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Home / Antibodies

STING Antibody (TMEM173) (F51890)

SKU : BHA17101981

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NSJ Bioreagents

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Mfr.No.	F51890, F51890-0.08ML, F51890-0.4ML
Antigen	STING
Clonality	Polyclonal
Description	Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. (UniProt)
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 311-340 from the human protein was used as the immunogen for this STING antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q86WV6

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the STING antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	FACS, WB, ELISA
Dilution	Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101981-1	F51890-0.08ML	0.08ml	$165		Add to Cart
BHA17101981-2	F51890-0.4ML	0.4ml	$379		Add to Cart

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