Anti-CPS1 / Carbamoyl-Phosphate Synthetase Antibody BHA10200575

Mfr.No.	1373-MSM1-P0
Alternative Names	Carbamoyl-phosphate synthetase 1 (CPS1) ; Carbamoylphosphate synthetase 1 ; CPSase 1 ; CPSASE1
Antigen	CPS1 / Carbamoyl-Phosphate Synthetase
Categories	Primary Antibodies
Cellular Localization	Finely granular cytoplasmic
Chromosome Location	2q35
Clonality	monoclonal
Description	This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.ĀDeficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
Host	Mouse
Immunogen	Recombinant human CPS1 protein
Isotype	IgG1
Positive Control	HeLa cells. Liver or Hepatocellular Carcinoma (HCC)
Reactivity	Human, Dog
Recombinant	FALSE
Regulatory	RUO

Swissprot	P31327
Uniprot	149252
Gene Id	1373

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

IF, IHC-F, IHC(ap)

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., IF ; IHC-F ; IHC(ap)

Dilution

IF	0.5-1.0μg/ml
IHC-F	0.25-0.5μg/ml for 30 minutes at RT
IHC(ap)

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200575	1373-MSM1-P0	20µg	$204.67		Add to Cart
BHA10200575	1373-MSM1-P0	100µg	$393.20		Add to Cart

Anti-CPS1 / Carbamoyl-Phosphate Synthetase Antibody BHA10200575

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