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Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941039981,"sku":"SIH-111A","price":74.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040964403565,"sku":"SIH-111B","price":228.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-111_Geldanamycin_Chemical_Structure.png?v=1771837629"},{"product_id":"ym-01-bhb11900012","title":"YM-01","description":"\u003cp\u003eYM-01 is an allosteric inhibitor of Hsp70 that binds within its nucleotide-binding domain, adjacent to the ATP\/ADP pocket. It disrupts Hsc70-Bag1 interactions and enhances Hsp70 binding to misfolded proteins. 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While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941105517,"sku":"SIH-112A","price":212.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-112_Geldanamycin_Biotin_Chemical_Structure.png?v=1771837626"},{"product_id":"17-gmb-apa-ga-bhb11900006","title":"17-GMB-APA-GA","description":"\u003cp\u003e17-GMB-APA-GA is a synthetic analog of geldanamycin engineered with a maleimido moiety, enabling its use in the development of immunoconjugates. While its primary application has been in targeted cancer therapies, its potential in neuroscience lies in its ability to selectively bind HSP90, a chaperone protein implicated in neurodegenerative disease pathways. By facilitating the targeted delivery of HSP90 inhibitors to specific cell types, 17-GMB-APA-GA may offer a novel strategy for modulating proteostasis in neural tissues. This targeted approach could enhance the clearance of misfolded proteins such as alpha-synuclein and tau, which are central to the pathology of Parkinson’s and Alzheimer’s diseases. 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It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. 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Originally developed as an anticancer agent due to its selective affinity for tumor-derived HSP90, 17-AAG has gained attention in neuroscience for its ability to modulate protein degradation pathways. Notably, 17-AAG induces autophagy, a cellular clearance mechanism critical for the removal of misfolded proteins such as alpha-synuclein—an aggregation-prone protein implicated in Parkinson’s disease and other synucleinopathies. By promoting autophagic flux, 17-AAG may help restore proteostasis in neural cells and reduce neurotoxicity associated with protein aggregation. Its dual role in inhibiting Akt signaling and enhancing protein clearance positions 17-AAG as a promising candidate for therapeutic exploration in neurodegenerative disorders characterized by proteotoxic stress.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040942743917,"sku":"SIH-100A","price":125.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040964436333,"sku":"SIH-100-5MG","price":412.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-100_17-AAG_Chemical_Structure.png?v=1771837631"},{"product_id":"r-gossypol-bhb11900047","title":"R(-)-Gossypol","description":"\u003cp\u003eR(-)-Gossypol is a natural phenolic compound derived from the cotton plant, known for its pro-apoptotic and enzyme-inhibitory properties. 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