{"title":"Cytokine Biology — Cells","description":null,"products":[{"product_id":"6t-cem-cell-bhc11101197","title":"6T-CEM cell","description":"The 6T-CEM cell line is a mutant derivative of the human acute lymphoblastic leukemia (ALL) T-cell line CCRF-CEM. It was developed by exposing the parent CEM cells to 6-thioguanine, leading to the selection of a subline that exhibits resistance to this compound. This resistance is a result of the inactivation of the HPRT gene, which is critical in the purine salvage pathway. The 6T-CEM cells have been particularly valuable in studying drug resistance mechanisms, especially concerning purine analogs like 6-thioguanine. Additionally, these cells are characterized by their secretion of a unique T-cell suppressor inducer factor (SIF), which is not only non-mitogenic and non-cytotoxic but also capable of suppressing T-cell proliferation while sparing B-cell proliferation at certain dilutions. 6T-CEM cells and their subclones, like 6T-CEM-20, have shown a significant increase in the production of this suppressor-inducer factor, which has potential applications in immunological research, particularly in the study of T-cell regulation and immune suppression. The SIF secreted by these cells has been shown to suppress up to 90% of mitogen-induced T-cell proliferation at extremely high dilutions (up to 10^-9), making these cells a potent model for exploring therapeutic strategies that involve modulation of the immune response. The use of these cells in various experimental setups has provided insights into the molecular underpinnings of immune suppression, with potential implications for the development of treatments for autoimmune diseases and in the context of organ transplantation to prevent graft rejection.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101197\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950195667309,"sku":"305132","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/6T-CEM-_282_29_1920x1920_3bf07d11-d276-419c-8828-0e64aedfa99c.jpg?v=1769068933"},{"product_id":"a3-cell-bhc11101286","title":"A3 cell","description":"A3 cells are human T lymphoblasts derived from the Jurkat cell line obtained from the laboratory of Gerald Crabtree at Stanford University. These cells possess a lymphoblast morphology, grow in suspension and are highly relevant in studying acute T cell leukaemia, 3D cell culture applications, immune system disorder research, and immunology.\nThese cells are derived from the Jurkat cell line, which was treated with Fas Antibody to obtain a low spontaneous resistance rate to Fas-mediated apoptosis. This characteristic makes A3 cells highly valuable for investigating immune system dysregulation and identifying potential therapeutic targets.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101286\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196191597,"sku":"305143","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A3_20WaKo_20P1_2010x01_20010824_ch00_1920x1920_aabce3f2-7a25-4578-94a2-4c9ad0264bd1.jpg?v=1769068937"},{"product_id":"ah-130-cell-bhc11100091","title":"AH-130 cell","description":"Yoshida et al. have established the ascites hepatoma by converting the aminoazo dyeinduced hepatoma of the rat into the ascetic form (Yoshida 1956). AH-130 is a strain of ascites hepatoma composed of free tumor cells, only small islands of tumor islets are present. The cell line described here was established as in vitro cell culture from this Yoshida AH-130 strain of ascites hepatoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100091\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196945261,"sku":"500412","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ah-130-_281_29_1920x1920_c7f9086b-5c1e-4005-b3d1-be31ef0b6f80.jpg?v=1769068944"},{"product_id":"ah-130-fn-cell-bhc11100152","title":"AH-130 FN cell","description":"AH-130 FN is a variant of the AH-130 rat ascites tumor cell line, used extensively in studies related to coagulation, fibrinolysis, and metastasis. These cells were derived from rats and are typically maintained by serial intraperitoneal implantation in male Donryu rats. The AH-130 line itself is known for its high thromboplastic and fibrinolytic activities, which are linked to its role in promoting blood-borne metastasis, especially in the lungs. In contrast, the AH-130 FN variant has lower thromboplastic and fibrinolytic activity. This difference in enzymatic activity between AH-130 and AH-130 FN is crucial as it influences the formation of thrombi and the number of metastatic foci in the lungs following intravenous inoculation. Research has shown that after intravenous injection, AH-130 cells cause a significant reduction in platelet count and fibrinogen levels, indicative of increased thrombus formation. This effect is notably more pronounced than in AH-130 FN. Histological studies demonstrate that AH-130 forms more abundant metastatic foci in the lungs compared to AH-130 FN, both at 72 hours and 7 days post-inoculation. AH-130 is associated with the formation of thrombi composed of platelets and fibrin around embolized tumor cells, whereas AH-130 FN shows sparse thrombus formation. These findings suggest that AH-130’s higher thromboplastic activity plays a significant role in promoting metastasis through platelet aggregation and fibrin deposition around the tumor cells, a process less prominent in AH-130 FN.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100152\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950196978029,"sku":"500451","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ah-130-fn-_282_29_1920x1920_64f4da1b-2481-4063-a4b1-491f09972c0b.jpg?v=1769068944"},{"product_id":"akata-cell-bhc11101519","title":"AKATA cell","description":"The AKATA cell line, derived from Burkitt’s lymphoma, is a widely used model to study Epstein-Barr virus (EBV) latency and reactivation. EBV is a ubiquitous herpesvirus linked to a range of cancers, including Burkitt lymphoma, and typically establishes a latent infection within B cells. In AKATA cells, EBV is maintained in an episomal state with a type I latency program, expressing a limited set of viral genes such as EBNA-1, EBER RNAs, and BamHI-A rightward transcripts (BARTs). This restricted gene expression allows the virus to persist in the host without initiating a full lytic cycle. However, AKATA cells can be triggered to enter the lytic phase, where the virus actively replicates and produces progeny. This reactivation is commonly induced through cross-linking surface immunoglobulins, which makes AKATA cells an excellent tool for studying EBV reactivation dynamics and viral gene regulation.\nResearch utilizing the AKATA cell line has also examined the impact of chemotherapeutic agents on EBV reactivation. For instance, drugs like etoposide and doxorubicin have been shown to influence viral latency. Etoposide induces apoptosis in AKATA cells but reactivates EBV less effectively than doxorubicin, which promotes higher levels of lytic gene expression and viral progeny production. Additionally, studies involving gene editing techniques, such as CRISPR\/Cas9, have explored the role of epigenetic regulators in AKATA cells. For example, knockout of the histone methyltransferase EZH2 in AKATA cells disrupts the maintenance of latency by reducing the trimethylation of histone H3K27, leading to increased expression of both latent and lytic EBV genes, as well as enhanced viral replication and cell proliferation.\nAKATA cells also display distinct phenotypic characteristics based on EBV presence, such as increased sensitivity to apoptosis-inducing agents and variations in gene expression related to apoptotic pathways. These differences make EBV-positive AKATA cells a powerful model for dissecting EBV's influence on host cell survival, gene expression, and the virus's lifecycle, particularly in the context of cancer development and potential therapeutic interventions targeting EBV-associated malignancies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101519\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197010797,"sku":"305510","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AKATA_20P3_2020x01_20110225_ch00_1920x1920_022aa6cd-476e-48c7-9501-05c2af3e1664.jpg?v=1769068945"},{"product_id":"ar42j-cell-bhc11100120","title":"AR42J cell","description":"AR42J cells are a rat pancreatic tumor cell line derived from azaserine-induced tumors in rats. They are widely used as a model for studying pancreatic exocrine cell functions, pancreatitis, and pancreatic cancer research. AR42J cells exhibit acinar-like characteristics, making them particularly valuable for investigating the physiology and pathology of pancreatic acinar cells.\nOne of the defining features of AR42J cells is their ability to differentiate into cell types exhibiting more pronounced pancreatic exocrine functions when treated with various agents, such as dexamethasone or activators of protein kinase C. Upon differentiation, these cells produce and secrete digestive enzymes, including amylase, lipase, and chymotrypsin, mimicking the enzyme secretion profile of normal pancreatic acinar cells.\nAR42J cells are also used to explore the mechanisms of acute pancreatitis. They respond to stimuli like cerulein, a cholecystokinin analog, which can induce a condition in the cells that resembles acute pancreatitis, characterized by enzyme overproduction, oxidative stress, and inflammatory responses. This makes AR42J cells a useful tool for testing potential therapeutic interventions for pancreatitis.\nFurthermore, the AR42J cell line is utilized in research focused on pancreatic cancer, particularly for studies on tumorigenesis and the malignant transformation of acinar cells. They are instrumental in examining the effects of oncogenes, tumor suppressor genes, and growth factors on the development and progression of pancreatic cancer.\nOverall, AR42J cells provide a versatile and dynamic model system for advancing our understanding of pancreatic diseases and for the development of new therapeutic strategies targeting these conditions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100120\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197272941,"sku":"500478","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ar42j-_284_29_1920x1920_b0c130b0-2f95-4d82-9854-0a0d210cdb1a.jpg?v=1769068947"},{"product_id":"arh-77-cell-bhc11101176","title":"ARH-77 cell","description":"The ARH-77 cell line is a human cell line derived from the peripheral blood of a 33-year-old female patient with plasma cell leukemia, a type of cancer that affects plasma cells in the bone marrow. ARH-77 cells are characterized by their B lymphoblastoid phenotype, which makes them particularly useful for studying B-cell maturation and function as well as plasma cell leukemia pathology. This cell line is also frequently used in research related to Epstein-Barr virus (EBV), as it is EBV-transformed.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101176\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197305709,"sku":"300306","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ARH-77_20P1_2020x01_20290823_20WaKo_ch00_1920x1920_1aff46bc-8eac-4932-81a9-4cb19405ee70.jpg?v=1769068947"},{"product_id":"as-30d-cell-bhc11100263","title":"AS-30D cell","description":"Established in vitro from the AS-30D tumor ascites.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100263\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197502317,"sku":"500116","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/as-30d-_282_29_1920x1920_87e5d908-051a-41a9-920d-7b0aec0c8fe4.jpg?v=1769068948"},{"product_id":"b95-8-cell-bhc11101222","title":"B95-8 cell","description":"The B95-8 cell line is an immortalized marmoset B lymphoblastoid line, derived from the peripheral blood leukocytes of a cotton-top marmoset (Saguinus oedipus). This cell line was established through infection with the Epstein-Barr virus (EBV), which is a common method for immortalizing B cells. The presence of EBV is central to the B95-8 line's utility in research, particularly for studies related to viral oncology, virus-host interactions, and the biology of EBV itself.\n\nB95-8 cells are frequently used as a source of Epstein-Barr virus in virology research. They produce infectious virus particles, making them an invaluable tool for the propagation of EBV and for experiments requiring active virus. Additionally, this cell line has been instrumental in the development of vaccines and therapeutic strategies against EBV-associated diseases, including Burkitt's lymphoma and Hodgkin's lymphoma. The cells are also relevant in the study of the immune response to EBV, as they can be used to model the transformation of B cells and to understand the mechanisms of EBV-induced tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101222\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197895533,"sku":"601102","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/20210802_B95-8_P5_d5_601102-117_10x_1920x1920_7c36b1e0-2d4f-4784-92ee-0bb4c042658f.jpg?v=1769068952"},{"product_id":"ball-1-cell-bhc11101029","title":"BALL-1 cell","description":"The BALL-1 cell line originates from a 75-year-old male patient diagnosed with acute lymphoblastic leukemia (ALL). Established from the peripheral blood, this cell line is of particular interest due to the patient's advanced age, offering a unique perspective on the disease in elderly populations. BALL-1 cells exhibit characteristics of B-cell lineage, notably expressing markers such as CD19 and CD10. These cells are negative for surface immunoglobulin, aligning with phenotypes observed in early stages of B-cell neoplastic development.\n\nAs a model, BALL-1 is pivotal for researching the pathogenesis of B-cell leukemia, particularly within older patients, where disease dynamics may differ significantly from those observed in younger individuals. This cell line facilitates the exploration of molecular and cellular mechanisms underlying leukemia progression, therapeutic resistance, and the emergence of new drug targets. BALL-1 is instrumental in drug discovery and testing, aiding in the assessment of new anti-leukemic compounds. Moreover, the genetic abnormalities present in BALL-1 provide essential insights into the chromosomal alterations involved in the pathogenesis of B-cell precursor acute lymphoblastic leukemia.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101029\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197993837,"sku":"305084","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BALL-1_20_281_29_1920x1920_8d857a44-8738-43c6-ba39-da7825161b2a.jpg?v=1769068954"},{"product_id":"bjab-cell-bhc11100978","title":"BJAB cell","description":"The BJAB cell line was established in 1973 from a 5-year-old African girl diagnosed with Epstein-Barr virus (EBV)-negative Burkitt’s lymphoma. This specific origin is crucial for research as it provides a distinct model for studying Burkitt’s lymphoma in the absence of EBV influence, which is common in many other lymphoma cell lines. The EBV-negative status of BJAB cells allows researchers to investigate the genetic and environmental factors contributing to lymphomagenesis without the confounding effects of the virus.\n\nBJAB cells are often used in oncological research, especially for exploring the pathophysiology of Burkitt's lymphoma, and for testing therapeutic strategies against it. The cell line displays many of the hallmark features of Burkitt’s lymphoma, including high proliferation rates and a characteristic immunophenotype. Its genetic stability and the robustness with which it can be cultured make it a valuable tool for in vitro experiments aimed at understanding lymphoma biology and assessing the efficacy of anti-cancer drugs.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100978\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198321517,"sku":"302006","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/bjab-_282_29_1920x1920_5e400807-e586-4351-9782-4812d720fbda.jpg?v=1769068958"},{"product_id":"b-lcl-cdg1-cell-bhc11101674","title":"B-LCL-CDG1 cell","description":"B-LCL-CDG1 is an EBV-transformed B lymphocyte cell line derived from a patient diagnosed with PMM2-CDG, a congenital disorder of glycosylation (CDG). This rare metabolic disorder arises from mutations in the *PMM2* gene, which encodes phosphomannomutase 2 (PMM2), an essential enzyme in the glycosylation pathway. Mutations in *PMM2* disrupt the synthesis of glycosylated oligosaccharide chains, leading to defective glycosylation of various glycoproteins and glycosphingolipids in tissues and blood. The disorder is characterized by multisystemic manifestations, often affecting neurological, hepatic, and endocrine functions.  \n\nAs an EBV-transformed lymphoblastoid cell line, B-LCL-CDG1 provides a valuable in vitro model for studying the molecular and cellular consequences of *PMM2* deficiency. This cell line can be used to investigate glycosylation defects, PMM2 enzyme activity, and potential therapeutic interventions, including gene correction and substrate supplementation. B-LCL-CDG1, alongside other CDG patient-derived cell lines, serves as a crucial resource for understanding the pathophysiology of CDGs and evaluating novel treatment strategies for these disorders.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101674\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198354285,"sku":"302012","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-LCL-CDG1_20P4_2020x_2002_2002052022_1920x1920_c3571dbe-acfb-4155-a575-a9b566ffdec5.jpg?v=1769068958"},{"product_id":"b-lcl-cdg2-cell-bhc11101078","title":"B-LCL-CDG2 cell","description":"B-LCL-CDG2 is an EBV-transformed B lymphocyte cell line derived from a young girl suffering from PMM2-CDG. PMM2-CDG is a rare inborn error of metabolism, which results in defective synthesis of glycosylated oligosaccharide chains of many tissue and blood glycoproteins and\/or glycosphingolipids. The primary cause of defective glycosylation is based on mutations in the enzyme phosphomannomutase 2 (PMM2). There are two distinct mutations for the PMM2 gene.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101078\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198387053,"sku":"302013","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/b-lcl-cdg2-_283_29_1920x1920_dfe3093f-8a79-41f1-b1df-5c8b95b7d783.jpg?v=1769068958"},{"product_id":"b-lcl-cdg3-cell-bhc11101675","title":"B-LCL-CDG3 cell","description":"B-LCL-CDG3 is an EBV-transformed B lymphocyte cell line derived from a patient with PMM2-CDG, a congenital disorder of glycosylation (CDG) caused by mutations in the *PMM2* gene. PMM2 encodes phosphomannomutase 2, a key enzyme in the N-glycosylation pathway, responsible for converting mannose-6-phosphate to mannose-1-phosphate. Deficiencies in PMM2 result in impaired glycosylation of multiple glycoproteins and glycolipids, leading to a broad spectrum of clinical manifestations, including neurological, hepatic, and endocrine dysfunction.  \n\nAs an EBV-immortalized B cell line, B-LCL-CDG3 serves as a valuable in vitro model for studying the molecular effects of *PMM2* mutations. This cell line can be used to analyze glycosylation defects, investigate PMM2 enzyme activity, and test potential therapeutic strategies, such as enzyme enhancement therapies or substrate supplementation. B-LCL-CDG3, along with other CDG patient-derived cell models, contributes to advancing research on CDG pathophysiology and treatment development.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101675\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198419821,"sku":"302014","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-LCL-CDG3_20P6_2020x_2001_2016052022_1920x1920_9ccf3147-3a13-4b3f-a794-0fa2009d7549.jpg?v=1769068959"},{"product_id":"b-lcl-cdg4-cell-bhc11100957","title":"B-LCL-CDG4 cell","description":"B-LCL-CDG4 is an EBV-transformed B lymphocyte cell line derived from a young girl with CDAII. CDAII is a rare genetic anaemia, affiliated to the class of CDG glycosylation disorders. CDAII patients have a defect in the COPII component SEC23B gene which is involved in the intracellular protein transport system (in particular vesicular budding from ER). The respective patient is homozygous for the mutation in this gene. Band 3 glycoprotein of erythrocyte membranes is under glycosylated by aberrant glycosylation of polylactosamine motifs of glycoproteins but not of glycosphingolipids, thus band 3 of CDA II erythrocytes have truncated hybrid-type oligosaccharides. This points to an additional defect in the Golgi glycosylation enzymes mannosidase II or Nacetylglucosaminyltransferase II.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100957\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198452589,"sku":"302015","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/b-lcl-cdg4-_281_29_1920x1920_d5f2a586-6b0e-4bea-8b7d-84a4a231e4f4.jpg?v=1769068959"},{"product_id":"b-lcl-cdg5-cell-bhc11101676","title":"B-LCL-CDG5 cell","description":"B-LCL-CDG5 is an EBV-transformed B lymphocyte cell line derived from a patient with PMM2-CDG, a congenital disorder of glycosylation (CDG) caused by mutations in the *PMM2* gene. This disorder impairs the proper synthesis and attachment of glycan structures to glycoproteins and glycolipids, affecting multiple organ systems. The deficiency in phosphomannomutase 2 (PMM2) disrupts the conversion of mannose-6-phosphate to mannose-1-phosphate, a critical step in glycosylation, leading to defects in cellular function and systemic complications.  \n\nAs an EBV-immortalized B cell line, B-LCL-CDG5 serves as a crucial model for studying the biochemical and molecular effects of *PMM2* mutations. This cell line enables researchers to investigate glycosylation defects, PMM2 enzymatic activity, and the cellular consequences of impaired glycosylation. Additionally, it provides a platform for testing potential therapeutic approaches, such as pharmacological chaperones, enzyme enhancement therapies, or substrate supplementation strategies. B-LCL-CDG5, in combination with other CDG patient-derived cell lines, aids in advancing our understanding of PMM2-CDG and the development of targeted treatment options.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101676\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198485357,"sku":"302016","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-LCL-CDG5_20P4_2010x_2001_2003052022_1920x1920_2597d0f0-b086-4038-a8a0-7ed6f45f3e0e.jpg?v=1769068960"},{"product_id":"b-lcl-cdg7-cell-bhc11100867","title":"B-LCL-CDG7 cell","description":"B-LCL-CDG7 is an EBV-transformed B lymphocyte cell line derived from a young boy with CDAII. CDAII is a rare genetic anaemia, affiliated to the class of CDG glycosylation disorders. CDAII patients have a defect in the COPII component SEC23B gene which is involved in the intracellular protein transport system (in particular vesicular budding from ER). The respective patient is homozygous for the mutation in this gene. Band 3 glycoprotein of erythrocyte membranes is under glycosylated by aberrant glycosylation of polylactosamine motifs of glycoproteins but not of glycosphingolipids, thus band 3 of CDA II erythrocytes have truncated hybrid-type oligosaccharides. This points to an additional defect in the Golgi glycosylation enzymes Beta-mannosidase II or Nacetylglucosaminyltransferase II.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100867\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198518125,"sku":"302018","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/B-LCL-CDG7_20P1_2010x02_20140725_ch00_1920x1920_5efcee02-b031-4c32-9c4a-4819fcef39ea.jpg?v=1769068960"},{"product_id":"b-lcl-hroc06-cell-bhc11101053","title":"B-LCL-HROC06 cell","description":"\u003cp style=\"display:none\"\u003eSKU:BHC11101053\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198550893,"sku":"302065","price":800.0,"currency_code":"USD","in_stock":true}]},{"product_id":"b-lcl-hroc10-cell-bhc11101055","title":"B-LCL-HROC10 cell","description":"\u003cp 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These findings emphasize the potential role of the cytoskeleton in maintaining cell shape and pluripotency, which is pivotal in both normal physiology and disease states involving cellular transformation and differentiation.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101268\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199566701,"sku":"305193","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BRL_20P1_20305193_20_2010x01_20060223_1920x1920_b243b40a-bf37-4fcd-8c32-77caaa5f0b72.jpg?v=1769068967"},{"product_id":"brl-3a-cell-bhc11100031","title":"BRL-3A cell","description":"The BRL-3A cell line is derived from the normal liver of a male Buffalo rat. Established in 1976, this cell line is an important in vitro model primarily used for studying hepatocyte function, liver regeneration mechanisms, and hepatotoxicity. 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The cells are known to respond to peroxisome proliferators and have been used to test the efficacy and safety of pharmaceuticals potentially affecting liver function.\n\nHowever, despite their versatility, users of the BRL-3A cell line must consider the limitations inherent to a non-human model, as results may not always directly translate to human liver physiology. 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CA46 cells are noteworthy for their study in oncology research, particularly in understanding the Epstein-Barr virus (EBV) negative Burkitt’s lymphoma pathogenesis and the underlying molecular biology of B-cell differentiation and transformation.\n\nScientifically, CA46 cells have been instrumental in the study of gene expression related to B-cell development and malignancy. They are EBV-negative, which allows researchers to investigate tumor characteristics and behaviors without the influence of EBV, a common confounder in many lymphoid malignancies. The cell line also provides a useful tool for examining the efficacy of therapeutic agents and the mechanisms of drug resistance in lymphoma, contributing to the development of targeted therapies in hematologic cancers.\n\nIn research settings, CA46 cells have been used to assess cytotoxic responses to chemotherapeutic agents and to explore signal transduction pathways involved in B-cell proliferation and apoptosis. 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