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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Thomsen-Friedenreich Antigen / CD176 Antibody BHA10207518

SKU : BHA10207518

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NeoBiotechnologies, Inc.

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Mfr.No.	MSM2-937-P0
Alternative Names	T-F Antigen ; TF Antigen ; Asialoglycophorin ; pan-carcinoma marker ; CD176
Antigen	Thomsen-Friedenreich Antigen / CD176
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Clonality	monoclonal
Description	Recognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. This MAb is capable to agglutinate desialylated red blood cells. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.
Host	Mouse
Immunogen	Neuraminidase-treated human red blood cells
Positive Control	KG1 cells or human colorectal carcinoma tissues.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	Not Applicable
Uniprot	Not Applicable
Gene Id	Not Applicable

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

IF, IHC-F

Description

Optimal dilution for a specific application should be determined., IF ; IHC-F

Dilution

IF	0.5-1μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10207518	MSM2-937-P0	20µg	$204.67		Add to Cart
BHA10207518	MSM2-937-P0	100µg	$393.20		Add to Cart

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