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Home / Biochemicals / Small Molecules

alpha-Asarone

SKU : BHB21300012

An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor

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Alomone Labs

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Mfr.No.	A-260, A-260_1 g, A-260_10 g, A-260_5 g
Description	alpha-Asarone (#A-260) is a highly pure, natural, and biologically active compound.
Molecular Formula	C12H16O3.
Synonyms	Natural
Background	alpha-Asarone is an active component of the Chinese medicinal plant Acorus tatarinouii Schott and exhibits a variety of pharmacological activities such as anti-hyperlipidemic, anti-coagulant, anti-tumor, anti-viral, and anti-inflammatory1,2.alpha-Asarone acts as a NaV channel blocker, GABA(A) receptor blocker and TrkB receptor inhibitor and is available in the market in the form of tablets, capsules and injections1.The neuroprotective actions of alpha-asarone are exhibited through the blockade of N-methyl-D-aspartate (NMDA) receptor and by inhibition of nitric oxide (NO) overproduction in brain tissue. alpha-Asarone also exhibits anti-oxidative properties, reduces levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase in the hippocampus against noise-stress and in various seizure models3.Recent studies have shown that alpha-asarone has the ability to improve multiple physiological actions, to produce a variety of pharmacological actions in the CNS and modulate immune system functions. The anti-convulsant activity of alpha-asarone has been reported in several recent studies in epileptic seizure animal models3.alpha-Asarone was shown to be effective in attenuating foam cell formation and enhancing cholesterol efflux4. In addition, it protects against angiotensin II-mediated damage of endothelial cells and can be developed for the prevention of injury to cardiovascular tissues2.alpha-Asarone may serve as a preventive and regenerative therapeutic agent to promote neurogenesis against age-related neurodegeneration and neurodegenerative disorders5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-500 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	2883-98-9
Molecular Weight	208.3
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NaV channels, GABA(A) receptors, TrkB receptors, NMDA receptors
Activity	alpha-Asarone 100 uM to 1 mM inhibits NaV1.2 channel currents. It also blocks GABA(A) receptors in neurons1. alpha-Asarone blocks corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,2,4-trimethoxy-5-((E)-prop-1-enyl)benzene.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Lee, B. et al. (2014) Korean J. Physiol. Pharmacol. 18, 191. Park, S.H . et al. (2015) Int. J. Mol. Med. 35, 957. Shin, J.W. et al. (2014) Biomol. Ther. (Seoul). 22,17. Shi, H.X. et al. (2014) Evid. Based Complement. Alternat. Med. 2014, 682041. Wang, Z.J. et al. (2014) Front. Pharmacol. 5, 1. Lee, B. et al. (2014) Korean J. Physiol. Pharmacol. 18, 191.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300012-1	A-260_1 g	1 g	$50		Add to Cart
BHB21300012-2	A-260_10 g	10 g	$287		Add to Cart
BHB21300012-3	A-260_5 g	5 g	$219		Add to Cart

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