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Home / Primary Antibodies / Monoclonal Antibodies

AHA1 Antibody, Clone 25F2.D10 - SMC-173

BHA11901116
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+1 866.986.9598
Email
[email protected]
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Swissprot Q8BK64, Q8BK64
Accession Number NP_666148.1
Gene Id 217737
Target AHA1, AHA1
Clone No 25F2.D10, 25F2.D10
Research Area Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking
Buffer 0.02M potassium phosphate, 0.15M sodium chloride, pH7.2
Concentration 1.59 mg/ml
Dilutions WB (1:1000), IHC (1:100), ICC/IF (1:1000), IP ( 1:1000); optimal dilutions for assays should be determined by the user., WB (1:1000), IHC (1:100), ICC/IF (1:1000), IP ( 1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4)., Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~38kDa. Can run up to 45kDa on SDS Page.
Storage -20ºC
Storage Buffer 0.02M potassium phosphate, 0.15M sodium chloride, pH7.2 *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications ELISA, IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP ; ELISA
Dilution WB (1:1000), IHC (1:100), ICC/IF (1:1000), IP ( 1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub.

2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.

3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.

4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

, 1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub.

2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.

3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.

4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11901116-1 SMC-173D Unconjugated 100 ug $345
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BHA11901116-2 SMC-173C Unconjugated 25 ug $156
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BHA11901116-3 SMC-173D-A390 ATTO 390 100 ug $399
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BHA11901116-4 SMC-173D-A488 ATTO 488 100 ug $398
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BHA11901116-5 SMC-173D-A594 ATTO 594 100 ug $398
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BHA11901116-6 SMC-173D-ALP Alkaline Phosphatase 100 ug $392
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BHA11901116-7 SMC-173D-APC APC 100 ug $397
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BHA11901116-8 SMC-173D-BI Biotin 100 ug $394
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BHA11901116-9 SMC-173D-FITC FITC 100 ug $389
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BHA11901116-10 SMC-173D-HRP HRP 100 ug $385
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BHA11901116-11 SMC-173D-PCP PerCP 100 ug $397
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BHA11901116-12 SMC-173D-RPE RPE 100 ug $395
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BHA11901116-13 SMC-173S Unconjugated 12 ug $44
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