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Home / Primary Antibodies / Phospho Antibodies

Anti-p53 Antibody (P53S15-1C11) Unconjugated BHA10600095

SKU : BHA10600095

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Abwiz Bio Inc.

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Mfr.No.	1186
Antigen	p53
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Conjugate	Unconjugated
Description	p53 is a tumor suppressor protein that plays a large role in the cellular response to DNA damage and other genomic aberrations. p53 activation can lead to cell cycle arrest and DNA repair or to apoptosis (1). p53 phosphorylation occurs at multiple sites in vivo, and p53 can be phosphorylated by several protein kinases in vitro (2). p53 phosphorylation at Ser15 and Ser20 is induced by DNA damage, leading to reduced interaction between p53 and its negative regulator, oncoprotein MDM2 (3). MDM2 targets p53 for ubiquitination and degradation (4). ATM, ATR, and DNA-PK can phosphorylate p53 at Ser15 and Ser37, while Chk2 and Chk1 can phosphorylate p53 at Ser20 (5). MDM2 does not strongly bind phospho p53, causing phospho p53 accumulation and activation in response to DNA damage (3).
Host	Rabbit
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Ser15 of human phospho p53.
Isotype	IgG1 Kappa
Modification	phospho-Ser15
Reactivity	Mouse, Human
Reregulatory	RUO

Clone No	P53S15-1C11

Buffer	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Concentration	0.5mg/ml
Dilutions	1.0 - 0.1 µg/ml
Storage	-20ºC

Applications	WB, FACS
Description	WB ; FACS

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600095	1186	200µl	$466.50		Add to Cart
BHA10600095	1186	20µl	$196.67		Add to Cart

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