Nuclear factor NF-kappa-B p105 subunit|DNA-binding factor KBF1|EBP-1|Nuclear factor of kappa light|polypeptide gene enhancer in B-cells 1|NFKB1|NFkB p105
Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity
Homo Sapiens (Human)
Synthetic peptide, corresponding to amino acids 850-900 of Human NFkB-p105.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: NFkB-p105 (V887) polyclonal antibody detects endogenous levels of NFκB-p105 protein.This antibody does not recognize NFkB-p50 subunit.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.