{"title":"Diabetes \u0026 Insulin Resistance — Cells","description":null,"products":[{"product_id":"aml12-cell-bhc11101265","title":"AML12 cell","description":"AML12 cells, also known as Alpha Mouse Liver 12 cells, are a non-tumorigenic epithelial cell line derived from the liver of a transgenic mouse. These cells were initially developed to provide a suitable in vitro model for studying the hepatocyte function and liver biology of the adult mouse. AML12 cells express characteristics typical of differentiated hepatocytes, including the production of albumin, transferrin, and other liver-specific proteins, making them an invaluable resource for research in toxicology, drug metabolism, and liver disease.\n\nThe cell line was established from hepatocytes isolated from a mouse harboring a transgene for human transforming growth factor alpha (TGF-alpha), under the control of the mouse metallothionein-I promoter. This genetic alteration contributes to the immortalization of the cells without disrupting their differentiated state. AML12 cells maintain a stable phenotype and karyotype under standard cell culture conditions, which includes a unique requirement for dexamethasone and insulin-transferrin-selenium in the growth medium to promote proliferation and maintain hepatocyte-specific functions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101265\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197076333,"sku":"300643","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/aml12-_282_29_1920x1920_fd1a83ba-979f-4ece-8666-1507a80d1af3.jpg?v=1769068946"},{"product_id":"aspc-1-cell-bhc11100143","title":"AsPC-1 cell","description":"The AsPC1 cell line, derived from a 62-year-old female patient with adenocarcinoma of pancreas and metastases to several abdominal organs, has become a pivotal model for studying pancreatic cancer, one of the most aggressive and lethal malignancies. They display a high degree of invasiveness compared to other pancreatic cancer cell lines, which makes them particularly useful for studies on cancer metastasis and tumor invasion.\nAsPC1 cells have been instrumental in understanding the metabolic pathways involved in pancreatic cancer, including glutamine and glycerophospholipid metabolism. AsPC1 cells have been used to investigate the function of matrix metalloproteinases (MMPs) in metastasis, a crucial component of the biology of pancreatic cancer.\nAsPC1 cells have further been used to evaluate the efficacy of treatments such as the HDAC inhibitor AR-42 and the antimitotic and STAT3 inhibitor LTP-1, demonstrating the potential of these compounds to suppress tumor growth and induce apoptosis in pancreatic cancer cell lines.\nThe development of xenograft models using AsPC1 cells has allowed researchers to study pancreatic cancer in a more physiologically relevant context and have provided valuable insights into the transformation of normal human pancreatic duct cells into adenocarcinomas.\nAsPC1 cells continue to be a valuable resource for exploring the therapeutic bispecific pathways and intracellular tumor antigens associated with pancreatic cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100143\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197600621,"sku":"300158","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ASPC-1_20P4_2010x01_20311023_ch00_1920x1920_6e8cf718-8789-431e-845a-7e78240900aa.jpg?v=1769068949"},{"product_id":"beta-tc-6-cell-bhc11101154","title":"Beta-TC-6 cell","description":"Beta-TC-6 cells is a cell line derived from insulinoma tissue in mice. These cells are crucial in scientific studies focused on diabetes and insulin signalling.\nOriginating from a transgenic mouse, Beta-TC-6 cells carry a pseudogene construct comprising the SV40 early region, which the rat insulin gene promoter regulates. This genetic composition leads to insulin secretion in response to glucose levels. \nThese cells exhibit epithelial morphology and primarily reside in the pancreas tissue. In addition to insulin production, these cells possess small amounts of glucagon and somatostatin. The adherence of Beta-TC-6 cells allows for convenient cultivation and manipulation during experiments and assays.\nBeta-TC-6 cells provide a valuable tool for scientific investigations in diabetes and insulin signalling. Their unique genetic composition, insulin-secreting capabilities, and adherence properties make them ideal for studying the intricate processes involved in glucose regulation and pancreatic function.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101154\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950198124909,"sku":"305181","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Beta-TC-6_20P1_2020x01_20010825_ch00_1920x1920_f05e068f-7deb-4177-9a22-faaf42530d4f.jpg?v=1769068955"},{"product_id":"bnl-cl-2-cell-bhc11101264","title":"BNL CL.2 cell","description":"BNL CL.2, a mouse liver cell line originally derived from BALB\/c embryonic liver cells, plays a significant role in the study of cellular biology and molecular mechanisms, especially regarding the cell cycle and its regulation. Researchers have extensively used BNL CL.2 to characterize cyclin-dependent kinase (CDK) protein complexes and investigate the alterations in these complexes following both chemical and viral transformation. This line serves as a progenitor for various transformed cell lines such as BNL 1ME A.7R.1, BNL 1NG A.2, and BNL SV A.8, all of which originate from BNL CL.2 and have proven essential for studying CDK alterations post-transformation.\n\nBNL CL.2 is distinguished by its non-tumorigenic nature when tested in immunosuppressed mice, and its inability to grow anchorage-independently, although it does possess the capability to form colonies in semisolid media. This makes it an invaluable model for exploring cellular processes and transformations in a controlled environment. In contrast, its derivative lines such as those transformed by 3-Methylcholanthrene epoxide, MNNG, and SV40 demonstrate the ability to grow in soft agar and form tumors in immunodeficient mice, highlighting the impact of genetic and environmental alterations on cellular behavior. The BNL CL.2 cell line and its derivatives continue to provide a robust foundation for research in cellular transformation, stable cell transfection, and related fields of cellular and molecular biology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101264\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199533933,"sku":"305177","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BNL_20CL.2_20_283_29_1920x1920_76d498ac-cd28-4fb4-93e5-e535e7a87690.jpg?v=1769068967"},{"product_id":"bxpc-3-cell-bhc11101173","title":"BxPC-3 cell","description":"BxPC-3 cells, originating from the pancreatic adenocarcinoma of a 61-year-old female patient who underwent radiation and chemotherapy, have become a fundamental asset in cancer research, particularly for studying pancreatic ductal adenocarcinoma. The absence of the SMAD4\/DPC4 protein due to homozygous deletions in BxPC 3 cells makes them an invaluable resource for research into pancreatic cancer's genetic landscape.\nTumors grown from BxPC-3 cells in nude mice produce carcinoembryonic antigen, human pancreas cancer-associated antigen, human pancreas-specific antigen, and traces of mucin. This highlights the ability of the cell line to closely replicate the histopathological traits of the primary tumor. The production of mucinous tissues, in particular, underscores the cell line's value for detailed pancreatic adenocarcinoma studies, reflecting the original tumor's characteristics.\nBxPC-3 cells' significant expression of angiogenic factors such as interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2) opens avenues for exploring angiogenesis in cancer progression and identifying potential therapeutic targets.\nIn summary, the pancreatic adenocarcinoma cell line BxPC-3 are pivotal in cancer research, especially for pancreatic ductal adenocarcinoma research. Their lack of SMAD4\/DPC4 protein because of homozygous deletions and their ability to replicate the primary tumor's histopathological features, including mucinous tissues, make them invaluable for studying the genetic landscape and pathology of pancreatic cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101173\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199828845,"sku":"305031","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BxPC-3_20WaKo_20P0_20305031-051022_2010x01_20141022_1920x1920_a3125722-8738-48f2-8e2a-3f670f71b710.jpg?v=1769068971"},{"product_id":"capan-1-cell-bhc11100185","title":"Capan-1 cell","description":"The Capan-1 cell line is derived from a human pancreatic adenocarcinoma and was established from the ascitic fluid of a 40-year-old Caucasian male. It was first characterized in 1975 and is particularly noted for its ductal epithelial morphology, which closely resembles that of primary pancreatic tumors. Capan-1 cells are extensively used in research aimed at understanding pancreatic cancer biology, including studies on tumor progression, metastasis, and treatment resistance. This cell line is well-regarded for its ability to produce mucin, a characteristic feature of many pancreatic adenocarcinomas, thus serving as a model for mucinous pancreatic cancer.\n\nGenetically, Capan-1 harbors mutations in the KRAS gene, which are typical of pancreatic cancer, as well as alterations in other cancer-related genes such as TP53 and SMAD4. These mutations make the Capan-1 cell line a valuable tool for studying the molecular mechanisms underlying pancreatic cancer and for the preclinical evaluation of new therapeutic agents targeting these pathways. Furthermore, Capan-1 cells are used to study the biology of pancreatic cancer stem cells, offering insights into the behaviors that drive cancer recurrence and resistance to conventional therapies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100185\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200582509,"sku":"300143","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/capan-1-_281_29_1920x1920_df02430a-19f1-418a-bb8f-cfe22fd105d5.jpg?v=1769068984"},{"product_id":"capan-2-cell-bhc11100023","title":"Capan-2 cell","description":"The Capan-2 cell line is a human pancreatic adenocarcinoma cell line first isolated from the pancreatic tumor tissue of a 56-year-old Caucasian male. It was derived from the metastatic site in the liver, indicating its origin from a secondary tumor which makes it particularly valuable for research on metastatic processes and pancreatic cancer biology. The cells exhibit epithelial morphology and have been utilized extensively to study pancreatic cancer, drug resistance, and tumor biology.\n\nCapan-2 cells are known to express a mutated form of the Kirsten rat sarcoma viral oncogene homolog (KRAS), a common mutation in pancreatic cancer, making them a robust model for studying KRAS-driven tumorigenesis. Additionally, they are characterized by the expression of tumor suppressor gene p53 mutations and have been observed to exhibit chromosomal instabilities, which are critical features relevant to cancer progression and treatment response. This cell line has been used in numerous studies, including those evaluating chemotherapeutic efficacy, exploring molecular pathways of cancer progression, and developing targeted therapy strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100023\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200615277,"sku":"300144","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/capan-2-_282_29_1920x1920_3828ed5b-205f-480d-8cfc-c4516e98c3a4.jpg?v=1769068984"},{"product_id":"cfpac-1-cell-bhc11101080","title":"CFPAC-1 cell","description":"CFPAC-1 cells, derived from a 26-year-old male with cystic fibrosis and liver metastasis of ductal adenocarcinoma, are a hyperdiploid cell line with notable features for biological research. Their adherence growth property and tumorigenic capability in nude mice make them a practical model for in vitro cancer studies. The cell line's karyotype includes a modal number of 73 chromosomes with several translocations, and importantly, two to three copies of chromosome 7, where the cystic fibrosis gene is located.\nThese cells express cancer-related antigens and genes like CA19-9, carcinoembryonic antigen (CEA), pancreatic oncofetal antigen (POA), adenocarcinoma associated antigen (ACAA), and epithelial keratins, offering insights into cancer biology. In terms of cystic fibrosis pathology, CFPAC-1 cells demonstrate unique ion transport activities. They do not respond to cAMP agonists, adenyl cyclase stimulators, or phosphodiesterase inhibitors for chloride ion flux but show increased chloride efflux in response to calcium ionophores.\nCFPAC-1 cells carry the common cystic fibrosis mutation - deletion of three nucleotides leading to phenylalanine absence at position 508 in the CFTR gene. Morphologically, they exhibit epithelial features with apical microvilli, tight junctions, and gap junctions, relevant for studying epithelial tissue interactions in both cancer and cystic fibrosis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101080\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201139565,"sku":"305066","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CFPAC-1_20P1_20305066-M_2010x01_20020323_1920x1920_4d458c15-0021-428c-b4ad-d6725d89ad98.jpg?v=1769068989"},{"product_id":"chang-liver-hela-cell-bhc11100019","title":"Chang Liver (HeLa) cell","description":"The Chang Liver cell line, originally believed to be derived from normal human liver tissue, has undergone significant reclassification following advanced genetic profiling. STR PCR DNA profiling techniques have demonstrated that the Chang Liver cell line is indistinguishable from the HeLa cell line, suggesting that it is not derived from hepatocyte cells as previously thought, but rather should be considered a HeLa derivative. This revelation has important implications for researchers using this cell line, emphasizing the need for careful interpretation of experimental results derived from its use.\n\nHeLa cells, originally taken from Henrietta Lacks, a Black woman, in the early 1950s, are known for their robust growth and genetic stability in vitro, characteristics likely shared by the Chang Liver cell line given its genetic similarity. This background necessitates that studies employing the Chang Liver cell line in research related to liver function or diseases may need to be re-evaluated or confirmed with additional hepatocyte-specific models. The misidentification also highlights broader issues in cell culture practices, including cross-contamination and mislabeling, underscoring the importance of regular authentication of cell lines used in research settings.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100019\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201172333,"sku":"300139","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Chang_20Liver_20_28Hela_29_20confluent_1920x1920_52ae121d-53ec-45e5-89f7-51e06a151ad3.jpg?v=1769068989"},{"product_id":"dan-g-cell-bhc11100221","title":"DAN-G cell","description":"The DAN-G cell line is derived from a human pancreatic carcinoma. It is extensively utilized in research focused on pancreatic cancer, particularly in studies pertaining to tumorigenesis, metastasis, and chemotherapy resistance. The genetic profile of DAN-G includes mutations in key oncogenes and tumor suppressor genes, which are characteristic of pancreatic adenocarcinomas. This makes the cell line a valuable model for understanding the molecular mechanisms underlying pancreatic cancer and for testing new therapeutic strategies.\n\nIn addition to its applications in cancer research, the DAN-G cell line has been used to study the cellular processes involved in the progression of pancreatic ductal adenocarcinoma, including cell cycle regulation, apoptosis, and signal transduction pathways. The cells exhibit aggressive in vitro growth characteristics and have the ability to form tumors in immunocompromised mice, which simulates the human disease and provides an in vivo system for evaluating the efficacy of anticancer drugs. Researchers also employ this cell line to investigate the role of the tumor microenvironment in pancreatic cancer progression and resistance to therapy.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100221\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950202679661,"sku":"300162","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/DAN-G_20P1_2010x01_20140525_ch00_1920x1920_ac915f28-8766-48fd-9bb7-75dfe5338eba.jpg?v=1769069006"},{"product_id":"fampac-cell-bhc11100068","title":"FAMPAC cell","description":"The Fampac cell line was established from the primary pancreatic adenocarcinoma of an adult female who had a familial predisposition to pancreatic cancer. These cells are epithelial in nature and have been utilized extensively in research focused on the biological behavior of pancreatic cancer, including studies on tumor progression, metastasis, and therapeutic response. The Fampac cell line is known for its aggressive tumor-forming capability in xenograft models, which makes it valuable for in vivo studies related to drug efficacy and cancer cell biology.\nIn vitro, Fampac cells exhibit characteristics typical of pancreatic adenocarcinoma, including resistance to apoptosis and the ability to proliferate under chemically defined conditions. This resistance to programmed cell death is a critical feature for studies looking to explore new chemotherapeutic agents and their potential to induce cancer cell death. Additionally, Fampac cells have been used to study the molecular mechanisms of pancreatic cancer pathogenesis, offering insights into genetic mutations, signaling pathways involved in cancer proliferation, and interactions with the tumor microenvironment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100068\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203826541,"sku":"300309","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fampac-_282_29_1920x1920_de4ac400-27f0-45d8-9ba4-4c6161b96f1d.jpg?v=1769069021"},{"product_id":"fampac-a-cell-bhc11100044","title":"FAMPAC-A cell","description":"Clonal subline of the pancreas cell line FAMPAC. Established from the primary pancreas adenocarcinoma of a 43- year-old female with a familial prediposition to pancreatic carcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100044\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203859309,"sku":"300310","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fampac-a-_282_29_1920x1920_b83c029f-ff40-41b2-ac9c-305b96fc6258.jpg?v=1769069021"},{"product_id":"h22-cell-bhc11101103","title":"H22 cell","description":"The H22 cell line is a murine hepatocellular carcinoma cell line derived from liver tumor cells. These cells are commonly used in cancer research to study liver cancer mechanisms, therapeutic interventions, and drug efficacy. H22 cells exhibit typical characteristics of hepatocellular carcinoma, including rapid proliferation, resistance to apoptosis, and the ability to form tumors when injected into suitable animal models. This makes them a valuable tool for in vivo studies aiming to understand tumor growth, metastasis, and the tumor microenvironment in liver cancer.\nOne of the significant advantages of the H22 cell line is its use in immunotherapy research. Since the cells are derived from a murine model, they are particularly useful for studying the interactions between cancer cells and the immune system in a controlled environment. Researchers utilize H22 cells to evaluate the efficacy of various immunotherapeutic agents, including checkpoint inhibitors and cancer vaccines. Additionally, H22 cells are employed in the investigation of liver-specific metabolic pathways and the role of genetic mutations in hepatocellular carcinoma progression.\nOverall, the H22 cell line serves as a robust model for hepatocellular carcinoma, providing insights into cancer biology and aiding in the development of novel therapeutic strategies. Its relevance to both in vitro and in vivo studies underscores its importance in the field of cancer research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101103\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950204449133,"sku":"305163","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/H22_20WaKo_20P1_2020x01_20091023_ch00_1920x1920_f47a6a4f-6821-4e4b-8eeb-9285fafe14f7.jpg?v=1769069029"},{"product_id":"hep3b-cell-bhc11101068","title":"HEP3B cell","description":"The Hep3B cell line, derived from an 8-year-old child with liver cancer, is a pivotal model in the study of human liver cancer cells and their responses to various therapeutic agents. Hep3B cells contain an integrated hepatitis B virus genome and is integral in the investigation of differential drug responses due to its unique genetic and phenotypic characteristics.\nThe Hep 3B human hepatoma cell line is renowned for its extensive expression of liver-specific proteins such as alpha-fetoprotein (AFP), albumin, and various other markers, making it an invaluable tool in drug metabolism and hepatotoxicity studies. This wide array of expressed proteins allows for a comprehensive assessment of how liver cancer cells interact with and metabolize therapeutic agents.\nThe Hep 3B cell line and its derivative cell lines enable the tracking of tumor growth and metastasis in vivo, facilitating the study of liver cancer progression and the efficacy of potential treatments.\nThe Hep3B cell line stands out as a crucial resource for advancing our understanding of liver cancer biology and the development of more effective therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101068\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206316909,"sku":"305141","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HEP3B_20P1_20300492-M_2010x01_2012092022_1920x1920_6ab45186-3fc8-471b-950e-54c4f18d52f9.jpg?v=1769069051"},{"product_id":"hep-53-4-cell-bhc11100378","title":"Hep-53.4 cell","description":"Hep-53.4 cells are a mouse-derived cell line originating from hepatocellular carcinoma in a C57BL\/6J mouse model. These cells are particularly useful in the study of hepatocellular carcinoma, one of the most common types of liver cancer. By providing a consistent, reproducible model system, Hep-53.4 cells allow researchers to delve into the intricacies of cancer biology specific to the liver. This includes the exploration of oncogenic pathways, the effects of genetic modifications, and the cellular environment's role in cancer progression.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100378\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206349677,"sku":"400200","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-53-4-_281_29_1920x1920_a56d4f1d-472b-45b5-866e-05305b80171d.jpg?v=1769069051"},{"product_id":"hep-55-1c-cell-bhc11100607","title":"Hep-55.1C cell","description":"The Hep-55.1c hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6J mouse strain. This cell line is characterized by its hepatocytic origin, confirmed through intermediate filament protein analysis. Hep-55.1c expresses simple keratins K8 and K18, which are typical of normal liver cells, as well as vimentin and keratin K19 to varying degrees. These protein patterns confirm the hepatocytic nature of the cell line and its classification as a hepatoma line.\n\nThe Hep-55.1c cell line displays a predominantly epithelial morphology, reflecting its origin from hepatocytes. This morphological phenotype is consistent with its protein expression profile. DNA fingerprint analysis of Hep-55.1c did not reveal any major structural abnormalities, indicating a degree of genomic stability. However, some changes in the relative intensities of specific bands were observed with increasing passage numbers, suggesting minor genomic variability over extended culture periods.\n\nDespite the absence of detectable p53 mutations in the primary mouse liver tumors, aberrations were found in some hepatoma lines during in vitro propagation. The Hep-55.1c cell line was analyzed for mutations in the p53 and c-Ha-ras genes. The absence of detectable mutations in the p53 gene in this line during early passages suggests a stable genetic background. This cell line serves as a valuable model for studying hepatocellular carcinoma, providing insights into the cellular and molecular mechanisms underlying liver tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100607\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206906733,"sku":"400201","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-55.1c-_281_29_1920x1920_d61c83c6-9e55-4721-b612-ee98a5eacf5d.jpg?v=1769069051"},{"product_id":"hep-56-1b-cell-bhc11100385","title":"Hep-56.1B cell","description":"The Hep-70.4 hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6J mouse strain. This cell line is notable for its mutations in the p53 gene, which were identified at different passages during in vitro propagation. At passage number 8, a weak additional signal was detected in the single-strand conformation polymorphism (SSCP) analysis, indicating the presence of a p53 mutation. By passage number 38, two distinct p53 point mutations were identified: a G:C to C:G transversion at codon 135 and a C:G to G:C transversion at codon 138 of exon 5. These mutations led to amino acid changes from alanine to proline and cysteine to tryptophan, respectively.\n\nThe Hep-70.4 cell line displays a morphological phenotype that varies significantly during its propagation. Some sublines exhibit an epithelial morphology, while others show a fibroblast-like appearance. This heterogeneity reflects the complex nature of the cell line and its adaptability under different culture conditions. The presence of both normal and mutated p53 alleles in the early passages suggests that the mutations confer a selective growth advantage, leading to the predominance of mutated clones over time.\n\nIntermediate filament protein analysis of the Hep-70.4 cell line revealed the expression of simple keratins K8 and K18, which are typical of normal liver cells, as well as vimentin and keratin K19 to varying degrees. These protein patterns confirm the hepatocytic origin of the cell line and its classification as a hepatoma line. The genomic stability of Hep-70.4 was further assessed through DNA fingerprint analysis, which did not reveal any major structural abnormalities, although changes in the relative intensities of certain bands were observed with increasing passage numbers.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100385\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206939501,"sku":"400202","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-56-1b-_281_29_1920x1920_7dedb684-308e-4fa6-8bb6-ec49d82e2e70.jpg?v=1769069052"},{"product_id":"hep-56-1c-cell-bhc11100707","title":"Hep-56.1C cell","description":"The Hep-56.1c hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6J mouse strain. This cell line is characterized by a notable mutation in the p53 gene, identified at different passages during in vitro propagation. Specifically, Hep-56.1c exhibits a C:G to G:C transversion at codon 132 of exon 5, resulting in an amino acid change from cysteine to tryptophan. This mutation was detected at passage number 17, suggesting a selective growth advantage conferred by the mutation, leading to its predominance in the cell population.\n\nThe Hep-56.1c cell line displays a predominantly epithelial morphology, reflecting its hepatocytic origin. This is consistent with its intermediate filament protein profile, which includes the simple keratins K8 and K18, as well as vimentin and keratin K19 to varying degrees. The presence of these proteins confirms the hepatocytic nature of the cell line and its classification as a hepatoma line.\n\nFurther analysis of Hep-56.1c using DNA fingerprinting did not reveal any major structural abnormalities, although some changes in the relative intensities of specific bands were observed with increasing passage numbers. This indicates genomic stability with some degree of variability over extended culture periods. The p53 mutation analysis and intermediate filament protein expression patterns together establish Hep-56.1c as a valuable model for studying hepatocellular carcinoma and the role of p53 mutations in liver tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100707\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950206972269,"sku":"400203","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-56-1c-_281_29_1920x1920_85055b65-1aa9-49c5-8caa-a823ca755068.jpg?v=1769069052"},{"product_id":"hep-56-1d-cell-bhc11100614","title":"Hep-56.1D cell","description":"The Hep-56.1D hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6J mouse strain. This cell line is characterized by a notable mutation in the p53 gene, identified at different passages during in vitro propagation. Specifically, Hep-56.1D exhibits a C:G to G:C transversion at codon 132 of exon 5, resulting in an amino acid change from cysteine to tryptophan. This mutation was detected at passage number 17, suggesting a selective growth advantage conferred by the mutation, leading to its predominance in the cell population.\n\nThe Hep-56.1D cell line displays a predominantly epithelial morphology, reflecting its hepatocytic origin. This is consistent with its intermediate filament protein profile, which includes the simple keratins K8 and K18, as well as vimentin and keratin K19 to varying degrees. The presence of these proteins confirms the hepatocytic nature of the cell line and its classification as a hepatoma line.\n\nFurther analysis of Hep-56.1D using DNA fingerprinting did not reveal any major structural abnormalities, although some changes in the relative intensities of specific bands were observed with increasing passage numbers. This indicates genomic stability with some degree of variability over extended culture periods. The p53 mutation analysis and intermediate filament protein expression patterns together establish Hep-56.1D as a valuable model for studying hepatocellular carcinoma and the role of p53 mutations in liver tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100614\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207005037,"sku":"400204","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-56-1d-_281_29_1920x1920_88f195ad-1236-4bd2-8eeb-36c84f6c5b08.jpg?v=1769069052"},{"product_id":"hep-64-1-cell-bhc11100803","title":"Hep-64.1 cell","description":"The Hep-64.1 hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6Jmouse strain. This cell line is notable for its hepatocytic origin, confirmed through intermediate filament protein analysis. Hep-64.1 expresses simple keratins K8 and K18, which are typical of normal liver cells, as well as vimentin and keratin K19 to varying degrees. These protein patterns confirm the hepatocytic nature of the cell line and its classification as a hepatoma line.\n\nThe Hep-64.1 cell line displays a predominantly epithelial morphology, reflecting its origin from hepatocytes. This morphological phenotype is consistent with its protein expression profile. DNA fingerprint analysis of Hep-64.1 did not reveal any major structural abnormalities, indicating a degree of genomic stability. However, some changes in the relative intensities of specific bands were observed with increasing passage numbers, suggesting minor genomic variability over extended culture periods.\n\nDespite the absence of detectable p53 mutations in the primary mouse liver tumors, aberrations were found in some hepatoma lines during in vitro propagation. The Hep-64.1 cell line was analyzed for mutations in the p53 and c-Ha-ras genes. The absence of detectable mutations in the p53 gene in this line during early passages suggests a stable genetic background. This cell line serves as a valuable model for studying hepatocellular carcinoma, providing insights into the cellular and molecular mechanisms underlying liver tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100803\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207037805,"sku":"400205","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Hep-64.1_20_20WaKo_20P1_2020x01_20290425_ch00_1920x1920_ba66f7bb-8be8-49e5-b8f1-5623c441c437.jpg?v=1769069053"},{"product_id":"hep-66-3a-cell-bhc11100843","title":"Hep-66.3A cell","description":"The Hep-66.4A hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6J mouse strain. This cell line is characterized by its hepatocytic origin, confirmed through intermediate filament protein analysis. Hep-66.4A expresses simple keratins K8 and K18, which are typical of normal liver cells, as well as vimentin and keratin K19 to varying degrees. These protein patterns confirm the hepatocytic nature of the cell line and its classification as a hepatoma line.\n\nThe Hep-66.4A cell line displays a predominantly epithelial morphology, reflecting its origin from hepatocytes. This morphological phenotype is consistent with its protein expression profile. DNA fingerprint analysis of Hep-66.4A did not reveal any major structural abnormalities, indicating a degree of genomic stability. However, some changes in the relative intensities of specific bands were observed with increasing passage numbers, suggesting minor genomic variability over extended culture periods.\n\nDespite the absence of detectable p53 mutations in the primary mouse liver tumors, aberrations were found in some hepatoma lines during in vitro propagation. The Hep-66.4A cell line was analyzed for mutations in the p53 and c-Ha-ras genes. The absence of detectable mutations in the p53 gene in this line during early passages suggests a stable genetic background. This cell line serves as a valuable model for studying hepatocellular carcinoma, providing insights into the cellular and molecular mechanisms underlying liver tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100843\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207070573,"sku":"400206","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-66-3a-_283_29_1920x1920_75e386e2-66fd-45b1-ad7c-3d0a21a8a3bf.jpg?v=1769069053"},{"product_id":"hep-70-4-cell-bhc11100509","title":"Hep-70.4 cell","description":"The Hep-70.4 hepatoma cell line is derived from a mouse liver tumor, specifically from the C57BL\/6J mouse strain. This cell line is notable for its mutations in the p53 gene, which were identified at different passages during in vitro propagation. At passage number 8, a weak additional signal was detected in the single-strand conformation polymorphism (SSCP) analysis, indicating the presence of a p53 mutation. By passage number 38, two distinct p53 point mutations were identified: a G:C to C:G transversion at codon 135 and a C:G to G:C transversion at codon 138 of exon 5. These mutations led to amino acid changes from alanine to proline and cysteine to tryptophan, respectively.\n\nThe Hep-70.4 cell line displays a morphological phenotype that varies significantly during its propagation. Some sublines exhibit an epithelial morphology, while others show a fibroblast-like appearance. This heterogeneity reflects the complex nature of the cell line and its adaptability under different culture conditions. The presence of both normal and mutated p53 alleles in the early passages suggests that the mutations confer a selective growth advantage, leading to the predominance of mutated clones over time.\n\nIntermediate filament protein analysis of the Hep-70.4 cell line revealed the expression of simple keratins K8 and K18, which are typical of normal liver cells, as well as vimentin and keratin K19 to varying degrees. These protein patterns confirm the hepatocytic origin of the cell line and its classification as a hepatoma line. The genomic stability of Hep-70.4 was further assessed through DNA fingerprint analysis, which did not reveal any major structural abnormalities, although changes in the relative intensities of certain bands were observed with increasing passage numbers.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100509\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207103341,"sku":"400207","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-70-4-_284_29_1920x1920_f8f20dcc-0dca-41f3-aeb8-954857fe734e.jpg?v=1769069054"},{"product_id":"hep-74-3a-cell-bhc11100670","title":"Hep-74.3A cell","description":"The Hep-74.3 hepatoma cell line is derived from a mouse liver tumor, specifically from the C3H\/He mouse strain. This cell line is characterized by its hepatocytic origin, confirmed through intermediate filament protein analysis. Hep-74.3 expresses simple keratins K8 and K18, which are typical of normal liver cells, as well as vimentin and keratin K19 to varying degrees. These protein patterns confirm the hepatocytic nature of the cell line and its classification as a hepatoma line.\n\nThe Hep-74.3 cell line displays a predominantly epithelial morphology, reflecting its origin from hepatocytes. This morphological phenotype is consistent with its protein expression profile. DNA fingerprint analysis of Hep-74.3 did not reveal any major structural abnormalities, indicating a degree of genomic stability. However, some changes in the relative intensities of specific bands were observed with increasing passage numbers, suggesting minor genomic variability over extended culture periods.\n\nDespite the absence of detectable p53 mutations in the primary mouse liver tumors, aberrations were found in some hepatoma lines during in vitro propagation. The Hep-74.3 cell line was analyzed for mutations in the p53 and c-Ha-ras genes. The absence of detectable mutations in the p53 gene in this line during early passages suggests a stable genetic background. This cell line serves as a valuable model for studying hepatocellular carcinoma, providing insights into the cellular and molecular mechanisms underlying liver tumorigenesis.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100670\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207136109,"sku":"400208","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-74-3a-_282_29_1920x1920_4a7fd4ab-e448-4f34-87a1-63492134f948.png?v=1769069054"},{"product_id":"hepa-1-6-cell-bhc11100400","title":"Hepa 1-6 cell","description":"The Hepa 1-6 cell line is a well-characterized model derived from a hepatoma induced in an adult mouse. This cell line is commonly used in biomedical research with a focus on studying liver cancer, liver metabolism, and toxicology. The cells are of epithelial morphology and exhibit an undifferentiated hepatocellular carcinoma phenotype. Hepa 1-6 is particularly valuable for investigating the biochemical pathways involved in liver function and the cellular mechanisms underlying hepatocarcinogenesis.\n\nHepa 1-6 cells are known for their ability to be cultured easily and maintain stable growth and reproduction under standard laboratory conditions. They express several cytochrome P450 enzymes, making them an excellent tool for pharmacological and toxicological studies. These cells are also used to explore the regulation of gene expression in liver cells and to understand the impact of various substances on liver function. Due to their robust nature and relevance to human liver diseases, Hepa 1-6 continues to be a crucial resource in the field of liver disease research.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100400\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207168877,"sku":"400474","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hepa-1-6-_283_29_1920x1920_007cf354-f411-45de-a3f5-b8f6be873513.jpg?v=1769069054"},{"product_id":"hep-cls-1h-cell-bhc11100475","title":"Hep-CLS-1H cell","description":"Established from the primary hepatocellular adenocarcinoma of C3H\/HE mice, these tumors were induced in C3H\/HE mice by single intraperitoneal injection of Nnitrosodiethylamine (NDEA).\n\u003cp style=\"display:none\"\u003eSKU:BHC11100475\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207201645,"sku":"400197","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-cls-1h-_281_29_1920x1920_583acf02-9b91-4e7e-b622-4fd5e4a21b7e.jpg?v=1769069055"},{"product_id":"hep-cls-1w-cell-bhc11100569","title":"Hep-CLS-1W cell","description":"Established from the primary hepatocellular carcinoma of C3H\/HE mice: tumors were induced in C3H\/HE mice by single intraperitoneal injection of N-nitrosodiethylamine (NDEA):\n\u003cp style=\"display:none\"\u003eSKU:BHC11100569\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207234413,"sku":"400414","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-cls-1w-_281_29_1920x1920_65e54434-b279-49aa-9f1b-dea84f9f8130.jpg?v=1769069055"},{"product_id":"hep-cls-c9-cell-bhc11100403","title":"Hep-CLS-C9 cell","description":"Established from the primary hepatocellular carcinoma of C3H\/HE mice: tumors were induced in C3H\/HE mice by single intraperitoneal injection of N-nitrosodiethylamine (NDEA):\n\u003cp style=\"display:none\"\u003eSKU:BHC11100403\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207267181,"sku":"400195","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-cls-c9-_283_29_1920x1920_b8be2973-fad3-49b9-baa7-ed723b852aeb.jpg?v=1769069055"},{"product_id":"hep-cls-e1-cell-bhc11100782","title":"Hep-CLS-E1 cell","description":"Established from the primary hepatocellular carcinoma of C3H\/HE mice, these tumor were induced in C3H\/HE mice by single intraperitoneal injection of N-nitrosodiethylamine (NDEA).\n\u003cp style=\"display:none\"\u003eSKU:BHC11100782\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207332717,"sku":"400196","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hep-cls-e1-_283_29_1920x1920_f5441e5a-0af5-49d9-a975-a2c65d9dc92d.jpg?v=1769069056"},{"product_id":"hepg2-cell-bhc11100234","title":"HepG2 cell","description":"HepG2 cells, a hepatoblastoma cell line, are a cornerstone in biological science, particularly in liver cancer research. The HepG2 cell line was first isolated in 1975 and initially misclassified as hepatocellular carcinoma, with the HepG2 cell line origin as hepatoblastoma being recognized later, clarifying years of scientific ambiguity.\nHuman hepatic cell lines such as HepG2 are commonly used as in vitro models for primary human hepatocytes. These cell lines offer advantages such as indefinite proliferation, stable phenotype, easy accessibility, and ease of manipulation. However, they exhibit reduced expression of some metabolic functions compared to primary hepatocytes. Derived from hepatocellular carcinoma, HepG2 cells proliferate quickly and have an epithelial-like morphology, performing many specialized hepatic functions. Despite these differences, HepG2 cells are widely used in studying drug metabolism and toxicity, thanks to their resemblance to hepatocellular carcinoma and hepatoblastoma cells in terms of drug metabolism and transport proteins.\nHepG2 is a human liver cancer cell line often used in research, including studies on drug metabolism and toxicity. However, one of the limitations of hepatoma HepG2 cells is their altered expression of certain liver-specific functions, including the expression of cytochrome P450 enzymes. Cytochrome P450 enzymes are essential for the metabolism of xenobiotics (foreign compounds such as drugs and carcinogens) in the liver. The altered or reduced expression of these enzymes in HepG2 cells can affect their ability to accurately model the metabolism and elimination of xenobiotics, which is a critical aspect of liver function.\nThe HepG2 cell line, alongside other hepatoma cell lines such as the Hep3B and human hepatoma HepaRG cell lines, contributes to a broader understanding of human liver carcinoma cells. The cell line stands out for its versatility, serving as an optimal choice for stable cell line generation, transfection studies, drug metabolism, and hepatotoxicity studies. Furthermore, the HepG2 cell line is pivotal in a range of applications, from 3D cell culture to high-throughput screening and toxicology.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100234\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950207365485,"sku":"300198","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HepG2_20waKo1_20P1_2020x01_20060625_ch00_1920x1920_61eef594-0083-4771-abc6-2502c1646880.jpg?v=1769069057"},{"product_id":"hpac-cell-bhc11101569","title":"HPAC cell","description":"The HPAC cell line, derived from human pancreatic ductal adenocarcinoma, serves as an essential model for studying pancreatic cancer's molecular and cellular characteristics. Known for its utility in evaluating the impact of various chemotherapeutic agents and signaling pathways, HPAC cells exhibit key features typical of pancreatic cancer, including resistance mechanisms. Recent studies involving HPAC have focused on understanding drug resistance, particularly to erlotinib, a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR). Research has demonstrated that resistance to erlotinib in HPAC cells is associated with significant metabolic alterations, such as changes in phospholipid and amino acid metabolism. Specifically, increased levels of short-chain acylcarnitines and changes in glycerophospholipid profiles have been linked to an elevated metabolic state in erlotinib-resistant HPAC cells.\n\nHPAC cells also express matrix metalloproteinases (MMPs), particularly MT1-MMP, which is crucial for their invasive behavior. The Wnt\/β-catenin signaling pathway has been implicated in regulating MMP expression, contributing to the cell's migration and invasion potential. The application of compounds like matrine has been shown to inhibit HPAC cell migration by downregulating MT1-MMP through the suppression of Wnt\/β-catenin signaling. These attributes highlight HPAC as a pivotal cell line for exploring therapeutic interventions aimed at mitigating pancreatic cancer's aggressive and treatment-resistant nature.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101569\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950209003885,"sku":"305309","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HPAC_20P1_2010x01_20040625_ch00_1920x1920_88031946-b138-4316-a092-74f359878424.jpg?v=1769069072"},{"product_id":"hpaf-ii-cell-bhc11101174","title":"HPAF-II cell","description":"HPAF-II is a human pancreatic adenocarcinoma cell line derived from an adult patient. This cell line is commonly used in cancer research due to its relevance in studying pancreatic cancer, a highly aggressive and lethal malignancy. HPAF-II cells exhibit epithelial morphology and are known for their ability to form tumors when xenografted into immunocompromised mice, making them a valuable model for in vivo studies of tumor growth, metastasis, and response to therapeutic interventions. Researchers often employ HPAF-II cells to investigate the molecular mechanisms underlying pancreatic cancer progression, including genetic and epigenetic alterations, signal transduction pathways, and interactions with the tumor microenvironment.\n\nHPAF-II cells are characterized by specific genetic mutations and alterations that are frequently observed in pancreatic adenocarcinomas. These include mutations in the KRAS gene, which plays a critical role in cell signaling and proliferation, and alterations in tumor suppressor genes such as TP53 and CDKN2A. The cell line also exhibits high levels of mucin production, a feature that contributes to the aggressive nature of pancreatic tumors. Studies utilizing HPAF-II cells have provided significant insights into the biology of pancreatic cancer and have facilitated the development of potential therapeutic strategies aimed at targeting key molecular pathways involved in the disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101174\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950209036653,"sku":"305088","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HPAF-II_20P1_2020x01_20200923_ch00_1920x1920_19c3e446-6ce3-4b3f-a262-556caf705e3d.jpg?v=1769069073"},{"product_id":"hroc284met-cell-bhc11100444","title":"HROC284Met cell","description":"This is one cell line of a series of tumor cell lines which have been established by PD Dr. Michael Linnebacher from Primary CRC resection specimens since 2006.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100444\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950209921389,"sku":"300816","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hroc284met-_281_29_1920x1920_090fcf05-3704-4225-bf37-36f65eec0235.jpg?v=1769069085"},{"product_id":"hroc348met-cell-bhc11100956","title":"HROC348Met cell","description":"\u003cp style=\"display:none\"\u003eSKU:BHC11100956\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950210281837,"sku":"300871","price":800.0,"currency_code":"USD","in_stock":true}]},{"product_id":"hroc395met1-cell-bhc11101672","title":"HROC395Met1 cell","description":"The HROC (Hansestadt Rostock Colorectal cancer) cell line panel comprises patient-derived colorectal cancer models developed from primary tumor tissue and\/or matched metastatic lesions. These cell lines are frequently accompanied by corresponding patient-derived xenografts (PDXs) and organoids, enabling integrative modeling of colorectal cancer (CRC) in both in vitro and in vivo systems. HROC models preserve critical clinical and molecular diversity found in colorectal cancer, including variations in microsatellite instability (MSI vs. MSS) and key genetic drivers such as mutations in APC, KRAS, BRAF, PIK3CA, and TP53. Cultured as adherent epithelial monolayers and typically used at low passage numbers, HROC lines maintain phenotypic and genomic fidelity to their patient tumors, supporting translational relevance in drug and biomarker research.\n\nThe nomenclature system for HROC cell lines provides detailed metadata on origin and experimental history. For example, “Tu” identifies cell lines derived from primary tumors, “Met” from metastatic lesions, while “T#” and “M#” indicate the number of PDX transfers and the specific mouse host, respectively. This systematic naming allows for easy tracking of matched sets, such as primary-metastasis pairs or in vitro-in vivo derivatives. These matched models support studies on clonal evolution, metastasis, therapy resistance, and pharmacokinetic behavior—including transporter expression and barrier integrity relevant for drug absorption. Cell lines undergo routine authentication (e.g., STR profiling) and are tested regularly for mycoplasma contamination. Characterization data for numerous HROC models are publicly available in Cellosaurus and in peer-reviewed publications.\n\nHROC cell lines are particularly valuable for subtype-stratified drug screening, biomarker discovery across MSI-H and MSS tumors, and mechanistic studies involving primary vs. metastatic disease. When paired with PDXs and\/or organoids, they provide a robust platform for preclinical evaluation, including drug sensitivity testing and modeling of tumor-stroma or immune interactions. Due to their comprehensive annotation and clinical relevance, HROC models are suitable for both basic and translational research in colorectal cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101672\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950210543981,"sku":"300854","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HROC395Met1_20WAKO_20P1_2020x01_20220825_ch00_1920x1920_0b76726f-e1c6-4060-84d2-d373e818f7b5.jpg?v=1769069091"},{"product_id":"hrohep03-cell-bhc11100118","title":"HROHep03 cell","description":"This is one cell line of a series of tumor cell lines which have been established by PD Dr. Michael Linnebacher since 2006.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100118\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950211625325,"sku":"300197","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hrohep03-_282_29_1920x1920_9c299ce4-8142-4370-b52a-8920226354bd.jpg?v=1769069104"},{"product_id":"hucc-t1-cell-bhc11101112","title":"HuCC-T1 cell","description":"HuCC-T1 is a human cholangiocarcinoma cell line established from an intrahepatic bile duct carcinoma. Cholangiocarcinoma is a highly aggressive malignancy with limited treatment options and a poor prognosis. HuCC-T1 cells have been utilized extensively in research to study the pathophysiology of cholangiocarcinoma and to explore potential therapeutic approaches. The cell line is particularly valuable in studying the effects of various chemotherapeutic agents, including statins, which have shown potential in suppressing the proliferation of cholangiocarcinoma cells.\n\nIn studies involving HuCC-T1, statins such as pitavastatin and atorvastatin were observed to significantly inhibit cell proliferation, particularly when combined with conventional chemotherapeutic agents like gemcitabine, cisplatin, and 5-fluorouracil (5-FU). The combination of these drugs resulted in enhanced suppression of cell growth, indicating potential synergistic effects. The mechanism of action involves the induction of apoptosis via suppression of the MAPK\/ERK signaling pathway, as evidenced by increased levels of cleaved caspase-3 and reduced levels of phosphorylated ERK (p-ERK). These findings suggest that statins may serve as a promising adjunct therapy in the treatment of cholangiocarcinoma, potentially improving outcomes when used alongside existing anticancer drugs.\n\nFurthermore, the HuCC-T1 cell line has been characterized for various molecular markers, including p53 gene status, which plays a critical role in cell cycle regulation and apoptosis. The precise p53 mutation status in HuCC-T1 could provide insights into the cell line's response to DNA-damaging agents and its overall tumorigenic potential. Given its molecular characteristics, HuCC-T1 continues to be a pivotal tool in cholangiocarcinoma research, offering insights into the disease's molecular underpinnings and aiding in the development of novel therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101112\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950212149613,"sku":"300469","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HuCCT-1_20P1_20300469_2010x01_20020323_1920x1920_178a6f7d-b98d-40a0-b046-cd1ae8731bcf.jpg?v=1769069110"},{"product_id":"huh-6-cell-bhc11101101","title":"HuH-6 cell","description":"The HuH-6 cell line is a human hepatoblastoma cell line derived from the liver tissue of a child diagnosed with hepatoblastoma, a rare malignant liver tumor that primarily affects pediatric patients. HuH-6 cells exhibit characteristics typical of hepatic lineage, including the expression of hepatocyte-associated markers such as alpha-fetoprotein (AFP), albumin, and cytokeratins. These cells are adherent in culture and display epithelial morphology, making them a valuable in vitro model for studying liver development, hepatoblastoma pathogenesis, and liver-specific metabolic functions.\n\nHuH-6 cells are particularly useful in research focused on pediatric liver cancers, as they retain many of the molecular features observed in primary hepatoblastoma tissues. These include the activation of Wnt\/β-catenin signaling, a pathway frequently implicated in hepatoblastoma tumorigenesis. The cell line has also been employed in studies investigating the effects of chemotherapeutic agents, drug metabolism, and resistance mechanisms, as well as in the exploration of gene expression profiles associated with tumor progression and differentiation. Due to their reproducibility and consistent growth characteristics, HuH-6 cells serve as a robust model system for both basic liver cancer research and preclinical drug screening.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101101\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950212182381,"sku":"305092","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HuH-6_20P1_2020x01_20150725_ch00_1920x1920_0912fe2c-6130-4028-8204-75e74f000e00.jpg?v=1769069111"},{"product_id":"huh7-cell-bhc11101666","title":"HuH7 cell","description":"HuH-7 cells are a type of epithelial-like, tumorigenic cell line initially taken from a liver tumor in a 57-year-old Japanese male in 1982. The human hepatoma-derived HuH-7 cell line and its derivatives have been widely used in research as a convenient experimental substitute for primary hepatocytes. In particular, they have been instrumental in hepatitis C research and used as host cells for propagating the virus in vitro. HuH-7 cells have played a crucial role in hepatitis C research, especially when it comes to drug development. Prior to 2005, researchers were unable to cultivate the hepatitis C virus in the laboratory, making it difficult to test potential drug candidates against it.\nThe introduction of the HuH-7 cell line changed that. These cells are highly permissive to the replication of the hepatitis C virus, making them ideal for in vitro testing. By using the HuH-7 cells, researchers were able to screen drug candidates against laboratory-grown hepatitis C, which paved the way for the development of new drugs to fight the virus. Unlike other established human hepatoma cell lines, HuH-7 cells can be propagated in a chemically defined medium containing trace amounts of selenium in place of serum. This allows for systematic studies of the in vitro effects of various compounds on their growth and metabolism.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101666\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950212215149,"sku":"300156","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/huh7-_281_29__281_29.jpg?v=1769069111"},{"product_id":"li-7-cell-bhc11101026","title":"Li-7 cell","description":"The Li-7 cell line is a human hepatocellular carcinoma (HCC) cell line that is commonly used in cancer research, particularly in the study of liver cancer. Derived from a primary liver tumor, Li-7 cells exhibit the typical characteristics of HCC, including the ability to produce alpha-fetoprotein (AFP), a marker often elevated in liver cancer. These cells are also known for their genetic stability, which makes them a reliable model for long-term studies.\nGenomic analysis of Li-7 cells has revealed various chromosomal abnormalities that are characteristic of HCC, including gains in regions such as 5p, 8q, and 11q, and losses in 13q and 14q. These chromosomal changes are indicative of the complex genetic alterations that drive hepatocarcinogenesis. Specifically, the gain in 8q is associated with the amplification of the MYC oncogene, which plays a crucial role in cell cycle progression and proliferation, further emphasizing the utility of Li-7 cells in oncogenic pathway studies.\nLi-7 cells also serve as a valuable model for studying the molecular mechanisms underlying HCC, including the pathways involving key genes like TFDP1, CUL4A, and CDC16, which have been identified as targets of amplification in HCC. These genes are involved in cell cycle regulation and DNA repair, processes that are often dysregulated in cancer. Thus, the Li-7 cell line is instrumental in elucidating the molecular events that lead to the development and progression of liver cancer, providing insights that could guide therapeutic strategies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101026\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950214574445,"sku":"305102","price":650.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Li-7_20_285_29_1920x1920_2a19a9ee-2a25-44ae-aec9-2885b1ab7f51.jpg?v=1769069133"},{"product_id":"lmh-cell-bhc11100162","title":"LMH cell","description":"LMH cells, derived from a Leghorn male hepatoma, are a versatile cell line widely used in biological research. Tomoyuki Kitagawa established them in 1981 at the Cancer Institute in Tokyo, Japan. These cells have an epithelial phenotype and are particularly useful for studying host-pathogen interactions in the gastrointestinal tract of poultry.\nLMH cells are adherent and exhibit a dendritic-like morphology. They express glucose-6-phosphatase and weak canalicular ATPase activity. With a triploid karyotype and six marker chromosomes, these cells display distinct genetic characteristics.Notably, LMH cells have been shown to efficiently support duck hepatitis B virus (DHBV) DNA synthesis when transfected with viral constructs. This makes them an invaluable tool for virology research, particularly in the context of poultry-related viral infections.The derivation of LMH cells involved inducing tumorous nodules in the liver of Leghorn chickens through long-term treatment with diethylnitrosamine. These cells have also been chemically transformed, allowing for their immortalization and continuous propagation in culture.\nIn terms of tumorigenicity, LMH cells have the ability to form tumors in athymic nude mice. This characteristic makes them an important model for studying hepatocellular carcinoma. LMH cells express the estrogen receptor and can be induced to express the liver-specific apolipoprotein II (apoII) gene. This indicates their involvement in estrogen signaling pathways and lipid metabolism. To culture LMH cells, it is necessary to precoat tissue culture vessels with collagen. This ensures proper cell adhesion and growth.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100162\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950214738285,"sku":"601411","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/LMH_20P0_20601411-817SF_2010x01_20190123_1920x1920_9e9365fa-8948-402b-a967-fb987f28cce2.jpg?v=1769069135"},{"product_id":"lx-2-cell-bhc11101263","title":"LX-2 cell","description":"LX-2 is a human hepatic stellate cell line that has become a standard model for studying liver fibrosis. This cell line was immortalized from primary human hepatic stellate cells, retaining many of the in vivo characteristics necessary for the study of stellate cell activation, interaction with other liver cell types, and response to inflammatory signals. LX-2 cells are particularly noted for their utility in research focused on the pathogenesis of liver fibrosis and the evaluation of anti-fibrotic drugs. They express a variety of markers relevant to stellate cell function and fibrogenesis, including alpha-smooth muscle actin (α-SMA), glial fibrillary acidic protein (GFAP), and type I collagen.\n\nThe cell line offers an advantageous model due to its stable phenotype and responsiveness to cytokines and growth factors typically involved in liver disease processes. LX-2 cells are used to examine the cellular and molecular mechanisms underlying liver fibrosis, including the role of stellate cells in extracellular matrix deposition and the modulation of these processes by therapeutic agents. These cells provide a reproducible and controlled in vitro environment that supports high-throughput screening and mechanistic studies, making them valuable for both basic research and pharmaceutical development targeting liver diseases.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101263\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950215065965,"sku":"305039","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/LX-2_20_283_29_1920x1920_11fa47ae-9b7c-4c3b-9965-58f256fc2f90.jpg?v=1769069138"},{"product_id":"mahlavu-cell-bhc11101102","title":"Mahlavu cell","description":"The Mahlavu cell line is a human hepatocellular carcinoma (HCC) cell line derived from an adult patient with liver cancer. Hepatocellular carcinoma is the most common type of primary liver cancer, often associated with chronic liver disease, including hepatitis B or C infection and cirrhosis. Mahlavu cells exhibit characteristics typical of aggressive liver cancer, such as high proliferative capacity, invasive behavior, and resistance to apoptosis, making them a valuable model for studying the molecular mechanisms underlying HCC progression and for testing potential anti-cancer therapies.\n\nMahlavu cells are known for their epithelial morphology and are typically cultured in conditions that support the growth of hepatic cells. These cells possess mutations in key oncogenes and tumor suppressor genes, which contribute to their tumorigenic properties. Researchers often use Mahlavu cells to study signaling pathways involved in HCC, such as the Wnt\/β-catenin pathway, which is frequently dysregulated in liver cancers. Additionally, this cell line is useful in drug resistance studies, as it can provide insights into the mechanisms by which HCC cells evade standard chemotherapy treatments.\n\nDue to its aggressive nature, the Mahlavu cell line is also employed in metastasis research. Studies involving these cells can help elucidate the processes by which liver cancer spreads to other organs, particularly the lungs and lymph nodes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101102\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950215360877,"sku":"300473","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Mahlavu_20P1_2020x01_20121023_ch00_1920x1920_a5baaec7-d018-4052-8759-0b0334f66163.jpg?v=1769069141"},{"product_id":"mia-paca-2-cell-bhc11100904","title":"MIA PaCa-2 cell","description":"The MIA PaCa-2 cell line is an indispensable asset in the field of cancer research and was derived from the pancreatic carcinoma tissue of a 65-year-old male. Mia PaCa 2 cells are widely used in the study of pancreatic ductal adenocarcinoma (PDAC), a notoriously aggressive and lethal cancer type. The cell line offer a solid tumor model that reflects the cellular characteristics of PDAC. One of the key attributes of this cell line is its genetic profile, which includes mutations in critical genes like KRAS and TP53, which are emblematic of the genetic landscape observed in pancreatic cancer patients.\nThe cells have been extensively utilized to investigate various aspects of pancreatic cancer growth, metastasis, and resistance to therapeutics. Mia Paca-2 cells are instrumental in assessing the efficacy of chemotherapeutic drugs. Furthermore, the cell line serves as a vital resource for probing into the signaling pathways pivotal for cancer cell survival and metastasis, including the MAPK, PI3K\/AKT, and Wnt pathways. Studies utilizing MIA PaCa-2 cells have also shed light on the dynamic interactions between cancer cells and their microenvironment. MIA PaCa-2's robust in vitro growth and its capacity to form tumors in xenograft models make it particularly suited for examining cancer progression and the mechanisms of tumorigenesis.\nIn summary, the Mia Paca-2 cell line, with its broad application in pancreatic cancer research, continues to be a critical resource for scientists worldwide.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100904\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950216671597,"sku":"300438","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MIA_20PaCa-2_20WaKo_20_20P1_2020x01_20110725_ch00_1920x1920_ffc38eba-8c94-4bcc-9749-2522d859c3f7.jpg?v=1769069153"},{"product_id":"min-6-cell-bhc11101368","title":"MIN-6 cell","description":"The MIN-6 cell line is a murine pancreatic beta cell line derived from insulinoma. It is commonly used in research to study insulin secretion mechanisms and beta-cell function due to its ability to synthesize and secrete insulin in response to glucose levels. This cell line is particularly valuable because it retains many of the functional characteristics of primary pancreatic beta cells, making it a useful model for diabetes research.\n\nMIN-6 cells exhibit glucose-responsive insulin secretion, which is a critical trait for studies focusing on the regulation of insulin release and the cellular responses to varying glucose concentrations. The cells are also used to investigate pancreatic beta-cell proliferation and apoptosis, as well as the role of various genes and environmental factors in these processes. Additionally, MIN-6 cells have been instrumental in testing potential pharmacological agents for their effects on beta-cell function and survival, thus contributing to the development of new therapeutic strategies for diabetes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101368\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950216704365,"sku":"302148","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MIN6_20P1_2010x01_20290823_ch00_1920x1920_7f0ec50a-0739-4862-b3bc-81b6f50a898a.jpg?v=1769069153"},{"product_id":"nctc-clone-1469-cell-bhc11100463","title":"NCTC clone 1469 cell","description":"It is characteristic of this line to shed viable cells into the medium, thus rendering the medium turbid and giving the gross impression of bacterial contamination. The shed cells are viable and may be used to initiate new cultures.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100463\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950219653485,"sku":"400300","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/nctc-clone-1469-_283_29_1920x1920_4d820c72-cf82-45b5-ac12-5fbe01432072.jpg?v=1769069177"},{"product_id":"panc-10-05-cell-bhc11101175","title":"Panc 10.05 cell","description":"The Panc 10.05 cell line is a human pancreatic ductal adenocarcinoma (PDAC) cell line, which is used in studies exploring the biology of pancreatic cancer and potential therapeutic interventions. Like other PDAC cell lines, Panc 10.05 cells are often employed in research focused on understanding the tumor microenvironment, cancer cell proliferation, and mechanisms of resistance to chemotherapy. This cell line, along with others such as BxPC-3 and HPAF-II, has been used to test the effects of novel anti-cancer agents, including iron chelators like deferasirox (DFX). Studies have shown that DFX exhibits dose-dependent antiproliferative activity against Panc 10.05 cells by inducing apoptosis and arresting the cell cycle in the S-phase.\nPanc 10.05 has also been used to explore the role of inflammation and immune modulation in pancreatic cancer. For example, in co-culture models with macrophages, Panc 10.05 cells were shown to interact with tumor-associated macrophages (TAMs), creating a pro-inflammatory microenvironment. This interaction leads to the activation of the NLRP3 inflammasome, which plays a critical role in promoting tumor growth and immune evasion. Inhibition of the NLRP3 inflammasome by specific inhibitors like MCC950 has been shown to reduce the pro-inflammatory cytokine response and tumor cell proliferation, highlighting its potential as a therapeutic target.\nOverall, the Panc 10.05 cell line serves as a robust model for studying both the direct effects of therapeutic agents and the complex interactions within the tumor microenvironment in pancreatic cancer, aiding in the development of new treatment strategies for this aggressive disease.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101175\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950220996973,"sku":"300599","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Panc_2010.05_20P2_2010x01_20220524_ch00_1920x1920_c493cc0f-cbf9-4520-8199-803ec81fe718.jpg?v=1769069191"},{"product_id":"panc02-cell-bhc11101160","title":"Panc02 cell","description":"The Panc02 cell line is a widely used murine model for studying pancreatic ductal adenocarcinoma (PDAC), the most common and aggressive form of pancreatic cancer. Panc02 cells were originally derived from a chemically induced pancreatic tumor in a C57BL\/6 mouse. This cell line is highly relevant in preclinical research because it can be implanted orthotopically in syngeneic mice, mimicking the natural tumor environment and offering insights into the immune responses and therapeutic resistance mechanisms of PDAC.\nResearch using Panc02 has provided significant insights into PDAC’s immunosuppressive microenvironment. One study showed that Panc02 tumors are heavily infiltrated by regulatory T cells (Tregs), which suppress the antitumor immune response. Treatment with low-dose gemcitabine was found to selectively deplete Tregs in Panc02 tumor-bearing mice, leading to an enhanced antitumor immune response and a modest increase in survival. This suggests that immunomodulation could be a promising therapeutic strategy for PDAC.\nIn addition to immunotherapy studies, Panc02 has also been used to investigate necroptosis, a form of programmed cell death. Inhibition of Aurora Kinase A in Panc02 cells has been shown to induce necroptosis, which is important for overcoming resistance to apoptosis in PDAC. This provides a potential therapeutic approach to target apoptosis-resistant cancer cells by promoting non-apoptotic cell death pathways.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101160\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950221029741,"sku":"300501","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Panc-02_20P3_2020x01_20080523_1920x1920_d612189e-5c93-4280-800a-11c98360ca6b.jpg?v=1769069191"},{"product_id":"panc-1-cell-bhc11100805","title":"Panc-1 cell","description":"PANC-1 cells, originating from a pancreatic duct carcinoma in a 56-year-old Caucasian male, stand as a pivotal epithelial cell line in the realm of cancer research, particularly in the study of pancreatic carcinoma. Panc1 cells offer a useful model for delving into the intricacies of pancreatic cancer, including ductal adenocarcinoma cell lines and their tumorigenic potential.\nThe cells' epithelial morphology and their capacity to exhibit diverse morphological patterns underscore their relevance in mimicking the clonal heterogeneity and complex tumor microenvironment seen in pancreatic ductal adenocarcinoma (PDAC).\nPANC-1 cells express markers such as vimentin and somatostatin receptors like SSTR2, which play a crucial role in neuroendocrine differentiation. This expression profile, coupled with the cells' ability to undergo epithelial-mesenchymal transition (EMT) marker expression and EMT subtype shifting, makes them an excellent platform for exploring therapeutic strategies targeting the EMT process and neuroendocrine features of pancreatic cancer.\nThe cell line's karyotypic analysis reveals a hyperdiploid state with notable genetic alterations, including the loss of the Y chromosome and mutations in critical genes such as CDKN2A and the p53 gene.\nIn summary, PANC-1 cells provide a multifaceted model for pancreatic cancer research, enabling detailed investigations into the phenotype and genotype of pancreatic adenocarcinoma, the efficacy of targeted therapies, and the molecular mechanisms driving cancer progression.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100805\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950221062509,"sku":"300228","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Panc-1_20P3_2020x01_20130825_ch00_1920x1920_5b1aa77b-0dcf-4e5b-8db3-d714223f4250.jpg?v=1769069191"},{"product_id":"patu8988t-cell-bhc11101172","title":"PATU8988T cell","description":"This cell line was established in 1985 from the liver metastasis of a primary pancreatic adenocarcinoma from a 64-year-old woman. PATU8988T and PATU8988S (DSM ACC 204) are pancreatic cell lines derived from the same patient.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101172\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950221095277,"sku":"305133","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/PATU8988T_2010x01_20080523_1920x1920_60d80adf-b185-4b29-940f-b197802b54ac.jpg?v=1769069191"},{"product_id":"plc-prf-5-cell-bhc11100131","title":"PLC\/PRF\/5 cell","description":"The cells produce HBsAg. At present, there is no evidence that this cell line produces infectious Hepatitis B virus.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100131\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950221422957,"sku":"300315","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/PLC-PRF-5_20WaKo_20P1_2020x01_20040925_ch00_1920x1920_02f46cb3-8331-4131-bb96-c7fb272dae64.jpg?v=1769069195"}],"url":"https:\/\/www.ebiohippo.com\/collections\/rtc-metabolic-endocrine-diabetes-insulin-resistance-cells.oembed?page=41","provider":"BioHippo","version":"1.0","type":"link"}