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Home / Primary Antibodies / Phospho Antibodies

Anti-CDKN1B Antibody BHA11302431

SKU : BHA11302431

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Mfr.No.	BS4143
Alternative Names	Cyclin-dependent kinase inhibitor 1B ; Cyclin-dependent kinase inhibitor ; p27 ; p27Kip1 ; CDKN1B ; KIP1
Antigen	CDKN1B
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	12p13.1
Clonality	polyclonal
Description	Cell cycle progression is regulated by a series of cyclin-dependent kinases that consist of catalytic subunits, designated Cdks, and activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has been recently described that function as “mitotic inhibitors.” These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner, p16 and a more recently described p16 related inhibitor designated p15. A p21 related protein, p27, has been described as a negative regulator of G1 progression and has been speculated to function as a possible mediator of TGFβ-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and to a lesser extent with cyclin E and Cdk2.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human p27 Kip1 around the phosphorylation site of Serine 10.
Modification	phospho-S10
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P46527
Uniprot	P46527
Weight	27 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-p27 Kip1 (S10) polyclonal antibody detects endogenous levels of p27 Kip1 protein only when phosphorylated at Ser10.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302431	BS4143	50µl	$199.33		Add to Cart
BHA11302431	BS4143	100µl	$314.89		Add to Cart

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