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Home / Primary Antibodies / Phospho Antibodies

Anti-ATM Antibody BHA11304727

SKU : BHA11304727

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Mfr.No.	BS64019
Alternative Names	Serine-protein kinase ATM ; Ataxia telangiectasia mutated ; A-T mutated ; ATM
Antigen	Atm
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	11q22.3
Clonality	polyclonal
Description	The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human ATM around the phosphorylation site of ser1981.
Modification	phospho-S1981
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q13315
Uniprot	Q13315
Weight	370 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-ATM (S1981) polyclonal antibody detects endogenous levels of ATM protein only when phosphorylated at ser1981.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304727	BS64019	50µl	$199.33		Add to Cart
BHA11304727	BS64019	100µl	$314.89		Add to Cart

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