Rabbit Anti-Human GSK-3beta Polyclonal

Mfr.No.	SPC-169, SPC-169D, SPC-169C, SPC-169D-A390, SPC-169D-A488, SPC-169D-A594, SPC-169D-ALP, SPC-169D-APC, SPC-169D-BI, SPC-169D-FITC, SPC-169D-HRP, SPC-169D-PCP, SPC-169D-RPE, SPC-169S
Immunogen Species	Human
Alternative Names	Glycogen Synthase kinase 3 beta Antibody, GSK 3 beta Antibody, GSK 3B Antibody, GSK-3 beta Antibody, GSK3B Antibody, GSK3B_Human Antibody, GSK3beta isoform Antibody
Antigen	GSK3 Beta
Categories	Antibodies
Cellular Localization	Cytoplasm, Nucleus, Cell Membrane
Certificate Of Analysis	1 ug/ml of SPC-169 was sufficient for detection of GSK-beta in 20 ug of Hela cell lysate by colorimetric immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human GSK-3beta Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide corresponding to the sequence near the C-terminus of human GSK-3Beta, Homo Sapiens (Human)
Immunogen Region	Synthetic peptide corresponding to the sequence near the C-terminus of human GSK-3Beta
Launch Date	2012/07/25
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human, Bovine
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Bovine, Human

Swissprot	P49841
Accession Number	NP_001139628.1
Gene Id	2932
Target	GSK3 Beta
Research Area	Cell Signaling, Post-translational Modifications, Phosphorylation

Buffer	PBS pH7.4
Concentration	1.3 mg/ml
Dilutions	WB (1:2000), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Glycogen synthase kinase 3, is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. It has also been shown to regulate immune and migratory processes, and is tied to pathways of cell proliferation and apoptosis (1-3). In mammals, it is encoded by two genes- GSK-3Alpha and GSK-3Beta. They are structurally similar, but functionally non-identical. GSK-3Alpha is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3Beta negatively regulates cardiac hypertrophy and cardiac development through its effect on WNT signaling (4). GSK-3 alpha and GSK-3 beta share 85% amino acid identity. GSK-3 has been implicated in a number of diseases including Type II diabetes, Alzheimer's, cancer and bipolar (4, 5).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~47kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4 *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:2000), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Jope R.S. (2007) Neurochem Res. 32(4-5): 577-595. 2. Wang H. (2011) Cytokind. 53(2): 130-140. 3. Mills C.N. (2011) Front Mol Neurosci. 47(4): 47. 4. Hardt S.E., Sadoshima J. (2002) Circ Res. 90(10): 1055-1063. 5. Doble D.W., Woodgett J.R. (2003) J Cell Sci. 116(Pt7): 1175-1186.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11906962-1	SPC-169D	Unconjugated	100 ug	$277	Add to Cart
BHA11906962-2	SPC-169C	Unconjugated	25 ug	$125	Add to Cart
BHA11906962-3	SPC-169D-A390	ATTO 390	100 ug	$331	Add to Cart
BHA11906962-4	SPC-169D-A488	ATTO 488	100 ug	$330	Add to Cart
BHA11906962-5	SPC-169D-A594	ATTO 594	100 ug	$330	Add to Cart
BHA11906962-6	SPC-169D-ALP	Alkaline Phosphatase	100 ug	$323	Add to Cart
BHA11906962-7	SPC-169D-APC	APC	100 ug	$329	Add to Cart
BHA11906962-8	SPC-169D-BI	Biotin	100 ug	$326	Add to Cart
BHA11906962-9	SPC-169D-FITC	FITC	100 ug	$321	Add to Cart
BHA11906962-10	SPC-169D-HRP	HRP	100 ug	$317	Add to Cart
BHA11906962-11	SPC-169D-PCP	PerCP	100 ug	$329	Add to Cart
BHA11906962-12	SPC-169D-RPE	RPE	100 ug	$327	Add to Cart
BHA11906962-13	SPC-169S	Unconjugated	12 ug	$44	Add to Cart

GSK-3beta Antibody - SPC-169