{"title":"Metabolic \u0026 Endocrine Cells","description":null,"products":[{"product_id":"15p-1-cell-bhc11101301","title":"15P-1 cell","description":"15p-1 cells are a mammalian cell line derived from Mus musculus, specifically utilized for the study of cellular responses to steroid hormones. Originating from the testicular tissue of mice, these cells exhibit a unique sensitivity to androgens, which makes them particularly valuable in endocrinology and cancer research. The 15p-1 cell line expresses the androgen receptor (AR), enabling the study of androgenic effects on gene expression, cell growth, and differentiation processes.\nCharacteristically, 15p-1 cells are used to explore the molecular pathways influenced by androgens and their role in diseases such as prostate cancer. They provide a controlled in vitro environment to dissect the interactions between androgens and their cellular receptors, facilitating insights into both normal physiological and pathological states. This cell line is also instrumental in screening potential pharmaceuticals targeting androgen-related pathways, contributing to the development of therapeutic strategies.\nMaintained under standard cell culture conditions, 15p-1 cells require a medium enriched with fetal bovine serum (FBS) and an optimal temperature of 37°C, along with a CO2 concentration of 5% to mimic physiological conditions. Rigorous quality control is essential to preserve their genetic and phenotypic characteristics, ensuring reliable and reproducible results in research applications.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101301\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195044717,"sku":"305191","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/15P-1_20P1_2010x01_20230525_ch00_1920x1920_9839ac6f-f868-4bbd-87aa-9fe50956e0cc.jpg?v=1769068929"},{"product_id":"8305c-cell-bhc11101203","title":"8305C cell","description":"The 8305C cell line is a human thyroid carcinoma cell line derived from an undifferentiated anaplastic carcinoma of the thyroid. These cells are characterized by their aggressive growth behavior and poor differentiation, which are hallmarks of anaplastic thyroid carcinomas. This cell line retains several key features that are relevant to the study of thyroid cancer pathophysiology, including alterations in gene expression profiles and signaling pathways that are pivotal in thyroid carcinogenesis.\n\nStudies utilizing the 8305C cell line have demonstrated its utility in exploring the molecular mechanisms underlying thyroid cancer progression, resistance to therapy, and metastasis. Specifically, this cell line has been used to investigate the efficacy of various chemotherapeutic agents and targeted therapies, making it a valuable model for preclinical drug testing. Additionally, 8305C has been employed in research focusing on the role of genetic and epigenetic modifications in thyroid cancer, offering insights into potential therapeutic targets and biomarkers for this aggressive cancer type.\n\nDue to its derivation from a high-grade malignancy, the 8305C cell line serves as an important tool in thyroid cancer research, particularly in studies aimed at understanding the aggressive behavior of anaplastic thyroid carcinoma and developing strategies for its effective treatment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101203\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195765613,"sku":"305101","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/8305C_20P1_2020x01_20090125_ch00_1920x1920_318ff090-2415-4134-b390-45ea0c0bce86.jpg?v=1769068934"},{"product_id":"a2780-cell-bhc11101365","title":"A2780 cell","description":"A2780 is a human ovarian cancer cell line that was first established in 1972 from a patient with advanced epithelial ovarian cancer. The cells were characterized as being sensitive to cisplatin and doxorubicin, two commonly used chemotherapy drugs for ovarian cancer. Since its establishment, A2780 has been widely used in cancer research studies, particularly in the development and testing of new cancer treatments. \nResearch using A2780 cells has provided valuable insights into the biology of ovarian cancer, including the identification of specific genetic mutations such as TP53 and BRCA1. These mutations are associated with increased risk of ovarian cancer and are also found in other types of cancer. \nAdditionally, A2780 cells have been used to study the role of angiogenesis, the process by which new blood vessels form, in ovarian cancer progression and to evaluate the efficacy of anti-angiogenic drugs. Angiogenesis plays a critical role in the growth and progression of ovarian cancer as it provides oxygen and nutrients for the cancer cells to grow. \nStudies using A2780 cells have demonstrated the overexpression of pro-angiogenic factors such as VEGF and angiopoietin-2, which promote the formation of new blood vessels. Additionally, A2780 cells have been used to test the efficacy of anti-angiogenic drugs such as bevacizumab, which target VEGF and inhibit the formation of new blood vessels. \nFurthermore, A2780 cells have been used to evaluate the efficacy of various therapeutic agents, including chemotherapy drugs, targeted therapies such as PARP inhibitors, and immunotherapies. \nIn particular, A2780 cells have been used to study the effect of different drug combinations on cancer cell proliferation, apoptosis, and drug resistance. Overall, the A2780 cell line has played a significant role in the advancement of ovarian cancer research, providing a valuable tool for understanding the disease and developing new treatments.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101365\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196126061,"sku":"300491","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A2780_20P0_2040x01_2007092022_1920x1920_255020e7-b42a-41be-8126-bd752712eeb5.jpg?v=1769068937"},{"product_id":"aml12-cell-bhc11101265","title":"AML12 cell","description":"AML12 cells, also known as Alpha Mouse Liver 12 cells, are a non-tumorigenic epithelial cell line derived from the liver of a transgenic mouse. These cells were initially developed to provide a suitable in vitro model for studying the hepatocyte function and liver biology of the adult mouse. AML12 cells express characteristics typical of differentiated hepatocytes, including the production of albumin, transferrin, and other liver-specific proteins, making them an invaluable resource for research in toxicology, drug metabolism, and liver disease.\n\nThe cell line was established from hepatocytes isolated from a mouse harboring a transgene for human transforming growth factor alpha (TGF-alpha), under the control of the mouse metallothionein-I promoter. This genetic alteration contributes to the immortalization of the cells without disrupting their differentiated state. AML12 cells maintain a stable phenotype and karyotype under standard cell culture conditions, which includes a unique requirement for dexamethasone and insulin-transferrin-selenium in the growth medium to promote proliferation and maintain hepatocyte-specific functions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101265\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197076333,"sku":"300643","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/aml12-_282_29_1920x1920_fd1a83ba-979f-4ece-8666-1507a80d1af3.jpg?v=1769068946"},{"product_id":"an3-ca-cell-bhc11100043","title":"AN3 Ca cell","description":"The An3 Ca cell line is derived from a human endometrial adenocarcinoma, a type of cancer originating from the lining of the uterus. This cell line is estrogen receptor negative (ER-) and exhibits aggressive tumorigenic potential when assessed in vivo. An3 Ca cells are used extensively in research focused on understanding the molecular and cellular mechanisms underlying endometrial cancer progression, including studies on cancer cell proliferation, metastasis, and response to therapeutic agents.\n\nCharacteristically, An3 Ca cells display an epithelial morphology and have been utilized to study the impact of various genetic and environmental factors on cancer cell behavior. Research using this cell line has contributed to identifying potential therapeutic targets and understanding the resistance mechanisms against conventional treatments. They serve as a valuable model for evaluating new drugs or treatment strategies that could be effective against aggressive forms of endometrial cancer.\n\nOverall, the An3 Ca cell line is instrumental in advancing the scientific knowledge of endometrial adenocarcinoma, offering insights that might lead to more effective interventions for this challenging and often lethal disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100043\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197109101,"sku":"300119","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/an3-ca-_284_29_1920x1920_59defe71-9b26-4a96-84f0-aa3ac093f9f3.jpg?v=1769068946"},{"product_id":"anglne-cell-bhc11101282","title":"Anglne cell","description":"The Anglne cell line was established by German scholars and is mainly applied to pathological research of ovarian cancer and screening of anti-tumor drugs. The Anglne cell line is adherent and more convenient to culture than the COC1 cell line.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101282\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197207405,"sku":"305144","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Anglne_20_20WaKo_20P1_2020x01_20100425_ch00_1920x1920_f2ffce7b-448a-4633-a21e-4d0984669046.jpg?v=1769068947"},{"product_id":"aspc-1-cell-bhc11100143","title":"AsPC-1 cell","description":"The AsPC1 cell line, derived from a 62-year-old female patient with adenocarcinoma of pancreas and metastases to several abdominal organs, has become a pivotal model for studying pancreatic cancer, one of the most aggressive and lethal malignancies. They display a high degree of invasiveness compared to other pancreatic cancer cell lines, which makes them particularly useful for studies on cancer metastasis and tumor invasion.\nAsPC1 cells have been instrumental in understanding the metabolic pathways involved in pancreatic cancer, including glutamine and glycerophospholipid metabolism. AsPC1 cells have been used to investigate the function of matrix metalloproteinases (MMPs) in metastasis, a crucial component of the biology of pancreatic cancer.\nAsPC1 cells have further been used to evaluate the efficacy of treatments such as the HDAC inhibitor AR-42 and the antimitotic and STAT3 inhibitor LTP-1, demonstrating the potential of these compounds to suppress tumor growth and induce apoptosis in pancreatic cancer cell lines.\nThe development of xenograft models using AsPC1 cells has allowed researchers to study pancreatic cancer in a more physiologically relevant context and have provided valuable insights into the transformation of normal human pancreatic duct cells into adenocarcinomas.\nAsPC1 cells continue to be a valuable resource for exploring the therapeutic bispecific pathways and intracellular tumor antigens associated with pancreatic cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100143\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197600621,"sku":"300158","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ASPC-1_20P4_2010x01_20311023_ch00_1920x1920_6e8cf718-8789-431e-845a-7e78240900aa.jpg?v=1769068949"},{"product_id":"att-20-cell-bhc11101161","title":"AtT-20 cell","description":"The AtT-20 cell line is a well-characterized mouse pituitary tumor cell line derived from anterior pituitary cells. These cells originate from a strain of mice known as AtT-20\/D16v-F2, and are primarily used for the study of pituitary function and regulation, especially focusing on the synthesis and secretion of adrenocorticotropic hormone (ACTH). ACTH is crucial for adrenal gland function and is a key player in the stress response and metabolic regulation.\n\nAtT-20 cells exhibit typical features significant for studies in neuroendocrinology and pharmacology, such as the production and secretion of pro-opiomelanocortin (POMC), the precursor molecule for ACTH. The cells are responsive to corticotropin-releasing hormone (CRH) and other hypothalamic hormones, making them an excellent model for exploring the hypothalamic-pituitary-adrenal (HPA) axis in vitro. Moreover, AtT-20 cells can be used to investigate the mechanisms of peptide hormone processing, packaging, and secretion, given their well-defined secretory pathways.\n\nIn terms of applications, AtT-20 cells have been utilized in various studies including those focusing on gene expression profiles under different treatment conditions, intracellular signaling pathways involving cAMP, and the effects of genetic modifications on hormone secretion. These cells are also valuable in the assessment of the pharmacological properties of potential drug candidates targeting HPA axis components.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101161\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197698925,"sku":"305161","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AtT-20_20P3_2020x01_20011024_ch00_1920x1920_e54c084c-843e-454a-8c78-5caea8c2813c.jpg?v=1769068950"},{"product_id":"b-cpap-cell-bhc11101200","title":"B-CPAP cell","description":"B-CPAP is a human papillary thyroid carcinoma cell line that was established from the primary tumor of a 74-year-old woman. The cell line exhibits epithelial-like morphology and is commonly used in research to study thyroid cancer biology, including mechanisms of tumorigenesis and metastasis. B-CPAP cells are notable for harboring a BRAF V600E mutation, which is a common genetic alteration associated with aggressive thyroid cancers and serves as a critical model for evaluating BRAF inhibitors as therapeutic agents.\n\nIn addition to the BRAF mutation, B-CPAP cells express thyroid-specific markers such as thyroglobulin and thyroid-stimulating hormone receptor, making them a valuable model for studying thyroid gland function and pathology. They have been extensively used in studies investigating the signaling pathways involved in thyroid cancer progression, including MAPK\/ERK pathway activation. These cells are also employed in drug resistance and apoptosis studies, providing insights into the mechanisms that might underpin therapeutic failures in thyroid cancer treatments.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101200\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198026605,"sku":"305081","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-CPAP_20P4_2010x01_20040923_ch00_1920x1920_78a77fc0-6747-4857-9a9b-75e09bf7d3aa.jpg?v=1769068954"},{"product_id":"beta-tc-6-cell-bhc11101154","title":"Beta-TC-6 cell","description":"Beta-TC-6 cells is a cell line derived from insulinoma tissue in mice. These cells are crucial in scientific studies focused on diabetes and insulin signalling.\nOriginating from a transgenic mouse, Beta-TC-6 cells carry a pseudogene construct comprising the SV40 early region, which the rat insulin gene promoter regulates. This genetic composition leads to insulin secretion in response to glucose levels. \nThese cells exhibit epithelial morphology and primarily reside in the pancreas tissue. In addition to insulin production, these cells possess small amounts of glucagon and somatostatin. The adherence of Beta-TC-6 cells allows for convenient cultivation and manipulation during experiments and assays.\nBeta-TC-6 cells provide a valuable tool for scientific investigations in diabetes and insulin signalling. Their unique genetic composition, insulin-secreting capabilities, and adherence properties make them ideal for studying the intricate processes involved in glucose regulation and pancreatic function.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101154\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198124909,"sku":"305181","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Beta-TC-6_20P1_2020x01_20010825_ch00_1920x1920_f05e068f-7deb-4177-9a22-faaf42530d4f.jpg?v=1769068955"},{"product_id":"bewo-cell-bhc11100033","title":"BEWO cell","description":"BeWo cells, a cell line derived from malignant gestational choriocarcinoma of the fetal male placenta, have become a widely used in vitro model for studying the placenta. \nThe cell-cell fusion during the human trophoblast syncytialization phase during placental development is one of the most significant yet least understood events. Due to the difficulty of studying this process in a placenta in vivo, BeWo cells are utilized as a cell culture model to simulate in vivo syncytialization of the placental villous trophoblast.\nThese cells exhibit an epithelial-like phenotype and are adherent. The b30 subclone of BeWo cells is particularly useful for studying nutrient uptake and transport due to its dense growth on permeable membranes.\nCK 7 and E-cadherin are molecular markers that are expressed by BeWo cells. VE-cadherin is found in BeWo cells and is enhanced upon treatment with forskolin. The cells also express keratin and are positive for G6PD, B isoenzyme. The karyotype of BeWo cells is modal number = 86, with a range of 71 to 178, and the stemline number is hypotetraploid. \nThe karyotype is relatively stable within the stemline number. BeWo cells secrete various hormones, including human chorionic gonadotropin (hCG), human chorionic somatomammotropin (placental lactogen), and steroid hormones as estrone, estriol, and estradiol. \nHowever, the levels of β-hCG and estradiol secreted by BeWo cells are lower than those secreted by other choriocarcinoma-derived cell lines such as JEG-3. Upon Forskolin treatment, the secretion of β-hCG in BeWo cells increases to a level similar to that observed in the other choriocarcinoma-derived cell lines. Furthermore, Forskolin treatment also increases the progesterone levels secreted by BeWo cells.\nIn summary, BeWo cells are a widely used in vitro model for studying placental development and the human trophoblast syncytialization process. They exhibit an epithelial-like phenotype, express various molecular markers, and secrete multiple hormones, including hCG, placental lactogen, and steroid hormones. Overall, BeWo cells are a valuable tool for investigating the complex processes involved in placental development.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100033\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198157677,"sku":"300123","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/bewo-_281_29_1920x1920_f975a6b5-8edd-4f11-8b59-cda5f21e8d0b.jpg?v=1769068955"},{"product_id":"bht101-cell-bhc11101028","title":"BHT101 cell","description":"The BHT101 cell line is derived from the lymph node metastasis of a 63-year-old woman diagnosed with anaplastic papillary thyroid carcinoma. This cell line is established from a highly aggressive and lethal form of thyroid cancer, known for its rapid progression and poor prognosis. BHT101 cells are notable for their lack of hormone production, which is typical for cells originating from anaplastic thyroid carcinoma, as these cells often lose the ability to synthesize thyroid hormones that are characteristic of more differentiated thyroid tissues.\n\nIn terms of biomarker expression, BHT101 cells are partially positive for thyroglobulin and thyroxine (T4). Thyroglobulin is a precursor glycoprotein critical for the production of the thyroid hormones T3 and T4 and is commonly used as a tumor marker in differentiating thyroid cancer types. The presence of thyroglobulin in BHT101 cells, even if only partial, is significant for research focused on thyroid cancer pathology and the molecular mechanisms underlying dedifferentiation in thyroid carcinomas. This cell line's unique profile makes it a valuable model for studying the progression and metastatic behavior of anaplastic thyroid carcinoma, providing insights into the molecular alterations that drive these processes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101028\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198255981,"sku":"305112","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BHT101_20P1_2020x01_20170823_ch00_1920x1920_69f2b4d0-62ac-450a-b742-aedc65d36d49.jpg?v=1769068957"},{"product_id":"bnl-cl-2-cell-bhc11101264","title":"BNL CL.2 cell","description":"BNL CL.2, a mouse liver cell line originally derived from BALB\/c embryonic liver cells, plays a significant role in the study of cellular biology and molecular mechanisms, especially regarding the cell cycle and its regulation. Researchers have extensively used BNL CL.2 to characterize cyclin-dependent kinase (CDK) protein complexes and investigate the alterations in these complexes following both chemical and viral transformation. This line serves as a progenitor for various transformed cell lines such as BNL 1ME A.7R.1, BNL 1NG A.2, and BNL SV A.8, all of which originate from BNL CL.2 and have proven essential for studying CDK alterations post-transformation.\n\nBNL CL.2 is distinguished by its non-tumorigenic nature when tested in immunosuppressed mice, and its inability to grow anchorage-independently, although it does possess the capability to form colonies in semisolid media. This makes it an invaluable model for exploring cellular processes and transformations in a controlled environment. In contrast, its derivative lines such as those transformed by 3-Methylcholanthrene epoxide, MNNG, and SV40 demonstrate the ability to grow in soft agar and form tumors in immunodeficient mice, highlighting the impact of genetic and environmental alterations on cellular behavior. The BNL CL.2 cell line and its derivatives continue to provide a robust foundation for research in cellular transformation, stable cell transfection, and related fields of cellular and molecular biology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101264\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199533933,"sku":"305177","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BNL_20CL.2_20_283_29_1920x1920_76d498ac-cd28-4fb4-93e5-e535e7a87690.jpg?v=1769068967"},{"product_id":"bxpc-3-cell-bhc11101173","title":"BxPC-3 cell","description":"BxPC-3 cells, originating from the pancreatic adenocarcinoma of a 61-year-old female patient who underwent radiation and chemotherapy, have become a fundamental asset in cancer research, particularly for studying pancreatic ductal adenocarcinoma. The absence of the SMAD4\/DPC4 protein due to homozygous deletions in BxPC 3 cells makes them an invaluable resource for research into pancreatic cancer's genetic landscape.\nTumors grown from BxPC-3 cells in nude mice produce carcinoembryonic antigen, human pancreas cancer-associated antigen, human pancreas-specific antigen, and traces of mucin. This highlights the ability of the cell line to closely replicate the histopathological traits of the primary tumor. The production of mucinous tissues, in particular, underscores the cell line's value for detailed pancreatic adenocarcinoma studies, reflecting the original tumor's characteristics.\nBxPC-3 cells' significant expression of angiogenic factors such as interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2) opens avenues for exploring angiogenesis in cancer progression and identifying potential therapeutic targets.\nIn summary, the pancreatic adenocarcinoma cell line BxPC-3 are pivotal in cancer research, especially for pancreatic ductal adenocarcinoma research. Their lack of SMAD4\/DPC4 protein because of homozygous deletions and their ability to replicate the primary tumor's histopathological features, including mucinous tissues, make them invaluable for studying the genetic landscape and pathology of pancreatic cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101173\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199828845,"sku":"305031","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BxPC-3_20WaKo_20P0_20305031-051022_2010x01_20141022_1920x1920_a3125722-8738-48f2-8e2a-3f670f71b710.jpg?v=1769068971"},{"product_id":"c-33-a-cell-bhc11101353","title":"C-33 A cell","description":"C-33 A cells originate from the cervical tissue of a 66-year-old Caucasian female diagnosed with uterine cancer. This cell line is characterized by a unique genetic alteration in the TP53 gene, where a point mutation at codon 273 results in an arginine to cysteine substitution, leading to elevated expression of the p53 protein. This mutation plays a critical role in the pathophysiology of the cells, influencing their growth properties and tumorigenic potential.\n\nNotably, C-33 A cells are confirmed to be tumorigenic. When introduced into immunodeficient nude mice, these cells have the capability to form undifferentiated carcinomas, which highlights their utility in cancer research, particularly in studies aimed at understanding the mechanisms of tumor initiation and progression in cervical cancer. Furthermore, these cells are negative for both DNA and RNA of human papillomavirus (HPV), distinguishing them from many other cervical cancer cell lines which often carry HPV integrations. This aspect makes C-33 A cells particularly valuable for studying cervical cancer that develops independently of HPV infection, offering insights into alternative pathways of carcinogenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101353\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199992685,"sku":"305072","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C33A_20_286_29_1920x1920_09d64786-8497-450e-8203-3637ccd48290.jpg?v=1769068974"},{"product_id":"c643-cell-bhc11100235","title":"C643 cell","description":"The cell line C643 was established from a fine-needle biopsy of an anaplastic thyroid carcinoma of a 76-year-old man by Mark et al. in 1987. The patient died within 5 months after diagnosis. Demonstration of thyroglobulin mRNA ascertained a thyroid epithelial origin of the cell line. C643 cells emerge as a valuable tool for thyroid cancer research. \nThese cells originated from human thyroid cancer tissue and represented metastatic PTC, FTC, and ATC. Their genetic makeup reflects the common mutations observed in thyroid cancer, such as alterations in BRAF, RAS, and PI3K genes, which activate critical signalling pathways. \nThis makes C643 cells an ideal model for investigating the mechanisms involved in thyroid cancer development and progression. Furthermore, C643 cells are a crucial resource for testing potential targeted therapies. \nTheir inclusion in preclinical studies can aid in identifying and evaluating novel compounds that specifically target the altered signalling pathways implicated in thyroid cancer. By accurately representing human thyroid cancer, C643 cells contribute to developing more effective treatments for patients with advanced thyroid cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100235\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200090989,"sku":"300298","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/c643-_284_29_1920x1920_a699ea70-9747-42c1-b4c1-db5983b299da.jpg?v=1769068976"},{"product_id":"cal-62-cell-bhc11101202","title":"CAL-62 cell","description":"The CAL-62 cell line was established from the right lobe of the thyroid gland of a 70-year-old Caucasian woman in 1988 and has been extensively used in the study of thyroid anaplastic carcinoma. These human epithelial-like cells exhibit a distinctive monolayer growth pattern and demonstrate pronounced tumorigenic properties, making them a significant model for in vivo studies of thyroid cancer progression. When transplanted into immunodeficient nude mice, CAL-62 cells have shown a robust capability to form tumors, providing a practical and effective model to analyze tumor dynamics and evaluate potential therapeutic strategies in real-time biological settings.\n\nCharacterized by a rapid proliferation rate with a doubling time of approximately 24 hours, CAL-62 enables accelerated research outputs in studies that are time-sensitive, enhancing the efficiency of experimental workflows in cancer research. Genetic characterization of this cell line reveals the presence of the KRAS p.G12R mutation and alterations at the 9p21.3 locus, indicating complex genetic underpinnings associated with thyroid anaplastic carcinoma. This cell line’s stable epithelial phenotype and inherent radioresistance further underscore its utility in uncovering novel insights into the pathophysiology of aggressive thyroid cancers and in the development of new therapeutic modalities. The unique attributes of CAL-62, including its aggressive tumor-forming ability and genetic markers, make it a pivotal resource in the ongoing efforts to better understand and treat thyroid anaplastic carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101202\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200418669,"sku":"305114","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CAL-62_20P1_20305114-M_2010x01_2013022023_1920x1920_147d98cf-b0cd-44b5-84e0-f682f0759a44.jpg?v=1769068982"},{"product_id":"caov-3-cell-bhc11101105","title":"Caov-3 cell","description":"Caov-3 cells are derived from the ovary of a 54-year-old Caucasian woman with adenocarcinoma, provide researchers with a representative model for high-grade ovarian cancer. The cell line was established in 1976 and has since been used in numerous studies. \nWith their epithelial morphology, Caov-3 cells closely resemble the characteristics of primary ovarian cancer cells. When cultured, these cells form densely packed colonies that mimic the behavior observed in the human body. Their unique properties make them an ideal choice for researchers studying the growth, behavior and response of ovarian cancer cells. \nAn important finding in this field is the effect of all-trans retinoic acid on Caov-3 cells. Studies have shown that this compound suppresses the growth of these ovarian cancer cells in vitro. In addition, Caov-3 cells express various tumor-associated antigens, including NB\/70K, CA-125, Ba-2, and Ca-1, which increases their utility for research into targeted therapies and immunotherapies. \nThe genome of Caov-3 cells exhibits significant abnormalities explaining their tumorigenic properties. For example, these cells have a nonsense mutation in the p53 tumor suppressor gene and possess multiple copies of the ovarian cancer oncogene PIK3CA, which plays a critical role in cancer development and progression. In terms of drug sensitivity, Caov-3 cells respond to several commonly used chemotherapeutic agents. \nVinblastine, cisplatin and adriamycin have been shown to have an effect on these cells. Another characteristic of Caov-3 cells is their behavior under different culture conditions. While these cells do not grow in soft agar, they exhibit tumorigenic properties when injected into immunocompromised mice. Therefore, among their many applications in research, Caov-3 cells are particularly suitable for 3D cell culture experiments. \nDue to their epithelial morphology and ability to form dense colonies, they are the ideal choice for studying cell-cell interactions, tissue organization and behavior of ovarian cancer cells in a more physiologically relevant environment. However, the long doubling time of approximately 78 hours must be considered in experimental design.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101105\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200549741,"sku":"300319","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Caov-3_20P6_2020x01_20310523_1920x1920_42058ec7-d6a8-436b-8fba-71b03bb6e603.jpg?v=1769068983"},{"product_id":"capan-1-cell-bhc11100185","title":"Capan-1 cell","description":"The Capan-1 cell line is derived from a human pancreatic adenocarcinoma and was established from the ascitic fluid of a 40-year-old Caucasian male. It was first characterized in 1975 and is particularly noted for its ductal epithelial morphology, which closely resembles that of primary pancreatic tumors. Capan-1 cells are extensively used in research aimed at understanding pancreatic cancer biology, including studies on tumor progression, metastasis, and treatment resistance. This cell line is well-regarded for its ability to produce mucin, a characteristic feature of many pancreatic adenocarcinomas, thus serving as a model for mucinous pancreatic cancer.\n\nGenetically, Capan-1 harbors mutations in the KRAS gene, which are typical of pancreatic cancer, as well as alterations in other cancer-related genes such as TP53 and SMAD4. These mutations make the Capan-1 cell line a valuable tool for studying the molecular mechanisms underlying pancreatic cancer and for the preclinical evaluation of new therapeutic agents targeting these pathways. Furthermore, Capan-1 cells are used to study the biology of pancreatic cancer stem cells, offering insights into the behaviors that drive cancer recurrence and resistance to conventional therapies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100185\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200582509,"sku":"300143","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/capan-1-_281_29_1920x1920_df02430a-19f1-418a-bb8f-cfe22fd105d5.jpg?v=1769068984"},{"product_id":"capan-2-cell-bhc11100023","title":"Capan-2 cell","description":"The Capan-2 cell line is a human pancreatic adenocarcinoma cell line first isolated from the pancreatic tumor tissue of a 56-year-old Caucasian male. It was derived from the metastatic site in the liver, indicating its origin from a secondary tumor which makes it particularly valuable for research on metastatic processes and pancreatic cancer biology. The cells exhibit epithelial morphology and have been utilized extensively to study pancreatic cancer, drug resistance, and tumor biology.\n\nCapan-2 cells are known to express a mutated form of the Kirsten rat sarcoma viral oncogene homolog (KRAS), a common mutation in pancreatic cancer, making them a robust model for studying KRAS-driven tumorigenesis. Additionally, they are characterized by the expression of tumor suppressor gene p53 mutations and have been observed to exhibit chromosomal instabilities, which are critical features relevant to cancer progression and treatment response. This cell line has been used in numerous studies, including those evaluating chemotherapeutic efficacy, exploring molecular pathways of cancer progression, and developing targeted therapy strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100023\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200615277,"sku":"300144","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/capan-2-_282_29_1920x1920_3828ed5b-205f-480d-8cfc-c4516e98c3a4.jpg?v=1769068984"},{"product_id":"caski-cell-bhc11100052","title":"CaSki cell","description":"CaSki is a cell line exhibiting epithelial morphology, isolated from the cervix of a 40-year-old White female patient with epidermoid carcinoma. The establishment of this cell line provides a critical model for the study of cervical cancer, particularly in the context of HPV-mediated oncogenesis. CaSki cells are characterized by their capacity to replicate HPV16 DNA, which is integrated into the host's genome, offering insights into the viral life cycle and its role in malignant transformation.\n\nThese cells are an essential resource in cancer research, particularly for studies focusing on the pathogenesis of HPV-associated cervical cancer. The presence of high-risk HPV16 in CaSki cells facilitates the exploration of viral oncogene functions, notably the E6 and E7 proteins and their interactions with cellular tumor suppressor pathways, including those involving p53 and pRB. This aspect makes CaSki cells invaluable for evaluating potential therapeutic targets and developing interventions aimed at HPV-induced malignancies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100052\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200648045,"sku":"300145","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/caski-_281_29_1920x1920_03746bf0-2bce-4e5b-8320-37d63e8f30f0.jpg?v=1769068984"},{"product_id":"cerv-186-cell-bhc11100006","title":"CERV-186 cell","description":"The CERV-186 cell line, derived in vitro from the xenotransplant of cervical carcinoma MRI-H-186, serves as a biological model for invasive, large-cell, non-keratinizing squamous cell carcinoma. This cell line was established and adapted for in vivo transplantation under the direction of Dr. Bodgen at the Mason Research Institute. Characterized by its genomic properties, MRI-H186 contains approximately 26 integrated copies of both full-length and truncated forms of the HPV16 genome, which significantly influence its transcriptomic profile.\n\nMRI-H186 cells are distinguished by their robust expression of both full-length and truncated early HPV16 transcripts, notably displaying high levels of E5 full-length (fl) RNA. This transcriptional signature is notably distinct from that observed in other cervical carcinoma cell lines such as CaSki and MRI-H196. Additionally, the transcriptional activity of MRI-H186, in terms of the expression of various other transcripts, shows a close alignment with the patterns observed in the HPK-IA and C3 cell lines, indicating a similar transcriptional behavior across these models. The presence of both full-length and truncated HPV16 genomic integrations in MRI-H186 cells is a key factor in their vigorous expression of early viral transcripts, particularly underscored by the significant expression of E5 fl RNA. This intense transcriptional activity culminates at the early polyadenylation signal, highlighting the unique transcriptional dynamics within the MRI-H186 cell line.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100006\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200975725,"sku":"300290","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cerv-186-_284_29_1920x1920_8efa94bf-8d5d-49b3-8406-c05d351c7885.jpg?v=1769068988"},{"product_id":"cerv-196-cell-bhc11100112","title":"CERV-196 cell","description":"The MRI-H196 cell line, derived from HPV16-positive cervical carcinoma, displays a unique HPV16 transcript expression profile characterized by the presence of the full-length L1 transcript and a marked absence of the E5 full-length RNA. This pattern suggests an integration of the HPV16 genome within the cell line, particularly affecting the E2 region and causing rearrangement of the L1 DNA sequence. The absence of E5 full-length RNA expression indicates a disruption in the transcription of full-length early RNAs, which typically conclude at the polyadenylation signal located downstream of the E5 open reading frame (ORF). Such a disruption is indicative of the integrated state of HPV16 genomes, where the crucial E2 region-key for viral replication and transcription regulation-is often compromised during the integration into the host genome. This disruption potentially impacts the expression of downstream genes, including E5.\n\nThis integration phenomenon within MRI-H196 cells highlights the complexity of HPV16 genome behavior post-integration, emphasizing the cell line's utility in studying the genomic and transcriptional intricacies associated with HPV integration in cervical carcinomas. Understanding these dynamics is crucial for insights into the mechanisms of oncogenesis and the progression of HPV-associated cancers, making the MRI-H196 cell line a valuable resource for medical and biological research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100112\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201008493,"sku":"300291","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cerv-196-_288_29_1920x1920_8e2effa2-b5d3-4d20-a77e-52a738593f50.jpg?v=1769068988"},{"product_id":"cerv-215-cell-bhc11100208","title":"CERV-215 cell","description":"The CERV-215 cell line, established by Dr. Bodgen at the Mason Research Institute, originates from a primary xenotransplant termed MRI-H215, which has been adapted for in vivo transplantation. \nThis cell line represents an aggressive form of epidermoid carcinoma, categorized as invasive, large cell, non-keratinizing, and poorly differentiated. \nThe Cerv-215 cell line, is a pivotal resource for cancer research, especially in the study of genetic alterations and their roles in cervical carcinogenesis. This cell line is characterized by unique genetic modifications in the Smad4 gene, where specific exons are replaced by sequences from other genomic regions, leading to the expression of truncated and likely non-functional Smad4 proteins. These alterations provide insights into the cell line's oncogenic properties and the molecular mechanisms underlying cervical cancer.\nNotably, MRI-215 is HPV45 positive, yet its Smad4 gene alterations are independent of HPV integration, suggesting a complex interplay of genetic factors contributing to cancer development beyond viral influences. This cell line serves as an invaluable tool for researchers focusing on the genetic aspects of cancer, the role of Smad4 in tumor progression, and the interaction between human papillomavirus and host cellular mechanisms.\nMRI-H215 offers a unique platform for exploring the intricacies of cervical cancer at the molecular level, making it an essential component of cancer research laboratories aiming to uncover new therapeutic targets and understand the genetic basis of tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100208\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201041261,"sku":"300292","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CERV-215_20_284_29_1920x1920_a87fcf08-68b6-41f5-b60b-65a3c2eb446f.jpg?v=1769068989"},{"product_id":"cfpac-1-cell-bhc11101080","title":"CFPAC-1 cell","description":"CFPAC-1 cells, derived from a 26-year-old male with cystic fibrosis and liver metastasis of ductal adenocarcinoma, are a hyperdiploid cell line with notable features for biological research. Their adherence growth property and tumorigenic capability in nude mice make them a practical model for in vitro cancer studies. The cell line's karyotype includes a modal number of 73 chromosomes with several translocations, and importantly, two to three copies of chromosome 7, where the cystic fibrosis gene is located.\nThese cells express cancer-related antigens and genes like CA19-9, carcinoembryonic antigen (CEA), pancreatic oncofetal antigen (POA), adenocarcinoma associated antigen (ACAA), and epithelial keratins, offering insights into cancer biology. In terms of cystic fibrosis pathology, CFPAC-1 cells demonstrate unique ion transport activities. They do not respond to cAMP agonists, adenyl cyclase stimulators, or phosphodiesterase inhibitors for chloride ion flux but show increased chloride efflux in response to calcium ionophores.\nCFPAC-1 cells carry the common cystic fibrosis mutation - deletion of three nucleotides leading to phenylalanine absence at position 508 in the CFTR gene. Morphologically, they exhibit epithelial features with apical microvilli, tight junctions, and gap junctions, relevant for studying epithelial tissue interactions in both cancer and cystic fibrosis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101080\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201139565,"sku":"305066","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CFPAC-1_20P1_20305066-M_2010x01_20020323_1920x1920_4d458c15-0021-428c-b4ad-d6725d89ad98.jpg?v=1769068989"},{"product_id":"chang-liver-hela-cell-bhc11100019","title":"Chang Liver (HeLa) cell","description":"The Chang Liver cell line, originally believed to be derived from normal human liver tissue, has undergone significant reclassification following advanced genetic profiling. STR PCR DNA profiling techniques have demonstrated that the Chang Liver cell line is indistinguishable from the HeLa cell line, suggesting that it is not derived from hepatocyte cells as previously thought, but rather should be considered a HeLa derivative. This revelation has important implications for researchers using this cell line, emphasizing the need for careful interpretation of experimental results derived from its use.\n\nHeLa cells, originally taken from Henrietta Lacks, a Black woman, in the early 1950s, are known for their robust growth and genetic stability in vitro, characteristics likely shared by the Chang Liver cell line given its genetic similarity. This background necessitates that studies employing the Chang Liver cell line in research related to liver function or diseases may need to be re-evaluated or confirmed with additional hepatocyte-specific models. The misidentification also highlights broader issues in cell culture practices, including cross-contamination and mislabeling, underscoring the importance of regular authentication of cell lines used in research settings.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100019\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201172333,"sku":"300139","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Chang_20Liver_20_28Hela_29_20confluent_1920x1920_52ae121d-53ec-45e5-89f7-51e06a151ad3.jpg?v=1769068989"},{"product_id":"cho-cell-bhc11100241","title":"CHO cell","description":"Chinese hamster ovary (CHO) cells are a cornerstone in the field of biotechnology and are heavily utilized in the process of CHO cell line development for the manufacture of biopharmaceuticals. These include monoclonal antibodies, recombinant antibody expression, and vaccines. The many advantages of CHO cells underscore their popularity in biomanufacturing, positioning them as a robust and versatile animal cell line with a proven track record in genetics, molecular biology, toxicity screening, nutrition, and gene expression studies.\nThe contribution of CHO cells to the biopharmaceutical industry is immense, with their role in the development of recombinant antibodies and monoclonal antibody production being particularly significant. Nearly 50 biotherapeutics developed using these cells have been approved in the USA and EU, which speaks to the efficacy of CHO cells and their integral role in antibody development. Their hamster origin contributes to lower susceptibility to viruses, enhancing biosafety in biomanufacturing settings and reducing batch-to-batch variation.\nCHO cells are well-suited to produce proteins that undergo post-translational modifications, which is critical for therapeutic protein production. The versatility of the Chinese Hamster Ovary-derived cells is further highlighted by their fast proliferation rates and high protein expression rates of 1-5 grams per liter of culture. The ease of cultivating CHO cells and their ability to be genetically modified makes CHO cells an optimal choice for both transient and stable expression studies.\nThe CHO-K1 cell line, a derivative of the original Chinese hamster ovary (CHO) cells is frequently utilized in expressing recombinant proteins, especially for the production of therapeutic proteins and recombinant antibodies. They excel in producing therapeutic proteins and antibodies due to efficient post-translational modification, notably glycosylation. Researchers modify CHO-K1 cells to enhance protein expression and tailor glycosylation for specific therapies, crucial in biomedicine.\nIn conclusion, the Chinese hamster ovary cell line, known for its remarkable ability to mimic human post-translational modifications, is an invaluable scientific resource. Whether overcoming the difficulty of expressing challenging proteins or monoclonal antibody production, CHO cells have revolutionized the development and production of recombinant protein therapeutics. They remain pivotal in modern medicine, serving as a cornerstone for biopharmaceutical production and reflecting the advancements in biotechnology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100241\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201205101,"sku":"603479","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CHO_P1_2020x01_20301023_ch00_1920x1920_c5b2526e-0047-4a3f-acb3-b53acf45bdfc.jpg?v=1769068990"},{"product_id":"cho-b7h3-cell-bhc11101491","title":"CHO-B7H3 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-B7H3 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the B7-H3 receptor at a high level, approximately 395,000 molecules per cell. This cell line was developed using innovative landing pad technology, which ensures precise and reproducible integration of the B7-H3 gene at a specific, pre-validated genomic locus. B7-H3, also known as CD276, is a member of the B7 family of immune checkpoint proteins and is overexpressed in various cancers. It plays a critical role in immune evasion by tumor cells and is associated with poor prognosis in cancer patients. This makes B7-H3 a promising target for cancer immunotherapy, particularly in the development of checkpoint inhibitors and antibody-drug conjugates.\nThe expression of B7-H3 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101491\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201237869,"sku":"305417","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_5e76e15e-17b7-4b33-b52d-a8b8a6040417.jpg?v=1769068990"},{"product_id":"cho-ccr8-cell-bhc11101492","title":"CHO-CCR8 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CCR8 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CCR8 receptor at a medium-high level, approximately 8,000 molecules per cell. This cell line was developed using advanced landing pad technology, ensuring precise and reproducible integration of the CCR8 gene at a specific, pre-validated genomic locus. CCR8, also known as CHEMR1 or CDw198, is a G protein-coupled receptor (GPCR) expressed on various immune cells, particularly regulatory T cells (Tregs). CCR8 plays a critical role in the immune suppression process within the tumor microenvironment, facilitating tumor cells' ability to evade immune detection. As such, targeting CCR8 has become a promising strategy in cancer immunotherapy to reduce Treg-mediated suppression and enhance anti-tumor immunity.\nThe expression of CCR8 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101492\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201270637,"sku":"305418","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_29452378-9937-4200-92b0-746f8594eb7c.jpg?v=1769068991"},{"product_id":"cho-ctla4-cell-bhc11101488","title":"CHO-CTLA4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.\nThe CHO-CTLA4 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CTLA4 receptor at a medium-low level, approximately 3,000 molecules per cell. This cell line was created using an innovative landing pad technology that facilitates the targeted integration of the CTLA4 gene at a specific, pre-validated genomic locus. CTLA4, also known as CD152, is a critical immune checkpoint protein found primarily on T-cells. It functions by competing with CD28 for binding to B7 molecules (CD80 and CD86) on antigen-presenting cells, leading to the downregulation of T cell activation. This mechanism is vital for maintaining immune self-tolerance and preventing autoimmunity. CTLA4's role in modulating immune responses has made it a significant target in cancer immunotherapy, particularly in immune checkpoint blockade strategies.\nThe expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101488\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201303405,"sku":"305414","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_8414bae3-ee9f-42ef-bb53-1cda0600a649.jpg?v=1769068991"},{"product_id":"cho-cxcr4-cell-bhc11101481","title":"CHO-CXCR4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR4-Low cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line that expresses the CXCR4 receptor at a low level, approximately 400 molecules per cell. This cell line was developed using an innovative landing pad technology, which allows for targeted integration of the CXCR4 gene at a pre-validated genomic locus. This approach ensures consistent and reproducible expression of the CXCR4 receptor across cell populations.\nCXCR4, also known as CD184, is a chemokine receptor that is significant in immune cell trafficking, hematopoiesis, and as a co-receptor for HIV entry into cells. It plays a key role in the migration and homing of hematopoietic stem cells and leukocytes through its interaction with the ligand CXCL12. In oncology, CXCR4 is implicated in various aspects of tumor biology, including growth, metastasis, and angiogenesis. It is often overexpressed in hematological malignancies, where it is associated with therapy resistance and poor prognosis. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101481\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201336173,"sku":"305411L","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_83770518-b4dc-42be-b1e2-41d45cf5af2a.jpg?v=1769068991"},{"product_id":"cho-cxcr4-cell-bhc11101480","title":"CHO-CXCR4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR4-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line expressing the CXCR4 receptor at a medium-high level, approximately 9500 molecules per cell. This cell line was developed using an innovative landing pad technology, which ensures targeted integration of the CXCR4 gene at a pre-validated genomic locus. This approach results in consistent and reliable expression of the CXCR4 receptor, facilitating reproducible experimental outcomes.\nCXCR4, also known as CD184, is a chemokine receptor involved in critical biological processes such as immune cell trafficking, hematopoiesis, and as a co-receptor for HIV entry into cells. The receptor's interaction with its ligand, CXCL12, is essential for the migration and homing of hematopoietic stem cells and leukocytes. In oncology, CXCR4 plays a significant role in tumor growth, metastasis, and angiogenesis, with its expression often upregulated in various cancers, including hematological malignancies. This upregulation is frequently associated with therapy resistance and poor prognosis. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101480\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201368941,"sku":"305411MH","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_c59b25fb-5522-47fa-bcf7-d69f0948ba5d.jpg?v=1769068992"},{"product_id":"cho-cxcr7-cell-bhc11101483","title":"CHO-CXCR7 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR7-Low cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line expressing the CXCR7 receptor at a low level. This cell line was generated using an innovative landing pad technology, allowing for reproducible and precise integration of the CXCR7 gene at a validated genomic locus. CXCR7, also known as ACKR3, is an atypical chemokine receptor involved in various biological processes, including immune modulation and tumor biology. Unlike classical GPCRs, CXCR7 does not signal through G proteins but instead modulates cellular responses by scavenging chemokines, such as CXCL12 and CXCL11, and interacting with CXCR4 through heterodimer formation.\nOverexpression of CXCR7 has been implicated in several cancers, including breast, lung, and prostate, where it is associated with enhanced tumor progression, metastasis, and poor prognosis. CXCR7 contributes to cancer progression by altering the tumor microenvironment, promoting angiogenesis, and facilitating cancer cell migration and invasion. Due to its significant role in cancer biology, CXCR7 is an important target in oncology research. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101483\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201401709,"sku":"305412L","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_b3a66b4e-01a5-49a5-8872-f377dd20cde2.jpg?v=1769068992"},{"product_id":"cho-cxcr7-cell-bhc11101484","title":"CHO-CXCR7 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR7-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CXCR7 receptor at a medium-high level. This cell line was created using an innovative landing pad technology, which allows for targeted integration of the CXCR7 gene at a pre-validated genomic locus, ensuring consistent and reproducible expression. CXCR7, also known as ACKR3, is an atypical chemokine receptor involved in immune modulation and cancer biology. Unlike typical GPCRs, CXCR7 does not signal through G proteins but instead scavenges chemokines such as CXCL12 and CXCL11, and forms heterodimers with CXCR4, influencing processes like tumor progression, metastasis, and angiogenesis.\nCXCR7 is notably overexpressed in various cancers, including breast, lung, and prostate cancers, where it is linked to increased tumor growth, metastasis, and poorer prognosis. This makes the CHO-CXCR7-Medium-high cell line particularly valuable for oncology research, allowing for the study of CXCR7's role in cancer progression and its potential as a therapeutic target. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101484\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201467245,"sku":"305412MH","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_91dc6831-e880-4cbf-af6a-128880547444.jpg?v=1769068992"},{"product_id":"cho-folr1-cell-bhc11101490","title":"CHO-FOLR1 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-FOLR1 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the FOLR1 receptor at a medium-high level, approximately 15,000 molecules per cell. This cell line was developed using advanced landing pad technology, which ensures precise and reproducible integration of the FOLR1 gene at a specific, pre-validated genomic locus. FOLR1, also known as Folate Receptor Alpha (FRα) or FBP, is a GPI-anchored membrane protein with high affinity for folate, facilitating its transport into cells. FOLR1 is significantly overexpressed in various epithelial cancers, including ovarian, breast, and non-small cell lung cancers, making it a valuable target for cancer immunotherapies, including CAR T cell therapies and bispecific antibodies.\nThe expression of FOLR1 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101490\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201500013,"sku":"305416","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_ce503825-70d6-48fa-ba6c-b9e4bdcba60f.jpg?v=1769068993"},{"product_id":"cho-her2-cell-bhc11101486","title":"CHO-HER2 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-HER2-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line that expresses the HER2 receptor at a medium-high level, approximately 13,000 molecules per cell. This cell line was developed using an innovative landing pad technology, ensuring the HER2 gene's targeted integration at a specific, pre-validated genomic locus. HER2, also known as ERBB2 or CD340, is a member of the epidermal growth factor receptor (EGFR) family and plays a critical role in regulating cell growth and differentiation. It is a significant biomarker and target in breast and ovarian cancers, where its overexpression is associated with increased tumor aggressiveness and poorer patient outcomes. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101486\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201565549,"sku":"305413MH","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_135344c6-0bba-49bf-811b-6a1a37905934.jpg?v=1769068993"},{"product_id":"cho-her2-cell-bhc11101487","title":"CHO-HER2 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-HER2-High cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the HER2 receptor at a high level, approximately 85,000 molecules per cell. This cell line was generated using an innovative landing pad technology that ensures the HER2 gene is integrated at a specific, pre-validated genomic locus, allowing for consistent and reliable expression. HER2, also known as ERBB2 or CD340, is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in regulating cell growth and differentiation. It is well-known for its involvement in breast and ovarian cancers, where its overexpression is linked to increased tumor aggressiveness and poorer patient outcomes. HER2 is a key target for cancer therapies such as Trastuzumab (Herceptin) and Pertuzumab (Perjeta). This cell line is versatile, supporting both adherent and suspension culture conditions, with adherent cells exhibiting an epithelial-like morphology. The expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101487\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201598317,"sku":"305413H","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_0417f2de-5b6b-4070-86b4-17db1050ece2.jpg?v=1769068993"},{"product_id":"cho-k1-cell-bhc11100061","title":"CHO-K1 cell","description":"CHO-K1 cells are a subline derived from the CHO cell line, which was originally established in the early 1950s from a Chinese hamster ovary. CHO-K1 cells are widely utilized in the production of therapeutic monoclonal antibodies and other biopharmaceuticals. Their extensive use in biopharmaceutical protein production and vaccines is attributed to their eukaryotic nature, which allows for proper folding, assembly, and post-translational modifications such as glycosylation, which influences the stability, efficacy, and safety of the produced proteins.\nIn the realm of recombinant protein production, the CHO-K1 cell line is used to express a wide array of proteins, including monoclonal antibodies, growth factors, cytokines, and enzymes. These proteins have applications in therapeutic treatments, diagnostic assays, and vaccine formulations.\nCHO-K1 cells exhibit a robust growth rate and are adaptable to various culture conditions, including suspension and adherent cultures, making them highly valuable for large-scale bioproduction processes. They possess a high level of genetic stability and are used for  stable cell line development as they are capable of amplifying and expressing exogenous genes efficiently, which is critical for producing high yields of recombinant proteins.\nCHO-K1 chinese hamster cells can be easily transfected with a variety of vectors for gene expression, facillitating gene editing or knockdown. This flexibility allows researchers to introduce specific genes, silence genes, or even perform targeted gene editing using technologies like CRISPR-Cas9 in CHO-K1 host cells.\nIn conclusion, the chinese hamster CHO-K1 cells and CHO cells are pivotal in biotechnological research and biopharmaceutical production, offering a versatile platform for the study of gene function and the large-scale production of recombinant proteins.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100061\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201631085,"sku":"603480","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-k1-_283_29_1920x1920_81bf2861-9573-4baf-ab8e-9093771c7411.jpg?v=1769068994"},{"product_id":"cho-tacd2-cell-bhc11101489","title":"CHO-TACD2 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-TACD2 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the TACD2 receptor at a medium-high level, approximately 12,600 molecules per cell. This cell line was developed using an innovative landing pad technology, ensuring precise and reproducible integration of the TACD2 gene at a specific, pre-validated genomic locus. TACD2, also known as TROP2 or GA733-1, is a tumor-associated calcium signal transducer. It plays a critical role in intracellular calcium signaling, which is crucial for various cellular processes, including growth, division, and differentiation. Overexpression of TACD2 has been observed in various carcinomas, such as colorectal, gastric, and pancreatic cancers, making it a potential target for antibody-drug conjugates and immunotherapy.\nThe expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101489\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201663853,"sku":"305415","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_4a2150a7-cf98-4472-9860-1f83722db9f1.jpg?v=1769068994"},{"product_id":"ctla4-ig-24-cell-bhc11101283","title":"CTLA4 Ig-24 cell","description":"CTLA4 Ig-24 cells, derived from an adult female Chinese hamster (Cricetulus griseus), are a spontaneously immortalized cell line which have been genetically modified by introducing the human CTLA-4 gene, resulting in the expression of a fusion protein. \nThe fusion protein possesses a dominant attribute of CTLA4Ig, making CTLA4 Ig-24 cells a unique and essential tool in immunology research. CTLA-4, a member of the immunoglobulin superfamily, is primarily expressed in activated T cells and acts as an inhibitory signal transmitter to regulate T cell function. \nIt shares homology with CD28, a T-cell co-stimulatory protein, and both molecules bind to CD80 (B7-1) and CD86 (B7-2) proteins on antigen-presenting cells. CTLA-4 demonstrates a greater affinity and avidity for CD80 and CD86 than CD28, allowing it to outcompete CD28 for binding to these ligands. By doing so, CTLA-4 transmits an inhibitory signal to T cells, while CD28 transmits a stimulatory signal. \nThis intricate regulatory mechanism is pivotal in maintaining immune balance and preventing excessive immune responses. \nInterestingly, CTLA-4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. \nWhen T cells are activated through the T cell receptor (TCR) and CD28, the expression of CTLA-4 increases. Furthermore, CTLA-4 may influence cell motility and signal signalling through the PI3 kinase pathway.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101283\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950202417517,"sku":"305014","price":395.0,"currency_code":"USD","in_stock":true}]},{"product_id":"dan-g-cell-bhc11100221","title":"DAN-G cell","description":"The DAN-G cell line is derived from a human pancreatic carcinoma. It is extensively utilized in research focused on pancreatic cancer, particularly in studies pertaining to tumorigenesis, metastasis, and chemotherapy resistance. The genetic profile of DAN-G includes mutations in key oncogenes and tumor suppressor genes, which are characteristic of pancreatic adenocarcinomas. This makes the cell line a valuable model for understanding the molecular mechanisms underlying pancreatic cancer and for testing new therapeutic strategies.\n\nIn addition to its applications in cancer research, the DAN-G cell line has been used to study the cellular processes involved in the progression of pancreatic ductal adenocarcinoma, including cell cycle regulation, apoptosis, and signal transduction pathways. The cells exhibit aggressive in vitro growth characteristics and have the ability to form tumors in immunocompromised mice, which simulates the human disease and provides an in vivo system for evaluating the efficacy of anticancer drugs. Researchers also employ this cell line to investigate the role of the tumor microenvironment in pancreatic cancer progression and resistance to therapy.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100221\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950202679661,"sku":"300162","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/DAN-G_20P1_2010x01_20140525_ch00_1920x1920_ac915f28-8766-48fd-9bb7-75dfe5338eba.jpg?v=1769069006"},{"product_id":"es-2-cell-bhc11101171","title":"ES-2 cell","description":"The ES-2 cell line is derived from a poorly differentiated ovarian clear cell carcinoma, offering a unique in vitro model to study the biological behaviors and treatment responses of this aggressive cancer subtype. Originally cultured in soft agar, a method favoring the growth of cancer cells while suppressing fibroblast growth, ES-2 cells provide a robust system for analyzing tumor cell interactions and drug resistance mechanisms in a three-dimensional matrix that closely mimics the in vivo environment.\nPharmacologically, ES-2 cells display low to moderate resistance to several chemotherapeutic agents, including doxorubicin, cisplatin, carmustine, etoposide, and cyanomorpholinodoxorubicin (MRA-CN). This resistance profile makes ES-2 an essential tool for oncology research, particularly in the development and testing of new chemotherapeutic regimens and combination therapies. Furthermore, the expression of P-glycoprotein in ES-2 cells is low, which is significant as P-glycoprotein is often implicated in the efflux of drugs from cancer cells, contributing to multidrug resistance. Studying ES-2 cells can therefore provide insights into overcoming drug resistance in ovarian clear cell carcinomas.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101171\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203695469,"sku":"305038","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ES-2_20P1_2020x01_20030723_1920x1920_e745cb60-05f9-4908-92c3-49cdd22fbf1c.jpg?v=1769069017"},{"product_id":"f9-cell-bhc11100633","title":"F9 cell","description":"The F9 cell line, a murine embryonal carcinoma model derived from a testicular teratoma of the C57BL\/6 mice, serves as an important tool in developmental biology and embryology. F9 cells are capable of differentiation into parietal endoderm when exposed to retinoic acid and dibutyryl cyclic AMP (cAMP). This differentiation is marked by significant changes in cellular behavior and protein expression, including the synthesis of plasminogen activator, laminin, and type IV collagen. These proteins are crucial for understanding the processes of tissue development and matrix formation in early embryonic stages.\n\nIt is noted that cAMP's effectiveness in inducing differentiation in F9 cells is conditional upon prior treatment with retinoic acid, indicating a complex interplay between these signaling molecules in triggering developmental pathways. Additionally, F9 cells are characterized by having three copies of the beta 1 integrin gene, which may influence cell adhesion and mobility, further underscoring their utility in studying cell interactions and extracellular matrix composition. Safety profiling of these cells includes testing for ectromelia virus (mousepox), for which they have been found negative, ensuring their suitability for a broad range of experimental applications without the risk of viral contamination.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100633\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203761005,"sku":"400174","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/f9-_282_29_1920x1920_65dbe6f9-ad82-42ca-a0f2-020e82562dbe.jpg?v=1769069018"},{"product_id":"fampac-cell-bhc11100068","title":"FAMPAC cell","description":"The Fampac cell line was established from the primary pancreatic adenocarcinoma of an adult female who had a familial predisposition to pancreatic cancer. These cells are epithelial in nature and have been utilized extensively in research focused on the biological behavior of pancreatic cancer, including studies on tumor progression, metastasis, and therapeutic response. The Fampac cell line is known for its aggressive tumor-forming capability in xenograft models, which makes it valuable for in vivo studies related to drug efficacy and cancer cell biology.\nIn vitro, Fampac cells exhibit characteristics typical of pancreatic adenocarcinoma, including resistance to apoptosis and the ability to proliferate under chemically defined conditions. This resistance to programmed cell death is a critical feature for studies looking to explore new chemotherapeutic agents and their potential to induce cancer cell death. Additionally, Fampac cells have been used to study the molecular mechanisms of pancreatic cancer pathogenesis, offering insights into genetic mutations, signaling pathways involved in cancer proliferation, and interactions with the tumor microenvironment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100068\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203826541,"sku":"300309","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fampac-_282_29_1920x1920_de4ac400-27f0-45d8-9ba4-4c6161b96f1d.jpg?v=1769069021"},{"product_id":"fampac-a-cell-bhc11100044","title":"FAMPAC-A cell","description":"Clonal subline of the pancreas cell line FAMPAC. Established from the primary pancreas adenocarcinoma of a 43- year-old female with a familial prediposition to pancreatic carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100044\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203859309,"sku":"300310","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fampac-a-_282_29_1920x1920_b83c029f-ff40-41b2-ac9c-305b96fc6258.jpg?v=1769069021"},{"product_id":"ftc-133-cell-bhc11101548","title":"FTC-133 cell","description":"FTC-133 is a human follicular thyroid carcinoma cell line derived from a lymph node metastasis. It is widely used to investigate the mechanisms underlying thyroid cancer progression, resistance to therapies, and gene expression changes associated with tumor biology. This cell line has been employed to study treatment responses in differentiated thyroid cancer (DTC) models, especially those linked to drug resistance and apoptosis pathways. Research involving FTC-133 has revealed its sensitivity to various inhibitors targeting DNA damage response pathways, such as the ATR inhibitor BAY 1895344, which can arrest growth, induce apoptosis, and enhance therapeutic outcomes when combined with tyrosine kinase inhibitors.\n\nFTC-133 cells have also been significant in understanding multidrug resistance mechanisms. For example, this cell line demonstrates resistance to doxorubicin, associated with the overexpression of P-glycoprotein (P-gp) and interactions with the CD47 receptor. These factors contribute to reduced drug uptake and diminished apoptosis through pathways involving the JNK signaling cascade. The modulation of these resistance mechanisms has been studied by inhibiting P-gp, which restores sensitivity to doxorubicin. Such findings underscore the role of FTC-133 in exploring targeted therapies and resistance pathways, informing the development of more effective treatment regimens for thyroid cancers.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101548\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204154221,"sku":"305349","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/FTC-133_20WaKo_20P1_2020x01_20210325_ch00_1920x1920_2113c2b5-1cfd-4c1b-b631-6f8a9bf33a5b.jpg?v=1769069025"},{"product_id":"gc-1-spg-cell-bhc11101299","title":"GC-1 spg cell","description":"The GC-1 spg cell line was immortalized through transfection with the pSV3-neo plasmid, which harbors the coding sequences for the SV40 large T antigen and neomycin resistance. This genetic modification not only provides resistance to certain antibiotics but also promotes the continuous growth of the cells by altering their cell cycle regulation, thus bypassing the Hayflick limit typical of primary cells. This process of immortalization allows the cells to maintain proliferative capacity while retaining key phenotypic characteristics of spermatogonia.\n\nPhenotypically, the GC-1 spg cell line exhibits characteristics that are indicative of a transitional stage between type B spermatogonia and primary spermatocytes, making it an especially relevant model for studying the early stages of spermatogenesis. The cells express two testis-specific isoproteins: cytochrome c and lactate dehydrogenase C4. These markers are crucial for studying cell metabolism and energy management during spermatogenesis, reflecting the unique metabolic pathways active in germ cells. The expression of these specific isoproteins underscores the cell line's utility in exploring the biochemical and physiological aspects of testicular cell function and development.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101299\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204219757,"sku":"300375","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/GC-1_20spg_2020x01_2002062023_1920x1920_73ea826e-5ca6-4547-ae06-ac0dbda81164.jpg?v=1769069026"},{"product_id":"h22-cell-bhc11101103","title":"H22 cell","description":"The H22 cell line is a murine hepatocellular carcinoma cell line derived from liver tumor cells. These cells are commonly used in cancer research to study liver cancer mechanisms, therapeutic interventions, and drug efficacy. H22 cells exhibit typical characteristics of hepatocellular carcinoma, including rapid proliferation, resistance to apoptosis, and the ability to form tumors when injected into suitable animal models. This makes them a valuable tool for in vivo studies aiming to understand tumor growth, metastasis, and the tumor microenvironment in liver cancer.\nOne of the significant advantages of the H22 cell line is its use in immunotherapy research. Since the cells are derived from a murine model, they are particularly useful for studying the interactions between cancer cells and the immune system in a controlled environment. Researchers utilize H22 cells to evaluate the efficacy of various immunotherapeutic agents, including checkpoint inhibitors and cancer vaccines. Additionally, H22 cells are employed in the investigation of liver-specific metabolic pathways and the role of genetic mutations in hepatocellular carcinoma progression.\nOverall, the H22 cell line serves as a robust model for hepatocellular carcinoma, providing insights into cancer biology and aiding in the development of novel therapeutic strategies. Its relevance to both in vitro and in vivo studies underscores its importance in the field of cancer research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101103\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204449133,"sku":"305163","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/H22_20WaKo_20P1_2020x01_20091023_ch00_1920x1920_f47a6a4f-6821-4e4b-8eeb-9285fafe14f7.jpg?v=1769069029"},{"product_id":"hec-1-a-cell-bhc11101083","title":"HEC-1-A cell","description":"HEC-1-A cells are a well-characterized human endometrial adenocarcinoma cell line derived from the malignant tissue of a 71-year-old Caucasian woman. This cell line, established in the mid-1970s, is extensively used in gynecological cancer research, particularly for studying endometrial carcinoma.\nMorphologically, HEC-1-A cells are epithelial-like and form a monolayer of polygonal cells when cultured. They exhibit a robust and adherent growth pattern, which is typical of epithelial cells originating from solid tumors. The morphological characteristics of HEC-1-A cells make them a valuable model for studying cellular behaviors that are central to cancer progression, such as adhesion, migration, and invasion.\nGenotypically, HEC-1-A cells harbor several genetic aberrations that are relevant to cancer biology, including mutations in key regulatory genes like p53 and PTEN, both of which are commonly mutated in endometrial cancer. These genetic features contribute to the cells' utility in researching the molecular underpinnings of endometrial carcinogenesis and the cellular pathways leading to tumor growth and resistance to therapy.\nResearch using HEC-1-A cells has significantly advanced our understanding of endometrial cancer, particularly in terms of hormonal influences, genetic mutations, and responses to chemotherapeutic agents. As a result, this cell line continues to be instrumental in developing more effective diagnostic and therapeutic strategies for endometrial carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101083\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205432173,"sku":"305077","price":395.0,"currency_code":"USD","in_stock":true}]},{"product_id":"hec-1-b-cell-bhc11101084","title":"HEC-1-B cell","description":"The HEC-1-B cell line is a human endometrial adenocarcinoma cell line. This line has been utilized extensively in biomedical research related to the study of endometrial cancer, hormone responses, and cancer pharmacology. The cells are known to express estrogen and progesterone receptors, making them a valuable model for studying hormone-related dynamics in endometrial cancer progression and treatment. These cells have been used to investigate the molecular mechanisms of cancer cell proliferation, differentiation, and response to hormonal and chemotherapeutic treatments.\n\nIn terms of morphology, HEC-1-B cells typically exhibit an epithelial-like shape and grow in a monolayer. They are characterized by their high capacity for in vitro proliferation. Genetic studies have revealed several chromosomal alterations which are thought to contribute to the cancerous phenotype of these cells. Research using the HEC-1-B cell line has contributed to a deeper understanding of endometrial carcinogenesis and offers a robust system for testing potential therapeutic agents. This cell line is also commonly employed in studies focusing on cancer cell invasion and metastasis, providing insights into the cellular behaviors that underpin these processes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101084\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205464941,"sku":"305095","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HEC-1-B_20P3_20305095-M_2020x01_20100223_1920x1920_874fbf8f-1944-44fe-ae78-af4309b9b782.jpg?v=1769069041"}],"url":"https:\/\/www.ebiohippo.com\/collections\/rt-metabolic-endocrine-cells.oembed?page=10","provider":"BioHippo","version":"1.0","type":"link"}