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Home / Primary Antibodies / IHC Antibodies

SIRPA Antibody

SKU : BHA10559773

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA973893
Alternative Names	Bit; MFR; MYD-1 antigen; MYD1; Macrophage fusion receptor
Categories	Primary Antibodies
Clonality	polyclonal
Description	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.Kentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066. Thomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127. Shu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301. Gurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human SIRP-alpha1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Kentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066. Thomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127. Shu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301. Gurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Sirp α1 protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Antigen	SIRPA
Uniprot	P78324
Database Links	HGNC:9662 OMIM:602461 KEGG:hsa:140885 STRING:9606.ENSP00000348307 UniGene:Hs.581021
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Pathway	Osteoclast differentiation
Tissue Specificity	Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559773	CSB-PA973893	100ul	$297		Add to Cart

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