{"title":"Validated Cancer Antibodies","description":"Application-validated cancer-research antibodies, each validated for two or more applications spanning Western blot, immunohistochemistry and immunofluorescence. Check each datasheet for the applications validated for your target. Save 15% with code ONCO15.","products":[{"product_id":"anti-mmp9-polyclonal-antibody-bha21404468","title":"Anti-MMP9 Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003eAntibody against MMP9 (Matrix metalloproteinase-9) for research detection of protein expression and localization.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget biology\u003c\/strong\u003e\u003cbr\u003eMMP9 is a molecular target commonly interrogated by antibody-based methods to measure protein expression, localization and regulation across biological systems. Antibodies against MMP9 support studies ranging from baseline expression profiling to stimulus- or disease-associated changes in abundance and subcellular distribution. For pathway-level interpretation, pair MMP9 detection with appropriate controls and complementary readouts (e.g., genetic perturbation or orthogonal assays).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpected localization\u003c\/strong\u003e\u003cbr\u003eSubcellular localization is target- and context-dependent; use cell-type appropriate controls and, where possible, genetic KO\/KD as specificity controls.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch context\u003c\/strong\u003e\u003cbr\u003eThis target is frequently studied in the context of \u003cem\u003eECM \u0026amp; Cell Adhesion\u003c\/em\u003e research. Application suitability (e.g., ELISA, IHC, WB, IF) is indicated in the specifications; conditions should be optimized by titration. Species reactivity information is provided in the specifications (reported: Human).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended experimental notes\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eFor Western blotting, optimize lysis conditions and include reducing\/non-reducing conditions as appropriate; titrate antibody to balance sensitivity and background.\u003c\/li\u003e\n\u003cli\u003eFor IHC, fixation and antigen retrieval strongly influence epitope accessibility; test citrate- vs EDTA-based retrieval and include matched positive\/negative tissues.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, adjust permeabilization (e.g., mild detergent vs stronger conditions) based on expected localization; include secondary-only and isotype controls for background.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, ensure capture\/detection antibody compatibility and run a standard curve; verify sample matrix effects with spike-and-recovery and dilution linearity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eControls \u0026amp; interpretation\u003c\/strong\u003e\u003cbr\u003eWhere possible, confirm specificity using genetic perturbation (KO\/KD\/CRISPR), peptide competition (if applicable), or an orthogonal readout. Include a negative control sample expected to express low\/none of MMP9, and a positive control sample known to express MMP9.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eImmunogen context\u003c\/strong\u003e\u003cbr\u003eGenerated using an immunogen derived from E. coli - derived recombinant Human MMP9 (Val217-Asp390).. When interpreting results, note that epitope accessibility can vary with denaturation, fixation, or post‑translational modifications; empirical optimization is recommended.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53036895568237,"sku":"HB945014-50UG","price":100.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037480378733,"sku":"HB945014-100UG","price":160.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HB945014-abinscience-WB-1.jpg?v=1771745428"},{"product_id":"anti-cdk1-polyclonal-antibody-bha21404656","title":"Anti-CDK1 Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003eAntibody against CDK1 (Cell division control protein 2 homolog) for research detection of protein expression and localization.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget biology\u003c\/strong\u003e\u003cbr\u003eCDK1 encodes a cyclin-dependent kinase (CDK) family serine\/threonine kinase involved in phosphorylation-driven signaling. CDKs coordinate cell-state transitions by partnering with regulatory proteins and substrates such as RB-family proteins and transcriptional regulators. Antibodies against CDK1 are commonly used to study kinase expression, activation-state changes (often via upstream cues), and pathway rewiring in proliferation and cancer models.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpected localization\u003c\/strong\u003e\u003cbr\u003eCDK family kinases are typically detected in nuclear and cytoplasmic compartments; distribution can shift with cell-cycle state and binding partners.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch context\u003c\/strong\u003e\u003cbr\u003eThis target is frequently studied in the context of \u003cem\u003eCell Signaling\u003c\/em\u003e research. Application suitability (e.g., ELISA, IF, IHC, WB) is indicated in the specifications; conditions should be optimized by titration. Species reactivity information is provided in the specifications (reported: Human, Mouse, Rat).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended experimental notes\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eFor Western blotting, optimize lysis conditions and include reducing\/non-reducing conditions as appropriate; titrate antibody to balance sensitivity and background.\u003c\/li\u003e\n\u003cli\u003eFor IHC, fixation and antigen retrieval strongly influence epitope accessibility; test citrate- vs EDTA-based retrieval and include matched positive\/negative tissues.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, adjust permeabilization (e.g., mild detergent vs stronger conditions) based on expected localization; include secondary-only and isotype controls for background.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, ensure capture\/detection antibody compatibility and run a standard curve; verify sample matrix effects with spike-and-recovery and dilution linearity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eControls \u0026amp; interpretation\u003c\/strong\u003e\u003cbr\u003eWhere possible, confirm specificity using genetic perturbation (KO\/KD\/CRISPR), peptide competition (if applicable), or an orthogonal readout. Include a negative control sample expected to express low\/none of CDK1, and a positive control sample known to express CDK1.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eImmunogen context\u003c\/strong\u003e\u003cbr\u003eGenerated using an immunogen derived from E. coli - derived recombinant Human CDK1 (Met1-Met297).. When interpreting results, note that epitope accessibility can vary with denaturation, fixation, or post‑translational modifications; empirical optimization is recommended.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53036902023533,"sku":"HY308014-50UG","price":100.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037486539117,"sku":"HY308014-100UG","price":160.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HY308014-abinscience-WB-1.jpg?v=1771745471"},{"product_id":"anti-human-crept-antibody-3e10-bha21407654","title":"Anti-Human CREPT Antibody (3E10#)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Human CREPT Antibody (3E10#) targets \u003cstrong\u003eCREPT\u003c\/strong\u003e (Regulation of nuclear pre-mRNA domain-containing protein 1B). Frequently used across ELISA, IF, IHC, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Oncology \u0026amp; Angiogenesis research.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eCREPT (Regulation of nuclear pre-mRNA domain-containing protein 1B) is a protein annotated as regulation of nuclear pre-mrna domain-containing protein 1b, and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Oncology \u0026amp; Angiogenesis. Based on the annotated name\/class, the target is most often associated with nucleus localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, optimize capture\/detection pairing and run a standard curve in matrix-matched diluent when possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037003014509,"sku":"HP069013-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037678002541,"sku":"HP069013-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037678035309,"sku":"HP069013-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HP069013-SDS-PAGE-1.jpg?v=1771747453"},{"product_id":"anti-human-ctnnb1-nanobody-saa1197-bha21408012","title":"Anti-Human CTNNB1 Nanobody (SAA1197)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Human CTNNB1 Nanobody (SAA1197) targets \u003cstrong\u003eCTNNB1\u003c\/strong\u003e (Catenin beta-1). Frequently used across ELISA, IF, IHC, IP, SPR, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Molecular \u0026amp; Cellular Biology research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Catenin beta-1, Beta-catenin, CTNNB.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eCTNNB1 (Catenin beta-1) is annotated as catenin beta-1 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Molecular \u0026amp; Cellular Biology. Common alternative names and symbols used in the literature include: Beta-catenin, CTNNB. Based on the annotated name\/class, the target is most often associated with context-dependent localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003cli\u003eFor immunoprecipitation, use gentle lysis conditions, maintain cold temperatures, and validate enrichment relative to an isotype control.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, optimize capture\/detection pairing and run a standard curve in matrix-matched diluent when possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037014483309,"sku":"HW518013-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037701955949,"sku":"HW518013-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037701988717,"sku":"HW518013-1MG","price":1858.0,"currency_code":"USD","in_stock":true}]},{"product_id":"anti-human-fn1-fibronectin-antibody-saa0522-bha21408518","title":"Anti-Human FN1\/Fibronectin Antibody (SAA0522)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Human FN1\/Fibronectin Antibody (SAA0522) targets \u003cstrong\u003eFN1\/Fibronectin\u003c\/strong\u003e (Cold-insoluble globulin). Frequently used across ELISA, IF, IHC, SPR, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in ECM \u0026amp; Cell Adhesion research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Cold-insoluble globulin, Fibronectin, CIG, FN1, FN.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eFN1\/Fibronectin (Cold-insoluble globulin) is annotated as cold-insoluble globulin and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to ECM \u0026amp; Cell Adhesion. Common alternative names and symbols used in the literature include: Fibronectin, CIG, FN1, FN. Based on the annotated name\/class, the target is most often associated with context-dependent localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, optimize capture\/detection pairing and run a standard curve in matrix-matched diluent when possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037031620973,"sku":"HY259013-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037734658413,"sku":"HY259013-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037734691181,"sku":"HY259013-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HY259013-SDS-PAGE-1.jpg?v=1771747859"},{"product_id":"anti-human-fgf13-antibody-n235-22r-bha21408550","title":"Anti-Human FGF13 Antibody (N235\/22R)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Human FGF13 Antibody (N235\/22R) targets \u003cstrong\u003eFGF13\u003c\/strong\u003e (Fibroblast growth factor homologous factor 2). Frequently used across IF, IHC, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Oncology \u0026amp; Angiogenesis research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Fibroblast growth factor homologous factor 2, Fibroblast growth factor 13, FGF-13, FHF-2, FHF2.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eFGF13 (Fibroblast growth factor homologous factor 2) is annotated as fibroblast growth factor homologous factor 2 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Oncology \u0026amp; Angiogenesis. Common alternative names and symbols used in the literature include: Fibroblast growth factor 13, FGF-13, FHF-2, FHF2. Based on the annotated name\/class, the target is most often associated with secreted \/ extracellular localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037032407405,"sku":"HV462013-50UG","price":196.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037737214317,"sku":"HV462013-100UG","price":326.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037737247085,"sku":"HV462013-1MG","price":1638.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HV462013-SDS-PAGE-1.jpg?v=1771747847"},{"product_id":"anti-mouse-tp53-p53-antibody-pab242-bha21408804","title":"Anti-Mouse TP53\/p53 Antibody (PAb242)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Mouse TP53\/p53 Antibody (PAb242) targets \u003cstrong\u003eTP53\/p53\u003c\/strong\u003e (Cellular tumor antigen p53). Frequently used across ELISA, IF, IHC, IP, RIA, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Oncology \u0026amp; Angiogenesis research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Cellular tumor antigen p53, Phosphoprotein p53, Tumor suppressor p53, Antigen NY-CO-13, TP53, P53.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eTP53\/p53 (Cellular tumor antigen p53) is annotated as cellular tumor antigen p53 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Oncology \u0026amp; Angiogenesis. Common alternative names and symbols used in the literature include: Phosphoprotein p53, Tumor suppressor p53, Antigen NY-CO-13, TP53, P53. Based on the annotated name\/class, the target is most often associated with context-dependent localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003cli\u003eFor immunoprecipitation, use gentle lysis conditions, maintain cold temperatures, and validate enrichment relative to an isotype control.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, optimize capture\/detection pairing and run a standard curve in matrix-matched diluent when possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037040468333,"sku":"MY039013-50UG","price":196.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037753729389,"sku":"MY039013-100UG","price":326.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037753762157,"sku":"MY039013-1MG","price":1638.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MY039013-bioactivity-binding-1.jpg?v=1771748048"},{"product_id":"anti-mouse-fgf13-antibody-n235-22-bha21408794","title":"Anti-Mouse FGF13 Antibody (N235\/22)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Mouse FGF13 Antibody (N235\/22) targets \u003cstrong\u003eFGF13\u003c\/strong\u003e (Fibroblast growth factor homologous factor 2). Frequently used across FCM, IF, IHC, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Oncology \u0026amp; Angiogenesis research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Fibroblast growth factor homologous factor 2, Fibroblast growth factor 13, FGF-13, FHF-2, FHF2.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eFGF13 (Fibroblast growth factor homologous factor 2) is annotated as fibroblast growth factor homologous factor 2 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Oncology \u0026amp; Angiogenesis. Common alternative names and symbols used in the literature include: Fibroblast growth factor 13, FGF-13, FHF-2, FHF2. Based on the annotated name\/class, the target is most often associated with secreted \/ extracellular localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037041189229,"sku":"MV462013-50UG","price":196.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037752942957,"sku":"MV462013-100UG","price":326.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037752975725,"sku":"MV462013-1MG","price":1638.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MV462013-SDSPAGE-1.jpg?v=1771748012"},{"product_id":"anti-human-trop2-tacstd2-trop-2-antibody-fu-mk1-bha21409054","title":"Anti-Human TROP2\/TACSTD2\/TROP-2 Antibody (FU-MK1)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nAnti-Human TROP2\/TACSTD2\/TROP-2 Antibody (FU-MK1) targets \u003cstrong\u003eTROP2\/TACSTD2\/TROP-2\u003c\/strong\u003e (Membrane component chromosome 1 surface marker 1). Frequently used across ELISA, ICC, IHC, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Oncology \u0026amp; Angiogenesis research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, GA733-1, TACSTD2, TROP2, M1S1.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eTROP2\/TACSTD2\/TROP-2 (Membrane component chromosome 1 surface marker 1) is annotated as membrane component chromosome 1 surface marker 1 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Oncology \u0026amp; Angiogenesis. Common alternative names and symbols used in the literature include: Pancreatic carcinoma marker protein GA733-1, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, GA733-1, TACSTD2, TROP2, M1S1. Based on the annotated name\/class, the target is most often associated with plasma membrane and\/or intracellular membranes localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003cli\u003eFor ELISA, optimize capture\/detection pairing and run a standard curve in matrix-matched diluent when possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037048693101,"sku":"HY373013-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037770309997,"sku":"HY373013-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037770342765,"sku":"HY373013-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HY373013-SDS-PAGE-1.jpg?v=1771748137"},{"product_id":"invivomab-anti-mouse-cd274-pd-l1-b7-h1-antibody-10f-9g2-d265a-bha21409498","title":"InVivoMAb Anti-Mouse CD274\/PD-L1\/B7-H1 Antibody (10F.9G2) (D265A)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nInVivoMAb Anti-Mouse CD274\/PD-L1\/B7-H1 Antibody (10F.9G2) (D265A) targets \u003cstrong\u003eCD274\/PD-L1\/B7-H1\u003c\/strong\u003e (Programmed cell death 1 ligand 1). Frequently used across in vivo PD-L1 blockade, in vitro PD-L1 blockade, IF, IHC-F, FCM, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Immunology \u0026amp; Inflammation research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Programmed cell death 1 ligand 1, Programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, PD-L1, B7-H1, Pdcd1lg1, Pdcd1l1.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eCD274\/PD-L1\/B7-H1 (Programmed cell death 1 ligand 1) is annotated as programmed cell death 1 ligand 1 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Immunology \u0026amp; Inflammation. Common alternative names and symbols used in the literature include: Programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, PD-L1, B7-H1, Pdcd1lg1, Pdcd1l1. Based on the annotated name\/class, the target is most often associated with context-dependent localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only. Not suitable for clinical or therapeutic use.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53037062881645,"sku":"MV974050-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037792264557,"sku":"MV974050-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037792297325,"sku":"MV974050-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MV974050-SDS-PAGE-1.jpg?v=1771748343"},{"product_id":"invivo-plus-anti-mouse-cd274-pd-l1-b7-h1-antibody-10f-9g2-bha21418001","title":"InVivo Plus Anti-Mouse CD274\/PD-L1\/B7-H1 Antibody (10F.9G2)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003e\nInVivo Plus Anti-Mouse CD274\/PD-L1\/B7-H1 Antibody (10F.9G2) targets \u003cstrong\u003eCD274\u003c\/strong\u003e (Programmed cell death 1 ligand 1). Frequently used across in vivo PD-L1 blockade, in vitro PD-L1 blockade, IF, IHC-F, FCM, WB workflows, depending on experimental design and sample type. This antibody is suited for workflows commonly used in Immunology \u0026amp; Inflammation research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Programmed cell death 1 ligand 1, Programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, PD-L1, B7-H1, Pdcd1lg1, Pdcd1l1, B7h1, Pdl1.\u003c\/p\u003e\n\n\u003ch3\u003eTarget biology\u003c\/h3\u003e\n\u003cp\u003eCD274 (Programmed cell death 1 ligand 1) is annotated as programmed cell death 1 ligand 1 and is commonly profiled for expression and localization in relevant model systems. It is frequently investigated in contexts related to Immunology \u0026amp; Inflammation. Common alternative names and symbols used in the literature include: Programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, PD-L1, B7-H1, Pdcd1lg1, Pdcd1l1, B7h1, Pdl1. Based on the annotated name\/class, the target is most often associated with context-dependent localization, though this can vary by model system.\u003c\/p\u003e\n\n\u003ch3\u003eHow this antibody helps\u003c\/h3\u003e\n\u003cp\u003eAs a monoclonal reagent, this antibody is designed for clone-to-clone consistency and epitope-focused recognition. For best performance, interpret signal in the context of appropriate biological controls and orthogonal readouts when available.\u003c\/p\u003e\n\n\u003ch3\u003eRecommended experimental notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTitrate the antibody to optimize signal-to-noise for your specific sample type and detection system.\u003c\/li\u003e\n\u003cli\u003eUse appropriate positive and negative controls (e.g., target-high vs target-low samples, KO\/KD where available).\u003c\/li\u003e\n\u003cli\u003eFor Western blotting, use fresh protease (and phosphatase, if relevant) inhibitors and confirm the primary band at the expected molecular weight; additional bands may reflect isoforms or processing.\u003c\/li\u003e\n\u003cli\u003eFor IHC, optimize fixation and antigen retrieval (buffer\/pH\/heat) and include an isotype\/secondary-only control to assess background.\u003c\/li\u003e\n\u003cli\u003eFor IF\/ICC, test fixation (PFA vs methanol) and permeabilization conditions to preserve epitope accessibility while minimizing background.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAdditional notes\u003c\/h3\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"1 mg","offer_id":53037253394797,"sku":"MV974029-1MG","price":128.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53037897417069,"sku":"MV974029-5MG","price":500.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53037897449837,"sku":"MV974029-25MG","price":1714.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53037897482605,"sku":"MV974029-50MG","price":2572.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53037897515373,"sku":"MV974029-100MG","price":3572.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MV974029-SDSPAGE-1.jpg?v=1771750012"},{"product_id":"hsp90-alpha-beta-antibody-bha11900480","title":"HSP90 alpha\/beta Antibody","description":"\u003cp\u003eHSP90α and HSP90β are the two major cytosolic isoforms of the highly conserved heat shock protein 90 (HSP90) family, essential for maintaining protein homeostasis in all eukaryotic cells. While they share 85% amino acid sequence identity, the isoforms differ in structure and function: HSP90α primarily forms homodimers and is stress-inducible, whereas HSP90β exists mainly as a monomer and is constitutively expressed.\u003c\/p\u003e\n\n\u003cp\u003eBoth isoforms are abundantly expressed in the brain and play critical roles in the folding, maturation, and stabilization of a wide range of client proteins involved in neuronal signaling, synaptic plasticity, and cellular stress responses. These include kinases (e.g., c-Raf), transcription factors (e.g., p53), and hormone receptors—many of which are implicated in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease.\u003c\/p\u003e\n\n\u003cp\u003eHSP90α and HSP90β function as part of dynamic chaperone complexes, interacting with co-chaperones like Cdc37 and p23. ATP binding drives conformational changes that enable these complexes to stabilize client proteins and prevent their degradation. However, in disease contexts, this protective mechanism can inadvertently preserve toxic protein species, contributing to pathogenesis.\u003c\/p\u003e\n\n\u003cp\u003eBy recognizing both HSP90α and HSP90β, this antibody provides a powerful tool for researchers exploring the dual roles of HSP90 in neuronal health and disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040786112877,"sku":"SMC-135D","price":352.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040802234733,"sku":"SMC-135D-A390","price":407.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040802267501,"sku":"SMC-135D-A488","price":406.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040802300269,"sku":"SMC-135D-A594","price":406.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040802333037,"sku":"SMC-135D-BI","price":402.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040802365805,"sku":"SMC-135D-FITC","price":397.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040802398573,"sku":"SMC-135S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-135_Hsp90-alpha-beta_Antibody_K41220A_ICC-IF_Human_HeLa-Cells_100x_Composite.png?v=1771832129"},{"product_id":"hsc70-hsp73-antibody-bha11900720","title":"HSC70 (HSP73) Antibody","description":"\u003cp\u003eThe HSP70 family comprises highly conserved, heat-inducible 70-kDa proteins that play a pivotal role in maintaining cellular proteostasis, particularly under stress conditions. Encoded by a multigene family in most eukaryotes, HSP70 proteins are ubiquitously distributed across cellular compartments—including the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts—and are also present in prokaryotes. Their evolutionary conservation, with over 50% sequence identity, underscores their essential biological functions.\u003c\/p\u003e\n\n\u003cp\u003eHSP70 proteins exhibit high-affinity ATP binding and possess ATPase activity, which is enhanced upon interaction with unfolded proteins and synthetic peptides. Structurally, the N-terminal domain mediates ATP binding, while the C-terminal domain governs substrate interaction. This dual-domain architecture enables HSP70s to act as molecular chaperones, facilitating protein folding, preventing aggregation, and promoting recovery from proteotoxic stress.\u003c\/p\u003e\n\n\u003cp\u003eIn the context of neurodegenerative diseases, inducible HSP70 (HSP72) and its constitutively expressed counterpart HSC70 are of particular interest. Following cellular stress, such as heat shock, HSP72 is rapidly upregulated and forms ATP-dependent complexes with HSC70. This interaction is critical for restoring centrosomal integrity and function—processes often disrupted in neurodegenerative pathologies like Alzheimer’s and Parkinson’s disease.\u003c\/p\u003e\n\n\u003cp\u003eGiven their central role in protein quality control and cellular resilience, HSP70 proteins are emerging as promising therapeutic targets in neuroscience and neurodegeneration research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040786211181,"sku":"SMC-151B","price":370.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040806691181,"sku":"SMC-151B-A390","price":474.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040806723949,"sku":"SMC-151B-A488","price":471.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040806756717,"sku":"SMC-151B-A594","price":471.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040806789485,"sku":"SMC-151B-APC","price":470.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040806822253,"sku":"SMC-151B-BI","price":461.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040806855021,"sku":"SMC-151B-FITC","price":453.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040806887789,"sku":"SMC-151B-HRP","price":447.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040806920557,"sku":"SMC-151B-PCP","price":470.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040806953325,"sku":"SMC-151B-RPE","price":463.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040806986093,"sku":"SMC-151S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-151_Hsc70-Hsp73_Antibody_1F2-H5_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png?v=1771832139"},{"product_id":"hsp70-antibody-bha11900001","title":"HSP70 Antibody","description":"\u003cp\u003eHSP70 proteins are a highly conserved family of 70-kDa molecular chaperones encoded by a multigene family in most eukaryotes and prokaryotes. Found in nearly all cellular compartments—including the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts—HSP70s are constitutively expressed and strongly upregulated in response to cellular stress.\u003c\/p\u003e\n\n\u003cp\u003eThese chaperones play a vital role in protein homeostasis by binding to nascent polypeptides and partially folded or misfolded proteins, preventing aggregation and facilitating proper folding. HSP70s exhibit high-affinity ATP binding and weak ATPase activity, which is stimulated upon interaction with unfolded substrates. ATP hydrolysis triggers conformational changes that regulate substrate binding and release, enabling dynamic cycles of protein folding and refolding.\u003c\/p\u003e\n\n\u003cp\u003eStructurally, the N-terminal domain of HSP70 is responsible for ATP binding, while the C-terminal domain mediates substrate interaction. This modular design allows HSP70s to coordinate with co-chaperones such as HSP40, HIP, HOP, and BAG-1, integrating folding with degradation and transport pathways.\u003c\/p\u003e\n\n\u003cp\u003eIn neurodegenerative disease research, HSP70 is of particular interest due to its ability to counteract protein misfolding and aggregation—hallmarks of disorders like Alzheimer’s, Parkinson’s, and Huntington’s disease. 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