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Home / Biochemicals / Small Molecules

7-Chlorokynurenic acid

SKU : BHB21300089

An Antagonist of NMDA Receptors

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Alomone Labs

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Mfr.No.	C-285, C-285_10 mg, C-285_100 mg, C-285_25 mg, C-285_50 mg
Description	7-Chlorokynurenic acid (#C-285) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H6ClNO3.
Synonyms	Synthetic
Background	7-Chlorokynurenic acid (7-CKA), a derivative of kynurenic acid, is a potent and selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. 7-CKA acts and binds with high affinity to the glycine binding site located on the NMDA receptor. This compound has neuroprotective, antinociceptive and anticonvulsive effects lacking the ability to penetrate the blood-brain-barrier and has therapeutic potential in some types of epilepsy1-3. Several studies that conducted radioligand binding experiments showed that 7-chlorokynurenic acid binds to the strychnine-glycine binding site with high affinity (IC50 value of 0.56 uM)5.Several studies have shown that acute administration of 7-CKA can produce rapid antidepressant-like effects without showing addictive potential2. It seems that inhibition of the phospho-glycogen synthase kinase-3beta pathway and activation of the mammalian target of rapamycin in the medial prefrontal cortex are connected to the 7-CKA rapid behavioural response2.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate several physiological functions including learning and memory formation, they play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	18000-24-3
Molecular Weight	223.61
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
Target	NMDA receptors
Activity	7-Chlorokynurenic acid is an NMDA receptor antagonist that acts at the glycine site with IC50 of 3.4 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Green, T. et al. (2002) Mol. Pharmacol. 61, 326. Zhu, W.L. et al. (2013) J. Psychiatry. Neurosci. 38, 306. Wu, H.Q. et al. (2005) Epilepsia 46, 1010. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45. Kemp, J.A . et al. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 6547. Green, T. et al. (2002) Mol. Pharmacol. 61, 326.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300089-1	C-285_10 mg	10 mg	$66		Add to Cart
BHB21300089-2	C-285_100 mg	100 mg	$476		Add to Cart
BHB21300089-3	C-285_25 mg	25 mg	$145		Add to Cart
BHB21300089-4	C-285_50 mg	50 mg	$263		Add to Cart

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