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Home / Antibodies

Anti-SCN4A Antibody BHA11303026

SKU : BHA11303026

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Mfr.No.	BS5812
Alternative Names	Sodium channel protein type 4 subunit alpha ; SkM1 ; Sodium channel protein skeletal muscle subunit alpha ; Sodium channel protein type IV subunit alpha ; Voltage-gated sodium channel subunit alpha Nav1.4 ; SCN4A
Antigen	SCN4A
Categories	Primary Antibodies
Chromosome Location	17q23.3
Clonality	polyclonal
Description	Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disulfide-linked β2 subunit. The two β subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. The β1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, β1 and β2 are highly expressed in Purkinje cells, and β1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 472-517 of Human Na+ CP type IVα.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P35499
Uniprot	P35499
Weight	208 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: Na+ CP type IVα polyclonal antibody detects endogenous levels of Na+ CP type IVα protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303026	BS5812	50µl	$190.44		Add to Cart
BHA11303026	BS5812	100µl	$294.44		Add to Cart

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