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Home / Primary Antibodies

Caspase-9 Antibody (R30673)

SKU : BHA17104274

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NSJ Bioreagents

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Mfr.No.	R30673
Clonality	Polyclonal
Description	Caspase-9, also called APAF3, is an initiator caspase, encoded by the CASP9 gene. The gene is mapped to chromosome 1p36.3-p36.1 by FISH. CASP9 is identified as a member of the caspase family that participates in <a href=../search_result.php?search_txt=caspase-3>CASP3</a> activation in vitro. And it also regarded as the most upstream member of the apoptotic protease cascade that is triggered by Cytochrome C and dATP. The crystal structure of CASP9 is complex with the BIR3 in an inhibitory domain of XIAP at 2.4-angstrom resolution and the gene contains 9 exons and spans approximately 35 kb of genomic DNA. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of <a href=../search_result.php?search_txt=cytochrome%20c>Cytochrome C</a> and dATP, an event that leads to CASP9 activation. Activity increases dramatically upon association with the apoptosome complex. And the majority of CASP9 knockout mice died perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	Amino acids 183-198 (SNIDCEKLRRRFSSLH-human) were used as the immunogen for this Caspase-9 antibody. This sequence is on the large subunit.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	Caspase-9
Uniprot	P55211

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the Caspase-9 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104274	R30673	100 ug	$419		Add to Cart

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