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Home / Primary Antibodies / IHC Antibodies

Anti-ZAP70 Antibody BHA11302773

SKU : BHA11302773

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Mfr.No.	BS4884
Alternative Names	Tyrosine-protein kinase ZAP-70 ; 70 kDa zeta-chain associated protein ; Syk-related tyrosine kinase ; ZAP70 ; SRK
Antigen	ZAP70
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	2q11.2
Clonality	polyclonal
Description	The activation of T lymphocytes by antigens is mediated by the T cell receptor (TCR), which is a multisubunit complex assembled from at least six different genes . The TCR subunits include the Ti a and b chains, the CD3 g , d and e chains and a z -containing homodimer or heterodimer . The protein tyrosine kinase ZAP-70 binds to the phosphorylated immunoreceptor tyrosine-base activation motifs (ITAMs) of the TCR z chain through two src-homology (SH2) domains . This binding results in the phosphorylation of ZAP-70 on multiple tyrosine residues, including Tyr292 and Tyr319 . ZAP-70 is autophosphorylated on Tyr292, which is thought to negatively regulate ZAP-70 function in lymphocytes . Alternatively, ZAP-70 is positively regulated by phosphorylation on Tyr319, which mediates the SH2-dependent interaction between Lck and ZAP-70 .
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human ZAP70 around the phosphorylation site of Tyrosine 315.
Modification	phospho-Y315
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P43403
Uniprot	P43403
Weight	70 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-ZAP70 (Y315) polyclonal antibody detects endogenous levels of ZAP70 protein only when phosphorylated at Tyr315.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302773	BS4884	50µl	$199.33		Add to Cart
BHA11302773	BS4884	100µl	$314.89		Add to Cart

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