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Home / Antibodies

Anti-TWIST1 Antibody BHA11300007

SKU : BHA11300007

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Mfr.No.	AP0020
Alternative Names	Twist-related protein 1 ; Class A basic helix-loop-helix protein 38 ; bHLHa38 ; H-twist ; BHLHA38 ; TWIST
Antigen	TWIST1
Categories	Primary Antibodies
Chromosome Location	7p21.1
Clonality	polyclonal
Description	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to amino acids 1-50 of Human TWIST1.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q15672
Uniprot	Q15672
Weight	22 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: TWIST1 (M1) polyclonal antibody detects endogenous levels of TWIST1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300007	AP0020	50µl	$190.44		Add to Cart
BHA11300007	AP0020	100µl	$294.44		Add to Cart

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