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ELISA Kit for Mouse Transcription factor GATA-4

SKU : BHE13804226

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0374m
Alternative Names	GATA-binding factor 4 ; Gata-4
Categories	Elisa
Function	Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Regulates the expression of the HSP47/J6 gene in F9 cells. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement.
Specificity	Natural and recombinant Mouse Transcription factor GATA-4
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	GATA4_MOUSE
Method Type	Sandwich
Platform	PF00320
Protein Name	Transcription factor GATA-4
Sensitivity	0.09ng/mL
Sequence	50: MYQSLAMAAN ; HGPPPGAYEA ; GGPGAFMHSA ; GAASSPVYVP ; TPRVPSSVLG ; 100: LSYLQGGGSA ; AAAGTTSGGS ; SGAGPSGAGP ; GTQQGSPGWS ; QAGAEGAAYT ; 150: PPPVSPRFSF ; PGTTGSLAAA ; AAAAAAREAA ; AYGSGGGAAG ; AGLAGREQYG ; 200: RPGFAGSYSS ; PYPAYMADVG ; ASWAAAAAAS ; AGPFDSPVLH ; SLPGRANPGR ; 250: HPNLDMFDDF ; SEGRECVNCG ; AMSTPLWRRD ; GTGHYLCNAC ; GLYHKMNGIN ; 300: RPLIKPQRRL ; SASRRVGLSC ; ANCQTTTTTL ; WRRNAEGEPV ; CNACGLYMKL ; 350: HGVPRPLAMR ; KEGIQTRKRK ; PKNLNKSKTP ; AGPAGETLPP ; SSGASSGNSS ; 400: NATSSSSSSE ; EMRPIKTEPG ; LSSHYGHSSS ; MSQTSVCVRP ; RALHPSSAVC ; 440: SKLSPQGYAS ; PVTQTSQASS ; KQDSWNSLVL ; ADSHGDIITA ;
Sequence Length	440
String	Q08369
Sub Unit	Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Uniprot	Q08369
Gene Name	Gata4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14463
Unigene	Mm.247669

Reference	1. "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart." Arceci R.J., King A.A., Simon M.C., Orkin S.H., Wilson D.B. Mol. Cell. Biol.13:2235-2246(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut." Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T. J. Biol. Chem.269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS 3. "Murine GATA-4 is expressed in heart and gut tissues." Morrisey E.E., Parmacek M.S. Submitted (1997-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. Katsuoka F., Motohashi H., Yamamoto M. Submitted (1999-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6 X DBA/2. tissue: Heart. 5. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain. 8. "Regulation of J6 gene expression by transcription factor GATA-4." Bielinska M., Wilson D.B. Biochem. J.307:183-189(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION 9. "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy." Molkentin J.D., Lu J.-R., Antos C.L., Markham B., Richardson J., Robbins J., Grant S.R., Olson E.N. Cell93:215-228(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFATC4 10. "The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression." Lee Y., Shioi T., Kasahara H., Jobe S.M., Wiese R.J., Markham B.E., Izumo S. Mol. Cell. Biol.18:3120-3129(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NKX2-5 11. "Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors." Kim T.-G., Chen J., Sadoshima J., Lee Y. Mol. Cell. Biol.24:10151-10160(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JARID2 12. "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding." Rath N., Wang Z., Lu M.M., Morrisey E.E. Mol. Cell. Biol.25:8864-8873(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LMCD1 13. "Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors." Farin H.F., Bussen M., Schmidt M.K., Singh M.K., Schuster-Gossler K., Kispert A. J. Biol. Chem.282:25748-25759(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBX18 14. "PRC2 directly methylates GATA4 and represses its transcriptional activity." He A., Shen X., Ma Q., Cao J., von Gise A., Zhou P., Wang G., Marquez V.E., Orkin S.H., Pu W.T. Genes Dev.26:37-42(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-299

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