RAC-alpha serine/threonine-protein kinase|Protein kinase B|PKB|Protein kinase B alpha|PKB alpha|Proto-oncogene c-Akt|RAC-PK-alpha|AKT1|PKB|RAC|PKBα|RAC-beta serine/threonine-protein kinase|Protein kinase Akt-2|Protein kinase B beta|PKB beta|RAC-PK-beta|AKT2|PKBβ|RAC-gamma serine/threonine-protein kinase|Protein kinase Akt-3|Protein kinase B gamma|PKB gamma|RAC-PK-gamma|STK-2|AKT3|PKBG|PKBγ
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer.
Synthetic peptide, corresponding to amino acids 450-500 of Human AKT1.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: AKT (P470) polyclonal antibody detects endogenous levels of total AKT protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.