{"title":"Protein Quality Control — Biochemicals","description":null,"products":[{"product_id":"j9-bhb11900024","title":"J9","description":"\u003cp\u003eJ9 is a small molecule that enhances glucocorticoid receptor expression, thereby sensitizing T-cell acute lymphoblastic leukemia (T-ALL) cells to dexamethasone. While primarily studied in oncology, its mechanism of modulating steroid receptor pathways may have implications in neuroinflammation and stress-related neural disorders. Glucocorticoid signaling plays a role in brain function and resilience to stress, suggesting that J9 could be explored for its potential to modulate neuroendocrine responses in psychiatric and neurodegenerative conditions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941007213,"sku":"SIH-182-10MG","price":144.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-182_J9_Chemical_Structure.png?v=1771837628"},{"product_id":"ym-01-bhb11900012","title":"YM-01","description":"\u003cp\u003eYM-01 is an allosteric inhibitor of Hsp70 that binds within its nucleotide-binding domain, adjacent to the ATP\/ADP pocket. It disrupts Hsc70-Bag1 interactions and enhances Hsp70 binding to misfolded proteins. In neuroscience, YM-01 has shown efficacy in reducing tau protein levels in cellular and animal models of tauopathy, including Alzheimer's disease. It restores long-term potentiation in brain slices from tau-overexpressing mice, indicating potential for cognitive recovery. YM-01’s dual activity in protein quality control and synaptic function makes it a valuable tool for studying and potentially treating tau-related neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941072749,"sku":"SIH-121-10MG","price":189.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040963715437,"sku":"SIH-121-25MG","price":378.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-121_YM-01_Chemical_Structure.png?v=1771837627"},{"product_id":"geldanamycin-biotin-bhb11900003","title":"Geldanamycin: Biotin","description":"\u003cp\u003eGeldanamycin is a benzoquinone ansamycin antibiotic that targets HSP90, disrupting its chaperone function and leading to the degradation of oncogenic and neurotoxic client proteins. While extensively studied in oncology, geldanamycin has demonstrated neuroprotective effects in models of Parkinson’s disease. It reduces alpha-synuclein toxicity in dopaminergic neurons and destabilizes mutant p53, a protein linked to neuronal apoptosis. Geldanamycin also inhibits c-Jun N-terminal kinase (JNK) signaling and suppresses hypoxia-induced stress responses, both of which are implicated in neurodegeneration. By modulating protein folding, stress signaling, and autophagy, geldanamycin offers a mechanistic framework for targeting neurodegenerative pathways. Despite its therapeutic potential, clinical use is limited by hepatotoxicity and poor solubility, prompting the development of safer analogs such as 17-AAG and 17-DMAG.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941105517,"sku":"SIH-112A","price":212.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-112_Geldanamycin_Biotin_Chemical_Structure.png?v=1771837626"},{"product_id":"fcr1-bhb11900022","title":"FCR1","description":"\u003cp\u003eFCR1 (Flavin Coumarin Redox Sensor 1) is a ratiometric fluorescent probe designed to monitor cellular redox states with high sensitivity. In neuroscience, FCR1 enables real-time visualization of oxidative stress dynamics in neural tissues using fluorescence lifetime imaging microscopy and flow cytometry. Its reversible fluorescence shift upon redox changes allows researchers to track oxidative capacity in neurons and glial cells without interference from background signals. This makes FCR1 a valuable tool for studying neurodegenerative diseases where redox imbalance plays a critical role.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941269357,"sku":"SIH-180-1MG","price":487.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-180_FCR1_Design-of-FCR1.png?v=1771837633"},{"product_id":"cct196969-bhb11900027","title":"CCT196969","description":"\u003cp\u003eCCT196969 is a dual pan-RAF\/SFK inhibitor with potent activity against BRAF and SRC kinases. While primarily developed for melanoma treatment, its inhibition of SRC kinase—a key player in neuronal signaling—suggests potential applications in neuroscience. SRC kinases are involved in synaptic plasticity and neuroinflammation, and their dysregulation is linked to neurodegenerative diseases. CCT196969’s ability to modulate these pathways may offer therapeutic insights into CNS disorders characterized by aberrant kinase activity.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941302125,"sku":"SIH-185-10MG","price":403.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-185_CCT196969_Chemical_Structure.png?v=1771837630"},{"product_id":"npfr1-bhb11900023","title":"NpFR1","description":"\u003cp\u003eNpFR1 (Napthalimide-Flavin Redox Sensor 1) is a highly sensitive fluorescent probe that exhibits a dramatic increase in fluorescence upon oxidation. Its reversible redox behavior allows for dynamic monitoring of oxidative stress in live cells. In neuroscience, NpFR1 is particularly useful for detecting redox fluctuations in neuronal environments, aiding in the study of neurodegenerative conditions such as ALS and Parkinson’s disease. Its high signal-to-noise ratio and responsiveness to mild oxidants make it ideal for tracking oxidative damage in neural tissues.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040941400429,"sku":"SIH-181-1MG","price":487.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-181_NpFR1_Fluorescence_Response.png?v=1771837631"},{"product_id":"sphingosine-bhb11900031","title":"Sphingosine","description":"\u003cp\u003eSphingosine is a bioactive lipid and precursor to ceramide and sphingosine-1-phosphate, both of which are critical regulators of cell fate. In the nervous system, sphingosine modulates signaling pathways involved in neuroinflammation, apoptosis, and synaptic function. It selectively inhibits protein kinase C and calmodulin-dependent enzymes, influencing neurotransmission and neuronal survival. Alterations in sphingolipid metabolism are associated with neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease, making sphingosine a molecule of interest in neurobiology.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"25 mg","offer_id":53040941433197,"sku":"SIH-202-25MG","price":105.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53040966271341,"sku":"SIH-202-100MG","price":312.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-202_Sphingosine_Chemical_Structure.png?v=1771837630"},{"product_id":"herbimycin-a-bhb11900007","title":"Herbimycin A","description":"\u003cp\u003eHerbimycin A is a benzoquinoid ansamycin antibiotic known for its irreversible inhibition of tyrosine kinases through thiol group interaction. While predominantly studied in oncology, Herbimycin A’s ability to modulate kinase signaling cascades positions it as a candidate for neurodegenerative disease research. Tyrosine kinases play critical roles in neuronal survival, synaptic plasticity, and neuroinflammation. By inhibiting kinases such as Src and Abl, Herbimycin A may help attenuate aberrant signaling associated with neurodegenerative conditions. Its potential to influence phospholipase C activity and downstream pathways further supports its relevance in neuroscience, particularly in the context of cellular stress responses and neuroprotection.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug","offer_id":53040941564269,"sku":"SIH-116A","price":170.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53040963584365,"sku":"SIH-116B","price":941.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-116_Herbimycin_A_Chemical_Structure.png?v=1771837629"},{"product_id":"andrographolide-bhb11900044","title":"Andrographolide","description":"\u003cp\u003eAndrographolide is a labdane diterpenoid derived from Andrographis paniculata, known for its anti-inflammatory and immunomodulatory effects. In neuroscience, it has been investigated for its ability to inhibit T-cell proliferation and macrophage chemotaxis, processes implicated in neuroinflammation. These properties suggest potential utility in modulating immune responses in neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 mg","offer_id":53040941760877,"sku":"SIH-220-100MG","price":40.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":53040964927853,"sku":"SIH-220-500MG","price":159.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-220_Andrographolide_Chemical_Structure.png?v=1771837635"},{"product_id":"vu0467154-bhb11900026","title":"VU0467154","description":"\u003cp\u003eVU0467154 is an allosteric activator of the M4 muscarinic acetylcholine receptor, offering a novel approach to treating psychotic symptoms in schizophrenia and other neuropsychiatric disorders. In preclinical models, it reverses stimulant-induced behavioral deficits and enhances associative learning and memory. Its ability to modulate cholinergic signaling positions it as a promising candidate for cognitive enhancement and therapeutic intervention in disorders involving impaired synaptic plasticity and neurotransmission, such as Alzheimer’s disease and schizophrenia.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941793645,"sku":"SIH-184-10MG","price":235.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-184_VUO467154_Chemical_Structure.png?v=1771837634"},{"product_id":"irinotecan-hcl-bhb11900065","title":"Irinotecan HCl","description":"\u003cp\u003eIrinotecan is a semisynthetic analogue of camptothecin that inhibits topoisomerase I. It is converted to its active metabolite SN-38, which interferes with DNA replication and transcription. In neurobiology, irinotecan is used to study DNA damage responses and has potential applications in understanding neuronal vulnerability to genotoxic stress.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"50 mg","offer_id":53040941924717,"sku":"SIH-243-50MG","price":116.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":53040962470253,"sku":"SIH-243-250MG","price":423.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-243_Irinotecan_HCl_Chemical_Structure.png?v=1771837626"},{"product_id":"hsp70-tkd-peptide-fitc-bhb11900010","title":"Hsp70 TKD Peptide: FITC","description":"\u003cp\u003eThe Hsp70 TKD peptide is a synthetic fragment derived from the heat shock protein 70 (Hsp70), specifically the amino acid sequence TKDNNLLGRFELSG. In neurodegenerative disease research, Hsp70 and its derivatives are of interest due to their roles in protein folding, stress response, and immune modulation. The TKD peptide has been shown to activate natural killer (NK) cells and enhance immune surveillance, which may be beneficial in clearing damaged or aggregated proteins in neurodegenerative conditions. Its immunomodulatory properties suggest potential for therapeutic strategies aimed at enhancing neuroimmune interactions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040942383469,"sku":"SIH-119A","price":301.0,"currency_code":"USD","in_stock":true}]},{"product_id":"edaravone-bhb11900017","title":"Edaravone","description":"\u003cp\u003eEdaravone is a free radical scavenger and antioxidant that has demonstrated neuroprotective effects in models of ischemic stroke and neurodegeneration. It mitigates oxidative stress by inhibiting lipid peroxidation and the lipoxygenase pathway, thereby preserving neuronal integrity. Edaravone has been shown to protect dopaminergic neurons from MPTP-induced neurotoxicity, a model of Parkinson’s disease. Its ability to cross the blood-brain barrier and reduce reactive oxygen species makes it a valuable agent in the treatment of neurodegenerative conditions characterized by oxidative damage and mitochondrial dysfunction.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"50 mg","offer_id":53040942481773,"sku":"SIH-152-50MG","price":93.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":53040965943661,"sku":"SIH-152-250MG","price":352.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-152_Edaravone_Chemical_Structure.png?v=1771837631"},{"product_id":"r-gossypol-bhb11900047","title":"R(-)-Gossypol","description":"\u003cp\u003eR(-)-Gossypol is a natural phenolic compound derived from the cotton plant, known for its pro-apoptotic and enzyme-inhibitory properties. In neuroscience, it has been studied for its ability to modulate apoptotic pathways through regulation of Bcl-2 family proteins and inhibition of calcineurin. These mechanisms are relevant to neurodegenerative diseases characterized by dysregulated cell death and calcium signaling.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040942776685,"sku":"SIH-223-10MG","price":148.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040963879277,"sku":"SIH-223-50MG","price":583.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-223_R-Gossypol_Chemical_Structure.png?v=1771837637"},{"product_id":"forskolin-bhb11900037","title":"Forskolin","description":"\u003cp\u003eForskolin is a diterpene that activates adenylate cyclase, leading to increased intracellular cAMP levels. In neurodegenerative disease research, forskolin is widely used to modulate synaptic plasticity, memory formation, and neuroprotection. Its role in enhancing cAMP signaling makes it a key compound in studies of learning, long-term potentiation, and neuropsychiatric disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040942874989,"sku":"SIH-208-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040964141421,"sku":"SIH-208-50MG","price":171.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-208_Forskolin_Chemical_Structure.png?v=1771837630"},{"product_id":"valinomycin-bhb11900054","title":"Valinomycin","description":"\u003cp\u003eValinomycin is a potassium-selective ionophore that facilitates the transport of K+ ions across lipid membranes. It is used in neuroscience to study membrane potential, ion homeostasis, and mitochondrial function. Valinomycin-induced changes in potassium gradients can influence neuronal excitability and apoptosis, making it a useful tool in neurodegenerative disease models.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040942940525,"sku":"SIH-230-10MG","price":49.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040964501869,"sku":"SIH-230-50MG","price":164.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-230_Valinomycin_Chemical_Structure.png?v=1771837629"},{"product_id":"cytochalasin-d-bhb11900063","title":"Cytochalasin D","description":"\u003cp\u003eCytochalasin D binds to actin filaments and inhibits their polymerization and elongation, leading to changes in cellular morphology and apoptosis. In neuroscience, it is widely used to study cytoskeletal dynamics, synaptic plasticity, and neuronal migration. Its ability to disrupt actin networks makes it a powerful agent for probing the role of the cytoskeleton in neurodevelopment and neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040943235437,"sku":"SIH-241-1MG","price":92.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040963551597,"sku":"SIH-241-5MG","price":360.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-241_Cytochalasin_D_Chemical_Structure.png?v=1771837624"},{"product_id":"cyclosporine-bhb11900030","title":"Cyclosporine","description":"\u003cp\u003eCyclosporine A is a cyclic peptide immunosuppressant that inhibits calcineurin, thereby preventing the activation of NF-AT and downstream T-cell responses. In neuroscience, cyclosporine has been investigated for its neuroprotective effects, particularly in models of traumatic brain injury, stroke, and neurodegenerative diseases. By inhibiting mitochondrial permeability transition pore (mPTP) opening, cyclosporine helps preserve mitochondrial integrity and prevent apoptosis in neurons. Its ability to modulate calcium signaling and reduce oxidative stress makes it a promising agent for protecting neural tissue under pathological conditions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"25 mg","offer_id":53040943432045,"sku":"SIH-201-25MG","price":125.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53040965091693,"sku":"SIH-201-100MG","price":366.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-201_Cyclosporine_Chemical_Structure.png?v=1771837626"},{"product_id":"etoposide-bhb11900066","title":"Etoposide","description":"\u003cp\u003eEtoposide is a topoisomerase II inhibitor that induces DNA strand breaks by preventing the re-ligation of cleaved DNA. This mechanism leads to apoptosis, making etoposide a useful tool in studying DNA damage pathways in neurons. It is also used in models of neurotoxicity and to investigate the role of DNA repair in neurodegenerative conditions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 mg","offer_id":53040943661421,"sku":"SIH-244-100MG","price":57.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":53040964239725,"sku":"SIH-244-500MG","price":187.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-244_Etoposide_Chemical_Structure.png?v=1771837628"},{"product_id":"radicicol-bhb11900008","title":"Radicicol","description":"\u003cp\u003eRadicicol is a macrocyclic antifungal compound that functions as a potent inhibitor of HSP90, a molecular chaperone involved in protein folding and stability. In neuroscience, Radicicol’s ability to bind HSP90 and disrupt its interaction with client proteins offers a mechanism for modulating neurodegenerative disease pathways. It selectively depletes kinases such as Raf and inhibits src-like kinases, contributing to the regulation of cellular stress responses and apoptosis. Radicicol also exhibits anti-angiogenic properties and induces morphological reversion in transformed cells, which may be relevant in neuro-oncology. Its strong binding affinity to HSP90 across species, including yeast and bacterial homologs, underscores its utility in translational research models. By targeting chaperone-mediated proteostasis, Radicicol holds promise for therapeutic intervention in disorders characterized by protein misfolding and aggregation.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040944087405,"sku":"SIH-117A","price":141.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-117_Radicicol_Chemical_Structure.png?v=1771837632"},{"product_id":"camptothecin-bhb11900064","title":"Camptothecin","description":"\u003cp\u003eCamptothecin is a cytotoxic quinoline alkaloid that inhibits topoisomerase I, stabilizing the DNA-topoisomerase complex and preventing DNA re-ligation. This leads to DNA damage and apoptosis. In neuroscience, camptothecin is used to model DNA damage-induced neuronal death and to explore mechanisms of genomic instability in neurodegenerative diseases.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 mg","offer_id":53040944382317,"sku":"SIH-242-100MG","price":43.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":53040962634093,"sku":"SIH-242-1G","price":287.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-242_Camptothecin_Chemical_Structure.png?v=1771837631"},{"product_id":"tpen-bhb11900055","title":"TPEN","description":"\u003cp\u003eTPEN is a high-affinity chelator of transition metals such as zinc and iron. In neuroscience, TPEN is used to investigate the role of metal ions in oxidative stress, synaptic signaling, and neurotoxicity. Its ability to modulate intracellular metal levels makes it a valuable agent for studying metal dyshomeostasis in neurodegenerative disorders like Alzheimer's and Parkinson's disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 mg","offer_id":53040944709997,"sku":"SIH-231-100MG","price":105.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":53040966566253,"sku":"SIH-231-500MG","price":411.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-231_TPEN_Chemical_Structure.png?v=1771837632"},{"product_id":"mitomycin-c-bhb11900068","title":"Mitomycin C","description":"\u003cp\u003eMitomycin C is a DNA crosslinking agent that undergoes reductive activation followed by sequence-specific alkylation. It is used in neuroscience to induce DNA damage and study cellular responses such as apoptosis and repair mechanisms. Its potent genotoxic effects make it a valuable compound for modeling neurodegenerative processes involving DNA integrity.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040944775533,"sku":"SIH-246-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040966074733,"sku":"SIH-246-50MG","price":315.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-246_Mitomycin_C_Chemical_Structure.png?v=1771837628"},{"product_id":"epothilone-b-bhb11900060","title":"Epothilone B","description":"\u003cp\u003eEpothilone B is a microtubule-stabilizing agent that promotes tubulin polymerization and inhibits cell division. In neuroscience, it is recognized for its neurotrophic properties, including the promotion of axonal regeneration and stabilization of microtubules in models of neurodegeneration. Epothilone B is being explored as a therapeutic candidate for diseases such as Alzheimer's, where microtubule destabilization contributes to neuronal dysfunction.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040945004909,"sku":"SIH-238-1MG","price":98.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040963322221,"sku":"SIH-238-5MG","price":401.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-238_Epothilone_B_Chemical_Structure.png?v=1771837635"},{"product_id":"deprenyl-bhb11900038","title":"Deprenyl","description":"\u003cp\u003eDeprenyl (Selegiline) is a selective, irreversible monoamine oxidase B (MAO-B) inhibitor. It is clinically used in the treatment of early-stage Parkinson’s disease and has neuroprotective properties. Deprenyl enhances dopaminergic transmission and reduces oxidative stress, making it a cornerstone in neurodegenerative disease therapeutics.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 mg","offer_id":53040945856877,"sku":"SIH-209-100MG","price":57.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":53040964338029,"sku":"SIH-209-1G","price":161.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-209_Deprenyl_Chemical_Structure.png?v=1771837630"},{"product_id":"iox1-bhb11900165","title":"IOX1","description":"\u003cp\u003eIOX1 is a broad-spectrum inhibitor of 2-oxoglutarate-dependent dioxygenases, including histone demethylases. In neuroscience, IOX1 is used to investigate epigenetic regulation of gene expression in neuronal cells. Epigenetic modifications play a crucial role in neurodevelopment, synaptic plasticity, and the pathogenesis of neurodegenerative diseases. By inhibiting histone demethylation, IOX1 alters chromatin structure and transcriptional activity, providing insights into the molecular mechanisms underlying memory formation, neuroinflammation, and neuronal survival. Its utility in epigenetic studies makes it a valuable tool for exploring therapeutic strategies targeting chromatin remodeling in the brain.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040946086253,"sku":"SIH-377-5MG","price":93.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040967319917,"sku":"SIH-377-25MG","price":389.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-377_IOX1_Chemical_Structure.png?v=1771837642"},{"product_id":"thiolutin-bhb11900163","title":"Thiolutin","description":"\u003cp\u003eThiolutin is a sulfur-containing antibiotic that inhibits RNA polymerases and has been shown to block transcription initiation. In neuroscience, it is used to study transcriptional regulation and stress responses in neurons. Thiolutin also exhibits antioxidant properties and can modulate proteasome activity, making it relevant in models of oxidative stress and protein aggregation. These features are particularly important in neurodegenerative diseases where transcriptional dysregulation and oxidative damage contribute to neuronal loss.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"1 mg","offer_id":53040946577773,"sku":"SIH-375-1MG","price":110.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53040966926701,"sku":"SIH-375-5MG","price":447.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-375_Thiolutin_Chemical_Structure.png?v=1771837644"},{"product_id":"d-ap5-bhb11900198","title":"D-AP5","description":"\u003cp\u003eD-AP5 (D-(-)-2-Amino-5-phosphonopentanoic acid) is a selective, competitive antagonist of the NMDA receptor, specifically targeting the glutamate binding site. NMDA receptors are critical for synaptic plasticity, learning, and memory, but their overactivation leads to excitotoxicity—a key contributor to neuronal death in neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. D-AP5 is widely used in neuroscience to investigate NMDA receptor-mediated signaling, synaptic transmission, and neuroprotection. By blocking excitotoxic calcium influx, D-AP5 serves as a valuable tool for studying mechanisms of neuronal injury and for developing therapeutic strategies aimed at modulating glutamatergic dysfunction in the CNS.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040946938221,"sku":"SIH-411-5MG","price":109.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040967778669,"sku":"SIH-411-25MG","price":436.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-411_DAP5_Chemical_Structure.png?v=1771837644"},{"product_id":"aal-993-bhb11900210","title":"AAL-993","description":"\u003cp\u003eAAL-993 is a very potent inhibitor of VEGFR-1, VEGFR-2 and VEGFR-3, as well as PDGFR-β, c-Kit and CSF-1R at higher concentrations.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040947036525,"sku":"SIH-424-5MG","price":155.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040967745901,"sku":"SIH-424-25MG","price":624.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-424_AAL-993_Chemical_Structure.png?v=1771837649"},{"product_id":"6bio-bhb11900208","title":"6BIO","description":"\u003cp\u003e6BIO is a potent, reversible, and ATP-competitive inhibitor of glycogen synthase kinase-3α\/β (GSK-3α\/β), as well as an inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Its ability to modulate the Wnt signaling pathway has made it a valuable tool in stem cell biology, particularly for maintaining self-renewal and pluripotency in embryonic stem cells. Although its primary applications have been in developmental biology and cancer research, emerging evidence suggests that GSK-3 inhibition may have neuroprotective effects. In the context of neurodegenerative diseases, 6BIO’s modulation of GSK-3 activity could influence tau phosphorylation and amyloid precursor protein processing, both of which are implicated in Alzheimer’s disease. This positions 6BIO as a compound of growing interest in neuroscience, particularly for its potential to modulate key signaling pathways involved in neuronal survival and plasticity.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040947265901,"sku":"SIH-422-5MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968532333,"sku":"SIH-422-25MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-422_6BIO_Chemical_Structure.png?v=1771837646"},{"product_id":"d-lap5-bhb11900200","title":"D-LAP5","description":"\u003cp\u003eD-LAP5 (D-2-Amino-5-phosphonopentanoic acid) is a competitive antagonist of NMDA receptors, specifically targeting the glutamate binding site. It is used extensively in neuroscience research to investigate excitotoxicity, synaptic transmission, and neuroprotection. NMDA receptor overactivation is a hallmark of several neurodegenerative diseases, and D-LAP5 helps elucidate the role of glutamatergic signaling in neuronal injury. Its application in electrophysiological and behavioral studies provides insights into learning, memory, and neurodegenerative mechanisms.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040947462509,"sku":"SIH-413-10MG","price":74.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040968171885,"sku":"SIH-413-50MG","price":298.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-413_DLAP5_Chemical_Structure.png?v=1771837645"},{"product_id":"lenalidomide-bhb11900197","title":"Lenalidomide","description":"\u003cp\u003eLenalidomide is an immunomodulatory and anti-inflammatory agent known for its ability to modulate cytokine production and enhance T-cell and natural killer cell activity. In neuroscience, lenalidomide is investigated for its neuroprotective effects in models of neurodegeneration and brain injury. It reduces neuroinflammation and promotes neuronal survival, making it a candidate for therapeutic intervention in diseases such as Alzheimer's and Parkinson's. Lenalidomide’s influence on immune signaling and neurotrophic factors contributes to its potential in modulating neurodegenerative processes and improving cognitive outcomes.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040947495277,"sku":"SIH-410-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040967647597,"sku":"SIH-410-50MG","price":258.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-410_Lenalidomide_Chemical_Structure.png?v=1771837646"},{"product_id":"ag490-bhb11900214","title":"AG490","description":"\u003cp\u003eAG490 is a selective inhibitor of JAK2\/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a\/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040947528045,"sku":"SIH-428-5MG","price":68.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968073581,"sku":"SIH-428-25MG","price":223.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-428_AG-490_Chemical_Structure.png?v=1771837647"},{"product_id":"flupirtine-maleate-bhb11900164","title":"Flupirtine maleate","description":"\u003cp\u003eFlupirtine maleate is a non-opioid analgesic with neuroprotective properties, acting as a selective neuronal potassium channel opener and NMDA receptor antagonist. In neurodegenerative disease research, flupirtine has been shown to reduce excitotoxicity, oxidative stress, and apoptosis in neuronal cells. It enhances mitochondrial function and supports neuronal survival, making it a candidate for therapeutic intervention in conditions such as Alzheimer’s and Parkinson’s disease. Its dual action on pain modulation and neuroprotection underscores its relevance in neuroscience.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040947659117,"sku":"SIH-376-10MG","price":111.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040966992237,"sku":"SIH-376-50MG","price":436.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-376_Flupirtine_maleate_Chemical_Structure.png?v=1771837641"},{"product_id":"3-methyladenine-bhb11900196","title":"3-Methyladenine","description":"\u003cp\u003e3-Methyladenine (3-MA) is a widely used inhibitor of phosphatidylinositol 3-kinase (PI3K), effectively blocking autophagy by preventing autophagosome formation. In neuroscience and neurodegenerative disease research, 3-MA serves as a critical tool for dissecting the role of autophagy in neuronal survival and death. Dysregulated autophagy is a hallmark of several neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s diseases. By modulating autophagic flux, 3-MA enables researchers to explore therapeutic strategies aimed at restoring cellular homeostasis and preventing neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"20 mg","offer_id":53040947691885,"sku":"SIH-408-20MG","price":68.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53040968008045,"sku":"SIH-408-100MG","price":246.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-408_3-Methyladenine_Chemical_Structure.png?v=1771837644"},{"product_id":"a83-01-bhb11900209","title":"A83-01","description":"\u003cp\u003eA83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase. It blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A83-01 also inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040948085101,"sku":"SIH-423-5MG","price":94.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968204653,"sku":"SIH-423-25MG","price":372.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-423_A83-01_Chemical_Structure.png?v=1771837646"},{"product_id":"gw2580-bhb11900233","title":"GW2580","description":"\u003cp\u003eGW2580 is a potent and selective ATP-competitive inhibitor of cFMS kinase, the receptor for macrophage colony-stimulating factor (M-CSF\/CSF-1). In neurodegenerative disease research, GW2580 is used to study microglial activation and neuroinflammation, as CSF-1 signaling regulates immune cell proliferation and survival in the brain. By inhibiting cFMS, GW2580 helps elucidate the role of microglia in neurodegeneration and supports the development of anti-inflammatory therapies for conditions such as Alzheimer’s and multiple sclerosis.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040948150637,"sku":"SIH-449-5MG","price":77.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040969679213,"sku":"SIH-449-25MG","price":315.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-449_GW2580_Chemical_Structure.png?v=1771837646"},{"product_id":"imatinib-mesylate-bhb11900237","title":"Imatinib mesylate","description":"\u003cp\u003eImatinib Mesylate is a tyrosine kinase inhibitor that selectively targets Bcr-Abl, c-Kit, and platelet-derived growth factor receptors (PDGFR). While primarily used in oncology, Imatinib has gained interest in neuroscience for its potential to modulate neuroinflammatory and neurodegenerative pathways. PDGFR signaling is involved in blood-brain barrier integrity, glial activation, and neuronal survival. Inhibition of PDGFR by Imatinib may reduce neuroinflammation and protect against neuronal damage in models of stroke, multiple sclerosis, and Alzheimer's disease. Its ability to cross the blood-brain barrier and influence kinase-driven signaling cascades makes it a valuable tool for exploring therapeutic strategies in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"20 mg","offer_id":53040948216173,"sku":"SIH-453-20MG","price":63.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53040969056621,"sku":"SIH-453-100MG","price":171.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-453_Imatinib_mesylate_Chemical_Structure.png?v=1771837653"},{"product_id":"ag-1296-bhb11900212","title":"AG-1296","description":"\u003cp\u003eAG-1296 is a potent, cell-permeable inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase, a key regulator of cellular proliferation, survival, and migration. While originally developed for oncology and vascular biology, AG-1296 has gained attention in neuroscience for its potential role in modulating neuroinflammation and glial cell activation—processes central to the progression of neurodegenerative diseases.\u003c\/p\u003e \u003cp\u003ePDGFR signaling is involved in the regulation of astrocytes and microglia, the primary immune cells of the central nervous system. Dysregulated PDGF signaling has been implicated in neuroinflammatory responses, blood-brain barrier dysfunction, and abnormal neuronal-glial interactions. By selectively inhibiting PDGFR, AG-1296 may attenuate these pathological processes, offering a mechanistic approach to reducing neuroinflammation and promoting neural tissue stability.\u003c\/p\u003e \u003cp\u003eAdditionally, PDGF pathways are involved in neural development and repair, suggesting that AG-1296 could be used to study regenerative mechanisms in the brain. Its ability to penetrate cells and selectively block receptor activity makes it a valuable tool for dissecting the role of tyrosine kinase signaling in neurodegeneration, particularly in conditions such as Alzheimer’s disease, multiple sclerosis, and gliosis-related disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040948412781,"sku":"SIH-426-5MG","price":109.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040967614829,"sku":"SIH-426-25MG","price":452.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-426_AG-1296_Chemical_Structure.png?v=1771837646"},{"product_id":"kt5720-bhb11900241","title":"KT5720","description":"\u003cp\u003eKT5720 is a potent and selective inhibitor of protein kinase A (PKA), acting through competitive inhibition. It does not significantly affect PKC, PKG, or mlCK, making it a valuable tool for studying PKA-specific signaling pathways. In neuroscience, KT5720 is used to investigate the role of PKA in synaptic plasticity, memory formation, and neuronal survival. It is also employed in studies of cell cycle regulation and neuroprotection, particularly in models of neurodegenerative disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug","offer_id":53040948576621,"sku":"SIH-457-100UG","price":144.0,"currency_code":"USD","in_stock":true},{"title":"500 ug","offer_id":53040969285997,"sku":"SIH-457-500UG","price":515.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-457_KT-5720_Chemical_Structure.png?v=1771837647"},{"product_id":"dasatinib-bhb11900224","title":"Dasatinib","description":"\u003cp\u003eDasatinib is a dual Src and Abl kinase inhibitor with significantly greater potency against BCR-ABL than imatinib. In neuroscience, Src family kinases are involved in synaptic signaling, neuroinflammation, and blood-brain barrier integrity. Dasatinib is used to investigate the role of tyrosine kinase signaling in neurodegenerative diseases and has shown potential in modulating microglial activation and reducing neuroinflammatory responses. Its ability to cross the blood-brain barrier and inhibit multiple kinases makes it a promising candidate for repurposing in neurodegenerative and neuroinflammatory conditions.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040948838765,"sku":"SIH-440-5MG","price":70.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040968368493,"sku":"SIH-440-25MG","price":137.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-440_Dasatinib_Chemical_Structure.png?v=1771837647"},{"product_id":"k252b-bhb11900240","title":"K252B","description":"\u003cp\u003eK252B is a non-selective protein kinase inhibitor that targets CaMKII, MYLK, PKA, PKC, and cGKI by binding to the ATP-binding domain of these kinases. It is cell-permeable and used in neuroscience to study the regulation of intracellular signaling pathways involved in synaptic transmission, plasticity, and neuronal survival. K252B is particularly useful in dissecting the roles of calcium\/calmodulin-dependent kinases and cyclic nucleotide-dependent kinases in neurodevelopment and neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug","offer_id":53040948937069,"sku":"SIH-456-100UG","price":120.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53040969253229,"sku":"SIH-456-1MG","price":515.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-456_K252B_Chemical_Structure.png?v=1771837647"},{"product_id":"quisqualic-acid-bhb11900204","title":"Quisqualic Acid","description":"\u003cp\u003eQuisqualic acid is a potent agonist of AMPA and metabotropic glutamate receptors, used to induce excitotoxicity in experimental models. In neuroscience, it is employed to study glutamate-mediated neuronal injury, synaptic transmission, and neurodegeneration. Quisqualic acid triggers calcium influx and oxidative stress, mimicking pathological conditions observed in stroke and neurodegenerative diseases. Its application helps elucidate the role of glutamatergic signaling in neuronal survival and the development of excitotoxic damage. Quisqualic acid is instrumental in evaluating neuroprotective agents and understanding excitatory neurotransmission in the brain.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040949166445,"sku":"SIH-418-10MG","price":194.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040968499565,"sku":"SIH-418-50MG","price":778.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-418_Quisqualic_Acid_Chemical_Structure.png?v=1771837646"},{"product_id":"src-i1-bhb11900261","title":"Src I1","description":"\u003cp\u003eSrc I1 is a potent and competitive dual-site inhibitor of Src family kinases, including Src and Lck, as well as VEGFR2 and c-Fms. In neuroscience, Src I1 is used to study the role of Src kinases in synaptic signaling, neuroinflammation, and neuronal survival. Src signaling is implicated in neurodegenerative diseases such as Alzheimer's and ALS, where it contributes to excitotoxicity and glial activation. Src I1 is cell-permeable and has been shown to induce apoptosis, making it a useful compound for exploring kinase-targeted neuroprotective strategies.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040949264749,"sku":"SIH-478-5MG","price":68.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970105197,"sku":"SIH-478-25MG","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-478_Src-I1_Chemical_Structure.png?v=1771837650"},{"product_id":"bml-259-bhb11900219","title":"Bml 259","description":"\u003cp\u003eBml 259 is a potent inhibitor of cyclin-dependent kinase 5 (Cdk5)\/p25, with additional inhibitory activity against Cdk2\/cyclin E. Cdk5 is a critical regulator of neuronal development, synaptic function, and neurodegeneration. Aberrant activation of Cdk5, particularly through its association with p25, has been implicated in tau hyperphosphorylation and neuronal death in Alzheimer’s disease. Bml 259 is used in neuroscience to explore the pathological role of Cdk5\/p25 signaling and to evaluate neuroprotective strategies targeting kinase dysregulation.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040949363053,"sku":"SIH-435-5MG","price":80.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040969843053,"sku":"SIH-435-25MG","price":303.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-435_BML-259_Chemical_Structure.png?v=1771837646"},{"product_id":"sto-609-bhb11900262","title":"STO 609","description":"\u003cp\u003eSTO 609 is a potent, competitive, and selective inhibitor of Ca²⁺\/calmodulin-dependent protein kinase kinase (CaM-KK). It binds to the catalytic domain of CaMKK and inhibits its autophosphorylation. In neurodegenerative disease research, STO 609 is used to investigate calcium signaling pathways involved in neuronal plasticity, metabolism, and survival. CaMKK signaling is implicated in neuroinflammation and neurodegeneration, making STO 609 a valuable tool for dissecting calcium-dependent regulatory mechanisms in the brain. It is cell-permeable and widely used in both in vitro and in vivo models.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040949920109,"sku":"SIH-479-5MG","price":89.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040969613677,"sku":"SIH-479-25MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-479_STO-609_Chemical_Structure.png?v=1771837651"},{"product_id":"lh-846-bhb11900286","title":"LH 846","description":"\u003cp\u003eLH 846 is a selective inhibitor of Casein Kinase 1 delta (CK1δ), a key regulator of circadian rhythm and PER1 protein stability. CK1δ has been implicated in neurodegenerative diseases such as Alzheimer’s, where circadian disruption and abnormal protein phosphorylation are common. By modulating CK1δ activity, LH 846 offers a valuable tool for exploring the links between circadian regulation, neurodegeneration, and cognitive decline.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040950870381,"sku":"SIH-503-5MG","price":79.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970465645,"sku":"SIH-503-25MG","price":320.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-503_LH-846_Chemical_Structure.png?v=1771837656"},{"product_id":"potassium-iodide-bhb20400321","title":"Potassium iodide","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003ePotassium iodide\u003c\/strong\u003e (CAS 7681-11-0) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e7681-11-0\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eIK\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e166.01 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003e(K+).(I-)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003ePotassium iodide is used as the treatment of overactive thyroid and as protection of the thyroid gland from the influences of radiation from swallowed or inhaled radioactive iodine. It may be used after accidental exposure to radioactive iodine or before and after administration of medicine containing radioactive iodine.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e Tyrosinase\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e Proteases\/Proteasome\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"50 mg","offer_id":53327158673773,"sku":"T0357-50MG","price":29.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327428977005,"sku":"T0357-1MLX10MM","price":39.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEWZGsD-ENwfJAAAAAJmAWNs113.jpg?v=1778721988"},{"product_id":"brd-6929-bhb20401325","title":"BRD-6929","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eBRD-6929\u003c\/strong\u003e (CAS 849234-64-6) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e849234-64-6\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC19H17N3O2S\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e351.42 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eN(C(=O)C1=CC=C(NC(C)=O)C=C1)C=2C=C(C=CC2N)C3=CC=CS3\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eBRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: ?1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) (2). BRD-6929 potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1. BRD-6929 can be used for mood-related behavioral model research(3).\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e HIV Protease, HDAC\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e Proteases\/Proteasome, Chromatin\/Epigenetic, DNA Damage\/DNA Repair, Microbiology\/Virology\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"5 mg","offer_id":53327160017261,"sku":"T10603-5MG","price":43.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327459909997,"sku":"T10603-1MLX10MM","price":47.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327459942765,"sku":"T10603-10MG","price":83.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327459975533,"sku":"T10603-25MG","price":178.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327460008301,"sku":"T10603-50MG","price":322.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327460041069,"sku":"T10603-100MG","price":465.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":53327460073837,"sku":"T10603-200MG","price":653.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEGayKXuEXDP8AAAAALOfxnY033.png?v=1778721988"},{"product_id":"ebselen-bhb20400646","title":"Ebselen","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eEbselen\u003c\/strong\u003e (CAS 60940-34-3) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eAlternative names:\u003c\/strong\u003e CCG-39161\u003c\/p\u003e\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e60940-34-3\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC13H9NOSe\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e274.18 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eO=C1N((Se)C=2C1=CC=CC2)C3=CC=CC=C3\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eEbselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+\/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e Virus Protease, Phosphatase, Calcium Channel, COX, HIV Protease\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e Proteases\/Proteasome, Microbiology\/Virology, Membrane transporter\/Ion channel, Immunology\/Inflammation, Neuroscience, Metabolism\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"5 mg","offer_id":53327161459053,"sku":"T0825-5MG","price":42.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327599731053,"sku":"T0825-1MLX10MM","price":46.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327599763821,"sku":"T0825-10MG","price":58.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327599796589,"sku":"T0825-25MG","price":86.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327599829357,"sku":"T0825-50MG","price":115.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327599862125,"sku":"T0825-100MG","price":173.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":53327599894893,"sku":"T0825-200MG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEGY7LjWEaZ9XAAAAAAX2bbU968.png?v=1778721987"}],"url":"https:\/\/www.ebiohippo.com\/collections\/rtc-cell-biology-protein-quality-control-biochemicals.oembed","provider":"BioHippo","version":"1.0","type":"link"}