Small ubiquitin-related modifier 1|SUMO-1|GAP-modifying protein 1|GMP1|SMT3 homolog 3|Sentrin|Ubiquitin-homology domain protein PIC1|Ubiquitin-like protein SMT3C|Smt3C|Ubiquitin-like protein UBL1|SUMO1|SMT3C|SMT3H3|UBL1
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively.
Homo Sapiens (Human)
Synthetic peptide, corresponding to the N-terminal of Human SUMO1.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Sumo1 (S2) polyclonal antibody detects endogenous levels of Sumo1 protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.