{"title":"Cardiovascular Biochemicals","description":null,"products":[{"product_id":"ym-01-bhb11900012","title":"YM-01","description":"\u003cp\u003eYM-01 is an allosteric inhibitor of Hsp70 that binds within its nucleotide-binding domain, adjacent to the ATP\/ADP pocket. It disrupts Hsc70-Bag1 interactions and enhances Hsp70 binding to misfolded proteins. In neuroscience, YM-01 has shown efficacy in reducing tau protein levels in cellular and animal models of tauopathy, including Alzheimer's disease. It restores long-term potentiation in brain slices from tau-overexpressing mice, indicating potential for cognitive recovery. YM-01’s dual activity in protein quality control and synaptic function makes it a valuable tool for studying and potentially treating tau-related neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941072749,"sku":"SIH-121-10MG","price":189.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040963715437,"sku":"SIH-121-25MG","price":378.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-121_YM-01_Chemical_Structure.png?v=1771837627"},{"product_id":"sulindac-sulfone-bhb11900084","title":"Sulindac Sulfone","description":"\u003cp\u003eSulindac sulfone is a non-COX-inhibiting metabolite of sulindac that retains anti-inflammatory and pro-apoptotic properties. Unlike sulindac sulfide, it does not inhibit prostaglandin synthesis but selectively induces apoptosis in abnormal cells. In neurodegenerative disease research, sulindac sulfone is being explored for its ability to modulate cell survival pathways and reduce neuroinflammation, offering a complementary mechanism of action to traditional NSAIDs.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941498733,"sku":"SIH-262-10MG","price":116.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040965419373,"sku":"SIH-262-50MG","price":377.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-262_Sulindac_Sulfone_Chemical_Structure.png?v=1771837630"},{"product_id":"ambroxol-hcl-bhb11900018","title":"Ambroxol HCl","description":"\u003cp\u003eAmbroxol HCl is a mucolytic agent with potent sodium channel-blocking activity and notable antioxidant and anti-inflammatory properties. 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Although its primary research applications have been in oncology, particularly in inducing growth inhibition, apoptosis, and differentiation in leukemia cell lines, its mechanism of action is increasingly relevant to neuroscience. HDAC inhibitors are being explored for their neuroprotective effects, especially in the context of neurodegenerative diseases such as Alzheimer's and Huntington's disease. By modulating chromatin structure and gene expression, Bml-210 may influence neuronal plasticity, memory formation, and neuroinflammation. Its non-hydroxamic acid structure offers a unique pharmacological profile, potentially reducing off-target effects and improving therapeutic specificity. As interest in epigenetic therapies for neurological disorders grows, Bml-210 represents a valuable tool for probing the role of HDACs in the central nervous system.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040942350701,"sku":"SIH-348-5MG","price":206.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040963027309,"sku":"SIH-348-25MG","price":819.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-348_BML-210_Chemical_Structure.png?v=1771837634"},{"product_id":"caffeic-acid-phenethyl-ester-cape-bhb11900085","title":"Caffeic Acid Phenethyl Ester (CAPE)","description":"\u003cp\u003eCaffeic Acid Phenethyl Ester (CAPE) is a bioactive compound derived from propolis with potent antioxidant, anti-inflammatory, and neuroprotective properties. 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In neuroscience, CAPE has been studied for its ability to protect neurons from oxidative damage and inflammation, making it a promising candidate for therapeutic development in neurodegenerative diseases such as Parkinson’s and Alzheimer’s.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"50 mg","offer_id":53040942416237,"sku":"SIH-263-50MG","price":66.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":53040963944813,"sku":"SIH-263-250MG","price":270.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-263_CAPE_Chemical_Structure.png?v=1771837627"},{"product_id":"hsp70-tkd-peptide-fitc-bhb11900010","title":"Hsp70 TKD Peptide: FITC","description":"\u003cp\u003eThe Hsp70 TKD peptide is a synthetic fragment derived from the heat shock protein 70 (Hsp70), specifically the amino acid sequence TKDNNLLGRFELSG. 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Its dual role in immunology and neurobiology underscores its potential for repurposing in neuroprotective strategies.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040942711149,"sku":"SIH-361-10MG","price":89.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-361_Zafirlukast_Chemical_Structure.png?v=1771837629"},{"product_id":"resveratrol-bhb11900086","title":"Resveratrol","description":"\u003cp\u003eResveratrol is a polyphenolic compound found in grapes and berries, known for its antioxidant and anti-inflammatory effects. In neurodegenerative disease research, resveratrol has been shown to activate SIRT1 signaling, enhance mitochondrial function, and promote hippocampal neurogenesis. 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By blocking PI3Kγ activity, AS 041164 can modulate leukocyte trafficking and reduce neuroinflammation, making it a valuable tool for studying immune-mediated mechanisms in conditions such as multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease. 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It enhances mitochondrial function and supports neuronal survival, making it a candidate for therapeutic intervention in conditions such as Alzheimer’s and Parkinson’s disease. Its dual action on pain modulation and neuroprotection underscores its relevance in neuroscience.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040947659117,"sku":"SIH-376-10MG","price":111.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040966992237,"sku":"SIH-376-50MG","price":436.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-376_Flupirtine_maleate_Chemical_Structure.png?v=1771837641"},{"product_id":"ag-1517-bhb11900213","title":"AG 1517","description":"\u003cp\u003eAG 1517 is a potent and selective ATP-competitive inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. 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AG 1517’s cell-permeable nature enhances its utility in both in vitro and in vivo models, making it a valuable tool for dissecting EGFR-mediated mechanisms in the central nervous system.\u003c\/p\u003e \u003cp\u003eWhile originally developed for oncology, AG 1517 is gaining traction in neurobiology as a candidate for exploring therapeutic strategies aimed at reducing neuroinflammation, promoting neuronal resilience, and mitigating the molecular drivers of neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040947790189,"sku":"SIH-427-5MG","price":98.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968040813,"sku":"SIH-427-25MG","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-427_AG_1517_Chemical_Structure.png?v=1771837644"},{"product_id":"genistein-bhb11900230","title":"Genistein","description":"\u003cp\u003eGenistein is a naturally occurring isoflavone with a broad range of biological activities. 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It has been shown to inhibit glioblastoma cell adhesion and migration, as well as thrombin-induced platelet aggregation. Given the involvement of JAK\/STAT pathways in neuroimmune responses, WHI P131 is a valuable tool for studying neuroinflammatory mechanisms and potential therapeutic interventions in neurodegenerative diseases.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040949133677,"sku":"SIH-485-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040970203501,"sku":"SIH-485-50MG","price":326.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-485_WHI-P131_Chemical_Structure.png?v=1771837652"},{"product_id":"sorafenib-bhb11900260","title":"Sorafenib","description":"\u003cp\u003eSorafenib is a multi-kinase inhibitor that targets several receptor tyrosine kinases including VEGFR, PDGFR, and Raf kinases. 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Its ability to modulate MAPK pathways makes it a valuable compound for studying neuroprotective mechanisms and therapeutic targets in conditions such as stroke and neuroinflammation.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040949461357,"sku":"SIH-488-5MG","price":125.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970432877,"sku":"SIH-488-25MG","price":520.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-488_ZM-336372_Chemical_Structure.png?v=1771837652"},{"product_id":"auranofin-bhb11900276","title":"Auranofin","description":"\u003cp\u003eAuranofin is a gold-containing compound originally developed as an anti-arthritic drug. It inhibits leukocyte activation and the release of inflammatory mediators from immune cells. 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Nilotinib’s neuroprotective effects are also linked to its capacity to influence dopaminergic signaling and reduce neuroinflammation, making it a promising candidate for repurposing in neurodegenerative therapeutics.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040949592429,"sku":"SIH-463-5MG","price":74.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968565101,"sku":"SIH-463-25MG","price":287.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-463_Nilotinib_Chemical_Structure.png?v=1771837648"},{"product_id":"sc-514-bhb11900259","title":"SC 514","description":"\u003cp\u003eSC 514 is a selective and reversible inhibitor of IκB kinase 2 (IKKβ), a key regulator of the NF-κB signaling pathway. By blocking IKKβ activity, SC 514 prevents the phosphorylation and degradation of IκBα, thereby inhibiting NF-κB activation. In neurodegenerative disease research, SC 514 is used to explore the role of NF-κB in neuroinflammation, glial activation, and neuronal survival. Its \u0026gt;10-fold selectivity over other kinases such as JNK, p38, MK2, and ERK enhances its utility in dissecting inflammatory signaling in the brain. SC 514 is cell-permeable and is a valuable compound for studying therapeutic strategies targeting chronic inflammation in neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040949821805,"sku":"SIH-475-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040969908589,"sku":"SIH-475-50MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-475_SC-514_Chemical_Structure.png?v=1771837648"},{"product_id":"su-4312-bhb11900264","title":"SU 4312","description":"\u003cp\u003eSU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases, including VEGFR-2 (Flk-1\/KDR). In neurodegenerative disease research, SU 4312 is used to investigate the role of VEGF and PDGF signaling in neurovascular remodeling, glial activation, and neuronal survival. Its ability to modulate angiogenic and inflammatory pathways makes it a valuable tool for studying the vascular component of neurodegeneration and brain repair mechanisms.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950051181,"sku":"SIH-481-5MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040969154925,"sku":"SIH-481-25MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-481_SU-4312_Chemical_Structure.png?v=1771837649"},{"product_id":"pd325901-bhb11900290","title":"PD325901","description":"\u003cp\u003ePD325901 is a highly selective MEK1\/2 inhibitor that suppresses ERK1\/2 phosphorylation and downstream signaling. In neuroscience, the MEK\/ERK pathway is implicated in synaptic plasticity, memory formation, and neuroinflammation. PD325901 has shown promise in preclinical models of neurodevelopmental and neurodegenerative disorders, including fragile X syndrome and Alzheimer's disease, by modulating aberrant signaling and improving cognitive outcomes.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950182253,"sku":"SIH-507-5MG","price":109.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970760557,"sku":"SIH-507-25MG","price":406.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-507_PD-325901_Chemical_Structure.png?v=1771837650"},{"product_id":"ruxolitinib-bhb11900292","title":"Ruxolitinib","description":"\u003cp\u003eRuxolitinib is a selective inhibitor of Janus-associated kinases (JAK1 and JAK2), key mediators in cytokine signaling pathways. While primarily developed for hematologic malignancies and inflammatory disorders, Ruxolitinib has gained attention in neurodegenerative disease research due to its ability to modulate neuroinflammation. Dysregulated JAK\/STAT signaling is implicated in several neurodegenerative conditions, including Alzheimer's and Parkinson's disease. By suppressing pro-inflammatory cytokine signaling, Ruxolitinib may reduce microglial activation and neuronal damage. Its potential to cross the blood-brain barrier further supports its exploration as a neuroprotective agent.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950411629,"sku":"SIH-509-5MG","price":177.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970924397,"sku":"SIH-509-25MG","price":572.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-509_Ruxolitinib_Chemical_Structure.png?v=1771837653"},{"product_id":"ml167-bhb11900288","title":"ml167","description":"\u003cp\u003eml167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4), a member of the Clk family involved in alternative mRNA splicing. Aberrant splicing is increasingly recognized as a contributor to neurodegenerative diseases, including ALS and frontotemporal dementia. By modulating Clk4 activity, ml167 enables the study of splicing regulation in neuronal systems and may inform therapeutic approaches targeting RNA metabolism in neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950444397,"sku":"SIH-505-5MG","price":109.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970662253,"sku":"SIH-505-25MG","price":452.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-505_ML-167_Chemical_Structure.png?v=1771837653"},{"product_id":"vatalanib-dihydrochloride-bhb11900267","title":"Vatalanib Dihydrochloride","description":"\u003cp\u003eVatalanib Dihydrochloride is an inhibitor of Flk, c-Kit, and PDGFR-β, with demonstrated activity against VEGFR-dependent angiogenesis and EGFR- and RET-mediated tumor cell proliferation. In neuroscience, Vatalanib is used to explore the role of angiogenic and growth factor signaling in neurodegenerative diseases. Its ability to modulate vascular and glial responses makes it a useful tool for studying neuroinflammation, blood-brain barrier dysfunction, and tumor progression in the CNS.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040950542701,"sku":"SIH-484-10MG","price":74.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040969548141,"sku":"SIH-484-50MG","price":258.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-484_Vatalanib_Dihydrochloride_Chemical_Structure.png?v=1771837649"},{"product_id":"su1498-bhb11900263","title":"SU1498","description":"\u003cp\u003eSU1498 is a potent and selective inhibitor of Flk-1 (VEGFR2), a receptor tyrosine kinase involved in angiogenesis and vascular permeability. 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SU1498 is a valuable compound for exploring therapeutic strategies targeting vascular contributions to neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950575469,"sku":"SIH-480-5MG","price":78.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970006893,"sku":"SIH-480-25MG","price":315.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-480_SU-1498_Chemical_Structure.png?v=1771837648"},{"product_id":"zm-306416-bhb11900270","title":"ZM 306416","description":"\u003cp\u003eZM 306416 is a potent and selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, particularly Flk-1 (KDR) and Flt. In neuroscience, ZM 306416 is used to explore the role of VEGF signaling in neurovascular function, blood-brain barrier integrity, and neuroinflammation. Its ability to modulate angiogenic pathways makes it a useful tool in studying neurovascular contributions to neurodegenerative diseases such as Alzheimer’s and multiple sclerosis.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950804845,"sku":"SIH-487-5MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040969941357,"sku":"SIH-487-25MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-487_ZM-306416_Chemical_Structure.png?v=1771837649"},{"product_id":"bexarotene-bhb11900316","title":"Bexarotene","description":"\u003cp\u003eBexarotene is a highly potent and selective retinoid X receptor (RXR) agonist, originally developed as an antineoplastic agent for cutaneous T-cell lymphoma. In neuroscience, Bexarotene has garnered significant attention for its ability to enhance the clearance of soluble β-amyloid and improve cognitive function in animal models of Alzheimer’s disease. It has also been shown to reverse apoE4-driven brain pathology and behavioral deficits, highlighting its potential in targeting genetic risk factors for neurodegeneration. By modulating lipid metabolism, inflammation, and gene expression, Bexarotene represents a promising therapeutic avenue for neurodegenerative diseases. Its dual role in oncology and neurology underscores its versatility and scientific impact.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040950837613,"sku":"SIH-535-10MG","price":74.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53040971579757,"sku":"SIH-535-100MG","price":137.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-535-Bexarotene-Chemical-Structure.png?v=1771837658"},{"product_id":"ly364947-bhb11900287","title":"LY364947","description":"\u003cp\u003eLY364947 is a potent and selective inhibitor of TGF-β type I receptor kinase, blocking downstream SMAD signaling. TGF-β signaling is involved in neuroinflammation, synaptic plasticity, and glial activation—processes central to neurodegenerative disease progression. LY364947 has been used to investigate the role of TGF-β in central nervous system disorders, offering insights into therapeutic strategies targeting neuroinflammatory pathways.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040951066989,"sku":"SIH-504-5MG","price":92.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970629485,"sku":"SIH-504-25MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-504_LY-364947_Chemical_Structure.png?v=1771837653"},{"product_id":"ml297-bhb11900331","title":"ML297","description":"\u003cp\u003eML297 is a selective activator of the G protein-coupled inwardly rectifying potassium (GIRK) channels, particularly GIRK1\/2. In neuroscience, ML297 has been used to study neuronal excitability, synaptic transmission, and seizure susceptibility. Its ability to modulate inhibitory signaling pathways positions it as a promising tool in epilepsy and neurodegenerative disease models involving hyperexcitability.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040951624045,"sku":"SIH-553-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040972038509,"sku":"SIH-553-50MG","price":366.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-553-ML297-Chemical-Structure.png?v=1771837659"},{"product_id":"duloxetine-hydrochloride-bhb11900327","title":"Duloxetine Hydrochloride","description":"\u003cp\u003eDuloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) widely used in the treatment of depression and neuropathic pain. In neurodegenerative disease research, Duloxetine has been investigated for its ability to modulate neuroinflammation, enhance neuroplasticity, and protect against neuronal loss. Its dual-action mechanism on monoaminergic pathways supports its use in managing cognitive and emotional symptoms associated with neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040952082797,"sku":"SIH-549-10MG","price":57.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040971874669,"sku":"SIH-549-50MG","price":223.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-549-Duloxetine-HCl-Chemical-Structure.png?v=1771837661"},{"product_id":"bq-123-sodium-salt-bhb21300062","title":"BQ-123 sodium salt","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl] acetate sodium.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Cyclo(D-trp-D-asp-L-pro-D-val-L-leu) sodium\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 136655-57-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C31H41N6NaO7.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg\/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ET-A receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e BQ-123, a cyclic peptide provided as a sodium salt, is a potent and selective antagonist of ET-A endothelin receptors, exhibiting a 1000-fold selectivity for ET-A over ET-B receptors (inhibiting endothelin-1 radioligand binding to ET-A and ET-B with IC50 of 22 nM and 18 µM, respectively). In vitro, BQ-123 inhibits endothelin-1 induced contractions of porcine coronary artery with KB of 40 nM1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Cyclo(D-trp-D-asp-L-pro-D-val-L-leu) sodium\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eBQ-123 is a cyclic pentapeptide that acts as potent and selective antagonist of endothelin A (ET-A) receptors. BQ-123 exhibits a 1000-fold selectivity for ET-A receptors over ET-B receptors. It antagonizes endothelin-1 radioligand binding to ET-A and ET-B receptors with IC50 values of 22 nM and 18 µM, respectively1.Studies show that BQ-123 prevents production of TNF-α and IL-6 in skeletal muscle of LPS-treated rat and enhances antioxidant defense1,2.There are two subtypes of endothelin receptor: ET-A and ET-B. They are widely distributed in vascular and nonvascular tissues. ET-A receptors are predominantly expressed in peripheral tissues, especially in vascular smooth muscle where they mediate vasoconstriction. They are also detected in several regions of the brain. The ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has high affinity for all endothelin isopeptides3.\u003c\/p\u003e \u003ch3\u003eModifications\u003c\/h3\u003e \u003cp\u003eSupplied as sodium salt.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003ch3\u003eSequence\u003c\/h3\u003e \u003cpre\u003eCyclo (D-trp-D-asp-L-pro-D-val-L-leu).\u003c\/pre\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249703674221,"sku":"B-185-10MG-1","price":287.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311556288877,"sku":"B-185-25MG-1","price":502.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311556321645,"sku":"B-185-5MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311556354413,"sku":"B-185-50MG-1","price":714.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-185_graph.gif?v=1778544420"},{"product_id":"bq-123-trifluoroacetate-bhb21300063","title":"BQ-123 trifluoroacetate","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl] trifluoroacetate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Cyclo(D-trp-D-asp-L-pro-D-val-L-leu) trifluoroacetate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 136553-81-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C33H43F3N6O9.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (50 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ET-A receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e BQ-123, a cyclic peptide, is a potent and selective antagonist of ET-A endothelin receptors, exhibiting a 1000-fold selectivity for ET-A over ET-B receptors (inhibiting endothelin-1 radioligand binding to ET-A and ET-B with IC50 of 22 nM and 18 µM, respectively). In vitro, BQ-123 inhibits endothelin-1 induced contractions of porcine coronary artery with KB of 40 nM1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Cyclo(D-trp-D-asp-L-pro-D-val-L-leu) trifluoroacetate\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eBQ-123 is a cyclic pentapeptide that acts as potent and selective antagonist of endothelin A (ET-A) receptors. BQ-123 exhibits a 1000-fold selectivity for ET-A receptors over ET-B receptors. It antagonizes endothelin-1 radioligand binding to ET-A and ET-B receptors with IC50 values of 22 nM and 18 µM, respectively1.Studies show that BQ-123 prevents production of TNF-α and IL-6 in skeletal muscle of LPS-treated rat and enhances antioxidant defense1,2.There are two subtypes of endothelin receptor: ET-A and ET-B. They are widely distributed in vascular and nonvascular tissues. ET-A receptors are predominantly expressed in peripheral tissues, especially in vascular smooth muscle where they mediate vasoconstriction. They are also detected in several regions of the brain. The ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has high affinity for all endothelin isopeptides3.\u003c\/p\u003e \u003ch3\u003eModifications\u003c\/h3\u003e \u003cp\u003eSupplied as trifluoroacetate salt.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003ch3\u003eSequence\u003c\/h3\u003e \u003cpre\u003eCyclo (D-trp-D-asp-L-pro-D-val-L-leu).\u003c\/pre\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249706262893,"sku":"B-186-10MG-1","price":337.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311547081069,"sku":"B-186-25MG-1","price":588.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311547113837,"sku":"B-186-5MG-1","price":235.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311547146605,"sku":"B-186-50MG-1","price":808.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-186_gr.gif?v=1778544414"},{"product_id":"darusentan-bhb21300126","title":"Darusentan","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e LU 135252\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 171714-84-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C22H22N2O6.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 nM - 1 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ET-A receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Darusentan is a selective antagonist of ET-A Endothelin receptors, inhibiting Endothelin-1 radioligand binding to ET-A and ET-B receptors with Ki of 6 nM and 371 nM, respectively1. in vitro Darusentan inhibits Endothelin-induced vascular contractility in isolated endothelium-denuded rat aortic rings with pA2 of 8.12. Darusentan is orally bioavailable and active in vivo3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e LU 135252\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eDarusentan, (LU 135252), is a synthetic compound that acts as a selective antagonist of endothelin A (ET-A) receptors. Darusentan is orally bioavailable and is a potent inhibitor of vasoconstriction in large and small arteries. The compound is a propanoic acid based antagonist that consist of two enantiomers - (R) and (S). The (R) enantiomer shows no binding activity, indicating that the (S) enantiomer is the active drug1,2.in vitro, Darusentan inhibits endothelin-induced vascular contractility in isolated endothelium-denuded rat aortic rings with pA2 value of 8.11,2.Endothelin receptors include two subtypes: ET-A and ET-B. They are widely distributed in vascular and nonvascular tissues. ET-A receptors are predominantly expressed in peripheral tissues, especially in vascular smooth muscle tissues to mediate vasoconstriction. They are also detected in several different regions of the brain3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249706459501,"sku":"D-265-10MG-1","price":337.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311549833581,"sku":"D-265-25MG-1","price":595.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311549866349,"sku":"D-265-5MG-1","price":235.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311549899117,"sku":"D-265-50MG-1","price":917.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/D-265_gr-1.gif?v=1778544415"},{"product_id":"a-803467-bhb21300001","title":"A-803467","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 944261-79-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C19H16ClNO4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 10 μM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NaV1.8 Na+ channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e A-803467 is a potent and selective blocker of the TTX-resistant NaV1.8 channel. A-803467 is a state dependent inhibitor with IC50 of 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states1,2. A-803467 was used as a pharmacological tool to demonstrate the expression of NaV1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart3.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eThe TTX-resistant NaV1.8 channel is expressed almost exclusively in the PNS and has been shown to mediate most of the well documented TTX-resistant currents of DRG neurons' action potentials1. Hyperexcitability, manifested by increased action potential firing and coded information transfer to the CNS of nociceptive DRG neurons, probably lie on the basis of several pathological pain states. Both genetic and pharmacological evidence suggest that NaV1.8 channel might serve as a target in pain control2-4.A-803467 is a potent and selective blocker of the TTX-resistant NaV1.8 channel4. A-803467 is a state dependent inhibitor with IC50 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states4,5. A-803467 was used as a pharmacological tool to demonstrate the expression of NaV1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart6.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249706590573,"sku":"A-105-10MG-1","price":66.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311544164717,"sku":"A-105-100MG-1","price":543.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311544197485,"sku":"A-105-25MG-1","price":165.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311544230253,"sku":"A-105-50MG-1","price":296.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-105_gr-1.gif?v=1778544402"},{"product_id":"irl-2500-bhb21300179","title":"IRL 2500","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (2S)-2-[[(2R)-2-[(3,5-dimethylbenzoyl)-methylamino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 169545-27-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C36H35N3O4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;97%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in NaOH. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg\/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ET-B receptor\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e IRL 2500 is a potent antagonist of endothelin ET-B receptors, exhibiting selectivity for ET-B over ET-A receptors when inhibiting the binding of [125I]-Endothein-1 (IC50 of 1.3 nM and 94 nM, respectively). IRL 2500 attenuates the effects of ETB-selective agonists in vitro and in-vivo, such as saraphotoxin S6c-mediated dog saphenous vein contraction or IRL-1620-induced transient decrease in arterial pressure and increase in renal vascular resistance in rat1,2.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eIRL 2500 is a synthetic compound that acts as a potent and selective antagonist of ET-B (endothelin B) receptor, a receptor that belongs to the G protein-coupled receptors (GPCR).IRL 2500 is more selective for human ET-B over ET-A receptor and can be used to delineate responses mediated by the ETB receptor1. IRL 2500 demonstrates IC50 values of 1.3 nM and 94 nM for human ETB and ETA receptor expressed in transfected Chinese hamster ovary cells respectively1.Several in vitro studies have shown that IRL 2500 can inhibit the sarafotoxin S6c-mediated contraction of the dog saphenous vein and the sarafotoxin S6c-induced relaxation of the preconstricted rabbit mesenteric artery. IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance and decrease in arterial pressure in the anesthetized rat1,2.Endothelin receptors are widely distributed in vascular and nonvascular tissues. ET-B receptor has equally high affinity for all endothelin isopeptides3. ET-B receptors play an important role in regulating renal function and blood pressure and are expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249708884333,"sku":"I-190-10MG-1","price":184.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311561007469,"sku":"I-190-25MG-1","price":417.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311561040237,"sku":"I-190-5MG-1","price":134.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311561073005,"sku":"I-190-50MG-1","price":696.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/I-190_gr.gif?v=1778544433"},{"product_id":"sb209670-bhb21300327","title":"SB209670","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 157659-79-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C29H28O9.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.2-20 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Endothelin receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e SB209670 is a potent mixed antagonist of ET-A and ET-B Endothelin receptors, shown to inhibit Endothelin-1 radioligand binding to human ET-A and ET-B with Ki of 0.2 nM and 18 nM, respectively. SB209670 inhibits Endothelin-1-evoked vasoconstriction in isolated vascular tissues in vitro, and is orally bioavailable and active in vivo1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eSB209670 is a nonpeptide synthetic compound that acts as a potent and specific antagonist of endothelin A (ET-A) and B (ET-B) receptors. Intravenous or intraduodenal administration of SB209670 can produce concentration-dependent inhibition of ET-1-mediated vasoconstriction in isolated vascular tissues. Studies on hypertensive rats show that SB209670 produces a dose-dependent decrease in blood pressure. In a gerbil stroke model SB209670 is protective in ischemia-induced neuronal degeneration. Thus, SB209670 can be used as a useful tool in characterizing and classifying the physiological and pathophysiological roles of Endothelin receptors1.ET-A receptors are predominantly expressed in peripheral tissues, especially in vascular smooth muscle tissues where they mediate vasoconstriction. They are also present in several different regions of the brain. ET-B receptors play an important role in regulating renal function and blood pressure and are expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia.ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has high affinity equally for all endothelin isopeptides2,3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"0.5 mg \/ 1","offer_id":53249713701229,"sku":"S-205-0P5MG-1","price":235.0,"currency_code":"USD","in_stock":true},{"title":"1 mg \/ 1","offer_id":53311576768877,"sku":"S-205-1MG-1","price":459.0,"currency_code":"USD","in_stock":true},{"title":"2.5 mg \/ 1","offer_id":53311576801645,"sku":"S-205-2P5MG-1","price":798.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311576834413,"sku":"S-205-5MG-1","price":1117.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/s-205-bio.gif?v=1778544455"},{"product_id":"tyrphostin-ag-1296-bhb21300360","title":"Tyrphostin AG 1296","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 6,7-Dimethyl-2-phenylquinoxaline.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 146535-11-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C16H14N2O2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e \u0026gt;1-5 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDGF Receptor Tyrosine Kinase\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Tyrphostin AG 1296 is a highly selective blocker of platelet-derived growth factor (PDGF) α and β receptor tyrosine kinase1-3. It could also inhibit the signalling of stem cell factor (SCF) receptor (c-kit) and FLT3-ITD receptor4,5.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eTyrphostin AG1296 is a tyrosine kinase blocker which selectively inhibits platelet-derived growth factor (PDGF) a- and b-receptor kinases and the PDGF-dependent signaling in many cell types. Tyrphostin AG1296 also inhibits the PDGF dependent transactivation of the P2Y and Endothelin receptors-evoked cell proliferation and MAPK activation.1-4This PDGF receptor (PDGFR) blocker has no effect on epidermal growth factor (EGF) receptor autophosphorylation; weak effects on DNA synthesis stimulated by insulin, by EGF, or by a combination of both; and over an order of magnitude weaker blocking effect on fibroblast growth factor-dependent (FGF) DNA synthesis.5-8 Tyrphostin AG1296 also potently inhibits the signaling of stem cell factor (SCF) receptor (c-Kit) and its upstream effector Kit receptor tyrosine kinase and the tyrosine kinase activity of FLT3-ITD which both have a strong sequence similarity with other members of the class III receptor tyrosine kinase but has no effect on the autophosphorylation of vascular endothelial growth factor (VEGF) receptor. 7,8\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"1 mg \/ 1","offer_id":53249715241325,"sku":"T-770-1MG-1","price":75.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311579455853,"sku":"T-770-5MG-1","price":243.0,"currency_code":"USD","in_stock":true},{"title":"1 mg \/ 5","offer_id":53311579488621,"sku":"T-770-1MG-5","price":282.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/T-770_str.gif?v=1778544456"}],"url":"https:\/\/www.ebiohippo.com\/collections\/rt-cardiovascular-biochemicals.oembed?page=2","provider":"BioHippo","version":"1.0","type":"link"}