Anti-LH, alpha (Luteinizing Hormone, alpha) Antibody BHA10200323

Mfr.No.	1081-MSM2-P1ABX
Alternative Names	CG-alpha ; CGA ; Chorionic Gonadotrophin Alpha ; Follicle Stimulating Hormone Alpha ; Follitropin Alpha ; FSH-alpha ; FSHA ; GPH Alpha ; GPHA1 ; LHA
Antigen	LH, alpha (Luteinizing Hormone, alpha)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic (Secreted)
Chromosome Location	6q12-q21
Clonality	monoclonal
Description	This MAb reacts with a protein of ~13kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties. LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.
Host	Mouse
Immunogen	Recombinant full-length hLH alpha protein
Isotype	IgG1 Kappa
Positive Control	Anterior Pituitary
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01215
Uniprot	119689
Gene Id	1081

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

IHC-F

Description

(No special pre-treatment is required for staining of formalin-fixed tissues. Note that HIER is NOT recommended for this antibody.),Optimal dilution for a specific application should be determined., IHC-F

Dilution

IHC-F

1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200323	1081-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-LH, alpha (Luteinizing Hormone, alpha) Antibody BHA10200323

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