Class B basic helix-loop-helix protein 1 ; bHLHb1 ; Class E basic helix-loop-helix protein 19 ; bHLHe19 ; Protein kinase C-binding protein 2 ; Protein kinase C-binding protein RACK17 ; BHLHB1 ; BHLHE19 ; PRKCBP2 ; RACK17
Categories
Elisa
Function
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Specificity
Natural and recombinant Human Oligodendrocyte transcription factor 2
Subcellular Location
Nucleus Cytoplasm The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.