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RIPK1 Antibody

BHA10549641
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Rgd 1311010
Uniprot Q13546
Database Links

HGNC:10019

OMIM:603453

KEGG:hsa:8737

STRING:9606.ENSP00000259808

UniGene:Hs.519842
Function Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis Necroptosis NOD-like receptor signaling pathway Toll-like receptor signaling pathway
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
Format Liquid
Purification Antigen Affinity purified
Purity Antigen Affinity purified
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Applications ELISA, WB
Description ELISA ; WB, WB ; ELISA
Tested Application ELISA,WB
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
SKU Supplier No. Size Your price Quantity
BHA10549641 CSB-PA019735GA01HU 150μl $610.56
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BHA10549641 CSB-PA019735GA01HU 50μl $269.50
Add to Cart