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Home / Antibodies

RYR1 Antibody

SKU : BHA10556450

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA050519
Alternative Names	ryanodine receptor 1 (skeletal)
Antigen	RYR1
Categories	Primary Antibodies
Conjugate	Non-conjugated
Description	This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described.
Host	Rabbit
Immunogen	Synthetic peptide of human RYR1
Involvement In Disease	Malignant hyperthermia 1 (MHS1); Central core disease of muscle (CCD); Multiminicore disease with external ophthalmoplegia (MMDO)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described.
Species	Homo Sapiens (Human)
Subcellular Location	Sarcoplasmic reticulum membrane, Multi-pass membrane protein, Sarcoplasmic reticulum

Uniprot	P21817
Database Links	HGNC:10483 OMIM:117000 KEGG:hsa:6261 STRING:9606.ENSP00000352608 UniGene:Hs.466664
Function	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules
Pathway	Calcium signaling pathway Apelin signaling pathway
Protein Families	Ryanodine receptor (TC 1.A.3.1) family, RYR1 subfamily
Tissue Specificity	Skeletal muscle and brain (cerebellum and hippocampus).

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

ELISA	1:1000-1:2000
WB	1:200-1:1000

Tested Application

ELISA,WB;ELISA:1:1000-1:2000,WB:1:200-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10556450	CSB-PA050519	100μl	$279.30		Add to Cart
BHA10556450	CSB-PA050519	50μl	$168		Add to Cart

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