Oligodendrocyte transcription factor 2|Oligo2|Class B basic helix-loop-helix protein 1|bHLHb1|Class E basic helix-loop-helix protein 19|bHLHe19|Protein kinase C-binding protein 2|Protein kinase C-binding protein RACK17|OLIG2|BHLHB1|BHLHE19|PRKCBP2|RACK17
OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas.
Homo Sapiens (Human)
Synthetic peptide, corresponding to amino acids 120-170 of Human OLIG2.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: OLIG2 (S147) polyclonal antibody detects endogenous levels of OLIG2 protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.