Serine/threonine protein kinase SGK|Serine/threonine protein kinase Sgk1|Serine/threonine-protein kinase Sgk1|Serum and glucocorticoid regulated kinase|Serum/glucocorticoid regulated kinase 1|Serum/glucocorticoid regulated kinase|Serum/glucocorticoid-regulated kinase 1|SGK 1|SGK|SGK1|SGK1
Serum- and glucocorticoid-regulated kinase (SGK), also known as SGK1, is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1. SGK is a downstream target of PI 3-kinase-stimulated growth factor signaling, with 3-phosphoinositide-dependent protein kinase 1 (PDK1) capable of phosphorylating the activation-loop of SGK at Threonine-256.
Homo Sapiens (Human)
Synthetic peptide, corresponding to amino acids 51-100 of Human SGK1.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: SGK (P73) polyclonal antibody detects endogenous levels of SGK protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.