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Home / Primary Antibodies / Phospho Antibodies

Anti-BTK Antibody BHA11308970

SKU : BHA11308970

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Mfr.No.	BS9948M
Alternative Names	Tyrosine-protein kinase BTK ; Agammaglobulinemia tyrosine kinase ; ATK ; B-cell progenitor kinase ; BPK ; Bruton tyrosine kinase ; BTK ; AGMX1 ; ATK ; BPK
Antigen	Btk
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	Xq22.1
Clonality	monoclonal
Description	Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation.
Host	Rabbit
Immunogen	Recombinant antibody.
Modification	phospho-Y223
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q06187
Uniprot	Q06187
Weight	77 kDa

Description	Product: Recombinant Rabbit Monoclonal Antibody. 1TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. Specificity:* This antibody detects endogenous levels of BTK protein only when phosphorylated at Tyr223.
Purity	Protein A affinity purified
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:1,000-1:2,000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308970	BS9948M	50µl	$279.33		Add to Cart
BHA11308970	BS9948M	100µl	$403.78		Add to Cart

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