpretability improves when measured alongside biologically connected markers (e.g., upstream regulators, downstream effectors, and cell-type indicators). Designing panels around a pathway hypothesis can help distinguish primary pathway activation from general stress or inflammation.\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920903106925,"sku":"FEK1432","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fek1432.png?v=1769078435"},{"product_id":"rat-se-selectin-ez-set-and-trade-elisa-kit-diy-antibody-pairs-bhe21002095","title":"Rat sE-Selectin EZ-Set\u0026trade; ELISA Kit (DIY Antibody Pairs)","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e E-selectin, CD62 antigen-like family member E, Endothelial leukocyte adhesion molecule 1, ELAM-1, Leukocyte-endothelial cell adhesion molecule 2, LECAM2, CD62E, Sele.\u003c\/p\u003e\u003cp\u003eRat \u003cstrong\u003esE-Selectin\u003c\/strong\u003e (\u003cstrong\u003eSELE\u003c\/strong\u003e) is a commonly measured biological analyte that can provide insight into cellular state and tissue physiology. This target is frequently investigated in \u003cstrong\u003eReproductive Biology\u003c\/strong\u003e research contexts. This analyte is often discussed in the context of \u003cstrong\u003ecell-surface signaling and cell-state markers\u003c\/strong\u003e. Many receptors and surface markers act as gateways for signaling or as phenotypic indicators of specific cell populations and activation states.\u003c\/p\u003e\u003ch2\u003eBiological context\u003c\/h2\u003e\u003cp\u003eIn experimental systems, protein abundance can reflect regulated expression, secretion, processing, or clearance. Interpreting changes benefits from considering compartment (cell-associated vs soluble), the time scale of regulation, and whether complexes or modified forms contribute to the measured signal.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems-level readout:\u003c\/strong\u003e Quantification supports comparisons across conditions, time points, and treatment groups.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic interpretation:\u003c\/strong\u003e Pairing with upstream regulators and downstream markers helps contextualize changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiomarker-style profiling:\u003c\/strong\u003e Measuring panels of related analytes can improve interpretability in complex models.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Boster Bio","offers":[{"title":"5 plates\/kit","offer_id":52920911495533,"sku":"EZ0936","price":500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ez0936.png?v=1769078559"},{"product_id":"15p-1-cell-bhc11101301","title":"15P-1 cell","description":"15p-1 cells are a mammalian cell line derived from Mus musculus, specifically utilized for the study of cellular responses to steroid hormones. Originating from the testicular tissue of mice, these cells exhibit a unique sensitivity to androgens, which makes them particularly valuable in endocrinology and cancer research. The 15p-1 cell line expresses the androgen receptor (AR), enabling the study of androgenic effects on gene expression, cell growth, and differentiation processes.\nCharacteristically, 15p-1 cells are used to explore the molecular pathways influenced by androgens and their role in diseases such as prostate cancer. They provide a controlled in vitro environment to dissect the interactions between androgens and their cellular receptors, facilitating insights into both normal physiological and pathological states. This cell line is also instrumental in screening potential pharmaceuticals targeting androgen-related pathways, contributing to the development of therapeutic strategies.\nMaintained under standard cell culture conditions, 15p-1 cells require a medium enriched with fetal bovine serum (FBS) and an optimal temperature of 37°C, along with a CO2 concentration of 5% to mimic physiological conditions. Rigorous quality control is essential to preserve their genetic and phenotypic characteristics, ensuring reliable and reproducible results in research applications.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101301\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195044717,"sku":"305191","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/15P-1_20P1_2010x01_20230525_ch00_1920x1920_9839ac6f-f868-4bbd-87aa-9fe50956e0cc.jpg?v=1769068929"},{"product_id":"a2780-cell-bhc11101365","title":"A2780 cell","description":"A2780 is a human ovarian cancer cell line that was first established in 1972 from a patient with advanced epithelial ovarian cancer. The cells were characterized as being sensitive to cisplatin and doxorubicin, two commonly used chemotherapy drugs for ovarian cancer. Since its establishment, A2780 has been widely used in cancer research studies, particularly in the development and testing of new cancer treatments. \nResearch using A2780 cells has provided valuable insights into the biology of ovarian cancer, including the identification of specific genetic mutations such as TP53 and BRCA1. These mutations are associated with increased risk of ovarian cancer and are also found in other types of cancer. \nAdditionally, A2780 cells have been used to study the role of angiogenesis, the process by which new blood vessels form, in ovarian cancer progression and to evaluate the efficacy of anti-angiogenic drugs. Angiogenesis plays a critical role in the growth and progression of ovarian cancer as it provides oxygen and nutrients for the cancer cells to grow. \nStudies using A2780 cells have demonstrated the overexpression of pro-angiogenic factors such as VEGF and angiopoietin-2, which promote the formation of new blood vessels. Additionally, A2780 cells have been used to test the efficacy of anti-angiogenic drugs such as bevacizumab, which target VEGF and inhibit the formation of new blood vessels. \nFurthermore, A2780 cells have been used to evaluate the efficacy of various therapeutic agents, including chemotherapy drugs, targeted therapies such as PARP inhibitors, and immunotherapies. \nIn particular, A2780 cells have been used to study the effect of different drug combinations on cancer cell proliferation, apoptosis, and drug resistance. Overall, the A2780 cell line has played a significant role in the advancement of ovarian cancer research, providing a valuable tool for understanding the disease and developing new treatments.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101365\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196126061,"sku":"300491","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A2780_20P0_2040x01_2007092022_1920x1920_255020e7-b42a-41be-8126-bd752712eeb5.jpg?v=1769068937"},{"product_id":"an3-ca-cell-bhc11100043","title":"AN3 Ca cell","description":"The An3 Ca cell line is derived from a human endometrial adenocarcinoma, a type of cancer originating from the lining of the uterus. This cell line is estrogen receptor negative (ER-) and exhibits aggressive tumorigenic potential when assessed in vivo. An3 Ca cells are used extensively in research focused on understanding the molecular and cellular mechanisms underlying endometrial cancer progression, including studies on cancer cell proliferation, metastasis, and response to therapeutic agents.\n\nCharacteristically, An3 Ca cells display an epithelial morphology and have been utilized to study the impact of various genetic and environmental factors on cancer cell behavior. Research using this cell line has contributed to identifying potential therapeutic targets and understanding the resistance mechanisms against conventional treatments. They serve as a valuable model for evaluating new drugs or treatment strategies that could be effective against aggressive forms of endometrial cancer.\n\nOverall, the An3 Ca cell line is instrumental in advancing the scientific knowledge of endometrial adenocarcinoma, offering insights that might lead to more effective interventions for this challenging and often lethal disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100043\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197109101,"sku":"300119","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/an3-ca-_284_29_1920x1920_59defe71-9b26-4a96-84f0-aa3ac093f9f3.jpg?v=1769068946"},{"product_id":"anglne-cell-bhc11101282","title":"Anglne cell","description":"The Anglne cell line was established by German scholars and is mainly applied to pathological research of ovarian cancer and screening of anti-tumor drugs. The Anglne cell line is adherent and more convenient to culture than the COC1 cell line.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101282\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197207405,"sku":"305144","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Anglne_20_20WaKo_20P1_2020x01_20100425_ch00_1920x1920_f2ffce7b-448a-4633-a21e-4d0984669046.jpg?v=1769068947"},{"product_id":"bewo-cell-bhc11100033","title":"BEWO cell","description":"BeWo cells, a cell line derived from malignant gestational choriocarcinoma of the fetal male placenta, have become a widely used in vitro model for studying the placenta. \nThe cell-cell fusion during the human trophoblast syncytialization phase during placental development is one of the most significant yet least understood events. Due to the difficulty of studying this process in a placenta in vivo, BeWo cells are utilized as a cell culture model to simulate in vivo syncytialization of the placental villous trophoblast.\nThese cells exhibit an epithelial-like phenotype and are adherent. The b30 subclone of BeWo cells is particularly useful for studying nutrient uptake and transport due to its dense growth on permeable membranes.\nCK 7 and E-cadherin are molecular markers that are expressed by BeWo cells. VE-cadherin is found in BeWo cells and is enhanced upon treatment with forskolin. The cells also express keratin and are positive for G6PD, B isoenzyme. The karyotype of BeWo cells is modal number = 86, with a range of 71 to 178, and the stemline number is hypotetraploid. \nThe karyotype is relatively stable within the stemline number. BeWo cells secrete various hormones, including human chorionic gonadotropin (hCG), human chorionic somatomammotropin (placental lactogen), and steroid hormones as estrone, estriol, and estradiol. \nHowever, the levels of β-hCG and estradiol secreted by BeWo cells are lower than those secreted by other choriocarcinoma-derived cell lines such as JEG-3. Upon Forskolin treatment, the secretion of β-hCG in BeWo cells increases to a level similar to that observed in the other choriocarcinoma-derived cell lines. Furthermore, Forskolin treatment also increases the progesterone levels secreted by BeWo cells.\nIn summary, BeWo cells are a widely used in vitro model for studying placental development and the human trophoblast syncytialization process. They exhibit an epithelial-like phenotype, express various molecular markers, and secrete multiple hormones, including hCG, placental lactogen, and steroid hormones. Overall, BeWo cells are a valuable tool for investigating the complex processes involved in placental development.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100033\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198157677,"sku":"300123","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/bewo-_281_29_1920x1920_f975a6b5-8edd-4f11-8b59-cda5f21e8d0b.jpg?v=1769068955"},{"product_id":"c-33-a-cell-bhc11101353","title":"C-33 A cell","description":"C-33 A cells originate from the cervical tissue of a 66-year-old Caucasian female diagnosed with uterine cancer. This cell line is characterized by a unique genetic alteration in the TP53 gene, where a point mutation at codon 273 results in an arginine to cysteine substitution, leading to elevated expression of the p53 protein. This mutation plays a critical role in the pathophysiology of the cells, influencing their growth properties and tumorigenic potential.\n\nNotably, C-33 A cells are confirmed to be tumorigenic. When introduced into immunodeficient nude mice, these cells have the capability to form undifferentiated carcinomas, which highlights their utility in cancer research, particularly in studies aimed at understanding the mechanisms of tumor initiation and progression in cervical cancer. Furthermore, these cells are negative for both DNA and RNA of human papillomavirus (HPV), distinguishing them from many other cervical cancer cell lines which often carry HPV integrations. This aspect makes C-33 A cells particularly valuable for studying cervical cancer that develops independently of HPV infection, offering insights into alternative pathways of carcinogenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101353\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199992685,"sku":"305072","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C33A_20_286_29_1920x1920_09d64786-8497-450e-8203-3637ccd48290.jpg?v=1769068974"},{"product_id":"caov-3-cell-bhc11101105","title":"Caov-3 cell","description":"Caov-3 cells are derived from the ovary of a 54-year-old Caucasian woman with adenocarcinoma, provide researchers with a representative model for high-grade ovarian cancer. The cell line was established in 1976 and has since been used in numerous studies. \nWith their epithelial morphology, Caov-3 cells closely resemble the characteristics of primary ovarian cancer cells. When cultured, these cells form densely packed colonies that mimic the behavior observed in the human body. Their unique properties make them an ideal choice for researchers studying the growth, behavior and response of ovarian cancer cells. \nAn important finding in this field is the effect of all-trans retinoic acid on Caov-3 cells. Studies have shown that this compound suppresses the growth of these ovarian cancer cells in vitro. In addition, Caov-3 cells express various tumor-associated antigens, including NB\/70K, CA-125, Ba-2, and Ca-1, which increases their utility for research into targeted therapies and immunotherapies. \nThe genome of Caov-3 cells exhibits significant abnormalities explaining their tumorigenic properties. For example, these cells have a nonsense mutation in the p53 tumor suppressor gene and possess multiple copies of the ovarian cancer oncogene PIK3CA, which plays a critical role in cancer development and progression. In terms of drug sensitivity, Caov-3 cells respond to several commonly used chemotherapeutic agents. \nVinblastine, cisplatin and adriamycin have been shown to have an effect on these cells. Another characteristic of Caov-3 cells is their behavior under different culture conditions. While these cells do not grow in soft agar, they exhibit tumorigenic properties when injected into immunocompromised mice. Therefore, among their many applications in research, Caov-3 cells are particularly suitable for 3D cell culture experiments. \nDue to their epithelial morphology and ability to form dense colonies, they are the ideal choice for studying cell-cell interactions, tissue organization and behavior of ovarian cancer cells in a more physiologically relevant environment. However, the long doubling time of approximately 78 hours must be considered in experimental design.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101105\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200549741,"sku":"300319","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Caov-3_20P6_2020x01_20310523_1920x1920_42058ec7-d6a8-436b-8fba-71b03bb6e603.jpg?v=1769068983"},{"product_id":"caski-cell-bhc11100052","title":"CaSki cell","description":"CaSki is a cell line exhibiting epithelial morphology, isolated from the cervix of a 40-year-old White female patient with epidermoid carcinoma. The establishment of this cell line provides a critical model for the study of cervical cancer, particularly in the context of HPV-mediated oncogenesis. CaSki cells are characterized by their capacity to replicate HPV16 DNA, which is integrated into the host's genome, offering insights into the viral life cycle and its role in malignant transformation.\n\nThese cells are an essential resource in cancer research, particularly for studies focusing on the pathogenesis of HPV-associated cervical cancer. The presence of high-risk HPV16 in CaSki cells facilitates the exploration of viral oncogene functions, notably the E6 and E7 proteins and their interactions with cellular tumor suppressor pathways, including those involving p53 and pRB. This aspect makes CaSki cells invaluable for evaluating potential therapeutic targets and developing interventions aimed at HPV-induced malignancies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100052\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200648045,"sku":"300145","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/caski-_281_29_1920x1920_03746bf0-2bce-4e5b-8320-37d63e8f30f0.jpg?v=1769068984"},{"product_id":"cerv-186-cell-bhc11100006","title":"CERV-186 cell","description":"The CERV-186 cell line, derived in vitro from the xenotransplant of cervical carcinoma MRI-H-186, serves as a biological model for invasive, large-cell, non-keratinizing squamous cell carcinoma. This cell line was established and adapted for in vivo transplantation under the direction of Dr. Bodgen at the Mason Research Institute. Characterized by its genomic properties, MRI-H186 contains approximately 26 integrated copies of both full-length and truncated forms of the HPV16 genome, which significantly influence its transcriptomic profile.\n\nMRI-H186 cells are distinguished by their robust expression of both full-length and truncated early HPV16 transcripts, notably displaying high levels of E5 full-length (fl) RNA. This transcriptional signature is notably distinct from that observed in other cervical carcinoma cell lines such as CaSki and MRI-H196. Additionally, the transcriptional activity of MRI-H186, in terms of the expression of various other transcripts, shows a close alignment with the patterns observed in the HPK-IA and C3 cell lines, indicating a similar transcriptional behavior across these models. The presence of both full-length and truncated HPV16 genomic integrations in MRI-H186 cells is a key factor in their vigorous expression of early viral transcripts, particularly underscored by the significant expression of E5 fl RNA. This intense transcriptional activity culminates at the early polyadenylation signal, highlighting the unique transcriptional dynamics within the MRI-H186 cell line.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100006\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200975725,"sku":"300290","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cerv-186-_284_29_1920x1920_8efa94bf-8d5d-49b3-8406-c05d351c7885.jpg?v=1769068988"},{"product_id":"cerv-196-cell-bhc11100112","title":"CERV-196 cell","description":"The MRI-H196 cell line, derived from HPV16-positive cervical carcinoma, displays a unique HPV16 transcript expression profile characterized by the presence of the full-length L1 transcript and a marked absence of the E5 full-length RNA. This pattern suggests an integration of the HPV16 genome within the cell line, particularly affecting the E2 region and causing rearrangement of the L1 DNA sequence. The absence of E5 full-length RNA expression indicates a disruption in the transcription of full-length early RNAs, which typically conclude at the polyadenylation signal located downstream of the E5 open reading frame (ORF). Such a disruption is indicative of the integrated state of HPV16 genomes, where the crucial E2 region-key for viral replication and transcription regulation-is often compromised during the integration into the host genome. This disruption potentially impacts the expression of downstream genes, including E5.\n\nThis integration phenomenon within MRI-H196 cells highlights the complexity of HPV16 genome behavior post-integration, emphasizing the cell line's utility in studying the genomic and transcriptional intricacies associated with HPV integration in cervical carcinomas. Understanding these dynamics is crucial for insights into the mechanisms of oncogenesis and the progression of HPV-associated cancers, making the MRI-H196 cell line a valuable resource for medical and biological research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100112\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201008493,"sku":"300291","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cerv-196-_288_29_1920x1920_8e2effa2-b5d3-4d20-a77e-52a738593f50.jpg?v=1769068988"},{"product_id":"cerv-215-cell-bhc11100208","title":"CERV-215 cell","description":"The CERV-215 cell line, established by Dr. Bodgen at the Mason Research Institute, originates from a primary xenotransplant termed MRI-H215, which has been adapted for in vivo transplantation. \nThis cell line represents an aggressive form of epidermoid carcinoma, categorized as invasive, large cell, non-keratinizing, and poorly differentiated. \nThe Cerv-215 cell line, is a pivotal resource for cancer research, especially in the study of genetic alterations and their roles in cervical carcinogenesis. This cell line is characterized by unique genetic modifications in the Smad4 gene, where specific exons are replaced by sequences from other genomic regions, leading to the expression of truncated and likely non-functional Smad4 proteins. These alterations provide insights into the cell line's oncogenic properties and the molecular mechanisms underlying cervical cancer.\nNotably, MRI-215 is HPV45 positive, yet its Smad4 gene alterations are independent of HPV integration, suggesting a complex interplay of genetic factors contributing to cancer development beyond viral influences. This cell line serves as an invaluable tool for researchers focusing on the genetic aspects of cancer, the role of Smad4 in tumor progression, and the interaction between human papillomavirus and host cellular mechanisms.\nMRI-H215 offers a unique platform for exploring the intricacies of cervical cancer at the molecular level, making it an essential component of cancer research laboratories aiming to uncover new therapeutic targets and understand the genetic basis of tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100208\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201041261,"sku":"300292","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CERV-215_20_284_29_1920x1920_a87fcf08-68b6-41f5-b60b-65a3c2eb446f.jpg?v=1769068989"},{"product_id":"cho-cell-bhc11100241","title":"CHO cell","description":"Chinese hamster ovary (CHO) cells are a cornerstone in the field of biotechnology and are heavily utilized in the process of CHO cell line development for the manufacture of biopharmaceuticals. These include monoclonal antibodies, recombinant antibody expression, and vaccines. The many advantages of CHO cells underscore their popularity in biomanufacturing, positioning them as a robust and versatile animal cell line with a proven track record in genetics, molecular biology, toxicity screening, nutrition, and gene expression studies.\nThe contribution of CHO cells to the biopharmaceutical industry is immense, with their role in the development of recombinant antibodies and monoclonal antibody production being particularly significant. Nearly 50 biotherapeutics developed using these cells have been approved in the USA and EU, which speaks to the efficacy of CHO cells and their integral role in antibody development. Their hamster origin contributes to lower susceptibility to viruses, enhancing biosafety in biomanufacturing settings and reducing batch-to-batch variation.\nCHO cells are well-suited to produce proteins that undergo post-translational modifications, which is critical for therapeutic protein production. The versatility of the Chinese Hamster Ovary-derived cells is further highlighted by their fast proliferation rates and high protein expression rates of 1-5 grams per liter of culture. The ease of cultivating CHO cells and their ability to be genetically modified makes CHO cells an optimal choice for both transient and stable expression studies.\nThe CHO-K1 cell line, a derivative of the original Chinese hamster ovary (CHO) cells is frequently utilized in expressing recombinant proteins, especially for the production of therapeutic proteins and recombinant antibodies. They excel in producing therapeutic proteins and antibodies due to efficient post-translational modification, notably glycosylation. Researchers modify CHO-K1 cells to enhance protein expression and tailor glycosylation for specific therapies, crucial in biomedicine.\nIn conclusion, the Chinese hamster ovary cell line, known for its remarkable ability to mimic human post-translational modifications, is an invaluable scientific resource. Whether overcoming the difficulty of expressing challenging proteins or monoclonal antibody production, CHO cells have revolutionized the development and production of recombinant protein therapeutics. They remain pivotal in modern medicine, serving as a cornerstone for biopharmaceutical production and reflecting the advancements in biotechnology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100241\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201205101,"sku":"603479","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CHO_P1_2020x01_20301023_ch00_1920x1920_c5b2526e-0047-4a3f-acb3-b53acf45bdfc.jpg?v=1769068990"},{"product_id":"cho-b7h3-cell-bhc11101491","title":"CHO-B7H3 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-B7H3 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the B7-H3 receptor at a high level, approximately 395,000 molecules per cell. This cell line was developed using innovative landing pad technology, which ensures precise and reproducible integration of the B7-H3 gene at a specific, pre-validated genomic locus. B7-H3, also known as CD276, is a member of the B7 family of immune checkpoint proteins and is overexpressed in various cancers. It plays a critical role in immune evasion by tumor cells and is associated with poor prognosis in cancer patients. This makes B7-H3 a promising target for cancer immunotherapy, particularly in the development of checkpoint inhibitors and antibody-drug conjugates.\nThe expression of B7-H3 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101491\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201237869,"sku":"305417","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_5e76e15e-17b7-4b33-b52d-a8b8a6040417.jpg?v=1769068990"},{"product_id":"cho-ccr8-cell-bhc11101492","title":"CHO-CCR8 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CCR8 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CCR8 receptor at a medium-high level, approximately 8,000 molecules per cell. This cell line was developed using advanced landing pad technology, ensuring precise and reproducible integration of the CCR8 gene at a specific, pre-validated genomic locus. CCR8, also known as CHEMR1 or CDw198, is a G protein-coupled receptor (GPCR) expressed on various immune cells, particularly regulatory T cells (Tregs). CCR8 plays a critical role in the immune suppression process within the tumor microenvironment, facilitating tumor cells' ability to evade immune detection. As such, targeting CCR8 has become a promising strategy in cancer immunotherapy to reduce Treg-mediated suppression and enhance anti-tumor immunity.\nThe expression of CCR8 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101492\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201270637,"sku":"305418","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_29452378-9937-4200-92b0-746f8594eb7c.jpg?v=1769068991"},{"product_id":"cho-ctla4-cell-bhc11101488","title":"CHO-CTLA4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.\nThe CHO-CTLA4 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CTLA4 receptor at a medium-low level, approximately 3,000 molecules per cell. This cell line was created using an innovative landing pad technology that facilitates the targeted integration of the CTLA4 gene at a specific, pre-validated genomic locus. CTLA4, also known as CD152, is a critical immune checkpoint protein found primarily on T-cells. It functions by competing with CD28 for binding to B7 molecules (CD80 and CD86) on antigen-presenting cells, leading to the downregulation of T cell activation. This mechanism is vital for maintaining immune self-tolerance and preventing autoimmunity. CTLA4's role in modulating immune responses has made it a significant target in cancer immunotherapy, particularly in immune checkpoint blockade strategies.\nThe expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101488\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201303405,"sku":"305414","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_8414bae3-ee9f-42ef-bb53-1cda0600a649.jpg?v=1769068991"},{"product_id":"cho-cxcr4-cell-bhc11101481","title":"CHO-CXCR4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR4-Low cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line that expresses the CXCR4 receptor at a low level, approximately 400 molecules per cell. This cell line was developed using an innovative landing pad technology, which allows for targeted integration of the CXCR4 gene at a pre-validated genomic locus. This approach ensures consistent and reproducible expression of the CXCR4 receptor across cell populations.\nCXCR4, also known as CD184, is a chemokine receptor that is significant in immune cell trafficking, hematopoiesis, and as a co-receptor for HIV entry into cells. It plays a key role in the migration and homing of hematopoietic stem cells and leukocytes through its interaction with the ligand CXCL12. In oncology, CXCR4 is implicated in various aspects of tumor biology, including growth, metastasis, and angiogenesis. It is often overexpressed in hematological malignancies, where it is associated with therapy resistance and poor prognosis. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101481\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201336173,"sku":"305411L","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_83770518-b4dc-42be-b1e2-41d45cf5af2a.jpg?v=1769068991"},{"product_id":"cho-cxcr4-cell-bhc11101480","title":"CHO-CXCR4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR4-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line expressing the CXCR4 receptor at a medium-high level, approximately 9500 molecules per cell. This cell line was developed using an innovative landing pad technology, which ensures targeted integration of the CXCR4 gene at a pre-validated genomic locus. This approach results in consistent and reliable expression of the CXCR4 receptor, facilitating reproducible experimental outcomes.\nCXCR4, also known as CD184, is a chemokine receptor involved in critical biological processes such as immune cell trafficking, hematopoiesis, and as a co-receptor for HIV entry into cells. The receptor's interaction with its ligand, CXCL12, is essential for the migration and homing of hematopoietic stem cells and leukocytes. In oncology, CXCR4 plays a significant role in tumor growth, metastasis, and angiogenesis, with its expression often upregulated in various cancers, including hematological malignancies. This upregulation is frequently associated with therapy resistance and poor prognosis. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101480\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201368941,"sku":"305411MH","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_c59b25fb-5522-47fa-bcf7-d69f0948ba5d.jpg?v=1769068992"},{"product_id":"cho-cxcr7-cell-bhc11101483","title":"CHO-CXCR7 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR7-Low cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line expressing the CXCR7 receptor at a low level. This cell line was generated using an innovative landing pad technology, allowing for reproducible and precise integration of the CXCR7 gene at a validated genomic locus. CXCR7, also known as ACKR3, is an atypical chemokine receptor involved in various biological processes, including immune modulation and tumor biology. Unlike classical GPCRs, CXCR7 does not signal through G proteins but instead modulates cellular responses by scavenging chemokines, such as CXCL12 and CXCL11, and interacting with CXCR4 through heterodimer formation.\nOverexpression of CXCR7 has been implicated in several cancers, including breast, lung, and prostate, where it is associated with enhanced tumor progression, metastasis, and poor prognosis. CXCR7 contributes to cancer progression by altering the tumor microenvironment, promoting angiogenesis, and facilitating cancer cell migration and invasion. Due to its significant role in cancer biology, CXCR7 is an important target in oncology research. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101483\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201401709,"sku":"305412L","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_b3a66b4e-01a5-49a5-8872-f377dd20cde2.jpg?v=1769068992"},{"product_id":"cho-cxcr7-cell-bhc11101484","title":"CHO-CXCR7 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR7-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CXCR7 receptor at a medium-high level. This cell line was created using an innovative landing pad technology, which allows for targeted integration of the CXCR7 gene at a pre-validated genomic locus, ensuring consistent and reproducible expression. CXCR7, also known as ACKR3, is an atypical chemokine receptor involved in immune modulation and cancer biology. Unlike typical GPCRs, CXCR7 does not signal through G proteins but instead scavenges chemokines such as CXCL12 and CXCL11, and forms heterodimers with CXCR4, influencing processes like tumor progression, metastasis, and angiogenesis.\nCXCR7 is notably overexpressed in various cancers, including breast, lung, and prostate cancers, where it is linked to increased tumor growth, metastasis, and poorer prognosis. This makes the CHO-CXCR7-Medium-high cell line particularly valuable for oncology research, allowing for the study of CXCR7's role in cancer progression and its potential as a therapeutic target. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101484\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201467245,"sku":"305412MH","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_91dc6831-e880-4cbf-af6a-128880547444.jpg?v=1769068992"},{"product_id":"cho-folr1-cell-bhc11101490","title":"CHO-FOLR1 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-FOLR1 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the FOLR1 receptor at a medium-high level, approximately 15,000 molecules per cell. This cell line was developed using advanced landing pad technology, which ensures precise and reproducible integration of the FOLR1 gene at a specific, pre-validated genomic locus. FOLR1, also known as Folate Receptor Alpha (FRα) or FBP, is a GPI-anchored membrane protein with high affinity for folate, facilitating its transport into cells. FOLR1 is significantly overexpressed in various epithelial cancers, including ovarian, breast, and non-small cell lung cancers, making it a valuable target for cancer immunotherapies, including CAR T cell therapies and bispecific antibodies.\nThe expression of FOLR1 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101490\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201500013,"sku":"305416","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_ce503825-70d6-48fa-ba6c-b9e4bdcba60f.jpg?v=1769068993"},{"product_id":"cho-her2-cell-bhc11101486","title":"CHO-HER2 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-HER2-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line that expresses the HER2 receptor at a medium-high level, approximately 13,000 molecules per cell. This cell line was developed using an innovative landing pad technology, ensuring the HER2 gene's targeted integration at a specific, pre-validated genomic locus. HER2, also known as ERBB2 or CD340, is a member of the epidermal growth factor receptor (EGFR) family and plays a critical role in regulating cell growth and differentiation. It is a significant biomarker and target in breast and ovarian cancers, where its overexpression is associated with increased tumor aggressiveness and poorer patient outcomes. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101486\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201565549,"sku":"305413MH","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_135344c6-0bba-49bf-811b-6a1a37905934.jpg?v=1769068993"},{"product_id":"cho-her2-cell-bhc11101487","title":"CHO-HER2 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-HER2-High cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the HER2 receptor at a high level, approximately 85,000 molecules per cell. This cell line was generated using an innovative landing pad technology that ensures the HER2 gene is integrated at a specific, pre-validated genomic locus, allowing for consistent and reliable expression. HER2, also known as ERBB2 or CD340, is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in regulating cell growth and differentiation. It is well-known for its involvement in breast and ovarian cancers, where its overexpression is linked to increased tumor aggressiveness and poorer patient outcomes. HER2 is a key target for cancer therapies such as Trastuzumab (Herceptin) and Pertuzumab (Perjeta). This cell line is versatile, supporting both adherent and suspension culture conditions, with adherent cells exhibiting an epithelial-like morphology. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101487\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201598317,"sku":"305413H","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_0417f2de-5b6b-4070-86b4-17db1050ece2.jpg?v=1769068993"},{"product_id":"cho-k1-cell-bhc11100061","title":"CHO-K1 cell","description":"CHO-K1 cells are a subline derived from the CHO cell line, which was originally established in the early 1950s from a Chinese hamster ovary. CHO-K1 cells are widely utilized in the production of therapeutic monoclonal antibodies and other biopharmaceuticals. Their extensive use in biopharmaceutical protein production and vaccines is attributed to their eukaryotic nature, which allows for proper folding, assembly, and post-translational modifications such as glycosylation, which influences the stability, efficacy, and safety of the produced proteins.\nIn the realm of recombinant protein production, the CHO-K1 cell line is used to express a wide array of proteins, including monoclonal antibodies, growth factors, cytokines, and enzymes. These proteins have applications in therapeutic treatments, diagnostic assays, and vaccine formulations.\nCHO-K1 cells exhibit a robust growth rate and are adaptable to various culture conditions, including suspension and adherent cultures, making them highly valuable for large-scale bioproduction processes. They possess a high level of genetic stability and are used for  stable cell line development as they are capable of amplifying and expressing exogenous genes efficiently, which is critical for producing high yields of recombinant proteins.\nCHO-K1 chinese hamster cells can be easily transfected with a variety of vectors for gene expression, facillitating gene editing or knockdown. This flexibility allows researchers to introduce specific genes, silence genes, or even perform targeted gene editing using technologies like CRISPR-Cas9 in CHO-K1 host cells.\nIn conclusion, the chinese hamster CHO-K1 cells and CHO cells are pivotal in biotechnological research and biopharmaceutical production, offering a versatile platform for the study of gene function and the large-scale production of recombinant proteins.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100061\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201631085,"sku":"603480","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-k1-_283_29_1920x1920_81bf2861-9573-4baf-ab8e-9093771c7411.jpg?v=1769068994"},{"product_id":"cho-tacd2-cell-bhc11101489","title":"CHO-TACD2 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-TACD2 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the TACD2 receptor at a medium-high level, approximately 12,600 molecules per cell. This cell line was developed using an innovative landing pad technology, ensuring precise and reproducible integration of the TACD2 gene at a specific, pre-validated genomic locus. TACD2, also known as TROP2 or GA733-1, is a tumor-associated calcium signal transducer. It plays a critical role in intracellular calcium signaling, which is crucial for various cellular processes, including growth, division, and differentiation. Overexpression of TACD2 has been observed in various carcinomas, such as colorectal, gastric, and pancreatic cancers, making it a potential target for antibody-drug conjugates and immunotherapy.\nThe expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101489\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201663853,"sku":"305415","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_4a2150a7-cf98-4472-9860-1f83722db9f1.jpg?v=1769068994"},{"product_id":"ctla4-ig-24-cell-bhc11101283","title":"CTLA4 Ig-24 cell","description":"CTLA4 Ig-24 cells, derived from an adult female Chinese hamster (Cricetulus griseus), are a spontaneously immortalized cell line which have been genetically modified by introducing the human CTLA-4 gene, resulting in the expression of a fusion protein. \nThe fusion protein possesses a dominant attribute of CTLA4Ig, making CTLA4 Ig-24 cells a unique and essential tool in immunology research. CTLA-4, a member of the immunoglobulin superfamily, is primarily expressed in activated T cells and acts as an inhibitory signal transmitter to regulate T cell function. \nIt shares homology with CD28, a T-cell co-stimulatory protein, and both molecules bind to CD80 (B7-1) and CD86 (B7-2) proteins on antigen-presenting cells. CTLA-4 demonstrates a greater affinity and avidity for CD80 and CD86 than CD28, allowing it to outcompete CD28 for binding to these ligands. By doing so, CTLA-4 transmits an inhibitory signal to T cells, while CD28 transmits a stimulatory signal. \nThis intricate regulatory mechanism is pivotal in maintaining immune balance and preventing excessive immune responses. \nInterestingly, CTLA-4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. \nWhen T cells are activated through the T cell receptor (TCR) and CD28, the expression of CTLA-4 increases. Furthermore, CTLA-4 may influence cell motility and signal signalling through the PI3 kinase pathway.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101283\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950202417517,"sku":"305014","price":395.0,"currency_code":"USD","in_stock":true}]},{"product_id":"es-2-cell-bhc11101171","title":"ES-2 cell","description":"The ES-2 cell line is derived from a poorly differentiated ovarian clear cell carcinoma, offering a unique in vitro model to study the biological behaviors and treatment responses of this aggressive cancer subtype. Originally cultured in soft agar, a method favoring the growth of cancer cells while suppressing fibroblast growth, ES-2 cells provide a robust system for analyzing tumor cell interactions and drug resistance mechanisms in a three-dimensional matrix that closely mimics the in vivo environment.\nPharmacologically, ES-2 cells display low to moderate resistance to several chemotherapeutic agents, including doxorubicin, cisplatin, carmustine, etoposide, and cyanomorpholinodoxorubicin (MRA-CN). This resistance profile makes ES-2 an essential tool for oncology research, particularly in the development and testing of new chemotherapeutic regimens and combination therapies. Furthermore, the expression of P-glycoprotein in ES-2 cells is low, which is significant as P-glycoprotein is often implicated in the efflux of drugs from cancer cells, contributing to multidrug resistance. Studying ES-2 cells can therefore provide insights into overcoming drug resistance in ovarian clear cell carcinomas.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101171\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203695469,"sku":"305038","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ES-2_20P1_2020x01_20030723_1920x1920_e745cb60-05f9-4908-92c3-49cdd22fbf1c.jpg?v=1769069017"},{"product_id":"f9-cell-bhc11100633","title":"F9 cell","description":"The F9 cell line, a murine embryonal carcinoma model derived from a testicular teratoma of the C57BL\/6 mice, serves as an important tool in developmental biology and embryology. F9 cells are capable of differentiation into parietal endoderm when exposed to retinoic acid and dibutyryl cyclic AMP (cAMP). This differentiation is marked by significant changes in cellular behavior and protein expression, including the synthesis of plasminogen activator, laminin, and type IV collagen. These proteins are crucial for understanding the processes of tissue development and matrix formation in early embryonic stages.\n\nIt is noted that cAMP's effectiveness in inducing differentiation in F9 cells is conditional upon prior treatment with retinoic acid, indicating a complex interplay between these signaling molecules in triggering developmental pathways. Additionally, F9 cells are characterized by having three copies of the beta 1 integrin gene, which may influence cell adhesion and mobility, further underscoring their utility in studying cell interactions and extracellular matrix composition. Safety profiling of these cells includes testing for ectromelia virus (mousepox), for which they have been found negative, ensuring their suitability for a broad range of experimental applications without the risk of viral contamination.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100633\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203761005,"sku":"400174","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/f9-_282_29_1920x1920_65dbe6f9-ad82-42ca-a0f2-020e82562dbe.jpg?v=1769069018"},{"product_id":"gc-1-spg-cell-bhc11101299","title":"GC-1 spg cell","description":"The GC-1 spg cell line was immortalized through transfection with the pSV3-neo plasmid, which harbors the coding sequences for the SV40 large T antigen and neomycin resistance. This genetic modification not only provides resistance to certain antibiotics but also promotes the continuous growth of the cells by altering their cell cycle regulation, thus bypassing the Hayflick limit typical of primary cells. This process of immortalization allows the cells to maintain proliferative capacity while retaining key phenotypic characteristics of spermatogonia.\n\nPhenotypically, the GC-1 spg cell line exhibits characteristics that are indicative of a transitional stage between type B spermatogonia and primary spermatocytes, making it an especially relevant model for studying the early stages of spermatogenesis. The cells express two testis-specific isoproteins: cytochrome c and lactate dehydrogenase C4. These markers are crucial for studying cell metabolism and energy management during spermatogenesis, reflecting the unique metabolic pathways active in germ cells. The expression of these specific isoproteins underscores the cell line's utility in exploring the biochemical and physiological aspects of testicular cell function and development.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101299\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204219757,"sku":"300375","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/GC-1_20spg_2020x01_2002062023_1920x1920_73ea826e-5ca6-4547-ae06-ac0dbda81164.jpg?v=1769069026"},{"product_id":"hec-1-a-cell-bhc11101083","title":"HEC-1-A cell","description":"HEC-1-A cells are a well-characterized human endometrial adenocarcinoma cell line derived from the malignant tissue of a 71-year-old Caucasian woman. This cell line, established in the mid-1970s, is extensively used in gynecological cancer research, particularly for studying endometrial carcinoma.\nMorphologically, HEC-1-A cells are epithelial-like and form a monolayer of polygonal cells when cultured. They exhibit a robust and adherent growth pattern, which is typical of epithelial cells originating from solid tumors. The morphological characteristics of HEC-1-A cells make them a valuable model for studying cellular behaviors that are central to cancer progression, such as adhesion, migration, and invasion.\nGenotypically, HEC-1-A cells harbor several genetic aberrations that are relevant to cancer biology, including mutations in key regulatory genes like p53 and PTEN, both of which are commonly mutated in endometrial cancer. These genetic features contribute to the cells' utility in researching the molecular underpinnings of endometrial carcinogenesis and the cellular pathways leading to tumor growth and resistance to therapy.\nResearch using HEC-1-A cells has significantly advanced our understanding of endometrial cancer, particularly in terms of hormonal influences, genetic mutations, and responses to chemotherapeutic agents. As a result, this cell line continues to be instrumental in developing more effective diagnostic and therapeutic strategies for endometrial carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101083\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205432173,"sku":"305077","price":395.0,"currency_code":"USD","in_stock":true}]},{"product_id":"hec-1-b-cell-bhc11101084","title":"HEC-1-B cell","description":"The HEC-1-B cell line is a human endometrial adenocarcinoma cell line. This line has been utilized extensively in biomedical research related to the study of endometrial cancer, hormone responses, and cancer pharmacology. The cells are known to express estrogen and progesterone receptors, making them a valuable model for studying hormone-related dynamics in endometrial cancer progression and treatment. These cells have been used to investigate the molecular mechanisms of cancer cell proliferation, differentiation, and response to hormonal and chemotherapeutic treatments.\n\nIn terms of morphology, HEC-1-B cells typically exhibit an epithelial-like shape and grow in a monolayer. They are characterized by their high capacity for in vitro proliferation. Genetic studies have revealed several chromosomal alterations which are thought to contribute to the cancerous phenotype of these cells. Research using the HEC-1-B cell line has contributed to a deeper understanding of endometrial carcinogenesis and offers a robust system for testing potential therapeutic agents. This cell line is also commonly employed in studies focusing on cancer cell invasion and metastasis, providing insights into the cellular behaviors that underpin these processes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101084\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205464941,"sku":"305095","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HEC-1-B_20P3_20305095-M_2020x01_20100223_1920x1920_874fbf8f-1944-44fe-ae78-af4309b9b782.jpg?v=1769069041"},{"product_id":"hela-229-cell-bhc11101109","title":"Hela 229 cell","description":"The HeLa 229 cell line is a clonal derivative of the original HeLa cell line, which was the first human cell line to be continuously cultured. HeLa cells were derived from cervical cancer cells taken from Henrietta Lacks in 1951. The HeLa 229 subline is utilized in various areas of biomedical research, including cancer research, drug development, and toxicology, due to its robust growth and adaptability under laboratory conditions.\nOne of the main characteristics of the HeLa 229 cell line is its aggressive growth and proliferation, reflecting the cancerous origin of the cells. This makes it particularly useful for studies requiring high cell yields and rapid growth, such as high-throughput screening for drug discovery. HeLa 229 cells are also highly amenable to genetic manipulation, allowing researchers to introduce foreign genes or specific mutations to study their effects on cell behavior and pathology.\nHeLa 229 cells continue to be a critical model in virology, as they are susceptible to a wide variety of viruses. This susceptibility makes them an excellent tool for studying viral life cycles, host-virus interactions, and the efficacy of antiviral compounds. The cell line has also been instrumental in advancing our understanding of fundamental cellular processes, such as DNA replication, transcription, and apoptosis.\nDespite their utility, the use of HeLa cells, including HeLa 229, raises ethical considerations regarding consent and the origins of the cell line, as the cells were originally obtained without the consent of Henrietta Lacks or her family. However, ongoing research with HeLa cells continues to contribute significantly to science, driven by their unique characteristics and historical importance in the development of modern cell biology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101109\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206185837,"sku":"305056","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HeLa_20229_20_282_29_1920x1920_aedc59c0-459e-46cf-9ba4-71097f644069.jpg?v=1769069049"},{"product_id":"hela-cell-bhc11100790","title":"HeLa cell","description":"HeLa cells, derived from the cervical cancer cells of Henrietta Lacks, are an immortal cell line widely employed in biomedical research. The human cell line Hela has significantly contributed to significant research advances and continues to play a pivotal role in laboratories worldwide.\nIn 1951, Henrietta Lacks, a young mother of five, sought medical attention at The Johns Hopkins Hospital for vaginal bleeding, where Dr. Howard Jones identified a significant malignant tumor on her cervix. At that time, the Johns Hopkins Medicine Institute was among the few institutions offering medical care to impoverished African Americans. Henrietta Lacks underwent radium treatment for her cervical cancer, the leading therapy available then. During her treatment, a biopsy was conducted, and a sample of her cancerous cells was sent to Dr. George Otto Gey's lab. Dr. Gey had been attempting to cultivate cells from cervical cancer patients of diverse backgrounds, but without success until Henrietta's cells, which were the first cells to proliferate continuously, a discovery that set them apart from all previous samples.\nHenrietta Lacks' cervical carcinoma was later found to have been caused by the Human papillomavirus (HPV). HPV is a common virus that can lead to cervical cancer among other diseases. Research on HeLa cells has significantly contributed to understanding the role of HPV in cervical cancer, leading to the development of preventive HPV vaccines, which have had a profound impact on reducing the incidence of HPV-related cancers.\nThese extraordinary cells, termed \"HeLa\" cells after Henrietta Lacks' initials, have since become instrumental in medical research. They have enabled scientists to investigate cancer cell growth, the impact of various substances, and the workings of viruses, significantly contributing to medical advancements, including the development of vaccines for polio and COVID-19, without the ethical concerns of direct human experimentation.\nHeLa cells are widely used for gene function studies, recombinant protein production, and gene therapy due to their high transfection efficiency and susceptibility to viral infections. They are pivotal in researching viral behaviors, including replication and pathogenesis, and have played a key role in Hepatitis B research by expressing viral proteins and aiding in the development of diagnostic tests and vaccines, thereby significantly advancing global health measures.\nHeLa cells continue to be an invaluable resource for ongoing research in medicine and science. The significance of HeLa cells and other immortal cell lines cannot be overstated, as they continue to shape the field of medicine and infectious disease research, and they represent a lasting legacy of Henrietta Lacks and her contributions to scientific advancement.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100790\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206218605,"sku":"300194","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-_282_29_1920x1920_7bb4834f-4911-4796-b0d6-26c9cef2c057.jpg?v=1769069049"},{"product_id":"hela-s3-cell-bhc11100549","title":"HeLa S3 cell","description":"The HeLa S3 cell line is a clonal derivative of the original HeLa cell line, which was established from the cervical cancer cells of an adult woman. HeLa S3 cells are notable for their robust growth in suspension cultures and are frequently used in scientific research due to their adaptability to various medium formulations. This variant retains the key characteristics of the HeLa lineage, such as a rapid doubling time and a karyotype that is highly aneuploid, displaying numerous chromosomal abnormalities which are a hallmark of HeLa cells.\n\nHeLa S3 cells are widely utilized in virology, toxicology, and cancer research, particularly because they maintain the ability to be infected by poliovirus and other viruses, making them invaluable in pathogen-host interaction studies. They are also employed in the study of gene expression and regulation mechanisms under physiological and pathological conditions. The genetic and metabolic profiles of HeLa S3 have been extensively characterized, facilitating their use in high-throughput genetic screens and molecular biology applications.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100549\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206251373,"sku":"300384","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-s3-_281_29_1920x1920_460af90f-6762-4ead-b70a-6dabcb5d08b8.jpg?v=1769069050"},{"product_id":"hey-cell-bhc11101106","title":"Hey cell","description":"HEY Cells, derived from a human ovarian cancer xenograft, are a valuable resource for cancer researchers seeking to advance their understanding of papillary cystadenocarcinoma, a moderately differentiated form of ovarian cancer. The parental cell line, HEY, was initially obtained from a peritoneal sample of a Caucasian patient diagnosed with this specific type of cancer. These epithelial-like cells closely resemble human cells, making them an excellent model for studying ovarian cancer. HEY, Cells exhibit a rapid doubling time of approximately 30 hours, allowing for efficient and time-effective experimentation. Researchers can utilize these cells to investigate various aspects of cancer biology, such as tumour formation, metastasis, and drug response.\nHEY, Cells are particularly well-suited for applications involving 3D cell culture, a technique that more closely mimics the physiological environment of tumours. Their ability to grow in semisolid culture and as xenografts in immunologically deprived CBA\/CJ mice highlights their adaptability and potential for in vivo studies. By incorporating HEY Cells into cancer research, scientists can uncover crucial insights into the development and progression of papillary cystadenocarcinoma. These cells are invaluable for exploring novel therapeutic strategies, identifying potential drug targets, and evaluating treatment efficacy.\nIn summary, HEY Cells provide researchers with a robust and reliable resource for investigating ovarian cancer. With their origins in a patient sample and their epithelial-like morphology, these cells faithfully replicate key characteristics of papillary cystadenocarcinoma. Their applications in 3D cell culture and cancer research make them essential in advancing our understanding of this challenging disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101106\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207431021,"sku":"305017","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Hey_20P1_20305017-M_2020x01_2017032023_1920x1920_927383cb-0903-4d2e-8630-7d4599a4016e.jpg?v=1769069057"},{"product_id":"hk-eb3-egfp-cell-bhc11100656","title":"HK EB3-EGFP cell","description":"Hela Kyoto EB3-EGFP is a derivative of the HeLa Kyoto cell line, specifically engineered to express the End-Binding Protein 3 (EB3) tagged with Enhanced Green Fluorescent Protein (EGFP). This cell line is commonly utilized in research focused on understanding microtubule dynamics due to the fluorescent tagging of EB3, a protein that associates with the plus ends of microtubules. The expression of EGFP provides a fluorescent marker that allows for real-time visualization of microtubule behavior in live cells under a fluorescence microscope.\n\nThis cell line is particularly valuable in cell biology and cancer research, where understanding the mechanics of cell division and intracellular transport is crucial. The stable expression of EB3-EGFP does not interfere with the normal functions of the microtubules, making these cells a reliable tool for detailed studies of cellular processes that depend on microtubule dynamics.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100656\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207562093,"sku":"300668","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-kyoto-eb3-egfp-_281_29_1920x1920_a80e54b2-b79b-4a68-90e1-ca2bddd54578.jpg?v=1769069059"},{"product_id":"hk-egfp-alpha-tubulin-h2b-mcherry-cell-bhc11100676","title":"HK EGFP-alpha-tubulin\/H2B-mCherry cell","description":"The HK EGFP-alpha-tubulin\/H2B-mCherry HeLa Kyoto cell line is a meticulously engineered model designed for detailed visualization of cellular processes. This clonal line has been stably transfected to express two fluorescent protein fusions that enable real-time imaging of both chromatin and the microtubular network. The red fluorescent protein mCherry is fused to the core histone protein H2B, creating H2B-mCherry. This fusion protein is expressed from the pH2B-mCherry-IRES-neo3 plasmid and serves as a chromatin marker, highlighting the nuclear DNA in live-cell imaging and facilitating studies on chromatin dynamics and nuclear architecture.\nAdditionally, this cell line expresses monomeric enhanced GFP (Green Fluorescent Protein) fused to α-tubulin, introduced via the pmEGFP-α-tubulin-IRES-puro2b plasmid. The GFP-α-tubulin fusion provides a vivid green fluorescence that outlines the microtubule structures within the cell. This feature is crucial for studying microtubule organization, dynamics, and their role in cell division and intracellular transport. The stable integration of these constructs allows for continuous, long-term observation of these cellular components without the need for repeated transfection, thus reducing variability and enhancing the reliability of experimental results. Drug resistance selection following transfection ensures the stability and uniformity of expression among the cells in this line.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100676\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207594861,"sku":"300670","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HK-Kyoto-EGFP-alpha-tubulin-H2B-mCherry-_281_29_1920x1920_93d1bd4c-a016-4172-9797-c9d8b45317c2.jpg?v=1769069061"},{"product_id":"hk-egfp-cap-d2-cell-bhc11100079","title":"HK EGFP-Cap-D2 cell","description":"The HK EGFP-Cap-D2 cell line is an engineered variant of Hela Kyoto cells, specifically designed for advanced research in cellular biology and genetic engineering. This cell line expresses enhanced green fluorescent protein (EGFP) fused to the C-terminus of the D2 dopamine receptor, enabling the visualization of receptor dynamics and distribution in real-time under fluorescence microscopy. This feature is particularly beneficial for studying receptor trafficking, signaling pathways, and the effects of pharmacological agents on D2 receptor behavior.\n\nThese cells are used extensively in neurological research to understand better the mechanisms underlying dopamine signaling, which is crucial in many neurological disorders such as Parkinson's disease, schizophrenia, and depression. The fusion of EGFP to the D2 receptor does not affect the receptor's normal function or its cellular localization, making HK EGFP-Cap-D2 a valuable tool for physiological and pathological studies. The stable expression of EGFP also allows for longitudinal studies in live cells, providing insights into the dynamic processes of receptor regulation and interaction with other cellular components.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100079\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207627629,"sku":"300675","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-kyoto-egfp-cap-D2-_284_29_1920x1920_36eb8cf0-4f7a-4ef5-8d5c-445dcf812bde.jpg?v=1769069061"},{"product_id":"hk-egfp-h2b-cell-bhc11100035","title":"HK EGFP-H2B cell","description":"The HK EGFP-H2B cell line is a genetically modified Hela Kyoto cell line used primarily for the study of chromatin dynamics and nuclear processes. This cell line expresses a fusion protein consisting of Enhanced Green Fluorescent Protein (EGFP) and histone H2B. The integration of EGFP into the H2B protein allows for the real-time visualization of chromatin in living cells under fluorescence microscopy, providing valuable insights into the spatial and temporal organization of the nucleus.\n\nThe EGFP-H2B fusion facilitates numerous applications in cell biology, including the study of cell cycle progression, mitosis, and gene expression regulation. By observing the fluorescence patterns, researchers can identify and analyze phases of the cell cycle, chromosomal segregation, and structural changes within the nucleus. This cell line is derived from adult human cells, ensuring relevance to human biology, and is utilized in both basic biological research and more applied pharmaceutical studies.\n\nAdditionally, the HK EGFP-H2B cell line serves as a crucial tool in epigenetics research. The ability to directly observe histone behaviors helps in understanding the epigenetic mechanisms that underlie gene expression and silencing, as well as the effects of various epigenetic modifiers. The cell line's robust application in live-cell imaging experiments makes it indispensable for detailed studies requiring dynamic cellular analysis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100035\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207660397,"sku":"300673","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-kyoto-egfp-h2b-_283_29_1920x1920_f34d81e6-d2ad-4b16-9965-e78a954016cb.jpg?v=1769069061"},{"product_id":"hk-egfp-kleisin-beta-cell-bhc11100429","title":"HK EGFP-Kleisin-beta cell","description":"The HK EGFP-Kleisin-beta cell line represents a genetically modified variant of Hela Kyoto cells designed primarily for the study of chromosome cohesion during the cell cycle. This cell line expresses an enhanced green fluorescent protein (EGFP) fused with the Kleisin-beta protein, a crucial component of the cohesin complex that is vital for sister chromatid cohesion. The expression of EGFP-tagged Kleisin-beta allows for real-time visualization of cohesin dynamics and localization throughout the cell cycle, facilitating detailed analyses of chromosome structure and function in a cellular context.\n\nThis cell model is typically utilized in research focusing on the mechanisms of mitotic and meiotic chromosome segregation, particularly looking at how cohesin's regulation influences genetic stability and cell division. The fluorescent tagging of Kleisin-beta enables the investigation of its interaction with other cohesin components and chromosomal proteins, providing insights into the spatial and temporal assembly of cohesin on chromosomes. The use of this cell line extends to studies of genetic disorders and cancers where cohesin function is disrupted, offering a valuable tool for understanding pathogenesis and developing therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100429\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207693165,"sku":"300674","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HeLaKyoto_20EGFP_20Kleisin-_2020x01_a02dad0c-d238-4187-ae81-67847fc03db7.jpg?v=1782156380"},{"product_id":"hk-egfp-lamina-h2b-mcherry-cell-bhc11100713","title":"HK EGFP-LaminA\/H2B-mCherry cell","description":"The HK EGFP-LaminA\/H2B-mCherry cell line is a genetically engineered Hela Kyoto derived cell model developed to facilitate advanced studies in nuclear dynamics and chromatin organization within living cells. This cell line expresses two fusion proteins: EGFP (enhanced green fluorescent protein) fused with Lamin A, and mCherry (a red fluorescent protein) fused with Histone H2B. The EGFP-Lamin A fusion highlights the nuclear envelope and allows for the visualization of nuclear architecture changes during cell cycle progression or under various experimental conditions. Meanwhile, the H2B-mCherry fusion protein binds to DNA and provides a vivid red fluorescence that marks chromatin, enabling real-time observation of chromosomal processes during mitosis and interphase.\n\nThese cells are invaluable for real-time imaging applications, including studies on nuclear integrity, DNA replication, and cellular aging, as well as research into diseases where nuclear architecture is disrupted, such as cancer and laminopathies. The dual-color fluorescence feature of this cell line allows for simultaneous visualization of both the nuclear envelope and chromatin, facilitating a comprehensive understanding of nuclear-cytoplasmic interactions and the spatiotemporal organization of chromatin. Such capabilities make it a critical tool for molecular biology research and cellular biophysics, providing insights into the mechanics of gene expression regulation, nuclear organization, and the cell cycle.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100713\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207725933,"sku":"300921","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-kyoto-egfp-lamina-h2b-mcherry-_283_29_1920x1920_9c749888-329a-4956-b2d6-6db957904a34.jpg?v=1769069061"},{"product_id":"hk-egfp-laminb1-h2b-mcherry-cell-bhc11100048","title":"HK EGFP-LaminB1\/H2B-mCherry cell","description":"The HK EGFP-LaminB1\/H2B-mCherry cell line is an Hela Kyoto derived in vitro model designed for real-time visualization of chromatin dynamics and nuclear architecture in living cells. This cell line expresses two fluorescent protein fusions: EGFP (enhanced green fluorescent protein) fused with Lamin B1, and mCherry (a red fluorescent protein) fused with histone H2B. The fusion of EGFP with Lamin B1 allows for the observation of the nuclear envelope and nuclear lamina, structures critical for maintaining the integrity and functionality of the nucleus. Lamin proteins are type V intermediate filament proteins that form a meshwork underlying the inner nuclear membrane, playing key roles in nuclear stability, chromatin organization, and gene regulation.\n\nOn the other hand, the mCherry-tagged histone H2B enables the visualization of chromatin within the nucleus. Histones are fundamental components of the nucleosome, involved in the organization of DNA into chromatin, making them crucial for DNA replication, repair, and transcription. The mCherry tag on H2B provides a vivid red fluorescence that contrasts with the green fluorescence of EGFP, allowing for simultaneous dual-imaging of the nuclear structure and chromatin in live-cell experiments. This cell line is commonly used in studies focusing on nuclear mechanics, mitosis, and genome stability, providing a dynamic view of cellular processes that are otherwise difficult to observe in real time.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100048\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207758701,"sku":"300919","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hela-kyoto-egfp-laminb1-h2b-mcherry-_282_29_1920x1920_0396b7e2-1607-44fa-8078-2c514ccd88c2.jpg?v=1769069062"},{"product_id":"hk-mad2-lap-h2b-mcherry-cell-bhc11101326","title":"HK Mad2-LAP\/H2B-mCherry cell","description":"The HK Mad2-LAP\/H2B-mCherry cell line is a genetically engineered cell model extensively utilized for studying chromosome segregation and the spindle assembly checkpoint during mitosis. These cells are derived from HeLa Kyoto cells, a robust human cell line originally taken from a cervical carcinoma. The HK Mad2-LAP (LAP-tagged Mad2) aspect of the cell line facilitates the visualization and functional analysis of the Mad2 protein, a critical component of the spindle assembly checkpoint that prevents anaphase onset until all chromosomes are properly aligned at the metaphase plate.\nIncorporation of H2B-mCherry, where histone H2B is tagged with the mCherry fluorescent protein, allows for real-time imaging of chromatin dynamics during cell division. This feature makes the HK Mad2-LAP\/H2B-mCherry cell line an excellent tool for high-resolution live-cell imaging techniques to observe chromosomal movements and mitotic progression in human cells under various experimental conditions. The use of fluorescent tags aids in precise tracking and quantification, thereby providing valuable insights into the molecular mechanisms governing cell cycle regulation and chromosomal stability.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101326\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207791469,"sku":"300920","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/mad2-laph2bmcherry_20_281_29.jpg?v=1769069062"}],"url":"https:\/\/www.ebiohippo.com\/collections\/rc-metabolic-endocrine-reproductive-endocrinology.oembed?page=14","provider":"BioHippo","version":"1.0","type":"link"}