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Home / Primary Antibodies / IHC Antibodies

LRP1 Antibody

SKU : BHA10557208

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA013091KA01HU
Alternative Names	APR; LRP; A2MR; CD91; APOER; TGFBR5; IGFBP3R
Categories	Primary Antibodies
Description	The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
Hgnc	29911
Host	Rabbit
Immunogen	Recombinant protein of Human LRP1
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Keratosis pilaris atrophicans (KPA)
Isotype	IgG
Mgi	1927354
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane, Single-pass type I membrane protein, Membrane, coated pit, SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane, Peripheral membrane protein, Extracellular side, Membrane, coated pit, SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm, Nucleus

Antigen	LRP1
Rgd	1597424
Uniprot	Q07954
Gene Id	4035
Database Links	HGNC:6692 OMIM:107770 KEGG:hsa:4035 STRING:9606.ENSP00000243077 UniGene:Hs.162757
Function	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission
Pathway	Cholesterol metabolism
Protein Families	LDLR family
Tissue Specificity	Most abundant in liver, brain and lung.
Weight	31,631 Da

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557208	CSB-PA013091KA01HU	100μl	$387.33		Add to Cart

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