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Home / Primary Antibodies / Polyclonal Antibodies

FGFR3 Antibody (pTyr647 + pTyr648) - SPC-983

BHA11912510
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Swissprot P22607
Accession Number NP_000133
Gene Id 2261
Target FGFR3 (pTyr647 + pTyr648)
Research Area Cardiovascular System, Angiogenesis, Cardiovascular Growth Factors, FGF, Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Receptor Tyrosine Kinases, Neurogenesis, Cancer, Stem Cells, Lineage Markers, Ectoderm, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Expressed in brain, kidney and testis
Scientific Background FGFR3 is a receptor-tyrosine kinase that is activated upon binding fibroblast growth factor (FGF). Extracellular ligand binding induces homo- or hetero- dimerization of FGFR to activate signalling. FGFRs have an essential role in regulating cellular differentiation, proliferation and apoptosis. The FGFR3 isoform is specifically involved in chondrocyte development which is physiologically linked to normal skeleton development. Defects in FGFR3 can lead to dwarfism. Overexpressed FGFR3 can promote activation of SHP2 and STAT signalling pathways.Mutations which promote constitutive dimerization of FGFR and kinase activation or impairs internalization and degradation of the receptor have been observed in bladder, skin and oral cancers.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 87.710 (110-120) kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11912510-1 SPC-983D Unconjugated 100 ul $331
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BHA11912510-2 SPC-983D-A390 ATTO 390 100 ul $385
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BHA11912510-3 SPC-983D-A488 ATTO 488 100 ul $384
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BHA11912510-4 SPC-983D-A594 ATTO 594 100 ul $384
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BHA11912510-5 SPC-983D-BI Biotin 100 ul $380
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BHA11912510-6 SPC-983D-FITC FITC 100 ul $375
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