{"title":"Cancer Biomarkers — Biochemicals","description":null,"products":[{"product_id":"geldanamycin-bhb11900002","title":"Geldanamycin","description":"\u003cp\u003eGeldanamycin is a benzoquinone ansamycin antibiotic that targets HSP90, disrupting its chaperone function and leading to the degradation of oncogenic and neurotoxic client proteins. While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941039981,"sku":"SIH-111A","price":74.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040964403565,"sku":"SIH-111B","price":228.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-111_Geldanamycin_Chemical_Structure.png?v=1771837629"},{"product_id":"17-gmb-apa-ga-bhb11900006","title":"17-GMB-APA-GA","description":"\u003cp\u003e17-GMB-APA-GA is a synthetic analog of geldanamycin engineered with a maleimido moiety, enabling its use in the development of immunoconjugates. While its primary application has been in targeted cancer therapies, its potential in neuroscience lies in its ability to selectively bind HSP90, a chaperone protein implicated in neurodegenerative disease pathways. By facilitating the targeted delivery of HSP90 inhibitors to specific cell types, 17-GMB-APA-GA may offer a novel strategy for modulating proteostasis in neural tissues. This targeted approach could enhance the clearance of misfolded proteins such as alpha-synuclein and tau, which are central to the pathology of Parkinson’s and Alzheimer’s diseases. Although further research is needed to validate its efficacy in neural models, 17-GMB-APA-GA represents a promising tool for precision medicine in neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941171053,"sku":"SIH-115A","price":231.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-115_17-GMB-APA-GA_Chemical_Structure.png?v=1771837631"},{"product_id":"geldanamycin-fitc-bhb11900004","title":"Geldanamycin: FITC","description":"\u003cp\u003eGeldanamycin is a benzoquinone ansamycin antibiotic that targets HSP90, disrupting its chaperone function and leading to the degradation of oncogenic and neurotoxic client proteins. While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941203821,"sku":"SIH-113A","price":231.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-113_Geldanamycin_FITC_Chemical_Structure.png?v=1771837631"},{"product_id":"tempo-bhb11900020","title":"TEMPO","description":"\u003cp\u003eTEMPO (2,2,6,6-Tetramethylpiperidine 1-oxyl) is a stable nitroxide radical widely used as a spin label and redox probe in biological systems. In neuroscience, TEMPO has been explored for its antioxidant properties and ability to scavenge reactive oxygen species. Its membrane-permeable nature allows it to modulate oxidative stress in neuronal cells, potentially protecting against neurodegeneration. TEMPO derivatives have also been investigated for their role in reducing mitochondrial dysfunction and inflammation, key contributors to neurodegenerative pathology.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"500 mg","offer_id":53040941597037,"sku":"SIH-155-500MG","price":27.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-155_TEMPO_Chemical_Structure.png?v=1771837628"},{"product_id":"hsp70-tkd-peptide-bhb11900009","title":"Hsp70 TKD Peptide","description":"\u003cp\u003eThe Hsp70 TKD peptide is a synthetic fragment derived from the heat shock protein 70 (Hsp70), specifically the amino acid sequence TKDNNLLGRFELSG. In neurodegenerative disease research, Hsp70 and its derivatives are of interest due to their roles in protein folding, stress response, and immune modulation. The TKD peptide has been shown to activate natural killer (NK) cells and enhance immune surveillance, which may be beneficial in clearing damaged or aggregated proteins in neurodegenerative conditions. Its immunomodulatory properties suggest potential for therapeutic strategies aimed at enhancing neuroimmune interactions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040942252397,"sku":"SIH-118A","price":253.0,"currency_code":"USD","in_stock":true}]},{"product_id":"hsp70-tkd-peptide-fitc-bhb11900010","title":"Hsp70 TKD Peptide: FITC","description":"\u003cp\u003eThe Hsp70 TKD peptide is a synthetic fragment derived from the heat shock protein 70 (Hsp70), specifically the amino acid sequence TKDNNLLGRFELSG. In neurodegenerative disease research, Hsp70 and its derivatives are of interest due to their roles in protein folding, stress response, and immune modulation. The TKD peptide has been shown to activate natural killer (NK) cells and enhance immune surveillance, which may be beneficial in clearing damaged or aggregated proteins in neurodegenerative conditions. Its immunomodulatory properties suggest potential for therapeutic strategies aimed at enhancing neuroimmune interactions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040942383469,"sku":"SIH-119A","price":301.0,"currency_code":"USD","in_stock":true}]},{"product_id":"felodipine-bhb11900112","title":"Felodipine","description":"\u003cp\u003eFelodipine is an L-type calcium channel blocker with antihypertensive properties. In neuroscience, it has been shown to attenuate cyclosporine-induced hypertrophy in transplanted hearts and may influence calcium-dependent neuronal signaling. 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Originally developed as an anticancer agent due to its selective affinity for tumor-derived HSP90, 17-AAG has gained attention in neuroscience for its ability to modulate protein degradation pathways. Notably, 17-AAG induces autophagy, a cellular clearance mechanism critical for the removal of misfolded proteins such as alpha-synuclein—an aggregation-prone protein implicated in Parkinson’s disease and other synucleinopathies. By promoting autophagic flux, 17-AAG may help restore proteostasis in neural cells and reduce neurotoxicity associated with protein aggregation. Its dual role in inhibiting Akt signaling and enhancing protein clearance positions 17-AAG as a promising candidate for therapeutic exploration in neurodegenerative disorders characterized by proteotoxic stress.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040942743917,"sku":"SIH-100A","price":125.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040964436333,"sku":"SIH-100-5MG","price":412.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-100_17-AAG_Chemical_Structure.png?v=1771837631"},{"product_id":"actinomycin-d-bhb11900067","title":"Actinomycin D","description":"\u003cp\u003eActinomycin D is a polypeptide antibiotic that inhibits transcription by binding to DNA and preventing RNA polymerase elongation. In neuroscience, it is used to study gene expression regulation, transcriptional responses to stress, and the role of RNA synthesis in neuronal survival and plasticity.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040943268205,"sku":"SIH-245-10MG","price":103.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040964174189,"sku":"SIH-245-50MG","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-245_Actinomycin_D_Chemical_Structure.png?v=1771837629"},{"product_id":"17-dmag-bhb11900005","title":"17-DMAG","description":"\u003cp\u003e17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin) is a water-soluble, bioavailable analog of geldanamycin and 17-AAG, designed to overcome the solubility and toxicity limitations of its predecessors. As a high-affinity HSP90 inhibitor, 17-DMAG disrupts the stability of client proteins involved in neurodegenerative disease pathways. Preclinical studies highlight its ability to induce autophagy and promote the clearance of alpha-synuclein aggregates, a hallmark of Parkinson’s disease and related disorders. Its favorable pharmacokinetic profile, including efficient tissue distribution and reduced metabolic degradation, makes 17-DMAG a compelling candidate for CNS-targeted therapies. By enhancing proteostasis and mitigating protein aggregation, 17-DMAG represents a promising tool for modulating neurodegenerative processes at the molecular chaperone level.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040943366509,"sku":"SIH-114A","price":125.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040963846509,"sku":"SIH-114-5MG","price":412.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-114_17-DMAG_Chemical_Structure.png?v=1771837624"},{"product_id":"difluoromethylornithine-bhb11900029","title":"Difluoromethylornithine","description":"\u003cp\u003eDifluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. While primarily studied for its anti-cancer, anti-parasitic, and anti-angiogenic properties, DFMO has emerging relevance in neurodegenerative disease research. Polyamines are implicated in neuronal growth, differentiation, and synaptic plasticity, but their dysregulation contributes to neurotoxicity and oxidative stress. By modulating polyamine levels, DFMO may help mitigate excitotoxicity and inflammation in neurodegenerative conditions such as Alzheimer's disease and Huntington's disease. Its potential to reduce neuronal apoptosis and modulate neuroinflammation positions DFMO as a candidate for therapeutic intervention in neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040943694189,"sku":"SIH-200-10MG","price":31.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040963092845,"sku":"SIH-200-50MG","price":109.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-200_Difluoromethylornithine_Chemical_Structure.png?v=1771837629"},{"product_id":"cct241161-bhb11900028","title":"CCT241161","description":"\u003cp\u003eCCT241161 is a pan-RAF\/SFK inhibitor targeting BRAF and SRC kinases with high potency. Though its primary application is in oncology, its relevance to neuroscience stems from SRC kinase inhibition, which affects neuronal signaling and plasticity. 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Deguelin's dual role as a therapeutic agent and neurotoxin makes it a compound of interest in neurodegenerative disease research, especially for understanding mitochondrial dysfunction and oxidative stress pathways in dopaminergic neurons.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040944513389,"sku":"SIH-251-10MG","price":183.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040962404717,"sku":"SIH-251-50MG","price":706.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-251_Deguelin_Chemical_Structure.png?v=1771837626"},{"product_id":"bis-bht-bhb11900019","title":"bis-BHT","description":"\u003cp\u003ebis-BHT is a phenolic antioxidant compound known for its ability to neutralize free radicals and inhibit lipid peroxidation. 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GSK690693 is used to explore the role of Akt in neurodegenerative diseases, where its dysregulation contributes to apoptosis and impaired cellular signaling. The compound’s antiproliferative and pro-apoptotic effects make it a valuable tool for studying neurodegeneration and therapeutic strategies targeting the PI3K\/Akt pathway.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040948380013,"sku":"SIH-448-5MG","price":132.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968925549,"sku":"SIH-448-25MG","price":520.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-448_GSK-690693_Hydrochloride_Chemical_Structure.png?v=1771837649"},{"product_id":"k252a-bhb11900239","title":"K252A","description":"\u003cp\u003eK252A is a broad-spectrum protein kinase inhibitor that targets a wide range of kinases, including PKA, PKC, PKG, CaM kinase II, myosin light chain kinase (mlCK), and receptor tyrosine kinases. 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K252A is also used to investigate the role of kinase signaling in neurodegenerative processes and to explore therapeutic strategies targeting kinase dysregulation in the brain.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug","offer_id":53040949231981,"sku":"SIH-455-100UG","price":67.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53040969351533,"sku":"SIH-455-1MG","price":239.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-455_K252A_Chemical_Structure.png?v=1771837648"},{"product_id":"jx-401-bhb11900238","title":"JX 401","description":"\u003cp\u003eJX 401 is a potent and reversible inhibitor of p38α mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses and cellular stress signaling. In neurodegenerative disease research, p38α MAPK is implicated in microglial activation, cytokine production, and neuronal apoptosis. 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