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Home / Primary Antibodies / IHC Antibodies

Anti-SMC1A Antibody BHA11302458

SKU : BHA11302458

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Mfr.No.	BS4174
Alternative Names	Structural maintenance of chromosomes protein 1A ; SMC protein 1A ; SMC-1-alpha ; SMC-1A ; Sb1.8 ; SMC1A ; DXS423E ; KIAA0178 ; SB1.8 ; SMC1 ; SMC1L1
Antigen	SMC1A
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	Xp11.22
Clonality	polyclonal
Description	The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated HCAP for human chromosome-associated protein, and Bamacan), and SMC2 (also designated hCAP-E) with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed as a 150 kDa protein in various human tissues, including thymus, testis, and colon. SMC3 is expressed as a 146 kDa nuclear protein in the colon, but can also occur as a secreted proteoglycan (called Bamacan) expressed in testis and brain. Bamacan contains several glycosylation sites and is thought to play a role in basement membrane physiology.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human SMC 1 around the phosphorylation site of Serine 957.
Modification	phospho-S957
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q14683
Uniprot	Q14683
Weight	143 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-SMC1 (S957) polyclonal antibody detects endogenous levels of SMC1protein only when phosphorylated at Ser957
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302458	BS4174	50µl	$199.33		Add to Cart
BHA11302458	BS4174	100µl	$314.89		Add to Cart

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