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Home / Primary Antibodies / Phospho Antibodies

Anti-BAD Antibody BHA11302320

SKU : BHA11302320

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Mfr.No.	BS4021
Alternative Names	BAD, Bcl-2-binding component 6, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like 8 protein, BAD, BBC6, BCL2L8
Antigen	Bad
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	11q13.1
Clonality	polyclonal
Description	Bad is a proapoptotic member of the Bcl-2 family that promotes cell death by displacing Bax from binding to Bcl-2 and Bcl-xL. Survival factors, such as IL-3, inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser136. Phosphorylation at these sites promotes binding of Bad to 14-3-3 proteins to prevent an association between Bad with Bcl-2 and Bcl-xL. Akt phosphorylates Bad at Ser136 to promote cell survival. Bad is phosphorylated at Ser112 both in vivo and in vitro by p90RSK and mitochondria-anchored PKA. Phosphorylation at Ser155 in the BH3 domain by PKA plays a critical role in blocking the dimerization of Bad and Bcl-xL.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human Bad around the phosphorylation site of Serine 136.
Modification	phospho-S136
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q92934
Uniprot	Q92934
Weight	24 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-Bad (S136) polyclonal antibody detects endogenous levels of Bad protein only when phosphorylated at Ser136
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302320	BS4021	50µl	$199.33		Add to Cart
BHA11302320	BS4021	100µl	$314.89		Add to Cart

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