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Home / Biochemicals / Small Molecules

(+)-MK 801 maleate

SKU : BHB21300223

An Antagonist of NMDA Receptors

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Mfr.No.	M-230, M-230_10 mg, M-230_100 mg, M-230_25 mg, M-230_250 mg, M-230_5 mg, M-230_50 mg
Description	(+)-MK 801 maleate (#M-230) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C20H19NO4.
Synonyms	Synthetic
Background	MK-801 maleate is a non competitive, high affinity, open channel blocker of the N-methyl-D-aspartate (NMDA) receptors. MK-801 blocks NMDA-induced currents in a voltage-dependent manner, preventing the influx of calcium ions through the channel. This compound is being used as a pharmacological tool to explore NMDA receptor function.The drug exists in two isomers (+) and (-) and displays several biological properties such as anticonvulsant and anesthetic. MK-801 is not used clinically because it has been shown to promote the development of brain lesions in rats1,2.NMDA receptors are ion channels gated by the major excitatory neurotransmitter in the mammalian central nervous system, glutamate. Glutamate-mediated signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception3.In rats, MK-801 has the ability to induce a characteristic behavioral syndrome with ataxia, stereotypic behavior and hyperlocomotion. In addition, the compound can induce necrosis in a small population of neurons in the cortex of rats4.It has also been discerned that MK-801 induces schizophrenia-like symptoms in rodents, including cognitive functions5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.01-10 uM.
Reconstitution	Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Cas Number	77086-22-7
Molecular Weight	337.4
Solubility	Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	NMDA receptors
Activity	(+)-MK 801 maleate is a potent, selective and non-competitive NMDA receptor antagonist with an IC50 of 0.01 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Svoboda, J. et al. (2015) Front. Behav. Neurosci. 9, 75. Srebro, D.P. et al. (2014) Tohoku J. Exp. Med. 234, 287. Kovacic, P. et al. (2010) Oxid. Med. Cell. Longev. 3, 13. Talukder, I . et al. (2010) J. Neurosci. 30, 11792. Fix, A.S. et al. (2000) Toxicol. Pathol. 28, 84. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300223-1	M-230_10 mg	10 mg	$57		Add to Cart
BHB21300223-2	M-230_100 mg	100 mg	$401		Add to Cart
BHB21300223-3	M-230_25 mg	25 mg	$124		Add to Cart
BHB21300223-4	M-230_250 mg	250 mg	$950		Add to Cart
BHB21300223-5	M-230_5 mg	5 mg	$46		Add to Cart
BHB21300223-6	M-230_50 mg	50 mg	$221		Add to Cart

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