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Home / Primary Antibodies / Phospho Antibodies

Anti-CDK4 Antibody BHA11307589

SKU : BHA11307589

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Mfr.No.	BS74017
Alternative Names	Cyclin-dependent kinase 4 ; Cell division protein kinase 4 ; PSK-J3 ; PSKJ3 ; CDK4
Antigen	Cdk4
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	12q14.1
Clonality	polyclonal
Description	Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2–Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK)
Host	Rabbit
Immunogen	A phospho specific peptide corresponding to residues surrounding T172 of human CDK4
Modification	phospho-T172
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P11802
Uniprot	P11802
Weight	34 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: CDK4 (phospho-T172) polyclonal antibody detects endogenous levels of CDK4 protein only when phosphorylated at Thr172.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:2000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11307589	BS74017	50µl	$252.67		Add to Cart
BHA11307589	BS74017	100µl	$403.78		Add to Cart

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