APG6|ATG 6|ATG6|ATG6 autophagy related 6 homolog|Bcl-2-interacting protein beclin|Beclin 1 (coiled coil moesin like BCL2 interacting protein)|Beclin 1 autophagy related|Beclin-1|Beclin1|BECN 1|BECN1|BECN1|Coiled coil myosin like BCL2 interacting protein|Coiled-coil myosin-like BCL2-interacting protein|GT197|Protein GT197 antibod
BECN1 (beclin 1) is a coiled-coil protein that has been implicated as an inhibitor of tumorigenesis. BECN1, which associates with Bcl-2, plays a significant role in autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Autophagy is controlled by the same signal transduction pathway that induces the phosphorylation of the ribosomal protein S6, and both are mediated via amino acids. BECN1 expression in various carcinoma cell lines, such as MCF7, is low, whereas it is ubiquitously expressed in normal breast tissue. In transfected MCF7 cells, BECN1 complements autophagocytosis and, subsequently, inhibits cellular proliferation. Additionally, BECN1 shares structural similarity to the yeast autophagy gene product, APG6, and was one of the first mammalian proteins discovered to mediate autophagy.
Recombinant full length Human Beclin 1.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: Beclin 1 polyclonal antibody detects endogenous levels of Beclin 1 protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.