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Home / Antibodies

Anti-SLC8A1 Antibody BHA11303030

SKU : BHA11303030

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Mfr.No.	BS5816
Alternative Names	Sodium/calcium exchanger 1 ; Na(+)/Ca(2+)-exchange protein 1 ; Solute carrier family 8 member 1 ; CNC ; NCX1
Antigen	SLC8A1
Categories	Primary Antibodies
Chromosome Location	2p22.1
Clonality	polyclonal
Description	Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 336-381 of Human SLC8A1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P32418
Uniprot	P32418
Weight	108 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: SLC8A1 polyclonal antibody detects endogenous levels of SLC8A1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303030	BS5816	50µl	$190.44		Add to Cart
BHA11303030	BS5816	100µl	$294.44		Add to Cart

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