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Home / Primary Antibodies / Polyclonal Antibodies

APIP Antibody (CSB-PA555100)

SKU : BHA10549990

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA555100
Alternative Names	APAF1 interacting protein
Categories	Primary Antibodies
Description	APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria.
Host	Rabbit
Immunogen	Fusion protein of Human APIP
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria.
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm

Antigen	APIP
Uniprot	Q96GX9
Gene Id	51074
Database Links	HGNC:17581 OMIM:612491 KEGG:hsa:51074 STRING:9606.ENSP00000379133 UniGene:Hs.447794
Function	Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Protein Families	Aldolase class II family, MtnB subfamily
Tissue Specificity	Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Weight	22,858 Da

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

ELISA	1:500-1:5000
WB	1:200-1:1000
IHC	1:25-1:100

Tested Application

ELISA,WB,IHC;ELISA:1:500-1:5000,WB:1:200-1:1000,IHC:1:25-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10549990	CSB-PA555100	50ul	$166		Add to Cart
BHA10549990	CSB-PA555100	100ul	$299		Add to Cart

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