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Home / Primary Antibodies / Phospho Antibodies

Anti-PAK5/PAK6/PAK4 Antibody BHA11302746

SKU : BHA11302746

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Mfr.No.	BS4854
Alternative Names	Serine/threonine-protein kinase PAK 4 ; p21-activated kinase 4 ; PAK-4 ; PAK4 ; KIAA1142 ; Serine/threonine-protein kinase PAK 6 ; PAK-5 ; p21-activated kinase 6 ; PAK-6 ; PAK6 ; PAK5 ; Serine/threonine-protein kinase PAK 7 ; p21-activated kinase 5 ; p21-activated kinase 7 ; PAK-7 ; PAK7 ; KIAA1264
Antigen	PAK5/PAK6/PAK4
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction.PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human PAK4 around the phosphorylation site of Serine 474.
Modification	phospho-S474
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	O96013/Q9NQU5/Q9P286
Uniprot	O96013/Q9NQU5/Q9P286
Weight	72 kDa (PAK4), 82 kDa (PAK6), 90 (PAK7)

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-PAK4/5/6 (S474) polyclonal antibody detects endogenous levels of PAK4, PAK5 and PAK6 only when phosphorylated at serine 474, 602, or 560, respectively. The antibody does not cross-react with phosphorylated PAK1, PAK2 or PAK3.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, ICC

Description

WB ; IHC ; ICC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
ICC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302746	BS4854	50µl	$199.33		Add to Cart
BHA11302746	BS4854	100µl	$314.89		Add to Cart

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