SREBP-1 Polyclonal Antibody-BHA13703221

Mfr.No.	ABP52497
Alternative Names	SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1
Antigen	SREBP-1
Background	SREBF1 encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. Sterol regulatory element-binding protein 1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
Categories	Primary Antibodies
Clonality	Polyclonal
Description	Rabbit Anti-SREBP-1 Polyclonal Antibody
Formulation	Liquid solution
Host	Rabbit
Immunogen	Synthesized peptide derived from human SREBP-1 around the non-phosphorylation site of S439
Immunogen Region	Synthesized peptide derived from human SREBP-1 around the non-phosphorylation site of S439
Isotype	Rabbit IgG
Others	SREBP-1 Polyclonal Antibody detects endogenous levels of SREBP-1 protein. Observed Band (KD): 122
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity	Human, Rat
Shipping	Gel pack with blue ice.
Tag	Sterol regulatory element-binding protein 1
Note	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Accession Number	P36956
Gene Id	6720

Concentration	1 mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Storage Buffer	PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instructions	Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Applications	ELISA, IHC-P, WB
Dilution	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.